diff --git a/IRaCIS.Core.Application/IRaCIS.Core.Application.xml b/IRaCIS.Core.Application/IRaCIS.Core.Application.xml
index a5969cce7..7595caccd 100644
--- a/IRaCIS.Core.Application/IRaCIS.Core.Application.xml
+++ b/IRaCIS.Core.Application/IRaCIS.Core.Application.xml
@@ -7526,6 +7526,13 @@
             <param name="id"></param>
             <returns></returns>
         </member>
+        <member name="M:IRaCIS.Core.Application.Service.ReadingMedicineQuestionService.EmptMedicineTrialQuestion(IRaCIS.Core.Application.ViewModel.EmptMedicineTrialQuestionInDto)">
+            <summary>
+            清空医学审核问题
+            </summary>
+            <param name="inDto"></param>
+            <returns></returns>
+        </member>
         <!-- Badly formed XML comment ignored for member "M:IRaCIS.Core.Application.Service.ReadingMedicineQuestionService.GetReadingMedicineTrialQuestionList(IRaCIS.Core.Application.ViewModel.ReadingMedicineTrialQuestionQuery)" -->
         <member name="M:IRaCIS.Core.Application.Service.ReadingMedicineQuestionService.GetReadingMedicineTrialOtherQuestion(IRaCIS.Core.Application.ViewModel.GetReadingMedicineTrialOtherQuestionInDto)">
             <summary>
@@ -9618,6 +9625,13 @@
             项目QC 问题 管理
             </summary>	
         </member>
+        <member name="M:IRaCIS.Core.Application.Contracts.TrialQCQuestionConfigureService.EmptyQCQuestion(IRaCIS.Core.Application.Contracts.EmptyQCQuestionInDto)">
+            <summary>
+            清空Qc问题
+            </summary>
+            <param name="inDto"></param>
+            <returns></returns>
+        </member>
         <member name="M:IRaCIS.Core.Application.Contracts.TrialQCQuestionConfigureService.GetTrialQCQuestionSelectList(IRaCIS.Core.Application.Contracts.TrialQCQuestionFilterSelect)">
             <summary>
             父问题  下拉框选项  需要排除自己  、把自己设置为父亲 (互为父亲) 、是自己孙辈的（明明是自己子孙，却设置为自己父亲）
@@ -10322,6 +10336,13 @@
             <param name="queryTrialDocument"></param>
             <returns></returns>
         </member>
+        <member name="M:IRaCIS.Core.Application.Services.TrialDocumentService.GetNextUnSignDocument(IRaCIS.Core.Application.Contracts.GetNextUnSignDocumentInDto)">
+            <summary>
+            获取下一个未签名的文件
+            </summary>
+            <param name="inDto"></param>
+            <returns></returns>
+        </member>
         <member name="M:IRaCIS.Core.Application.Services.TrialDocumentService.GetUserDocumentList(IRaCIS.Core.Application.Contracts.TrialUserDocUnionQuery)">
             <summary>
              具体用户看到的 系统文件列表 + 项目类型文档
diff --git a/IRaCIS.Core.Application/Service/Document/DTO/SystemDocumentViewModel.cs b/IRaCIS.Core.Application/Service/Document/DTO/SystemDocumentViewModel.cs
index 574b33bf8..6c5a6999a 100644
--- a/IRaCIS.Core.Application/Service/Document/DTO/SystemDocumentViewModel.cs
+++ b/IRaCIS.Core.Application/Service/Document/DTO/SystemDocumentViewModel.cs
@@ -104,6 +104,15 @@ namespace IRaCIS.Core.Application.Contracts
 
     }
 
+    public class GetNextUnSignDocumentInDto
+    {
+        [NotDefault]
+        public Guid TrialId { get; set; }
+
+        public bool Asc { get; set; } = true;
+        public string SortField { get; set; } = "";
+    }
+
     public class TrialUserDocUnionQuery: PageInput
     {
         [NotDefault]
diff --git a/IRaCIS.Core.Application/Service/Document/TrialDocumentService.cs b/IRaCIS.Core.Application/Service/Document/TrialDocumentService.cs
index 3a9acc25e..808b2f680 100644
--- a/IRaCIS.Core.Application/Service/Document/TrialDocumentService.cs
+++ b/IRaCIS.Core.Application/Service/Document/TrialDocumentService.cs
@@ -66,6 +66,32 @@ namespace IRaCIS.Core.Application.Services
         }
 
 
+        /// <summary>
+        /// 获取下一个未签名的文件
+        /// </summary>
+        /// <param name="inDto"></param>
+        /// <returns></returns>
+        [HttpPost]
+        public async Task<UnionDocumentWithConfirmInfoView?> GetNextUnSignDocument(GetNextUnSignDocumentInDto inDto)
+        {
+            var result =await this.GetUserDocumentList(new TrialUserDocUnionQuery()
+            {
+                Asc = inDto.Asc,
+                IsSign = false,
+                SortField = inDto.SortField,
+                PageIndex = 1,
+                PageSize = 1,
+            });
+
+            if (result.Data.CurrentPageData.Count() > 0)
+            {
+                return result.Data.CurrentPageData.First();
+            }
+            else {
+                return null;
+            }
+
+        }
 
         /// <summary>
         ///  具体用户看到的 系统文件列表 + 项目类型文档
diff --git a/IRaCIS.Core.Application/Service/QC/DTO/TrialQCQuestionConfigureViewModel.cs b/IRaCIS.Core.Application/Service/QC/DTO/TrialQCQuestionConfigureViewModel.cs
index 2c95bd487..0d83d094d 100644
--- a/IRaCIS.Core.Application/Service/QC/DTO/TrialQCQuestionConfigureViewModel.cs
+++ b/IRaCIS.Core.Application/Service/QC/DTO/TrialQCQuestionConfigureViewModel.cs
@@ -71,6 +71,11 @@ namespace IRaCIS.Core.Application.Contracts
         public string TypeValue { get; set; }
     }
 
+    public class EmptyQCQuestionInDto
+    {
+        public Guid TrialId { get; set; }
+    }
+
     ///<summary>TrialQCQuestionQuery  列表查询参数模型</summary>
     public class TrialQCQuestionQuery
     {
diff --git a/IRaCIS.Core.Application/Service/QC/TrialQCQuestionService.cs b/IRaCIS.Core.Application/Service/QC/TrialQCQuestionService.cs
index 54b65d983..981fbcdd9 100644
--- a/IRaCIS.Core.Application/Service/QC/TrialQCQuestionService.cs
+++ b/IRaCIS.Core.Application/Service/QC/TrialQCQuestionService.cs
@@ -32,6 +32,18 @@ namespace IRaCIS.Core.Application.Contracts
             this._qCQuestionRepository = qCQuestionRepository;
         }
 
+        /// <summary>
+        /// 清空Qc问题
+        /// </summary>
+        /// <param name="inDto"></param>
+        /// <returns></returns>
+        [HttpPost]
+        public async Task<IResponseOutput> EmptyQCQuestion(EmptyQCQuestionInDto inDto)
+        {
+            await _trialQcQuestionRepository.DeleteFromQueryAsync(x => x.TrialId == inDto.TrialId);
+            await _trialQcQuestionRepository.SaveChangesAsync();
+            return ResponseOutput.Result(true);
+        }
 
         [HttpPost]
         public async Task<(List<TrialQCQuestionConfigureView>, object)> GetTrialQCQuestionConfigureList(TrialQCQuestionQuery queryTrialQCQuestionConfigure)
diff --git a/IRaCIS.Core.Application/Service/Reading/Dto/ReadingMedicineQuestionViewModel.cs b/IRaCIS.Core.Application/Service/Reading/Dto/ReadingMedicineQuestionViewModel.cs
index 6c8326c6a..e2e9128a2 100644
--- a/IRaCIS.Core.Application/Service/Reading/Dto/ReadingMedicineQuestionViewModel.cs
+++ b/IRaCIS.Core.Application/Service/Reading/Dto/ReadingMedicineQuestionViewModel.cs
@@ -319,6 +319,11 @@ namespace IRaCIS.Core.Application.ViewModel
         public List<GetMedicineQuestionPreviewOutDto> Childrens { get; set; }
     }
 
+    public class EmptMedicineTrialQuestionInDto
+    {
+        public Guid TrialReadingCriterionId { get; set; }
+    }
+
     ///<summary>ReadingMedicineTrialQuestionQuery  列表查询参数模型</summary>
     public class ReadingMedicineTrialQuestionQuery:PageInput
     {
diff --git a/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs b/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs
index 94fcf1e41..456eb480d 100644
--- a/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs
+++ b/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs
@@ -138,16 +138,29 @@ namespace IRaCIS.Core.Application.Service
 			return ResponseOutput.Result(result);
 		}
 
-		#endregion
+        #endregion
 
 
-		  #region 项目   
+        #region 项目   
 
-		/// 获取项目的医学审核问题
-		/// </summary>
-		/// <param name="inDto"></param>
-		/// <returns></returns>
-		[HttpPost]
+        /// <summary>
+        /// 清空医学审核问题
+        /// </summary>
+        /// <param name="inDto"></param>
+        /// <returns></returns>
+        [HttpPost]
+        public async Task<IResponseOutput> EmptMedicineTrialQuestion(EmptMedicineTrialQuestionInDto inDto)
+        {
+            await _readingMedicineTrialQuestionRepository.DeleteFromQueryAsync(x => x.TrialReadingCriterionId == inDto.TrialReadingCriterionId);
+            await _readingMedicineTrialQuestionRepository.SaveChangesAsync();
+            return ResponseOutput.Result(true);
+        }
+
+        /// 获取项目的医学审核问题
+        /// </summary>
+        /// <param name="inDto"></param>
+        /// <returns></returns>
+        [HttpPost]
 		public async Task<(PageOutput<ReadingMedicineTrialQuestionView>, object)> GetReadingMedicineTrialQuestionList(ReadingMedicineTrialQuestionQuery inDto)
 		{
 			var query = _readingMedicineTrialQuestionRepository.AsQueryable()