using DocumentFormat.OpenXml.EMMA; using DocumentFormat.OpenXml.Spreadsheet; using IRaCIS.Application.Contracts; using IRaCIS.Core.Application.Contracts; using IRaCIS.Core.Application.Helper; using IRaCIS.Core.Application.Service.Reading.Dto; using IRaCIS.Core.Domain.Models; using IRaCIS.Core.Domain.Share; using IRaCIS.Core.Infrastructure; using MailKit; using Microsoft.Extensions.Options; using Microsoft.VisualBasic; using MimeKit; using System; using System.Collections.Generic; using System.Linq; using System.Net.Mail; using System.Text; using System.Threading.Tasks; namespace IRaCIS.Core.Application.Service { public interface IEmailSendService { Task SendEnrollOrPdEmail(Guid visitTaskId, bool? isEnrollment, bool? isPDConfirm); Task SendClinicalDataQuestionAsync(Guid visitTaskId, string content); Task SendTrialImageQCTaskEmailAsync(Guid trialId); Task SendTrialQCQuestionEmailAsync(Guid trialId); Task SendTrialImageQuestionAsync(Guid trialId); Task SendPIAuditResultAsync(Guid visitTaskId); } public class EmailSendService : BaseService, IEmailSendService { private readonly IRepository _trialEmailNoticeConfigRepository; private readonly IRepository _emailNoticeConfigRepository; private readonly IRepository _trialRepository; private readonly IOptionsMonitor _SystemEmailSendConfig; public readonly static string EmailNamePlaceholder="EmailNamePlaceholder"; public EmailSendService(IRepository trialEmailNoticeConfigRepository, IRepository emailNoticeConfigRepository, IRepository trialRepository, IOptionsMonitor systemEmailSendConfig) { _trialEmailNoticeConfigRepository = trialEmailNoticeConfigRepository; _emailNoticeConfigRepository = emailNoticeConfigRepository; _trialRepository = trialRepository; _SystemEmailSendConfig = systemEmailSendConfig; } //入组确认/PD确认 public async Task SendEnrollOrPdEmail(Guid visitTaskId, bool? isEnrollment, bool? isPDConfirm) { EmailBusinessScenario businessScenarioEnum; bool? result = null; if (isEnrollment != null && isPDConfirm == null) { businessScenarioEnum = EmailBusinessScenario.EnrollConfirmed; result = isEnrollment; } else { businessScenarioEnum = EmailBusinessScenario.PDConfirmed; result = isPDConfirm; } var taskInfo = await _repository.Where(t => t.Id == visitTaskId).Select(t => new { t.Subject.SiteId, t.Trial.ResearchProgramNo, t.Subject.TrialSite.TrialSiteCode, SubjectCode = t.Subject.Code, t.Trial.Sponsor.SponsorName, t.SourceSubjectVisit.VisitName, t.TrialId, }).FirstNotNullAsync(); var isEn_us = _userInfo.IsEn_Us; var resultStr = isEn_us ? (result == true ? "Yes" : "No") : (result == true ? "是" : "否"); if (isEnrollment == true) { Func topicAndHtmlFunc = trialEmailConfig => { var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, taskInfo.ResearchProgramNo, taskInfo.SubjectCode); var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN, EmailNamePlaceholder, taskInfo.ResearchProgramNo, taskInfo.SubjectCode, resultStr); return (topicStr, htmlBodyStr,isEn_us, null); }; await SendTrialEmailAsync(taskInfo.TrialId, businessScenarioEnum, topicAndHtmlFunc); } else { Func topicAndHtmlFunc = trialEmailConfig => { var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, taskInfo.ResearchProgramNo, taskInfo.SubjectCode, taskInfo.VisitName); var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN, EmailNamePlaceholder, taskInfo.ResearchProgramNo, taskInfo.SubjectCode, taskInfo.VisitName, resultStr); return (topicStr, htmlBodyStr, isEn_us, null); }; await SendTrialEmailAsync(taskInfo.TrialId, businessScenarioEnum, topicAndHtmlFunc); } } /// /// 影像质控 /// /// /// public async Task SendTrialImageQCTaskEmailAsync(Guid trialId) { var isEn_us = false; var trialInfo = await _repository.Where(t => t.Id == trialId).Select(t => new { t.ResearchProgramNo, t.ExperimentName, t.TrialCode, t.TrialStatusStr }).FirstNotNullAsync(); //找到 该项目的IQC 用户Id var userList = await _repository.Where(t => t.TrialId == trialId).Where(t => t.User.UserTypeEnum == UserTypeEnum.IQC).Select(t => new { t.UserId, t.User.FullName }).ToListAsync(); //判断是否任务可以领取 ,可以的话 发送邮件 var userIdList = userList.Select(t => t.UserId).ToList(); foreach (var user in userList) { var userId = user.UserId; //过滤项目 并且 将 _userInfo.Id 换位 当前发送邮件的Id var query = _trialRepository.Where(t => t.Id == trialId) .Where(t => t.QCProcessEnum != TrialQCProcess.NotAudit) .Select(t => new { //待领取量 ToBeClaimedCount = t.SubjectVisitList.Where(u => u.SubmitState==SubmitStateEnum.Submitted && u.CurrentActionUserId == null && (u.PreliminaryAuditUserId == null || (u.PreliminaryAuditUserId != userId && u.ReviewAuditUserId == null))).Count(), //待审核通过,统计从已领取到QC提交之间的 已领取 待审核 审核中 (审核完成 领取人就会清理 所以只用查询当前领取人是自己的就好了) ToBeReviewedCount = t.SubjectVisitList.Where(u => u.CurrentActionUserId == userId).Count() }); var sendStat = await query.FirstOrDefaultAsync(); //当前人 有待领取的或者有待审核的才发邮件 if (sendStat != null && (sendStat.ToBeClaimedCount > 0 || sendStat.ToBeReviewedCount > 0)) { Func topicAndHtmlFunc = trialEmailConfig => { var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, trialInfo.ResearchProgramNo); var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN, user.FullName, DateTime.Now, sendStat.ToBeClaimedCount, sendStat.ToBeReviewedCount, _SystemEmailSendConfig.CurrentValue.SiteUrl); return (topicStr, htmlBodyStr, false,userId); }; await SendTrialEmailAsync(trialId, EmailBusinessScenario.QCTask, topicAndHtmlFunc); } } } /// /// QC质疑 /// /// /// public async Task SendTrialQCQuestionEmailAsync(Guid trialId) { var isEn_us = false; var trialInfo = _repository.Where(t => t.Id == trialId).Select(t => new { t.ResearchProgramNo, t.ExperimentName, t.TrialCode, t.TrialStatusStr,t.DeclarationTypeEnumList }).FirstOrDefault(); //找到 该项目的IQC 用户Id var userList = await _repository.Where(t => t.TrialId == trialId).Where(t => t.User.UserTypeEnum == UserTypeEnum.IQC).Select(t => new { t.UserId, t.User.FullName }).ToListAsync(); //判断是否任务可以领取 ,可以的话 发送邮件 foreach (var user in userList) { var userId = user.UserId; //过滤项目 并且 将 _userInfo.Id 换位 当前发送邮件的Id var query = _trialRepository .Where(t => t.Id == trialId) .Select(t => new { ReUploadTobeDealedCount = t.SubjectVisitList.SelectMany(c => c.QCChallengeList) .Where(u => u.CreateUserId == userId && u.IsClosed == false && u.LatestReplyUser.UserTypeEnum == UserTypeEnum.ClinicalResearchCoordinator && u.ReuploadEnum == QCChanllengeReuploadEnum.CRCRequestReupload).Count(), //质疑待处理 发送邮件的时候 需要减去ReUploadTobeDealedCount ToBeDealedCount = t.SubjectVisitList.SelectMany(c => c.QCChallengeList) .Where(u => u.CreateUserId == userId && u.IsClosed == false && u.LatestReplyUser.UserTypeEnum == UserTypeEnum.ClinicalResearchCoordinator).Count(), }); var sendStat = await query.FirstOrDefaultAsync(); //当前人 if (sendStat != null && (sendStat.ToBeDealedCount > 0 || sendStat.ReUploadTobeDealedCount > 0)) { Func topicAndHtmlFunc = trialEmailConfig => { var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, trialInfo.ResearchProgramNo); var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN, user.FullName, DateTime.Now, sendStat.ToBeDealedCount- sendStat.ReUploadTobeDealedCount, sendStat.ReUploadTobeDealedCount, _SystemEmailSendConfig.CurrentValue.SiteUrl); return (topicStr, htmlBodyStr, false, userId); }; await SendTrialEmailAsync(trialId, EmailBusinessScenario.QCQuestion, topicAndHtmlFunc); } } } /// /// 影像质疑 /// /// /// public async Task SendTrialImageQuestionAsync(Guid trialId) { var isEn_us = false; var trialInfo = _repository.Where(t => t.Id == trialId).Select(t => new { t.ResearchProgramNo, t.ExperimentName, t.TrialCode, t.TrialStatusStr }).FirstOrDefault(); //找到 该项目的CRC 用户Id var userList = await _repository.Where(t => t.TrialId == trialId).Where(t => t.User.UserTypeEnum == UserTypeEnum.ClinicalResearchCoordinator).Select(t => new { t.UserId, t.User.FullName }).ToListAsync(); //判断是否任务可以领取 ,可以的话 发送邮件 foreach (var user in userList) { var userId = user.UserId; //过滤项目 并且 将 _userInfo.Id 换位 当前发送邮件的Id var query = _trialRepository.Where(t=>t.Id==trialId) .Select(t => new { //质疑待处理 ToBeDealedCount = t.SubjectVisitList.Where(t=>t.TrialSite.CRCUserList.Any(t=>t.UserId==userId)).SelectMany(c => c.QCChallengeList) .Where(u => u.IsClosed == false && (u.LatestReplyUser.UserTypeEnum == UserTypeEnum.IQC || u.LatestReplyUserId==null)).Count(), }); var sendStat = await query.FirstOrDefaultAsync(); //当前人 if (sendStat != null && (sendStat.ToBeDealedCount > 0)) { Func topicAndHtmlFunc = trialEmailConfig => { var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, trialInfo.ResearchProgramNo); var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN, user.FullName, DateTime.Now, sendStat.ToBeDealedCount, _SystemEmailSendConfig.CurrentValue.SiteUrl); return (topicStr, htmlBodyStr, isEn_us, userId); }; await SendTrialEmailAsync(trialId, EmailBusinessScenario.ImageQuestion, topicAndHtmlFunc); } } } //临床数据质询 public async Task SendClinicalDataQuestionAsync(Guid visitTaskId, string content) { var isEn_us = _userInfo.IsEn_Us; var info = await _repository.Where(t => t.Id == visitTaskId, ignoreQueryFilters: true).Select(t => new { t.TrialId, t.Trial.ResearchProgramNo, t.Trial.TrialCode, t.SourceSubjectVisit.VisitName, t.Subject.Code }).FirstOrDefaultAsync(); Func topicAndHtmlFunc = trialEmailConfig => { var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, info.ResearchProgramNo,info.Code,info.VisitName); var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN, EmailNamePlaceholder, info.ResearchProgramNo, info.Code, info.VisitName,_userInfo.UserName,content, _SystemEmailSendConfig.CurrentValue.SiteUrl); return (topicStr, htmlBodyStr, isEn_us, null); }; await SendTrialEmailAsync(info.TrialId, EmailBusinessScenario.ClinicalDataQuestion, topicAndHtmlFunc); } public async Task SendPIAuditResultAsync(Guid visitTaskId) { var isEn_us = _userInfo.IsEn_Us; var info = await _repository.Where(t => t.Id == visitTaskId, ignoreQueryFilters: true).Select(t => new { t.TrialId, t.Trial.ResearchProgramNo, t.Trial.TrialCode, t.SourceSubjectVisit.VisitName, t.Subject.Code }).FirstOrDefaultAsync(); var answerList= await _repository.Where(t => t.Id == visitTaskId, ignoreQueryFilters: true).SelectMany(t=>t.ReadingTaskQuestionAnswerList).Select(t=>new { QuestionName= isEn_us? t.ReadingQuestionTrial.QuestionEnName:t.ReadingQuestionTrial.QuestionName,t.Answer}).ToListAsync(); //var template = "
Role: {2}
"; var piResult=string.Empty; Func topicAndHtmlFunc = trialEmailConfig => { var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, info.ResearchProgramNo, info.Code, info.VisitName); var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN, EmailNamePlaceholder, info.ResearchProgramNo, info.Code, info.VisitName, _userInfo.UserName, piResult, _SystemEmailSendConfig.CurrentValue.SiteUrl); return (topicStr, htmlBodyStr, isEn_us, null); }; await SendTrialEmailAsync(info.TrialId, EmailBusinessScenario.PIAuditResutl, topicAndHtmlFunc); } public async Task SendTrialEmailAsync(Guid trialId, EmailBusinessScenario businessScenario, Func topicAndHtmlFunc, Guid? trialReadingCriterionId = null, Guid? subjectId = null) { //找到配置 var trialEmailConfig = await _trialEmailNoticeConfigRepository.Where(t => t.TrialId == trialId && t.TrialReadingCriterionId == trialReadingCriterionId && t.BusinessScenarioEnum == businessScenario, ignoreQueryFilters: true) .Include(t => t.TrialEmailNoticeUserList).Include(t => t.TrialEmailBlackUserList).FirstOrDefaultAsync(); if (trialEmailConfig == null || trialEmailConfig.IsAutoSend == false) { return; } else { var sendEmailConfig = new SMTPEmailConfig(); var (topicStr, htmlBodyStr, isEn_us,onlyToUserId) = topicAndHtmlFunc(trialEmailConfig); sendEmailConfig.TopicDescription = topicStr; sendEmailConfig.HtmlBodyStr = htmlBodyStr; var blackUserIdList = trialEmailConfig.TrialEmailBlackUserList.Select(t => t.UserId).ToList(); //收件人 如果是CRC CRA 要按照中心发送 var toUserTypeEnumList = trialEmailConfig.TrialEmailNoticeUserList.Where(t => t.EmailUserType == EmailUserType.To).Select(c => c.UserType).ToList(); var copyUserTypeEnumList = trialEmailConfig.TrialEmailNoticeUserList.Where(t => t.EmailUserType == EmailUserType.Copy).Select(c => c.UserType).ToList(); var allUserTypeEnumList = toUserTypeEnumList.Union(copyUserTypeEnumList).Distinct().ToList(); var allUserList = await _repository.Where(t => t.TrialId == trialId && allUserTypeEnumList.Contains(t.User.UserTypeEnum)).Select(t => new { t.UserId, t.User.EMail, t.User.FullName, t.User.UserTypeEnum }).ToListAsync(); var toUserList = allUserList.Where(t => toUserTypeEnumList.Contains(t.UserTypeEnum)) .ToList(); if (subjectId != null) { toUserList = _repository.Where(t => t.TrialId == trialId && toUserTypeEnumList.Contains(t.User.UserTypeEnum) && t.TrialSite.SubjectList.Any(c => c.Id == subjectId)).Select(t => new { t.UserId, t.User.EMail, t.User.FullName, t.User.UserTypeEnum }).ToList(); } //去除黑名单 toUserList = toUserList.Where(t => !blackUserIdList.Contains(t.UserId)).ToList(); var copyUserList = allUserList.Where(t => copyUserTypeEnumList.Contains(t.UserTypeEnum)).Where(t => !blackUserIdList.Contains(t.UserId)).ToList(); if(onlyToUserId!=null) { toUserList= toUserList.Where(t=>t.UserId == onlyToUserId).ToList(); } else { htmlBodyStr = htmlBodyStr.Replace(EmailNamePlaceholder, string.Join(isEn_us ? ", " : "、", toUserList.Select(t => t.FullName).ToList())); } if (toUserList.Count() == 0) { //---没有收件人,无法发送邮件 throw new BusinessValidationFailedException(_localizer["TrialEmailN_NoRecipient"]); } if (trialEmailConfig.FromEmail.Contains("@") && !string.IsNullOrEmpty(trialEmailConfig.FromEmail)) { sendEmailConfig.FromEmailAddress = new MimeKit.MailboxAddress(trialEmailConfig.FromName, trialEmailConfig.FromEmail); sendEmailConfig.AuthorizationCode = trialEmailConfig.AuthorizationCode; sendEmailConfig.UserName = trialEmailConfig.FromName; sendEmailConfig.Host = trialEmailConfig.SMTPServerAddress; sendEmailConfig.Port = trialEmailConfig.SMTPServerPort; } else { //---项目发件邮箱配置有误,请核实 throw new BusinessValidationFailedException(_localizer["TrialEmailN_InvalidEmailConfig"]); } foreach (var item in toUserList) { if (item.EMail.Contains("@") && !string.IsNullOrEmpty(item.EMail)) { sendEmailConfig.ToMailAddressList.Add(new MimeKit.MailboxAddress(item.FullName, item.EMail)); } } foreach (var item in copyUserList) { if (item.EMail.Contains("@") && !string.IsNullOrEmpty(item.EMail)) { sendEmailConfig.CopyToMailAddressList.Add(new MimeKit.MailboxAddress(item.FullName, item.EMail)); } } await SendEmailHelper.SendEmailAsync(sendEmailConfig); } } } }