diff --git a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
index fb75f93ac..a1b3bbd29 100644
--- a/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
+++ b/IRaCIS.Core.Application/Service/TrialSiteUser/TrialConfigService.cs
@@ -965,8 +965,16 @@ namespace IRaCIS.Core.Application
                 return ResponseOutput.NotOk(_localizer["TrialConfig_ProjectNotInitialized"]);
             }
 
+            var clinicalDataTrialSetDataList = await _clinicalDataTrialSetRepository.Where(x => trialConfig.ClinicalDataTrialSetIds.Contains(x.Id)).Include(x => x.TrialClinicalDataSetCriteriaList).ToListAsync();
+            foreach (var item in clinicalDataTrialSetDataList)
+            {
+                var clinicalids = item.TrialClinicalDataSetCriteriaList.Select(x => x.TrialReadingCriterionId).ToList();
+                if (clinicalids.Intersect(trialConfig.TrialCriterionIds).ToList().Count() == 0)
+                {
+                    throw new BusinessValidationFailedException(_localizer["TrialConfig_NoCriteriaClinicalData"]);
+				}
 
-
+			}
 
             var trialInfo = await _trialRepository.Where(t => t.Id == trialConfig.TrialId, true).Include(t => t.TrialDicList.Where(u => u.KeyName == StaticData.Criterion)).FirstOrDefaultAsync();
             if (trialInfo == null) return Null404NotFound(trialInfo);