diff --git a/IRaCIS.Core.Application/Service/Reading/ReadingCriterion/ReadingQuestionService.cs b/IRaCIS.Core.Application/Service/Reading/ReadingCriterion/ReadingQuestionService.cs
index 0947548a3..18989d205 100644
--- a/IRaCIS.Core.Application/Service/Reading/ReadingCriterion/ReadingQuestionService.cs
+++ b/IRaCIS.Core.Application/Service/Reading/ReadingCriterion/ReadingQuestionService.cs
@@ -66,6 +66,13 @@ namespace IRaCIS.Core.Application.Service
                 throw new BusinessValidationFailedException(_localizer["ReadingQuestion_CDISCCodeRepeat"]);
             }
 
+            if(inDto.QuestionList.Any(x=>x.ExportResult.Contains(ExportResult.CDISC)&&x.CDISCCode.IsNullOrEmpty())
+                || inDto.TableQuestionList.Any(x => x.ExportResult.Contains(ExportResult.CDISC) && x.CDISCCode.IsNullOrEmpty())
+                )
+            {
+                throw new BusinessValidationFailedException(_localizer["ReadingQuestion_CDISCCodeCannotEmpty"]);
+            }
+
             List<ExportResult> needAdd = new List<ExportResult>()
             {
                 ExportResult.DetailedTableOfAdjudicationResults,