diff --git a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialService.cs b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialService.cs
index be9827b0..8608a3fc 100644
--- a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialService.cs
+++ b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialService.cs
@@ -196,6 +196,8 @@ namespace IRaCIS.Application.Services
 
                 trial.VisitPlanConfirmed = true;
 
+                trial.IsHaveFirstGiveMedicineDate = false;
+
                 trial.TrialStatusStr = StaticData.TrialState.TrialOngoing;
                 #endregion