diff --git a/IRaCIS.Core.Application/Service/ReadingCalculate/IRECIST1Point1CalculateService.cs b/IRaCIS.Core.Application/Service/ReadingCalculate/IRECIST1Point1CalculateService.cs
index b6b7b9094..035835bd7 100644
--- a/IRaCIS.Core.Application/Service/ReadingCalculate/IRECIST1Point1CalculateService.cs
+++ b/IRaCIS.Core.Application/Service/ReadingCalculate/IRECIST1Point1CalculateService.cs
@@ -2575,7 +2575,7 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
         /// {
         ///     疗效为 NE
         /// }
-        /// else if (靶病灶评估为ND && 非靶病灶评估为NE && 新病灶评估为否或疑似或NE)
+        /// else if (靶病灶评估为ND && 非靶病灶评估为NE && 新病灶评估为ND或疑似或NE)
         /// {
         ///     疗效为 NE
         /// }
@@ -2638,10 +2638,13 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
                 //     疗效为 iUPD
                 result = OverallAssessment.iUPD;
             }
-            // else if ((靶病灶评估为iCR || 非靶病灶评估为iCR) && 新病灶评估为ND)
-            else if (
-                (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.TargetLesion && x.Answer.EqEnum(TargetAssessment.iCR))
-               || inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NoTargetLesion && x.Answer.EqEnum(NoTargetAssessment.iCR)))
+            // else if ((靶病灶评估为iCR||靶病灶评估为ND) && (非靶病灶评估为iCR||非靶病灶评估为ND)) && 新病灶评估为ND)
+            else if (((inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.TargetLesion && x.Answer.EqEnum(TargetAssessment.iCR))
+                || inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.TargetLesion && x.Answer.EqEnum(TargetAssessment.ND)) )
+              &&
+               (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NoTargetLesion && x.Answer.EqEnum(NoTargetAssessment.iCR))
+                || inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NoTargetLesion && x.Answer.EqEnum(NoTargetAssessment.ND))
+               ))
                && inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NewLesionEvaluation && x.Answer.EqEnum(NewLesionAssessment.ND))
                 )
             {
@@ -2746,11 +2749,11 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
                 //     疗效为 NE
                 result = OverallAssessment.NE;
             }
-            // else if (靶病灶评估为ND && 非靶病灶评估为NE && 新病灶评估为否或疑似或NE)
+            // else if (靶病灶评估为ND && 非靶病灶评估为NE && 新病灶评估为ND或疑似或NE)
             else if (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.TargetLesion && x.Answer.EqEnum(TargetAssessment.ND))
                   && (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NoTargetLesion && x.Answer.EqEnum(NoTargetAssessment.NE))
 
-               ) && (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NewLesionEvaluation && x.Answer.EqEnum(NewLesionAssessment.No))
+               ) && (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NewLesionEvaluation && x.Answer.EqEnum(NewLesionAssessment.ND))
                || inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NewLesionEvaluation && x.Answer.EqEnum(NewLesionAssessment.Suspected))
                || inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.NewLesionEvaluation && x.Answer.EqEnum(NewLesionAssessment.NE))
                ))