diff --git a/IRaCIS.Core.Application/Service/QC/QCOperationService.cs b/IRaCIS.Core.Application/Service/QC/QCOperationService.cs
index 8ec87a3e4..6ead940a5 100644
--- a/IRaCIS.Core.Application/Service/QC/QCOperationService.cs
+++ b/IRaCIS.Core.Application/Service/QC/QCOperationService.cs
@@ -949,7 +949,7 @@ namespace IRaCIS.Core.Application.Image.QA
         #endregion
 
         [HttpGet]
-        public async Task IsQCCanOpt([FromQuery,NotDefault]Guid sujectVisitId)
+        public async Task IsQCCanOpt([FromQuery,Required]Guid sujectVisitId)
         {
              await VerifyIsCanQCAsync(null,sujectVisitId);
         }
diff --git a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
index a346833a0..efbcc9eb9 100644
--- a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
+++ b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
@@ -139,8 +139,6 @@ namespace IRaCIS.Core.Application
                     .IfNullThrowException();
 
               
-
-
                 var showOrderList = await _repository.Where<TrialQCQuestion>(t => t.TrialId == signConfirmDTO.TrialId).Select(t => 
                 new { t.ShowOrder , ParentShowOrder=(int?) t.ParentQCQuestion.ShowOrder} ).ToListAsync();
 
@@ -163,6 +161,11 @@ namespace IRaCIS.Core.Application
                     throw new BusinessValidationFailedException("父问题的序号要比子问题序号小，请确认");
                 }
 
+                if( await _trialRepository.AnyAsync(t =>t.Id== signConfirmDTO.TrialId && t.QCQuestionConfirmedUserId != null && t.QCQuestionConfirmedUserId!= _userInfo.Id))
+                {
+                    throw new BusinessValidationFailedException("QC审核问题已被其他QC确认，不允许再次确认");
+                }
+
                 await _trialRepository.UpdatePartialFromQueryAsync(t => t.Id == signConfirmDTO.TrialId, u => new Trial() { QCQuestionConfirmedTime = DateTime.Now, QCQuestionConfirmedUserId = _userInfo.Id, IsQCQuestionConfirmed = true });
             }