diff --git a/IRaCIS.Core.Application/Service/Allocation/DTO/TaskMedicalReviewViewModel.cs b/IRaCIS.Core.Application/Service/Allocation/DTO/TaskMedicalReviewViewModel.cs
index 2b6a9ce10..204ab5a22 100644
--- a/IRaCIS.Core.Application/Service/Allocation/DTO/TaskMedicalReviewViewModel.cs
+++ b/IRaCIS.Core.Application/Service/Allocation/DTO/TaskMedicalReviewViewModel.cs
@@ -104,6 +104,15 @@ namespace IRaCIS.Core.Application.ViewModel
 
     }
 
+
+    public class SetMedicalReviewInvalidCommand
+    {
+        [NotDefault]
+        public Guid TrialId { get; set; }
+
+        public List<Guid> MedicalReviewIdList { get; set; }
+    }
+
     public class GenerateMedicalReviewTaskQuery : TaskMedicalReviewQuery
     {
         public bool? IsGeneratedJudge { get; set; }
diff --git a/IRaCIS.Core.Application/Service/Allocation/TaskMedicalReviewService.cs b/IRaCIS.Core.Application/Service/Allocation/TaskMedicalReviewService.cs
index 81fe1334f..4475536be 100644
--- a/IRaCIS.Core.Application/Service/Allocation/TaskMedicalReviewService.cs
+++ b/IRaCIS.Core.Application/Service/Allocation/TaskMedicalReviewService.cs
@@ -56,7 +56,7 @@ namespace IRaCIS.Core.Application.Service
                              .WhereIf(!string.IsNullOrEmpty(inQuery.TaskName), t => t.VisitTask.TaskName.Contains(inQuery.TaskName) || t.VisitTask.TaskBlindName.Contains(inQuery.TaskName))
                              .WhereIf(inQuery.IsUrgent != null, t => t.VisitTask.IsUrgent == inQuery.IsUrgent)
                              .WhereIf(inQuery.DoctorUserId != null, t => t.VisitTask.DoctorUserId == inQuery.DoctorUserId)
-                             .WhereIf(!string.IsNullOrEmpty(inQuery.TrialSiteCode), t => (t.VisitTask.BlindTrialSiteCode.Contains(inQuery.TrialSiteCode) && t.VisitTask.IsAnalysisCreate) || (t.VisitTask.Subject.TrialSite.TrialSiteCode.Contains(inQuery.TrialSiteCode)&& t.VisitTask.IsAnalysisCreate==false))
+                             .WhereIf(!string.IsNullOrEmpty(inQuery.TrialSiteCode), t => (t.VisitTask.BlindTrialSiteCode.Contains(inQuery.TrialSiteCode) && t.VisitTask.IsAnalysisCreate) || (t.VisitTask.Subject.TrialSite.TrialSiteCode.Contains(inQuery.TrialSiteCode) && t.VisitTask.IsAnalysisCreate == false))
                              .WhereIf(inQuery.ReadingCategory != null, t => t.VisitTask.ReadingCategory == inQuery.ReadingCategory)
                              .WhereIf(inQuery.ReadingTaskState != null, t => t.VisitTask.ReadingTaskState == inQuery.ReadingTaskState)
                              .ProjectTo<TaskMedicalReviewView>(_mapper.ConfigurationProvider);
@@ -149,6 +149,25 @@ namespace IRaCIS.Core.Application.Service
         }
 
 
+        /// <summary>
+        /// 设置医学审核失效
+        /// </summary>
+        /// <param name="command"></param>
+        /// <returns></returns>
+        [HttpPost]
+        public async Task<IResponseOutput> SetMedicalReviewInvalid(SetMedicalReviewInvalidCommand command)
+        {
+
+            if (await _taskMedicalReviewRepository.Where(t => command.MedicalReviewIdList.Contains(t.Id)).AnyAsync(t => t.AuditState == MedicalReviewAuditState.HaveSigned))
+            {
+                return ResponseOutput.NotOk("已签名的不允许设置为失效");
+            }
+
+            await _taskMedicalReviewRepository.BatchUpdateNoTrackingAsync(t => command.MedicalReviewIdList.Contains(t.Id), c => new TaskMedicalReview() { IsInvalid = true });
+
+            return ResponseOutput.Ok();
+
+        }
 
 
 
diff --git a/IRaCIS.Core.Application/Service/Allocation/VisitTaskService.cs b/IRaCIS.Core.Application/Service/Allocation/VisitTaskService.cs
index 5ed24fb99..b228593d5 100644
--- a/IRaCIS.Core.Application/Service/Allocation/VisitTaskService.cs
+++ b/IRaCIS.Core.Application/Service/Allocation/VisitTaskService.cs
@@ -1316,12 +1316,16 @@ namespace IRaCIS.Core.Application.Service.Allocation
             origenalTask.TaskState = agreeReReadingCommand.RequestReReadingResultEnum == RequestReReadingResult.Agree ? TaskState.HaveReturned : origenalTask.TaskState;
         }
 
-        private async Task SetMedicalReviewInvalidAsync(List<VisitTask> influenceTaskList, bool isPM = true)
+        private async Task SetMedicalReviewInvalidAsync(List<VisitTask> influenceTaskList, bool isPMApply = true)
         {
             //将医学审核设置为失效
             var taskIdList = influenceTaskList.Select(t => t.Id).ToList();
 
-            if (isPM)
+            //PM 申请      医学审核任务状态为待审核、审核中的，设置为失效。
+
+            //IR 申请  当前任务进入医学审核，医学审核任务未签名且结论中是否有问题项，答案为否的，设置为失效
+
+            if (isPMApply)
             {
                 await _taskMedicalReviewRepository.UpdatePartialFromQueryAsync(t => taskIdList.Contains(t.VisitTaskId) && t.AuditState != MedicalReviewAuditState.HaveSigned, u => new TaskMedicalReview() { IsInvalid = true });