diff --git a/IRaCIS.Core.Application/Resources/en-US.json b/IRaCIS.Core.Application/Resources/en-US.json
index 829a4985c..ddbb461e4 100644
--- a/IRaCIS.Core.Application/Resources/en-US.json
+++ b/IRaCIS.Core.Application/Resources/en-US.json
@@ -39,7 +39,10 @@
 
   //-------------------------------------------------------------------------------------Reading-----------------------------------------------------------------
   //ClinicalDataSetService
+  "ClinicalDataSet_Apply": "",
   "ClinicalDataSet_DupTypeFail": "The same type of clinical data exists. The operation failed.",
+  //ClinicalQuestionService
+  "ClinicalQuestion_Repeat": "",
   //ReadingClinicalDataService
   "ReadingClinicalData_DupTypeFail": "The same type of clinical data exists. The operation failed.",
   "ReadingClinicalData_Unchecked": "The current clinical data status is not verified and signing is not allowed!",
diff --git a/IRaCIS.Core.Application/Resources/zh-CN.json b/IRaCIS.Core.Application/Resources/zh-CN.json
index 30eabe946..1e44d8da2 100644
--- a/IRaCIS.Core.Application/Resources/zh-CN.json
+++ b/IRaCIS.Core.Application/Resources/zh-CN.json
@@ -39,7 +39,10 @@
 
   // ------------------------------------------------------------Reading--------------------------------------------------------------------
   //ClinicalDataSetService
+  "ClinicalDataSet_Apply": "当前临床数据需要配置一个检查日期才能应用",
   "ClinicalDataSet_DupTypeFail": "存在同类型的临床数据,操作失败",
+  //ClinicalQuestionService
+  "ClinicalQuestion_Repeat": "存在相同的问题名称！",
   //ReadingClinicalDataService
   "ReadingClinicalData_DupTypeFail": "存在同类型的临床数据,操作失败",
   "ReadingClinicalData_Unchecked": "当前临床数据状态不是已核查状态，不允许签名！",
diff --git a/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs b/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs
index fe7aaa3b9..726d5388f 100644
--- a/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs
+++ b/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs
@@ -3,6 +3,8 @@ using IRaCIS.Core.Application.Service.Reading.Dto;
 using MassTransit;
 using IRaCIS.Core.Domain.Models;
 using IRaCIS.Core.Application.Interfaces;
+using IRaCIS.Core.Domain.Share;
+using IRaCIS.Core.Infrastructure;
 
 namespace IRaCIS.Application.Services
 {
@@ -20,7 +22,9 @@ namespace IRaCIS.Application.Services
         private readonly IRepository<PreviousPDF> _previousPDFRepository;
 		private readonly IRepository<Dictionary> _dictionaryRepository;
 		private readonly IRepository<Trial> _trialRepository;
-       
+        private readonly IRepository<TrialClinicalQuestion> _trialClinicalQuestionRepository;
+
+        private readonly IRepository<SystemClinicalQuestion> _systemClinicalQuestionRepository;
 
         public ClinicalDataSetService(IRepository<SubjectVisit> subjectVisitRepository,
               IClinicalQuestionService iClinicalQuestionService,
@@ -28,14 +32,18 @@ namespace IRaCIS.Application.Services
             IRepository<ClinicalDataSystemSet> ClinicalDataSystemSetRepository,
             IRepository<PreviousPDF> previousPDFRepository,
 			  IRepository<Dictionary> dictionaryRepository,
-			IRepository<Trial> trialRepository
+              IRepository<TrialClinicalQuestion> trialClinicalQuestionRepository,
+  IRepository<SystemClinicalQuestion> systemClinicalQuestionRepository,
+
+            IRepository<Trial> trialRepository
 
           
           )
         {
             _iClinicalQuestionService = iClinicalQuestionService;
             _subjectVisitRepository = subjectVisitRepository;
-
+            _trialClinicalQuestionRepository = trialClinicalQuestionRepository;
+            _systemClinicalQuestionRepository = systemClinicalQuestionRepository;
             _clinicalDataTrialSetRepository = ClinicalDataTrialSetRepository;
             _clinicalDataSystemSetRepository = ClinicalDataSystemSetRepository;
             this._previousPDFRepository = previousPDFRepository;
@@ -44,6 +52,58 @@ namespace IRaCIS.Application.Services
         }
 
 
+        /// <summary>
+        /// 应用系统临床数据
+        /// </summary>
+        /// <param name="inDto"></param>
+        /// <returns></returns>
+        /// <exception cref="BusinessValidationFailedException"></exception>
+        [HttpPost]
+        public async Task<IResponseOutput> ApplySystemClinical(ApplySystemClinicalInDto inDto)
+        {
+            if (_systemClinicalQuestionRepository.Where(x => x.SystemClinicalId == inDto.SystemClinicalId && x.IsCheckDate).Count() != 1)
+            {
+                throw new BusinessValidationFailedException(_localizer["ClinicalDataSet_Apply"]);
+              
+            }
+
+            await _clinicalDataSystemSetRepository.UpdatePartialFromQueryAsync(x => x.Id == inDto.SystemClinicalId, x => new ClinicalDataSystemSet()
+            {
+                IsApply = true
+            });
+
+
+            await _clinicalDataSystemSetRepository.SaveChangesAsync();
+
+            return ResponseOutput.Ok(true);
+        }
+
+        /// <summary>
+        /// 应用项目临床数据
+        /// </summary>
+        /// <param name="inDto"></param>
+        /// <returns></returns>
+        /// <exception cref="BusinessValidationFailedException"></exception>
+        [HttpPost]
+        public async Task<IResponseOutput> ApplyTrialClinical(ApplyTrialClinicalInDto inDto)
+        {
+            if (_trialClinicalQuestionRepository.Where(x => x.TrialClinicalId == inDto.TrialClinicalId && x.IsCheckDate).Count() != 1)
+            {
+                throw new BusinessValidationFailedException(_localizer["ClinicalDataSet_Apply"]);
+
+            }
+
+            await _clinicalDataTrialSetRepository.UpdatePartialFromQueryAsync(x => x.Id == inDto.TrialClinicalId, x => new ClinicalDataTrialSet()
+            {
+                IsApply = true
+            });
+
+
+            await _clinicalDataTrialSetRepository.SaveChangesAsync();
+
+            return ResponseOutput.Ok(true);
+        }
+
 
         #region 系统
         /// <summary>
@@ -54,7 +114,10 @@ namespace IRaCIS.Application.Services
         [HttpPost]
         public async Task<IResponseOutput> AddOrUpdateClinicalDataSystemSet(ClinicalDataSystemSetAddOrEdit indto)
         {
-
+            if (indto.ClinicalUploadType == ClinicalUploadType.Table || indto.ClinicalUploadType == ClinicalUploadType.PDF)
+            {
+                indto.IsApply = true;
+            }
             var dictionary = await _dictionaryRepository.Where(x => x.Parent.Code == "ClinicalDataType" && x.Code == indto.ClinicalDataSetEnum.ToString()).FirstNotNullAsync();
             indto.ClinicalDataSetName = dictionary.ValueCN;
             indto.ClinicalDataSetEnName = dictionary.Value;
@@ -130,6 +193,12 @@ namespace IRaCIS.Application.Services
         [HttpPost]
         public async Task<IResponseOutput> AddOrUpdateClinicalDataTrialSet(ClinicalDataTrialSetAddOrEdit indto)
         {
+
+            if (indto.ClinicalUploadType == ClinicalUploadType.Table || indto.ClinicalUploadType == ClinicalUploadType.PDF)
+            {
+                indto.IsApply = true;
+            }
+
             var existsQuery = _clinicalDataTrialSetRepository
              .WhereIf(indto.Id != null, x => x.Id != indto.Id)
              .Where(x => (x.ClinicalDataSetName == indto.ClinicalDataSetName||x.ClinicalDataSetEnName==indto.ClinicalDataSetEnName) && x.TrialId == indto.TrialId);
diff --git a/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalQuestionService.cs b/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalQuestionService.cs
index ec6d7c4f4..6d593a1ed 100644
--- a/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalQuestionService.cs
+++ b/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalQuestionService.cs
@@ -72,6 +72,11 @@ namespace IRaCIS.Core.Application.Service
         [HttpPost]
         public async Task<IResponseOutput> AddOrUpdateTrialClinicalQuestion(TrialClinicalQuestionDto inDto)
         {
+            if (await _trialClinicalQuestionRepository.AnyAsync(x =>x.TrialClinicalId==inDto.TrialClinicalId && x.Id != inDto.Id && x.QuestionName == inDto.QuestionName))
+            {
+                return ResponseOutput.NotOk(_localizer["ClinicalQuestion_Repeat"]);
+            }
+
             var entity = await _trialClinicalQuestionRepository.InsertOrUpdateAsync(inDto, true);
             return ResponseOutput.Ok(entity.Id.ToString());
 
@@ -149,6 +154,11 @@ namespace IRaCIS.Core.Application.Service
         [HttpPost]
         public async Task<IResponseOutput> AddOrUpdateSystemClinicalQuestion(SystemClinicalQuestionDto inDto)
         {
+
+            if (await _systemClinicalQuestionRepository.AnyAsync(x => x.SystemClinicalId == inDto.SystemClinicalId && x.Id != inDto.Id && x.QuestionName == inDto.QuestionName))
+            {
+                return ResponseOutput.NotOk(_localizer["ClinicalQuestion_Repeat"]);
+            }
             var entity = await _systemClinicalQuestionRepository.InsertOrUpdateAsync(inDto, true);
             return ResponseOutput.Ok(entity.Id.ToString());
 
@@ -230,6 +240,10 @@ namespace IRaCIS.Core.Application.Service
         [HttpPost]
         public async Task<IResponseOutput> AddOrUpdateSystemClinicalTableQuestion(SystemClinicalTableQuestionDto inDto)
         {
+            if (await _systemClinicalTableQuestionRepository.AnyAsync(x => x.QuestionId == inDto.QuestionId && x.Id != inDto.Id && x.QuestionName == inDto.QuestionName))
+            {
+                return ResponseOutput.NotOk(_localizer["ClinicalQuestion_Repeat"]);
+            }
 
             var entity = await _systemClinicalTableQuestionRepository.InsertOrUpdateAsync(inDto, true);
 
@@ -281,7 +295,10 @@ namespace IRaCIS.Core.Application.Service
         [HttpPost]
         public async Task<IResponseOutput> AddOrUpdateTrialClinicalTableQuestion(TrialClinicalTableQuestionDto inDto)
         {
-
+            if (await _trialClinicalTableQuestionRepository.AnyAsync(x => x.QuestionId == inDto.QuestionId && x.Id != inDto.Id && x.QuestionName == inDto.QuestionName))
+            {
+                return ResponseOutput.NotOk(_localizer["ClinicalQuestion_Repeat"]);
+            }
             var entity = await _trialClinicalTableQuestionRepository.InsertOrUpdateAsync(inDto, true);
 
             return ResponseOutput.Ok(entity.Id.ToString());
diff --git a/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalDataServiceViewModel.cs b/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalDataServiceViewModel.cs
index 672467388..8e0dd533f 100644
--- a/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalDataServiceViewModel.cs
+++ b/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalDataServiceViewModel.cs
@@ -13,6 +13,10 @@ namespace IRaCIS.Core.Application.Service.Reading.Dto
     {
         public Guid? Id { get; set; }
 
+        /// <summary>
+        /// 是否应用
+        /// </summary>
+        public bool IsApply { get; set; } = false;
 
         /// <summary>
         /// 名称
@@ -73,10 +77,23 @@ namespace IRaCIS.Core.Application.Service.Reading.Dto
         //public List<int> CriterionEnumList { get; set; }
     }
 
+    public class ApplySystemClinicalInDto
+    {
+        public Guid SystemClinicalId { get; set; }
+    }
+
+    public class ApplyTrialClinicalInDto
+    {
+        public Guid TrialClinicalId { get; set; }
+    }
     public class ClinicalDataSystemSetAddOrEdit
     {
         public Guid? Id { get; set; }
 
+        /// <summary>
+        /// 是否应用
+        /// </summary>
+        public bool IsApply { get; set; } = false;
 
         /// <summary>
         /// 枚举
diff --git a/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalQuestionDto.cs b/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalQuestionDto.cs
index fef9c511a..fa9e287ab 100644
--- a/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalQuestionDto.cs
+++ b/IRaCIS.Core.Application/Service/Reading/Dto/ClinicalQuestionDto.cs
@@ -88,6 +88,11 @@ namespace IRaCIS.Core.Application.Service.Reading.Dto
         /// 显示类型
         /// </summary>
         public ClinicalQuestionShow ClinicalQuestionShowEnum { get; set; } = ClinicalQuestionShow.Show;
+
+        /// <summary>
+        /// 是否是检查日期
+        /// </summary>
+        public bool IsCheckDate { get; set; }
     }
 
     /// <summary>
diff --git a/IRaCIS.Core.Domain/Reading/ClinicalQuestion/SystemClinicalQuestion.cs b/IRaCIS.Core.Domain/Reading/ClinicalQuestion/SystemClinicalQuestion.cs
index c55251892..b732fefcd 100644
--- a/IRaCIS.Core.Domain/Reading/ClinicalQuestion/SystemClinicalQuestion.cs
+++ b/IRaCIS.Core.Domain/Reading/ClinicalQuestion/SystemClinicalQuestion.cs
@@ -102,6 +102,11 @@ namespace IRaCIS.Core.Domain.Models
         /// </summary>
         public ClinicalQuestionShow ClinicalQuestionShowEnum { get; set; } = ClinicalQuestionShow.Show;
 
+        /// <summary>
+        /// 是否是检查日期
+        /// </summary>
+        public bool IsCheckDate { get; set; }
+
     }
 
 
diff --git a/IRaCIS.Core.Domain/Reading/ClinicalQuestion/TrialClinicalQuestion.cs b/IRaCIS.Core.Domain/Reading/ClinicalQuestion/TrialClinicalQuestion.cs
index 20e436b36..7d7ce713e 100644
--- a/IRaCIS.Core.Domain/Reading/ClinicalQuestion/TrialClinicalQuestion.cs
+++ b/IRaCIS.Core.Domain/Reading/ClinicalQuestion/TrialClinicalQuestion.cs
@@ -107,6 +107,11 @@ namespace IRaCIS.Core.Domain.Models
         /// </summary>
         public ClinicalQuestionShow ClinicalQuestionShowEnum { get; set; } = ClinicalQuestionShow.Show;
 
+        /// <summary>
+        /// 是否是检查日期
+        /// </summary>
+        public bool IsCheckDate { get; set; }
+
         /// <summary>
         /// 自定义计算标记
         /// </summary>