diff --git a/IRaCIS.Core.Application/Service/Reading/Dto/ReadingCalculateViewModel.cs b/IRaCIS.Core.Application/Service/Reading/Dto/ReadingCalculateViewModel.cs
index acc19c683..c50f93154 100644
--- a/IRaCIS.Core.Application/Service/Reading/Dto/ReadingCalculateViewModel.cs
+++ b/IRaCIS.Core.Application/Service/Reading/Dto/ReadingCalculateViewModel.cs
@@ -19,6 +19,11 @@ namespace IRaCIS.Core.Application.Service.Reading.Dto
 
     public class TargetLesionCalculateDto
     {
+        /// <summary>
+        /// 最低SOD
+        /// </summary>
+        public decimal LowSod { get; set; }
+
         /// <summary>
         /// 是否存在靶病灶
         /// </summary>
diff --git a/IRaCIS.Core.Application/Service/ReadingCalculate/RECIST1Point1CalculateService.cs b/IRaCIS.Core.Application/Service/ReadingCalculate/RECIST1Point1CalculateService.cs
index dc7e7cf2a..5fd5e9481 100644
--- a/IRaCIS.Core.Application/Service/ReadingCalculate/RECIST1Point1CalculateService.cs
+++ b/IRaCIS.Core.Application/Service/ReadingCalculate/RECIST1Point1CalculateService.cs
@@ -1106,6 +1106,7 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
 
             var taskIds = taskAnswerList.Select(x => x.VisitTaskId).ToList();
 
+            // 排除无法评估
             var unableEvaluateTaskIds = await _readingTableQuestionAnswerRepository.Where(x => taskIds.Contains(x.VisitTaskId) &&
             x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State
             && x.ReadingQuestionTrial.LesionType == LesionType.TargetLesion
@@ -1258,6 +1259,9 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
                 // 是否存在靶病灶
                 ExistsTargetLesion= tableQuestion.Count()>0,
 
+                // 最低SOD
+                LowSod=(await GetLowSODVisit(inDto)).Select(x=>x.SOD).FirstOrDefault(),
+
                 //非淋巴结靶病灶长径之和  decimal
                 SumOfDiameter = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SumOfDiameter).Sum(x => x.Answer.IsNullOrEmptyReturn0()),
 
@@ -1343,6 +1347,10 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
             {
                 if (resultData.LastTargetLesionEvaluate.EqEnum(TargetAssessment.CR))
                 {
+                    if (resultData.ExixtsNETargetLesion)
+                    {
+                        result = TargetAssessment.NE;
+                    }
                     if (resultData.CurrenShortBigger10 && resultData.IsAddFive)
                     {
                         result = TargetAssessment.PD;
@@ -1352,30 +1360,37 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
                         result = TargetAssessment.PD;
                     }
                 }
-                else if (resultData.LowPercentBigger20)
-                {
-                    result = TargetAssessment.PD;
-                }
+               
                 else
                 {
-                    if (resultData.ExixtsNETargetLesion)
+                    if (resultData.LowSod != 0 && resultData.LowPercentBigger20 && resultData.LowChangeBigger5)
                     {
-                        result = TargetAssessment.NE;
-                    } else  
+                        result = TargetAssessment.PD;
+                    }
+                    else
                     {
-                        if (resultData.SODPercentBigger30)
+                        if (resultData.ExixtsNETargetLesion)
                         {
-                            if (resultData.LowPercentLess20||resultData.LowChangeLess5)
+                            result = TargetAssessment.NE;
+                        }
+                        else
+                        {
+                            if (resultData.SODPercentBigger30)
                             {
-                                result = TargetAssessment.PR;
-                            }
+                                if (resultData.LowPercentLess20 || resultData.LowChangeLess5)
+                                {
+                                    result = TargetAssessment.PR;
+                                }
 
-                            if (resultData.SumOfDiameter == 0 && resultData.DiameterLessThan10)
-                            {
-                                result = TargetAssessment.CR;
+                                if (resultData.SumOfDiameter == 0 && resultData.DiameterLessThan10)
+                                {
+                                    result = TargetAssessment.CR;
+                                }
                             }
                         }
                     }
+
+                   
                 }
             }