diff --git a/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs b/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs
index 11f0d3e12..110f6c134 100644
--- a/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs
+++ b/IRaCIS.Core.Application/Service/Reading/ClinicalData/ClinicalDataSetService.cs
@@ -66,7 +66,10 @@ namespace IRaCIS.Application.Services
 			&& x.ClinicalUploadType == ClinicalUploadType.Structuring && x.UploadRole == UploadRole.CRC
             );
 
-
+			if (_systemClinicalQuestionRepository.Where(x => x.SystemClinicalId == inDto.SystemClinicalId).Count() == 0)
+			{
+				throw new BusinessValidationFailedException("当前临床数据未配置问题,请先配置问题之后再应用");
+			}
 			if (isNeedVerify&&_systemClinicalQuestionRepository.Where(x => x.SystemClinicalId == inDto.SystemClinicalId && x.IsCheckDate).Count() != 1)
             {
                 throw new BusinessValidationFailedException(_localizer["ClinicalDataSet_Apply"]);
@@ -98,6 +101,11 @@ namespace IRaCIS.Application.Services
 		  && x.ClinicalUploadType == ClinicalUploadType.Structuring && x.UploadRole == UploadRole.CRC
 		 );
 
+            if (_trialClinicalQuestionRepository.Where(x => x.TrialClinicalId == inDto.TrialClinicalId).Count() == 0)
+            {
+				throw new BusinessValidationFailedException("当前临床数据未配置问题,请先配置问题之后再应用");
+			}
+
 			if (isNeedVerify&&_trialClinicalQuestionRepository.Where(x =>  x.TrialClinicalId == inDto.TrialClinicalId && x.IsCheckDate).Count() != 1)
             {
                 throw new BusinessValidationFailedException(_localizer["ClinicalDataSet_Apply"]);