diff --git a/IRaCIS.Core.Application/Service/Reading/ReadingPeriod/ReadModuleService.cs b/IRaCIS.Core.Application/Service/Reading/ReadingPeriod/ReadModuleService.cs
index 7dd57492c..87908db6a 100644
--- a/IRaCIS.Core.Application/Service/Reading/ReadingPeriod/ReadModuleService.cs
+++ b/IRaCIS.Core.Application/Service/Reading/ReadingPeriod/ReadModuleService.cs
@@ -8,6 +8,7 @@ using IRaCIS.Core.Application.Service;
 using IRaCIS.Core.Application.ViewModel;
 using IRaCIS.Core.Infrastructure;
 using IRaCIS.Core.Application.Filter;
+using IRaCIS.Core.Domain.Models;
 
 namespace IRaCIS.Application.Services
 {
@@ -118,6 +119,13 @@ namespace IRaCIS.Application.Services
         [HttpPost]
         public async Task<bool> ChangeCutOffVisit(ChangeCutOffVisitInDto inDto)
         {
+
+            if (await _readModuleRepository.AnyAsync(x => x.Id == inDto.Id && x.IsCRCConfirm))
+            {
+                //---CRC已经确认临床数据 不允许编辑
+                throw new BusinessValidationFailedException(_localizer["ReadModule_CRCConfirmCanNtoEdit"]);
+            }
+
             await _readModuleRepository.UpdatePartialFromQueryAsync(x => x.Id == inDto.Id, x => new ReadModule() {
             SubjectVisitId=inDto.SubjectVisitIdId,
             ModuleName=inDto.Name,