using AutoMapper; using IRaCIS.Application.ExpressionExtend; using IRaCIS.Core.Application.Contracts; using IRaCIS.Core.Domain.Interfaces; using IRaCIS.Core.Domain.Models; using System; using System.Collections.Generic; using System.Linq.Dynamic.Core; using System.Linq; using IRaCIS.Core.Domain.Share.AuthUser; using IRaCIS.Core.Domain.Share; using Microsoft.EntityFrameworkCore.Internal; namespace IRaCIS.Core.Application { public class ReportService : IReportService { private readonly ITURepository _tURepository; private readonly ITRRepository _tRRepository; private readonly IRSRepository _rSRepository; private readonly IReportRepository _reportRepository; private readonly IVisitStageRepository _visitStageRepository; private readonly ISubjectVisitRepository _subjectVisitRepository; private readonly IWorkloadTPRepository _workloadTPRepository; private readonly IWorkloadGlobalRepository _workloadGlobalRepository; private readonly IMapper _mapper; private readonly IUserInfo _userInfo; private string linkGroupId; public ReportService(ITURepository tURepository, ITRRepository tRRepository, IRSRepository rSRepository, IReportRepository reportRepository, IWorkloadTPRepository workloadTPRepository, IVisitStageRepository visitStageRepository, ISubjectVisitRepository subjectVisitRepository, IWorkloadGlobalRepository workloadGlobalRepository, IMapper mapper, IUserInfo userInfo) { _tURepository = tURepository; _tRRepository = tRRepository; _rSRepository = rSRepository; _reportRepository = reportRepository; _workloadTPRepository = workloadTPRepository; _visitStageRepository = visitStageRepository; _subjectVisitRepository = subjectVisitRepository; _workloadGlobalRepository = workloadGlobalRepository; _mapper = mapper; _userInfo = userInfo; } public bool AddLesion(List lesionList, ReportDTO report) { TU lastTu = _tURepository.GetAll().OrderByDescending("TUSEQ").FirstOrDefault(); int tuSeq = 101; if (lastTu != null) { tuSeq = lastTu.TUSEQ + 1; } TR lastTr = _tRRepository.GetAll().OrderByDescending("TRSEQ").FirstOrDefault(); int trSeq = 1; if (lastTr != null) { trSeq = lastTr.TRSEQ + 1; } foreach (var lesion in lesionList) { var linkId = lesion.TULNKID; if (string.IsNullOrWhiteSpace(lesion.TULNKID)) { linkId = (lesion.TUORRES == "TARGET") ? "T" + tuSeq.ToString() : "NT" + tuSeq.ToString(); } _tURepository.Add(new TU { STUDYID = lesion.STUDYID, LesionType = lesion.LesionType, USUBJID = lesion.USUBJID, TUSEQ = tuSeq, TULNKID = linkId, TUTESTCD = lesion.TUTESTCD, TUTEST = lesion.TUTEST, TUORRES = lesion.TUORRES, TUSTRESC = lesion.TUSTRESC, TULOC = lesion.TULOC, LocDescription = lesion.LocDescription, TULAT = lesion.TULAT, TUDIR = lesion.TUDIR, TUPORTOT = lesion.TUPORTOT, TUMETHOD = lesion.TUMETHOD, TUEVAL = lesion.TUEVAL, VISIT = lesion.VISIT, VISITNUM = lesion.VISITNUM, VISITDY = lesion.VISITDY, TUREFID = lesion.TUREFID, TUACPTFL = lesion.TUACPTFL, TUEVALID = _userInfo.ReviewerCode,//lesion.TUEVALID, TUGRPID = string.Empty, TUDY = lesion.TUDY,// 检查日 EPOCH = lesion.EPOCH, TUDTC = lesion.TUDTC, TUNAM = lesion.TUNAM, TUSPID = lesion.TUSPID, TpCode = report.TpCode }); _tRRepository.Add(new TR { STUDYID = lesion.STUDYID, USUBJID = lesion.USUBJID, TRSEQ = trSeq, TRLNKID = linkId, TRGRPID = lesion.TRGRPID, TRLNKGRP = linkGroupId, TRTESTCD = lesion.TRTESTCD, TRTEST = lesion.TRTEST, TRORRES = lesion.TRORRES, TRORRESU = lesion.TRORRESU, TRNAM = lesion.TUNAM, TRMETHOD = lesion.TUMETHOD, TREVAL = lesion.TUEVAL, TREVALID = _userInfo.ReviewerCode,//lesion.TUEVALID, TRACPTFL = lesion.TUACPTFL, CoveredLesion = true, Note = lesion.Note, VISITNUM = lesion.VISITNUM, VISIT = lesion.VISIT, VISITDY = lesion.VISITDY, EPOCH = lesion.EPOCH, TRDTC = lesion.TRDTC, TRDY = lesion.TRDY, TpCode = report.TpCode }); tuSeq++; trSeq++; } return _rSRepository.SaveChanges(); } private IList GetBLLesion(string trialCode, string SubjectCode, string tpcodeGroup) { int[] t = { 1, 2, 3 }; var query = from tu in _tURepository.Find(u => t.Contains(u.LesionType) && u.STUDYID == trialCode && u.USUBJID == SubjectCode && u.TpCode.Contains(tpcodeGroup) /*u.TUEVALID==_userInfo.ReviewerCode*/) join tr in _tRRepository.Find(u => u.VISITNUM == 1 && u.STUDYID == trialCode && u.USUBJID == SubjectCode && u.TREVALID == _userInfo.ReviewerCode) on tu.TULNKID equals tr.TRLNKID into temp from tr in temp.DefaultIfEmpty() select new LesionInformation { TUId = tu.Id, LesionType = tu.LesionType, TULNKID = tu.TULNKID, TUSEQ = tu.TUSEQ, TULOC = tu.TULOC, LocDescription = tu.LocDescription, TULAT = tu.TULAT, TUDIR = tu.TUDIR, TUPORTOT = tu.TUPORTOT, TRORRES = tr.TRORRES, VISITNUM = tu.VISITNUM, Note = tr.Note }; return query.ToList(); } public BaseLineReportDTO GetBaseLineReport(string trialCode, string subjectCode, string tpCode) { var tpcodeGroup = tpCode.Substring(tpCode.Length - 3, 3); var report = _reportRepository.FindSingleOrDefault(u => u.TrialCode == trialCode && u.SubjectCode == subjectCode && u.VisitNum == 1); ; BaseLineReportDTO result = new BaseLineReportDTO { LesionInformation = GetBLLesion(trialCode, subjectCode, tpcodeGroup).Where(u => u.VISITNUM == 1).ToList(), ReportResult = _mapper.Map(report) }; return result; } public VisitLesionInfo GetVisitLesion(string trialCode, string subjectCode, decimal visitNum, string tpCode) { var tpcodeGroup = tpCode.Substring(tpCode.Length - 3, 3); VisitLesionInfo visitLesionInfo = new VisitLesionInfo(); var blLesionList = GetBLLesion(trialCode, subjectCode, tpcodeGroup); int[] t = { 1, 2, 3 }; var query = from tu in _tURepository.Find(u => u.STUDYID == trialCode && u.USUBJID == subjectCode && u.TpCode.Contains(tpcodeGroup) /*u.TUEVALID == _userInfo.ReviewerCode*/) join tr in _tRRepository.Find(u => u.VISITNUM == visitNum && u.STUDYID == trialCode && u.USUBJID == subjectCode && u.TpCode.Contains(tpcodeGroup)) on tu.TULNKID equals tr.TRLNKID into temp from tr in temp.DefaultIfEmpty() select new LesionInformation { TUId = tu.Id, TUSEQ = tu.TUSEQ, TULOC = tu.TULOC, LesionType = tu.LesionType, TULNKID = tu.TULNKID, LocDescription = tu.LocDescription, TULAT = tu.TULAT, TUDIR = tu.TUDIR, TUPORTOT = tu.TUPORTOT, TRORRESU = tr.TRORRESU, TRORRES = tr.TRORRES, Note = tr.Note, CoveredLesion = tr.CoveredLesion, VISITNUM = tr.VISITNUM }; var list = query.ToList(); var currentVisitLesion = list.Where(u => t.Contains(u.LesionType) && u.VISITNUM == visitNum).ToList(); foreach (var item in blLesionList) { var temp = _mapper.Map(item); temp.CurrentLesion = currentVisitLesion.Where(u => u.STUDYID == item.STUDYID && u.USUBJID == item.USUBJID && u.TUEVAL == item.TUEVAL && u.TULNKID == item.TULNKID).FirstOrDefault() ?? new LesionInformation(); visitLesionInfo.BLLesionList.Add(temp); } List blIdList = blLesionList.Select(u => u.TUId).ToList(); List visitIdList = currentVisitLesion.Where(u => t.Contains(u.LesionType)).Select(u => u.TUId).ToList(); var visitLesion = visitIdList.Except(blIdList); foreach (var item in visitLesion) { VisitLesion tempLesion = new VisitLesion(); tempLesion.CurrentLesion = currentVisitLesion.Where(u => u.TUId == item).FirstOrDefault() ?? new LesionInformation(); tempLesion.LesionType = tempLesion.CurrentLesion.LesionType; tempLesion.TUSEQ = tempLesion.CurrentLesion.TUSEQ; visitLesionInfo.BLLesionList.Add(tempLesion); } // 以往新病灶，病灶类型为5，且访视编号小于当前访视，且不是基线 var previousLesion = list.Where(u => u.VISITNUM < visitNum && u.VISITNUM != 1 && u.LesionType == 5).ToList(); foreach (var item in previousLesion) { var temp = _mapper.Map(item); temp.CurrentLesion = currentVisitLesion.Where(u => u.TULNKID==item.TULNKID && u.STUDYID == item.STUDYID && u.USUBJID == item.USUBJID && u.TUEVAL == item.TUEVAL).FirstOrDefault() ?? new LesionInformation(); visitLesionInfo.PreviousNewLesionList.Add(temp); } visitLesionInfo.EquivocalNewLesionList = list.Where(u => u.VISITNUM <= visitNum && u.LesionType == 4).ToList(); visitLesionInfo.UnequivocalNewLesionList = list.Where(u => u.VISITNUM == visitNum && u.LesionType == 5).ToList(); var report = _reportRepository.FindSingleOrDefault(u => u.TrialCode == trialCode && u.SubjectCode == subjectCode && u.VisitNum == visitNum); ; visitLesionInfo.ReportResult = _mapper.Map(report); var rs = _rSRepository.Find(u => u.STUDYID == trialCode && u.USUBJID == subjectCode && u.RSEVALID == _userInfo.ReviewerCode && u.VISITNUM == visitNum); var target = rs.FirstOrDefault(u => u.RSTESTCD == "TRGRESP"); var non_target = rs.FirstOrDefault(u => u.RSTESTCD == "NTRGRESP"); var overall = rs.FirstOrDefault(u => u.RSTESTCD == "OVRLRESP"); visitLesionInfo.Efficacy = new EfficacyAssessment { TargetLesion = target?.RSORRES, TargetLesionNote = target?.Note, Non_targetLesion = non_target?.RSORRES, Non_targetLesionNote = non_target?.Note, OverallAssessment = overall?.RSORRES, OverallAssessmentNote = overall?.Note }; var preRS = _rSRepository.Find(u => u.STUDYID == trialCode && u.USUBJID == subjectCode && u.VISITNUM < visitNum && u.RSTESTCD == "OVRLRESP" && u.RSEVAL == _userInfo.ReviewerCode /*&& u.VISITNUM == visitNum*/) .Select(u => new PreviousOverallAssessment { VisitName = u.VISIT, OverallAssessment = u.RSORRES }).ToList(); visitLesionInfo.PreviousOverallAssessment = preRS; var targetList = _tRRepository.Find(u => (!string.IsNullOrWhiteSpace(u.TRLNKID)) && (!u.TRLNKID.Contains("N")) && u.STUDYID == trialCode && u.USUBJID == subjectCode && u.TpCode.Contains(tpcodeGroup) && u.VISITNUM < visitNum).ToList(); var q = from ttt in targetList group ttt by ttt.VISIT into s select new MinVisit { MinSum = s.Sum(p => p.TRORRES_Double), MinVistName = s.Key }; var tempList = q.ToList(); MinVisit min = new MinVisit(); if (tempList.Count>0) { min = tempList.FirstOrDefault(); } foreach (var item in tempList) { if (min.MinSum > item.MinSum) { min = item; } } visitLesionInfo.MinVisitInfo = min; return visitLesionInfo; } public bool SubmiteReport(Guid tpId) { // 提交报告 同时查询VisitStage（项目访视计划，看是否需要添加全局） var query = from workloadTp in _workloadTPRepository.GetAll().Where(u => u.Id == tpId) join subjectVisit in _subjectVisitRepository.GetAll() on workloadTp.SubjectVisitId equals subjectVisit.Id join visitStage in _visitStageRepository.GetAll() on new { workloadTp.TrialId, subjectVisit.VisitNum } equals new { visitStage.TrialId, visitStage.VisitNum } select new { WorkloadTp = workloadTp, VisitNum = subjectVisit.VisitNum, VisitName = subjectVisit.VisitName, NeedGlobal = visitStage.NeedGlobal }; var workload = query.ToList().FirstOrDefault(); if (workload != null) { if (workload.NeedGlobal)// 需要产生全局 { var group = workload.WorkloadTp.TimepointCode.Substring(workload.WorkloadTp.TimepointCode.Length - 2, 2); _workloadGlobalRepository.Add(new WorkloadGlobal { GlobalCode = workload.WorkloadTp.TimepointCode + "G" + group, ReviewerId = Guid.Empty, SiteId = workload.WorkloadTp.SiteId, Status = -1, SubjectId = workload.WorkloadTp.SubjectId, TrialId = workload.WorkloadTp.TrialId, VisitId = workload.WorkloadTp.SubjectVisitId, VisitNum = workload.VisitNum, VisitName = workload.VisitName, UpdateTime = DateTime.Now }); } } return _workloadTPRepository.Update(u => u.Id == tpId, s => new WorkloadTP { Status = (int)WorkloadStatus.ReviewFinish }); } /// /// 保存基线期报告（病灶及测量数据，扩展报告的信息） /// /// /// public bool SaveBLReport(BaseLineReportCommand baseLineReportCommand) { if (baseLineReportCommand.LesionInformation.Count < 1) return false; var addedLesion = baseLineReportCommand.LesionInformation[0]; //删除已经有的数据 _tURepository.Delete(u => u.VISITNUM == addedLesion.VISITNUM && u.USUBJID == addedLesion.USUBJID && u.TUEVALID == _userInfo.ReviewerCode); _tRRepository.Delete(u => u.VISITNUM == addedLesion.VISITNUM && u.USUBJID == addedLesion.USUBJID && u.TREVALID == _userInfo.ReviewerCode); _reportRepository.Delete(u => u.TPId == baseLineReportCommand.ReportResult.TPId); _workloadTPRepository.Update(u => u.Id == baseLineReportCommand.ReportResult.TPId, s => new WorkloadTP { Status = (int)WorkloadStatus.Reading }); //序号按照每个项目、每个受试者、每个评估者，一条记录 TU lastTu = _tURepository.Find(u => u.STUDYID == addedLesion.STUDYID && u.USUBJID == addedLesion.USUBJID && u.TUEVAL == addedLesion.TUEVAL).OrderByDescending("TUSEQ").FirstOrDefault(); int tuSeq = 101; if (lastTu != null) { tuSeq = lastTu.TUSEQ; } TR lastTr = _tRRepository.GetAll().OrderByDescending("TRSEQ").FirstOrDefault(); int trSeq = 1; if (lastTr != null) { trSeq = lastTr.TRSEQ; } linkGroupId = Guid.NewGuid().ToString(); foreach (var lesion in baseLineReportCommand.LesionInformation) { var linkId = lesion.TULNKID; if (string.IsNullOrWhiteSpace(lesion.TULNKID)) { linkId = (lesion.TUORRES == "TARGET") ? "T" + tuSeq.ToString() : "NT" + tuSeq.ToString(); } _tURepository.Add(new TU { STUDYID = lesion.STUDYID, LesionType = lesion.LesionType, USUBJID = lesion.USUBJID, TUSEQ = tuSeq, TULNKID = linkId, TUTESTCD = lesion.TUTESTCD, TUTEST = lesion.TUTEST, TUORRES = lesion.TUORRES, TUSTRESC = lesion.TUSTRESC, TULOC = lesion.TULOC, LocDescription = lesion.LocDescription, TULAT = lesion.TULAT, TUDIR = lesion.TUDIR, TUPORTOT = lesion.TUPORTOT, TUMETHOD = lesion.TUMETHOD, TUEVAL = lesion.TUEVAL, VISIT = lesion.VISIT, VISITNUM = lesion.VISITNUM, VISITDY = lesion.VISITDY, TUREFID = lesion.TUREFID, TUACPTFL = lesion.TUACPTFL, TUEVALID = _userInfo.ReviewerCode,//lesion.TUEVALID, TUGRPID = string.Empty, TUDY = lesion.TUDY,// 检查日 EPOCH = lesion.EPOCH, TUDTC = lesion.TUDTC, TUNAM = lesion.TUNAM, TUSPID = lesion.TUSPID, TpCode = baseLineReportCommand.ReportResult.TpCode }); _tRRepository.Add(new TR { STUDYID = lesion.STUDYID, USUBJID = lesion.USUBJID, TRSEQ = trSeq, TRLNKID = linkId, TRGRPID = lesion.TRGRPID, TRLNKGRP = linkGroupId, TRTESTCD = lesion.TRTESTCD, TRTEST = lesion.TRTEST, TRORRES = lesion.TRORRES, TRORRESU = lesion.TRORRESU, TRNAM = lesion.TUNAM, TRMETHOD = lesion.TUMETHOD, TREVAL = lesion.TUEVAL, TREVALID = _userInfo.ReviewerCode,//lesion.TUEVALID, TRACPTFL = lesion.TUACPTFL, Note = lesion.Note, VISITNUM = lesion.VISITNUM, VISIT = lesion.VISIT, VISITDY = lesion.VISITDY, EPOCH = lesion.EPOCH, TRDTC = lesion.TRDTC, TRDY = lesion.TRDY, TpCode = baseLineReportCommand.ReportResult.TpCode }); tuSeq++; trSeq++; } _tRRepository.Add(new TR { STUDYID = addedLesion.STUDYID, USUBJID = addedLesion.USUBJID, TRSEQ = trSeq, TRLNKID = string.Empty, TRGRPID = addedLesion.TRGRPID, TRLNKGRP = linkGroupId, TRTESTCD = addedLesion.TRTESTCD, TRTEST = "Sum of Diameter", TRORRES = baseLineReportCommand.SumOfDiameter, TRORRESU = "mm",//addedLesion.TRORRESU, TRNAM = addedLesion.TUNAM, TRMETHOD = addedLesion.TUMETHOD, TREVAL = addedLesion.TUEVAL, TREVALID = _userInfo.ReviewerCode,//addedLesion.TUEVALID, TRACPTFL = addedLesion.TUACPTFL, Note = string.Empty, VISITNUM = addedLesion.VISITNUM, VISIT = addedLesion.VISIT, VISITDY = addedLesion.VISITDY, EPOCH = addedLesion.EPOCH, TRDTC = addedLesion.TRDTC, TRDY = addedLesion.TRDY, TpCode = baseLineReportCommand.ReportResult.TpCode }); trSeq++; _tRRepository.Add(new TR { STUDYID = addedLesion.STUDYID, USUBJID = addedLesion.USUBJID, TRSEQ = trSeq, TRLNKID = string.Empty, TRGRPID = addedLesion.TRGRPID, TRLNKGRP = linkGroupId, TRTESTCD = addedLesion.TRTESTCD, TRTEST = "Sum Diameters of Non Lymph Node Tumors", TRORRES = baseLineReportCommand.SumDiameterOfNonLymphNode, TRORRESU = "mm",//addedLesion.TRORRESU, TRNAM = addedLesion.TUNAM, TRMETHOD = addedLesion.TUMETHOD, TREVAL = addedLesion.TUEVAL, TREVALID = _userInfo.ReviewerCode,//addedLesion.TUEVALID, TRACPTFL = addedLesion.TUACPTFL, Note = string.Empty, VISITNUM = addedLesion.VISITNUM, VISIT = addedLesion.VISIT, VISITDY = addedLesion.VISITDY, EPOCH = addedLesion.EPOCH, TRDTC = addedLesion.TRDTC, TRDY = addedLesion.TRDY, TpCode = baseLineReportCommand.ReportResult.TpCode }); trSeq++; _reportRepository.Add(_mapper.Map(baseLineReportCommand.ReportResult)); return _reportRepository.SaveChanges(); } public bool SaveVisitReport(VisitReportCommand visitReportCommand) { linkGroupId = Guid.NewGuid().ToString(); var visitNum = visitReportCommand.ReportResult.VisitNum; var subjectId = visitReportCommand.ReportResult.SubjectCode; //删除已经有的数据 _tURepository.Delete(u => u.VISITNUM == visitNum && u.USUBJID == subjectId && u.TUEVALID == _userInfo.ReviewerCode); _tRRepository.Delete(u => u.VISITNUM == visitNum && u.USUBJID == subjectId && u.TREVALID == _userInfo.ReviewerCode); _reportRepository.Delete(u => u.TPId == visitReportCommand.ReportResult.TPId); _rSRepository.Delete(u => u.VISITNUM == visitNum && u.RSEVALID == _userInfo.ReviewerCode); var report = visitReportCommand.ReportResult; _workloadTPRepository.Update(u => u.Id == report.TPId, s => new WorkloadTP { Status = (int)WorkloadStatus.Reading }); if (visitReportCommand.LesionInformation.Count > 0) { AddLesion(visitReportCommand.LesionInformation, report); } TR lastTr = _tRRepository.GetAll().OrderByDescending("TRSEQ").FirstOrDefault(); int trSeq = 1; if (lastTr != null) { trSeq = lastTr.TRSEQ + 1; } foreach (var lesion in visitReportCommand.TRList) { _tRRepository.Add(new TR { STUDYID = lesion.STUDYID, USUBJID = lesion.USUBJID, TRSEQ = trSeq, TRLNKID = lesion.TRLNKID, TRGRPID = lesion.TRGRPID, TRLNKGRP = linkGroupId, TRTESTCD = lesion.TRTESTCD, TRTEST = lesion.TRTEST, TRORRES = lesion.TRORRES, TRORRESU = lesion.TRORRESU, TRNAM = lesion.TRNAM, TRMETHOD = lesion.TRMETHOD, TREVAL = lesion.TREVAL, TREVALID = _userInfo.ReviewerCode,// lesion.TREVALID, TRACPTFL = lesion.TRACPTFL, Note = lesion.Note, CoveredLesion = lesion.CoveredLesion, VISITNUM = lesion.VISITNUM, VISIT = lesion.VISIT, VISITDY = lesion.VISITDY, EPOCH = lesion.EPOCH, TRDTC = lesion.TRDTC, TRDY = lesion.TRDY, TpCode = visitReportCommand.ReportResult.TpCode }); trSeq++; } foreach (var rs in visitReportCommand.RSList) { _rSRepository.Add(new RS { STUDYID = rs.STUDYID, USUBJID = rs.USUBJID, RSSEQ = 0,// RSLNKGRP = linkGroupId, RSTESTCD = rs.RSTESTCD, RSTEST = rs.RSTEST, RSCAT = rs.RSCAT, RSORRES = rs.RSORRES, RSSTRESC = rs.RSSTRESC, RSSTAT = rs.RSSTAT, RSREASND = rs.RSCAT, RSEVAL = rs.RSEVAL, RSEVALID = _userInfo.ReviewerCode,// VISITNUM = rs.VISITNUM, VISIT = rs.VISIT, RSDTC = rs.RSDTC, RSDY = rs.RSDY, TpCode = visitReportCommand.ReportResult.TpCode, StudyGuid = rs.StudyGuid, TrialGuid = rs.TrialGuid, SubjectGuid = rs.SubjectGuid, Note = rs.Note }); } _reportRepository.Add(_mapper.Map(visitReportCommand.ReportResult)); return _rSRepository.SaveChanges(); } } }