diff --git a/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs b/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs
index 6330be83d..c92ff203c 100644
--- a/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs
+++ b/IRaCIS.Core.Application/Service/Reading/MedicalAudit/ReadingMedicineQuestionService.cs
@@ -637,6 +637,18 @@ namespace IRaCIS.Core.Application.Service
 			{
 				throw new BusinessValidationFailedException(_localizer["ReadingMed_NoOncologyQ"]);
 			}
+			if (!criterionInfo.IsReadingPeriod && (await _readingMedicineTrialQuestionRepository.AnyAsync(x => x.TrialReadingCriterionId == inDto.TrialReadingCriterionId && x.ReadingCategory == ReadingCategory.Global)))
+			{
+				throw new BusinessValidationFailedException(_localizer["ReadingMed_HaveGlobalQ"]);
+			}
+			if (!criterionInfo.IsArbitrationReading && (await _readingMedicineTrialQuestionRepository.AnyAsync(x => x.TrialReadingCriterionId == inDto.TrialReadingCriterionId && x.ReadingCategory == ReadingCategory.Judge)))
+			{
+				throw new BusinessValidationFailedException(_localizer["ReadingMed_HaveJudgeQ"]);
+			}
+			if (!criterionInfo.IsOncologyReading && (await _readingMedicineTrialQuestionRepository.AnyAsync(x => x.TrialReadingCriterionId == inDto.TrialReadingCriterionId && x.ReadingCategory == ReadingCategory.Oncology)))
+			{
+				throw new BusinessValidationFailedException(_localizer["ReadingMed_HaveOncologyQ"]);
+			}
 		}
 
 		/// <summary>