diff --git a/IRaCIS.Core.Application/Service/ReadingCalculate/LuganoCalculateService.cs b/IRaCIS.Core.Application/Service/ReadingCalculate/LuganoCalculateService.cs
index ba1ff2447..8e076fe53 100644
--- a/IRaCIS.Core.Application/Service/ReadingCalculate/LuganoCalculateService.cs
+++ b/IRaCIS.Core.Application/Service/ReadingCalculate/LuganoCalculateService.cs
@@ -452,6 +452,10 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
 
             List<ReadingCalculateData> calculateList = new List<ReadingCalculateData>()
             {
+
+                //垂直径乘积之和（SPD）
+				//new ReadingCalculateData (){QuestionType=QuestionType.sp,GetDecimalNullFun=GetSODData},
+
 				////靶病灶径线之和（SOD）
 				//new ReadingCalculateData (){QuestionType=QuestionType.SOD,GetDecimalNullFun=GetSODData},
 
@@ -1469,6 +1473,31 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
 
             TargetAssessment result = TargetAssessment.SD;
 
+            //1、基线非淋巴结靶病灶不存在，或者当前访视非淋巴结靶病灶全部消失；
+            //并且  2.当前访视淋巴结靶病灶的状态全部变为“消失”。	
+
+            var eqCR = true;
+            //当前访视中，靶病灶的Σ PPD；
+            decimal spd = 0;
+            foreach (var item in rowInfo)
+            {
+                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.No)))
+                {
+                    // 基线非淋巴结靶病灶不存在，或者当前访视非淋巴结靶病灶全部消失；
+                    eqCR = eqCR && item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(TargetState.Loss));
+                }
+
+                spd += (item.TableQuestionList.Where(x => x.QuestionMark == QuestionMark.PPD).Select(x => x.Answer).FirstOrDefault()).IsNullOrEmptyReturn0();
+
+
+                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.Yes)))
+                {
+                    // 当前访视淋巴结靶病灶的状态全部变为“消失”
+                    eqCR = eqCR && item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(TargetState.Loss));
+                }
+            }
+
+
             //基线未选择靶病灶
             if (rowInfo.Count() == 0)
             {
@@ -1480,13 +1509,22 @@ namespace IRaCIS.Core.Application.Service.ReadingCalculate
                 result = TargetAssessment.PD;
             }
             //在排除PD后，有任一靶病灶为NE状态
-             else if (tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(TargetState.UnableEvaluate)))
+            else if (tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(TargetState.UnableEvaluate)))
             {
                 result = TargetAssessment.PD;
             }
-
-
-
+            //1、基线非淋巴结靶病灶不存在，或者当前访视非淋巴结靶病灶全部消失；
+            //并且  2.当前访视淋巴结靶病灶的状态全部变为“消失”。	
+            else if (eqCR)
+            {
+                result = TargetAssessment.CR;
+            }
+            // 1、与基线相比SPD变化的百分比 ≥50%，；
+            // 并且 当前访视没有任何一个状态为“疾病进展”的靶病灶
+            else if (eqCR)
+            {
+                result = TargetAssessment.CR;
+            }
 
 
             return result.GetEnumInt();