diff --git a/IRC.Core.Dicom/Service/OSSService.cs b/IRC.Core.Dicom/Service/OSSService.cs
index 1ac5e80ee..fe6138055 100644
--- a/IRC.Core.Dicom/Service/OSSService.cs
+++ b/IRC.Core.Dicom/Service/OSSService.cs
@@ -231,8 +231,8 @@ public class OSSService : IOSSService
                     //提供awsEndPoint（域名）进行访问配置
                     var clientConfig = new AmazonS3Config
                     {
-                        RegionEndpoint = RegionEndpoint.USEast1,
-                        UseHttp = true,
+                        RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                        //,UseHttp = true,
                     };
 
                     var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -320,8 +320,8 @@ public class OSSService : IOSSService
             //提供awsEndPoint（域名）进行访问配置
             var clientConfig = new AmazonS3Config
             {
-                RegionEndpoint = RegionEndpoint.USEast1,
-                UseHttp = true,
+                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                //,UseHttp = true,
             };
 
             var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -397,8 +397,8 @@ public class OSSService : IOSSService
                 //提供awsEndPoint（域名）进行访问配置
                 var clientConfig = new AmazonS3Config
                 {
-                    RegionEndpoint = RegionEndpoint.USEast1,
-                    UseHttp = true,
+                    RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                    //,UseHttp = true,
                 };
 
                 var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -493,8 +493,8 @@ public class OSSService : IOSSService
                 //提供awsEndPoint（域名）进行访问配置
                 var clientConfig = new AmazonS3Config
                 {
-                    RegionEndpoint = RegionEndpoint.USEast1,
-                    UseHttp = true,
+                    RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                    //,UseHttp = true,
                 };
 
                 var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -625,8 +625,8 @@ public class OSSService : IOSSService
             //提供awsEndPoint（域名）进行访问配置
             var clientConfig = new AmazonS3Config
             {
-                RegionEndpoint = RegionEndpoint.USEast1,
-                UseHttp = true,
+                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                //,UseHttp = true,
             };
 
             var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
diff --git a/IRC.Core.SCP/Service/OSSService.cs b/IRC.Core.SCP/Service/OSSService.cs
index efea4770a..7657d8c51 100644
--- a/IRC.Core.SCP/Service/OSSService.cs
+++ b/IRC.Core.SCP/Service/OSSService.cs
@@ -535,8 +535,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
 
             var clientConfig = new AmazonS3Config
             {
-                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region),
-                UseHttp = true,
+                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                //,UseHttp = true,
             };
 
             using var client = new AmazonS3Client(credentials, clientConfig);
@@ -715,8 +715,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
             //提供awsEndPoint（域名）进行访问配置
             var clientConfig = new AmazonS3Config
             {
-                RegionEndpoint = RegionEndpoint.USEast1,
-                UseHttp = true,
+                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                //,UseHttp = true,
             };
 
             var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -1134,8 +1134,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
 
                 var clientConfig = new AmazonS3Config
                 {
-                    RegionEndpoint = RegionEndpoint.USEast1,
-                    UseHttp = true,
+                    RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                    //,UseHttp = true,
                 };
 
                 var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -1391,8 +1391,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
 
                 var clientConfig = new AmazonS3Config
                 {
-                    RegionEndpoint = RegionEndpoint.USEast1,
-                    UseHttp = true,
+                    RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                    //,UseHttp = true,
                 };
 
                 var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
diff --git a/IRaCIS.Core.Application/Helper/OSSService.cs b/IRaCIS.Core.Application/Helper/OSSService.cs
index d600988e6..b17bc2615 100644
--- a/IRaCIS.Core.Application/Helper/OSSService.cs
+++ b/IRaCIS.Core.Application/Helper/OSSService.cs
@@ -537,8 +537,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
 
             var clientConfig = new AmazonS3Config
             {
-                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region),
-                UseHttp = true,
+                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                //,UseHttp = true,
             };
 
             using var client = new AmazonS3Client(credentials, clientConfig);
@@ -717,8 +717,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
             //提供awsEndPoint（域名）进行访问配置
             var clientConfig = new AmazonS3Config
             {
-                RegionEndpoint = RegionEndpoint.USEast1,
-                UseHttp = true,
+                RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                //,UseHttp = true,
             };
 
             var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -1136,8 +1136,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
 
                 var clientConfig = new AmazonS3Config
                 {
-                    RegionEndpoint = RegionEndpoint.USEast1,
-                    UseHttp = true,
+                    RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                    //,UseHttp = true,
                 };
 
                 var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
@@ -1393,8 +1393,8 @@ public class OSSService(IOptionsMonitor<ObjectStoreServiceOptions> options,
 
                 var clientConfig = new AmazonS3Config
                 {
-                    RegionEndpoint = RegionEndpoint.USEast1,
-                    UseHttp = true,
+                    RegionEndpoint = RegionEndpoint.GetBySystemName(awsConfig.Region)
+                    //,UseHttp = true,
                 };
 
                 var amazonS3Client = new AmazonS3Client(credentials, clientConfig);
diff --git a/IRaCIS.Core.Application/IRaCIS.Core.Application.xml b/IRaCIS.Core.Application/IRaCIS.Core.Application.xml
index 27498f331..e92c01ef6 100644
--- a/IRaCIS.Core.Application/IRaCIS.Core.Application.xml
+++ b/IRaCIS.Core.Application/IRaCIS.Core.Application.xml
@@ -7573,6 +7573,13 @@
             影像阅片临床数据签名
             </summary>
         </member>
+        <member name="M:IRaCIS.Core.Application.Service.ReadingClinicalDataService.UpdateReadModuleClinicalData(IRaCIS.Core.Application.Service.Inspection.DTO.UpdateReadModuleClinicalDataInDto)">
+            <summary>
+            修改临床数据后  将签名状态变更为未签名
+            </summary>
+            <param name="inDto"></param>
+            <returns></returns>
+        </member>
         <member name="M:IRaCIS.Core.Application.Service.ReadingClinicalDataService.GetVisitClinicalDataName(IRaCIS.Core.Application.Service.Reading.Dto.GetVisitClinicalDataNameInDto)">
             <summary>
             获取访视临床数据名称