diff --git a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
index 53b0b9aea..c7e26a45a 100644
--- a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
+++ b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
@@ -6,6 +6,7 @@ using IRaCIS.Core.Application.Helper;
 using IRaCIS.Core.Application.Interfaces;
 using IRaCIS.Core.Application.Service.Reading.Dto;
 using IRaCIS.Core.Application.ViewModel;
+using IRaCIS.Core.Domain.Models;
 using IRaCIS.Core.Domain.Share;
 using IRaCIS.Core.Infra.EFCore.Common;
 using IRaCIS.Core.Infrastructure;
@@ -844,10 +845,14 @@ namespace IRaCIS.Core.Application
             }
             else if (signConfirmDTO.SignCode == ((int)SignEnum.SecondReviewConfirm).ToString())
             {
-                await _subjectVisitRepository.BatchUpdateNoTrackingAsync(t => t.Id == signConfirmDTO.TrialId && t.AuditState == AuditStateEnum.QCPassed, u => new SubjectVisit() { SecondReviewState = SecondReviewState.WaitAudit });
+                var trialConfirmTime = _trialRepository.Where(t => t.Id == signConfirmDTO.TrialId).Select(t => t.QCQuestionConfirmedTime).FirstOrDefault();
+
+                //重复二次复核签名
+                await _subjectVisitRepository.BatchUpdateNoTrackingAsync(t => t.Id == signConfirmDTO.TrialId && t.AuditState == AuditStateEnum.QCPassed 
+                && !t.TrialQCQuestionAnswerList.Any(t => t.SecondReviewTime == trialConfirmTime), u => new SubjectVisit() { SecondReviewState = SecondReviewState.WaitAudit });
 
                 //删除复审中间临时数据
-                await _qcQuestionAnswerRepository.BatchDeleteNoTrackingAsync(t => t.SubjectVisit.TrialId == signConfirmDTO.TrialId && t.SubjectVisit.AuditState != AuditStateEnum.QCPassed && t.CurrentQCEnum == CurrentQC.SecondReview);
+                await _qcQuestionAnswerRepository.BatchDeleteNoTrackingAsync(t => t.SubjectVisit.TrialId == signConfirmDTO.TrialId && t.SubjectVisit.SecondReviewState != SecondReviewState.AuditPassed && t.CurrentQCEnum == CurrentQC.SecondReview);
             }
             else if (signConfirmDTO.SignCode == ((int)SignEnum.TrialQCQuestionConfirm).ToString())
             {
diff --git a/IRaCIS.Core.Domain/Visit/SubjectVisit.cs b/IRaCIS.Core.Domain/Visit/SubjectVisit.cs
index 80ab5704e..3fa7e1278 100644
--- a/IRaCIS.Core.Domain/Visit/SubjectVisit.cs
+++ b/IRaCIS.Core.Domain/Visit/SubjectVisit.cs
@@ -6,6 +6,8 @@ namespace IRaCIS.Core.Domain.Models;
 public class SubjectVisit : BaseFullDeleteAuditEntity
 {
     #region 导航属性
+    [JsonIgnore]
+    public List<TrialQCQuestionAnswer> TrialQCQuestionAnswerList { get; set; }
 
     [JsonIgnore]
     public TrialSite TrialSite { get; set; }