using IRaCIS.Core.Application.Service.Reading.Dto;
using IRaCIS.Core.Domain.Share;
using Microsoft.AspNetCore.Mvc;
using IRaCIS.Core.Domain.Models;
using IRaCIS.Core.Application.Interfaces;
using IRaCIS.Core.Application.ViewModel;
using Panda.DynamicWebApi.Attributes;
using IRaCIS.Core.Infra.EFCore.Common;
using Microsoft.Extensions.Caching.Memory;

using IRaCIS.Core.Infrastructure;
using MassTransit;
using System.Reflection.Metadata.Ecma335;
using System.Linq;
using NPOI.SS.Formula.Functions;
using DocumentFormat.OpenXml.Drawing.Charts;
using IRaCIS.Core.Application.Contracts;
using IRaCIS.Core.Application.Service.ReadingCalculate.Interface;
using DocumentFormat.OpenXml.Office2016.Drawing.ChartDrawing;

namespace IRaCIS.Core.Application.Service.ReadingCalculate
{

    [ApiExplorerSettings(GroupName = "Reading")]
    public class LuganoCalculateService : BaseService, ICriterionCalculateService, ILuganoCalculateService
	{
        private readonly IRepository<ReadingTableQuestionAnswer> _readingTableQuestionAnswerRepository;
        private readonly IRepository<VisitTask> _visitTaskRepository;
        private readonly IRepository<ReadingQuestionCriterionTrial> _readingQuestionCriterionTrialRepository;
        private readonly IRepository<ReadingTableQuestionTrial> _readingTableQuestionTrialRepository;
        private readonly IRepository<ReadingTaskQuestionMark> _readingTaskQuestionMarkRepository;
        private readonly IRepository<ReadingTableAnswerRowInfo> _readingTableAnswerRowInfoRepository;
		private readonly IRepository<ReadingGlobalTaskInfo> _readingGlobalTaskInfoRepository;
		private readonly IRepository<ReadingQuestionTrial> _readingQuestionTrialRepository;
        private readonly IRepository<OrganInfo> _organInfoRepository;
        private readonly IRepository<SubjectVisit> _subjectVisitRepository;
        private readonly IRepository<DicomStudy> _dicomStudyRepository;
        private readonly IRepository<TumorAssessment_RECIST1Point1> _tumorAssessmentRepository;
        private readonly ISubjectVisitService _subjectVisitService;
        private readonly IGeneralCalculateService _generalCalculateService;
        private readonly IRepository<ReadingTaskQuestionAnswer> _readingTaskQuestionAnswerRepository;

        public LuganoCalculateService(
            IRepository<ReadingTableQuestionAnswer> readingTableQuestionAnswerRepository,
            IRepository<VisitTask> visitTaskRepository,
            IRepository<ReadingQuestionCriterionTrial> readingQuestionCriterionTrialRepository,
            IRepository<ReadingTableQuestionTrial> readingTableQuestionTrialRepository,
               IRepository<ReadingTaskQuestionMark> readingTaskQuestionMarkRepository,
            IRepository<ReadingTableAnswerRowInfo> readingTableAnswerRowInfoRepository,
			  IRepository<ReadingGlobalTaskInfo> readingGlobalTaskInfoRepository,
			IRepository<ReadingQuestionTrial> readingQuestionTrialRepository,
            IRepository<OrganInfo> organInfoRepository,
            IRepository<SubjectVisit> subjectVisitRepository,
               IRepository<DicomStudy> dicomStudyRepository,
            IRepository<TumorAssessment_RECIST1Point1> tumorAssessmentRepository,
            ISubjectVisitService subjectVisitService,
            IGeneralCalculateService generalCalculateService,
            IRepository<ReadingTaskQuestionAnswer> readingTaskQuestionAnswerRepository
            )
        {
            this._readingTableQuestionAnswerRepository = readingTableQuestionAnswerRepository;
            this._visitTaskRepository = visitTaskRepository;
            this._readingQuestionCriterionTrialRepository = readingQuestionCriterionTrialRepository;
            this._readingTableQuestionTrialRepository = readingTableQuestionTrialRepository;
            this._readingTaskQuestionMarkRepository = readingTaskQuestionMarkRepository;
            this._readingTableAnswerRowInfoRepository = readingTableAnswerRowInfoRepository;
			this._readingGlobalTaskInfoRepository = readingGlobalTaskInfoRepository;
			this._readingQuestionTrialRepository = readingQuestionTrialRepository;
            this._organInfoRepository = organInfoRepository;
            this._subjectVisitRepository = subjectVisitRepository;
            this._dicomStudyRepository = dicomStudyRepository;
            this._tumorAssessmentRepository = tumorAssessmentRepository;
            this._subjectVisitService = subjectVisitService;
            this._generalCalculateService = generalCalculateService;
            this._readingTaskQuestionAnswerRepository = readingTaskQuestionAnswerRepository;
        }

		/// <summary>
		/// 获取阅片的计算数据
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task<object> GetReadingCalculationData(GetReadingCalculationDataInDto inDto)
		{
			ReadingCalculateDto readingData = await _generalCalculateService.GetReadingCalculateDto(inDto.VisitTaskId);
            var baseLinePET5PS = 0m;
			if (!readingData.IsBaseLine)
			{
				var baseLineTaskId = await GetBaseLineTaskId(readingData);
				 baseLinePET5PS = (await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.PET5PS).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();

			}
			return new
            {
			   BaseLinePET5PS= baseLinePET5PS,

			};
		}

		#region 临时对象 单个请求的生命周期 避免重复查询数据库

		private List<VisitTaskAnswerInfo> visitTaskAnswerList;

        /// <summary>
        /// 获取Sod的值
        /// </summary>
        private decimal? sODData;

        /// <summary>
        /// 基线任务Id
        /// </summary>
        private Guid? BaseLineTaskId;

        private string nAString = "NA";
        #endregion

        #region 删除病灶获取起始病灶序号
        /// <summary>
        /// 删除病灶获取起始病灶序号（RECIST1Point1 固定是1）
        /// </summary>
        /// <returns></returns>
        public async Task<int> GetDeleteLesionStatrIndex(DeleteReadingRowAnswerInDto inDto)
        {
            return 1;
        }
        #endregion

        #region 获取阅片报告
        /// <summary>
        /// 获取阅片报告
        /// </summary>
        /// <param name="indto"></param>
        /// <returns></returns>
        [HttpPost]
        public async Task<GetReadingReportEvaluationOutDto> GetReadingReportEvaluation(GetReadingReportEvaluationInDto indto)
        {
            GetReadingReportEvaluationOutDto result = new GetReadingReportEvaluationOutDto();

            result.CalculateResult = await this.GetReportVerify(new GetReportVerifyInDto()
            {
                VisitTaskId = indto.VisitTaskId
            });


            var visitTaskInfo = await _visitTaskRepository.Where(x => x.Id == indto.VisitTaskId).FirstNotNullAsync();

            result.ReadingTaskState = visitTaskInfo.ReadingTaskState;
            var taskInfoList = await _generalCalculateService.GetReadingReportTaskList(indto.VisitTaskId);

            result.VisitTaskList = taskInfoList;

            var visitTaskIds = taskInfoList.Select(x => x.VisitTaskId).ToList();

            var criterionId = visitTaskInfo.TrialReadingCriterionId;
            var questionList = await _readingQuestionTrialRepository.Where(x => x.ReadingQuestionCriterionTrialId == criterionId && x.ShowQuestion != ShowQuestion.Hide).ToListAsync();
            var tableQuestionList = await _readingTableQuestionTrialRepository.Where(x => x.TrialCriterionId == criterionId).OrderBy(x => x.ShowOrder).ToListAsync();
            var tableAnsweRowInfos = await _readingTableAnswerRowInfoRepository.Where(x => x.VisitTaskId == indto.VisitTaskId).ProjectTo<TableAnsweRowInfo>(_mapper.ConfigurationProvider).ToListAsync();
            result.LesionCountList = tableAnsweRowInfos.GroupBy(x => x.LesionType).Select(x => new LesionDto
            {
                LesionType = x.Key,
                Count = x.ToList().Count()
            }).ToList();
            var answers = await _readingTaskQuestionAnswerRepository.Where(x => visitTaskIds.Contains(x.VisitTaskId)).ToListAsync();
            var tableAnswers = await _readingTableQuestionAnswerRepository.Where(x => visitTaskIds.Contains(x.VisitTaskId)).ToListAsync();

            var globalanswerList = await _readingGlobalTaskInfoRepository.Where(x => visitTaskIds.Contains(x.TaskId)&&x.GlobalVisitTask.TaskState== TaskState.Effect&&x.Answer!=string.Empty).Select(x => new
            {
                x.TaskId,
                x.GlobalVisitTask.VisitTaskNum,
                x.QuestionId,
                x.Answer
            }).ToListAsync();

			var alltableAnsweRowInfos = await _readingTableAnswerRowInfoRepository.Where(x => visitTaskIds.Contains(x.VisitTaskId)).ToListAsync();
            var organIds = alltableAnsweRowInfos.Where(x => x.OrganInfoId != null).Select(x => x.OrganInfoId).Distinct().ToList();
            var organInfos = await _organInfoRepository.Where(x => organIds.Contains(x.Id)).ToListAsync();

            var needChangeType = new List<QuestionMark?>() {
                QuestionMark.Organ,
                QuestionMark.Location,
                QuestionMark.Part,
            };

            // 第一级

            #region 构造问题
            List<ReadingReportDto> questions = questionList.Where(x => x.Type == ReadingQestionType.Group).OrderBy(x => x.ShowOrder).Select(x => new ReadingReportDto()
            {
                QuestionId = x.Id,
                GroupName = x.GroupName,
                GroupEnName = x.GroupEnName,
                IsShowInDicom = x.IsShowInDicom,
                Type = x.Type,
                GroupId = x.GroupId,
                QuestionType = x.QuestionType,
                LesionType = x.LesionType,
                QuestionGenre = x.QuestionGenre,
                DataSource = x.DataSource,
                DictionaryCode = x.DictionaryCode,
                TypeValue = x.TypeValue,
                QuestionName = x.QuestionName.LanguageName(x.QuestionEnName, _userInfo.IsEn_Us),
                ShowOrder = x.ShowOrder,
                ValueType = x.ValueType,
                Unit = x.Unit,
                CustomUnit = x.CustomUnit,
                ReportLayType = ReportLayType.Group,
            }).ToList();

            // 分组
            foreach (var item in questions)
            {
                item.Childrens = questionList.Where(x => x.GroupId == item.QuestionId).OrderBy(x => x.ShowOrder).Select(x => new ReadingReportDto()
                {
                    GroupName = x.GroupName,
                    QuestionId = x.Id,
                    IsShowInDicom = x.IsShowInDicom,
                    GroupEnName = x.GroupEnName,
                    QuestionName = x.QuestionName.LanguageName(x.QuestionEnName, _userInfo.IsEn_Us),
                    LesionType = x.LesionType,
                    QuestionGenre = x.QuestionGenre,
                    DataSource = x.DataSource,
                    DictionaryCode = x.DictionaryCode,
                    Type = x.Type,
                    QuestionType = x.QuestionType,
                    TypeValue = x.TypeValue,
                    ShowOrder = x.ShowOrder,
                    OrderMark = x.OrderMark,
                    ValueType = x.ValueType,
                    Unit = x.Unit,
                    CustomUnit = x.CustomUnit,
                    ReportLayType = ReportLayType.Question,
                }).ToList();

                // 问题
                foreach (var question in item.Childrens)
                {

                    foreach (var task in taskInfoList)
                    {

                        var globalAnswer = globalanswerList.Where(x => x.TaskId == task.VisitTaskId && x.QuestionId == question.QuestionId).OrderByDescending(x => x.VisitTaskNum).FirstOrDefault();
                        var answer = answers.Where(x => x.VisitTaskId == task.VisitTaskId && x.ReadingQuestionTrialId == question.QuestionId).FirstOrDefault();
                        question.Answer.Add(new TaskQuestionAnswer()
                        {
                            Answer = answer == null ? string.Empty : answer.Answer,
                            IsGlobalChange = globalAnswer == null ? false : true,
                            GlobalChangeAnswer = globalAnswer == null ? string.Empty : globalAnswer.Answer,
                            TaskName = task.TaskName,
                            VisitTaskId = task.VisitTaskId,

                        });
                    }

                    // 构造表格行数据


                    var rowlist = tableAnsweRowInfos.Where(x => x.QuestionId == question.QuestionId).OrderBy(x => x.RowIndex).ToList();


                    question.Childrens = rowlist.Select(x => new ReadingReportDto()
                    {
                        QuestionName = question.OrderMark + x.RowIndex.GetLesionMark(),
                        SplitOrMergeLesionName = x.MergeName.IsNullOrEmpty() ? x.SplitName : x.MergeName,
                        SplitOrMergeType = x.SplitOrMergeType,
                        LesionType = question.LesionType,
                        IsShowInDicom = question.IsShowInDicom,
                        IsCanEditPosition = x.IsCanEditPosition,
                        RowIndex = x.RowIndex,
                        BlindName = x.BlindName,
                        ReportLayType = ReportLayType.Lesions,
                    }).ToList();


                    foreach (var row in question.Childrens)
                    {
                        // tableQuestion
                        row.Childrens = tableQuestionList.Where(x => x.ReadingQuestionId == question.QuestionId).Select(x => new ReadingReportDto()
                        {
                            QuestionName = x.QuestionName.LanguageName(x.QuestionEnName, _userInfo.IsEn_Us),
                            QuestionId = x.ReadingQuestionId,
                            TableQuestionId = x.Id,
                            Type = x.Type,
                            LesionType = question.LesionType,
                            TableQuestionType = x.TableQuestionType,
                            RowId = row.RowId,
                            IsShowInDicom = question.IsShowInDicom,
                            DataSource = x.DataSource,
                            DictionaryCode = x.DictionaryCode,
                            QuestionMark = x.QuestionMark,
                            TypeValue = x.TypeValue,
                            RowIndex = row.RowIndex,
                            ShowOrder = x.ShowOrder,
                            ValueType = x.ValueType,
                            Unit = x.Unit,
                            ReportLayType = ReportLayType.TableQuestion,
                        }).ToList();


                        foreach (var tableQuestion in row.Childrens)
                        {
                            foreach (var task in taskInfoList)
                            {
                                var rowinfo = alltableAnsweRowInfos.Where(x => x.VisitTaskId == task.VisitTaskId && x.QuestionId == tableQuestion.QuestionId && x.RowIndex == tableQuestion.RowIndex).FirstOrDefault();
                                var taskQuestionAnswer = new TaskQuestionAnswer()
                                {
                                    Answer = tableAnswers.Where(x => x.VisitTaskId == task.VisitTaskId && x.QuestionId == tableQuestion.QuestionId && x.RowIndex == tableQuestion.RowIndex && x.TableQuestionId == tableQuestion.TableQuestionId).Select(x => x.Answer).FirstIsNullReturnEmpty(),
                                    TaskName = task.TaskName,
                                    VisitTaskId = task.VisitTaskId,
                                };
                                if (rowinfo != null && rowinfo.OrganInfoId != null)
                                {
                                    var organInfo = organInfos.Where(x => x.Id == rowinfo.OrganInfoId).FirstOrDefault();


                                    if (organInfo != null && needChangeType.Contains(tableQuestion.QuestionMark))
                                    {
                                        if (_userInfo.IsEn_Us)
                                        {
                                            switch (tableQuestion.QuestionMark)
                                            {
                                                case QuestionMark.Organ:
                                                    taskQuestionAnswer.Answer = organInfo.TULOCEN;

                                                    break;
                                                case QuestionMark.Location:
                                                    if (organInfo.IsCanEditPosition)
                                                    {

                                                    }
                                                    else
                                                    {
                                                        taskQuestionAnswer.Answer = organInfo.TULATEN;

                                                    }
                                                    break;
                                                case QuestionMark.Part:

                                                    taskQuestionAnswer.Answer = organInfo.PartEN;

                                                    break;

                                            }

                                        }
                                        else
                                        {
                                            switch (tableQuestion.QuestionMark)
                                            {
                                                case QuestionMark.Organ:
                                                    taskQuestionAnswer.Answer = organInfo.TULOC;
                                                    break;
                                                case QuestionMark.Location:
                                                    if (organInfo.IsCanEditPosition)
                                                    {

                                                    }
                                                    else
                                                    {
                                                        taskQuestionAnswer.Answer = organInfo.TULAT;

                                                    }
                                                    break;
                                                case QuestionMark.Part:
                                                    taskQuestionAnswer.Answer = organInfo.Part;
                                                    break;

                                            }
                                        }

                                    }
                                }
                                tableQuestion.Answer.Add(taskQuestionAnswer);
                            }
                        }


                    }


                };
            }
            #endregion



            result.TaskQuestions = questions;



            return result;

        }
        #endregion

        /// <summary>
        /// 测试计算
        /// </summary>
        /// <param name="visitTaskId"></param>
        /// <param name="type"></param>
        /// <returns></returns>
        [HttpPost]
        public async Task TestCalculate(Guid visitTaskId, QuestionType type)
        {
            ReadingCalculateDto readingData = await _generalCalculateService.GetReadingCalculateDto(visitTaskId);
            await ReadingCalculate(readingData, new List<QuestionType>() { type });
        }

        /// <summary>
        /// 获取最低PDD信息
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        [HttpPost]
        public async Task<GetPPDInfoOutDto> GetLowPPDInfo(GetPPDInfoInDto inDto)
        {
            GetPPDInfoOutDto result = new GetPPDInfoOutDto();
            var taskinfo = await _visitTaskRepository.Where(x => x.Id == inDto.VisitTaskId).ProjectTo<VisitTaskDto>(_mapper.ConfigurationProvider).FirstNotNullAsync();
            var visitTaskIds = await _visitTaskRepository.Where(x => x.ReadingCategory == ReadingCategory.Visit &&
                 x.TrialReadingCriterionId == taskinfo.TrialReadingCriterionId &&
                 x.IsAnalysisCreate == taskinfo.IsAnalysisCreate &&
                  x.DoctorUserId == taskinfo.DoctorUserId &&
                  x.IsSelfAnalysis == taskinfo.IsSelfAnalysis &&
                 x.SubjectId == taskinfo.SubjectId && x.ReadingTaskState == ReadingTaskState.HaveSigned && x.ArmEnum == taskinfo.ArmEnum
                 && x.VisitTaskNum < taskinfo.VisitTaskNum && x.TaskState == TaskState.Effect
                 ).OrderByDescending(x => x.VisitTaskNum).Select(x => x.Id).ToListAsync();

            var answerList = await _readingTableQuestionAnswerRepository.Where(x => visitTaskIds.Contains(x.VisitTaskId)
              && x.QuestionId == inDto.QuestionId
              && x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.PPD && x.RowIndex == inDto.RowIndex)
                  .Select(x => new
                  {
                      x.Answer,
                      x.VisitTaskId,
                  }).ToListAsync();

            var lowPddTaskid = answerList.Select(x => new
            {
                Answer = x.Answer.IsNullOrEmptyReturn0(),
                x.VisitTaskId
            }).OrderBy(x => x.Answer).Select(x => x.VisitTaskId).FirstOrDefault();

            if (lowPddTaskid != default(Guid))
            {
                var lowPPDAnswerList = await _readingTableQuestionAnswerRepository.Where(x => x.VisitTaskId == lowPddTaskid
              && x.QuestionId == inDto.QuestionId
             && x.RowIndex == inDto.RowIndex).Include(x => x.ReadingTableQuestionTrial)
                  .Select(x => new
                  {
                      x.Answer,
                      x.ReadingTableQuestionTrial.QuestionMark,
                  }).ToListAsync();

                result.NadirPPD = lowPPDAnswerList.Where(x => x.QuestionMark == QuestionMark.PPD).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
                result.LowPPDLDi = lowPPDAnswerList.Where(x => x.QuestionMark == QuestionMark.MajorAxis).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
                result.LowPPDSDi = lowPPDAnswerList.Where(x => x.QuestionMark == QuestionMark.ShortAxis).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
                result.LowPPDVisit = await _visitTaskRepository.Where(x => x.Id == lowPddTaskid).Select(x => x.TaskBlindName).FirstOrDefaultAsync();
            }

            return result;

        }

        /// <summary>
        /// 计算任务
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        [HttpPost]
        public async Task CalculateTask(CalculateTaskInDto inDto)
        {
            ReadingCalculateDto readingData = await _generalCalculateService.GetReadingCalculateDto(inDto.VisitTaskId);
            readingData.IsChangeOtherTask = inDto.IsChangeOtherTask;
            readingData.ComputationTrigger = inDto.ComputationTrigger;
            await ReadingCalculate(readingData);
        }

        /// <summary>
        /// 获取报告验证的信息(这里每个标准可能不一样 返回用object)
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<GetReportVerifyOutDto> GetReportVerify(GetReportVerifyInDto inDto)
        {
            var calculateDto = await _generalCalculateService.GetReadingCalculateDto(inDto.VisitTaskId);
            return new GetReportVerifyOutDto()
            {
                TumorEvaluate = calculateDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.ImgOncology).Select(x => x.Answer).FirstOrDefault(),
                IsExistDisease = await this.GetReportIsExistDisease(inDto.VisitTaskId),

            };
        }



        /// <summary>
        /// 自动计算
        /// </summary>
        /// <param name="inDto"></param>
        /// <param name="calculateType"></param>
        /// <returns></returns>
        public async Task ReadingCalculate(ReadingCalculateDto inDto, List<QuestionType>? calculateType = null)
        {

            #region 计算  这里顺序非常重要 后面计算的值要依赖前面计算的结果
            var needAddList = new List<ReadingTaskQuestionAnswer>();


            List<ReadingCalculateData> calculateList = new List<ReadingCalculateData>()
            {
                   // 是否存在Pet
                 new ReadingCalculateData (){QuestionType=QuestionType.ExistPET,GetStringFun=GetExistPET},

                //垂直径乘积之和（SPD）
				new ReadingCalculateData (){QuestionType=QuestionType.SPD,GetDecimalFun=GetSPD},

                 // 与基线相比SPD变化的百分比
			    new ReadingCalculateData (){QuestionType=QuestionType.SPDChange,GetStringFun=CompareBaselineSPD},

                // 与基线相比脾肿大增加的百分比
				new ReadingCalculateData (){QuestionType=QuestionType.SplenoncusChange,GetStringFun=GetSplenoncusChange},

                // 与最低点相比脾脏垂直径长度的增加值
                new ReadingCalculateData (){QuestionType=QuestionType.SplenoncusAdd,GetStringFun=GetSplenoncusAdd},

                // 与基线相比脾垂直径变化值
                new ReadingCalculateData (){QuestionType=QuestionType.SplenoncusDiameterChange,GetStringFun=GetSplenoncusDiameterChange},

                // 脾肿垂直径最低点访视
                new ReadingCalculateData (){QuestionType=QuestionType.LowestSplenoncusVisit,GetStringFun=GetLowestSplenoncusVisit},

                // 获取脾脏评估
                new ReadingCalculateData (){QuestionType=QuestionType.SplenicEvaluation,GetStringFun=GetSplenicEvaluation},

                //靶病灶评估
			    new ReadingCalculateData (){QuestionType=QuestionType.TargetLesion,GetStringFun=GetTargetLesionEvaluate},

				//非靶病灶评估
			    new ReadingCalculateData (){QuestionType=QuestionType.NoTargetLesion,GetStringFun=GetNoTargetLesionEvaluate},

				//新病灶评估
			    new ReadingCalculateData (){QuestionType=QuestionType.NewLesionEvaluation,GetStringFun=GetNewLesionEvaluate},

                    //获取肝脏评估
                 new ReadingCalculateData (){QuestionType=QuestionType.LiverAssessment,GetStringFun=GetLiverAssessment},

                  //  // 骨髓中是否存在局灶性 FDG亲和病灶的证据
                  //new ReadingCalculateData (){QuestionType=QuestionType.EvidenceFocalFDG,GetStringFun=GetEvidenceFocalFDG,ComputationTrigger=ComputationTrigger.Lesion},

                //CT/MRI
                new ReadingCalculateData (){QuestionType=QuestionType.CTandMRI,GetStringFun=CTMRIEvaluation},

                // PET 5PS评分
                new ReadingCalculateData (){QuestionType=QuestionType.PET5PS,GetStringFun=GetPET5PS,ComputationTrigger=ComputationTrigger.Lesion},

                // 修改PET 5PS评分备注
			   new ReadingCalculateData (){QuestionType=QuestionType.PSScoreRemarks,GetStringFun=GetPET5PSRemark,ComputationTrigger=ComputationTrigger.Lesion},

                //与基线相比摄取值变化
                new ReadingCalculateData (){QuestionType=QuestionType.UptakeChange,GetStringFun=GetUptakeChange,ComputationTrigger=ComputationTrigger.Lesion},

                // FDG-PET 评估结果
                 new ReadingCalculateData (){QuestionType=QuestionType.FDGPET,GetStringFun=GetFDGPETOverallAssessment},

                   // 上一次 FDG-PET 评估结果
                 new ReadingCalculateData (){QuestionType=QuestionType.LastFDGPET,GetStringFun=GetLastFDGPETOverallAssessment},

                 // 影像学整体肿瘤评估
                 new ReadingCalculateData (){QuestionType=QuestionType.ImgOncology,GetStringFun=GetImgOncology},

             
                     //SUVmax
                 new ReadingCalculateData (){QuestionType=QuestionType.SUVmax,GetDecimalNullFun=GetSuvMax},

                 // SUVmax所在病灶
                 new ReadingCalculateData (){QuestionType=QuestionType.SUVmaxLesion,GetStringFun=GetSuvMaxFocus},


                 	 //是否存在疾病
			    new ReadingCalculateData (){QuestionType=QuestionType.ExistDisease,GetStringFun=GetIsExistDisease},
             

               
				////靶病灶径线之和（SOD）
				//new ReadingCalculateData (){QuestionType=QuestionType.SOD,GetDecimalNullFun=GetSODData},

				////非淋巴结靶病灶长径之和
				//new ReadingCalculateData (){QuestionType=QuestionType.SumOfDiameter,GetDecimalNullFun=GetSumOfDiameter},

				////与基线SOD相比变化量（mm）
			 //   new ReadingCalculateData (){QuestionType=QuestionType.SODChange,GetDecimalNullFun=GetSODChange},

				////与基线访视相比SOD变化百分比
			 //   new ReadingCalculateData (){QuestionType=QuestionType.SODPercent,GetDecimalNullFun=GetSODPercent},

				////与整个访视期间SOD最低点相比增加的值（mm）  //其他任务需要改
			 //   new ReadingCalculateData (){QuestionType=QuestionType.LowestIncrease,GetDecimalNullFun=GetLowestIncrease,/*ChangeAllTaskFun=ChangeAllLowestIncrease*/},
		
			 //   //与整个访视期间SOD最低点相比增加的百分比   //其他任务需要改
			 //   new ReadingCalculateData (){QuestionType=QuestionType.LowPercent,GetDecimalNullFun=GetLowPercent,/*ChangeAllTaskFun=ChangeAllLowPercent*/},

				////整个访视期间SOD最低点访视名称            //其他任务需要改
			 //   new ReadingCalculateData (){QuestionType=QuestionType.LowVisit,GetStringFun=GetLowVisit,/*ChangeAllTaskFun=ChangeAllLowVisitName*/},

		  //  	//是否存在非淋巴结靶病灶
			 //   new ReadingCalculateData (){QuestionType=QuestionType.IsLymphTarget,GetStringFun=GetIsLymphTarget},

			 //   //是否存在淋巴结靶病灶且该病灶比上一访视短径增加5MM以上
			 //   new ReadingCalculateData (){QuestionType=QuestionType.IsAddFive,GetStringFun=GetIsAddFive},

			 //   //被评估为NE的单个靶病灶
			 //   new ReadingCalculateData (){QuestionType=QuestionType.NETarget,GetStringFun=GetNETarget},

			

       //         //脾脏评估
			    //new ReadingCalculateData (){QuestionType=QuestionType.SplenicEvaluation,GetStringFun=GetNewLesionEvaluate},

			 //   //整体肿瘤评估
			 //   new ReadingCalculateData (){QuestionType=QuestionType.Tumor,GetStringFun=GetTumor},

				// //是否存在疾病
			 //   new ReadingCalculateData (){QuestionType=QuestionType.ExistDisease,GetStringFun=GetIsExistDisease},

            };

            // 没有靶病灶只计算最后几个
            //if (inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).Sum(x => x.TableRowInfoList.Count()) == 0)
            //{

            //    List<QuestionType> questionTypes = new List<QuestionType>()
            //    {
            //        QuestionType.TargetLesion,
            //        QuestionType.NoTargetLesion,
            //        QuestionType.NewLesions,
            //        QuestionType.Tumor,
            //        QuestionType.ExistDisease,
            //    };

            //    // 没有靶病灶就删除其他几个答案的值
            //    var isNeedDeleteTypes = calculateList.Where(x => !questionTypes.Contains(x.QuestionType)).Select(x => x.QuestionType).ToList();


            //    var isNeedDeleteIds = inDto.QuestionInfo.Where(x => x.QuestionType != null && isNeedDeleteTypes.Contains(x.QuestionType.Value)).Select(x => x.QuestionId).ToList();

            //    await _readingTaskQuestionAnswerRepository.BatchUpdateNoTrackingAsync(x => x.VisitTaskId == inDto.VisitTaskId && isNeedDeleteIds.Contains(x.ReadingQuestionTrialId), x => new ReadingTaskQuestionAnswer
            //    {
            //        Answer = string.Empty
            //    });



            //    calculateList = calculateList.Where(x => questionTypes.Contains(x.QuestionType)).ToList();





            //}

            if (calculateType != null)
            {
                calculateList = calculateList.Where(x => calculateType.Contains(x.QuestionType)).ToList();
            }


            calculateList = calculateList.Where(x => x.ComputationTrigger == null || x.ComputationTrigger == inDto.ComputationTrigger).ToList();
            var typeNAList = new List<QuestionType>
            {
                QuestionType.SODChange,
                QuestionType.SODPercent,
                QuestionType.LowestIncrease,
                QuestionType.LowPercent,
            };

            foreach (var calculate in calculateList)
            {
                var item = inDto.QuestionInfo.FirstOrDefault(x => x.QuestionType == calculate.QuestionType);

                if (item != null)
                {
                    //计算答案  
                    if (inDto.IsOnlyChangeAllTask == false)
                    {

                        #region 计算答案
                        if (calculate.GetDecimalFun != null)
                        {
                            item.Answer = (await calculate.GetDecimalFun(inDto)).ToString();

                        }
                        else if (calculate.GetDecimalNullFun != null)
                        {
                            var value = await calculate.GetDecimalNullFun(inDto);
                            item.Answer = value == null ? string.Empty : value.Value.ToString();
                        }
                        else if (calculate.GetStringFun != null)
                        {
                            item.Answer = await calculate.GetStringFun(inDto);
                        }
                        #endregion
                        // 修改修约小数位数

                        List<ValueOfType?> valueOfTypes = new List<ValueOfType?>() {

                               ValueOfType.Decimals,
                               ValueOfType.Percentage
                            };

                        if (inDto.DigitPlaces != -1)
                        {
                            try
                            {

                                if (valueOfTypes.Contains(item.ValueType))
                                {
                                    item.Answer = decimal.Round(decimal.Parse(item.Answer ?? "0"), inDto.DigitPlaces).ToString("F" + inDto.DigitPlaces.ToString());
                                }
                            }
                            catch (Exception)
                            {


                            }
                        }



                        needAddList.Add(new ReadingTaskQuestionAnswer()
                        {
                            Answer = item.Answer,
                            ReadingQuestionTrialId = item.QuestionId,
                        });
                    }

                    // 修改全局
                    if (inDto.IsChangeOtherTask && calculate.ChangeAllTaskFun != null)
                    {
                        await calculate.ChangeAllTaskFun(new ChangeAllTaskDto()
                        {
                            calculateDto = inDto,
                            QuestionId = item.QuestionId,
                        });
                    }

                }
            }



            var questionIds = needAddList.Select(x => x.ReadingQuestionTrialId).ToList();

            await _readingTaskQuestionAnswerRepository.BatchDeleteNoTrackingAsync(x => questionIds.Contains(x.ReadingQuestionTrialId) && x.VisitTaskId == inDto.VisitTaskId);
            needAddList.ForEach(x =>
            {
                x.SubjectId = inDto.SubjectId;
                x.ReadingQuestionCriterionTrialId = inDto.CriterionId;
                x.VisitTaskId = inDto.VisitTaskId;
                x.TrialId = inDto.TrialId;
                x.SubjectId = inDto.SubjectId;
            });

            await _readingTaskQuestionAnswerRepository.AddRangeAsync(needAddList);

            await _readingTaskQuestionAnswerRepository.SaveChangesAsync();
            #endregion


        }


        /// <summary>
        /// 获取报告整体整体评估
        /// </summary>
        /// <param name="visitTaskId"></param>
        /// <returns></returns>
        public async Task<string> GetReportTumor(Guid visitTaskId)
        {
            return await GetTumor(await _generalCalculateService.GetReadingCalculateDto(visitTaskId));
        }

        /// <summary>
        /// 获取报告是否存在疾病
        /// </summary>
        /// <param name="visitTaskId"></param>
        /// <returns></returns>
        public async Task<string> GetReportIsExistDisease(Guid visitTaskId)
        {
            return await GetIsExistDisease(await _generalCalculateService.GetReadingCalculateDto(visitTaskId));
        }

        /// <summary>
        /// 验证访视提交
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task VerifyVisitTaskQuestions(VerifyVisitTaskQuestionsInDto inDto)
        {

            if (await _readingTaskQuestionAnswerRepository.AnyAsync(x => x.ReadingQuestionTrial.QuestionType == QuestionType.ImageQualityAssessment && x.VisitTaskId == inDto.VisitTaskId && x.Answer == ImageQualityEvaluation.Abnormal.GetEnumInt()))
            {

                return;
            }


            var taskinfo = await _visitTaskRepository.Where(x => x.Id == inDto.VisitTaskId).FirstNotNullAsync();


            var tableAnswerList = await _readingTableQuestionAnswerRepository.Where(x => x.VisitTaskId == inDto.VisitTaskId && (x.Answer == string.Empty || x.Answer == null)
      && x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State
      )
          .Select(x => new
          {
              x.ReadingQuestionTrial.OrderMark,
              x.RowIndex,
              QuestionMark = x.ReadingTableQuestionTrial.QuestionMark,
              Answer = x.Answer,

          }).ToListAsync();


            string errorMassage = string.Empty;

            var rowAnswerList = await _readingTableAnswerRowInfoRepository.Where(x => x.VisitTaskId == inDto.VisitTaskId && (x.MeasureData == string.Empty || x.MeasureData == null))
                .Select(x => new
                {
                    x.ReadingQuestionTrial.OrderMark,
                    x.RowIndex,
                    x.Id,
                }).ToListAsync();


            var unableEvaluateRowIds = await _readingTableQuestionAnswerRepository.Where(x => x.VisitTaskId == inDto.VisitTaskId &&
            (x.Answer == TargetState.UnableEvaluate.GetEnumInt()|| x.Answer == TargetState.Loss.GetEnumInt())
             && x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State
            )
             .Select(x => x.RowId).Distinct().ToListAsync();


            List<string> measureDataList = rowAnswerList.Where(x => !unableEvaluateRowIds.Contains(x.Id)).Select(x => x.OrderMark + x.RowIndex.GetLesionMark()).ToList();

            List<string> stateIsNullList = tableAnswerList.Select(x => x.OrderMark + x.RowIndex.GetLesionMark()).ToList();


            List<string> allExists = measureDataList.Intersect(stateIsNullList).ToList();
            measureDataList = measureDataList.Except(allExists).ToList();
            stateIsNullList = stateIsNullList.Except(allExists).ToList();


            if (measureDataList.Count() > 0)
            {
                errorMassage += _localizer["ReadingCalculate_NoMarker", string.Join(',', measureDataList)] + ",";
            }


            if (tableAnswerList.Count > 0)
            {
                errorMassage += _localizer["ReadingCalculate_StatusIsEmpty", string.Join(',', stateIsNullList)] + ",";
            }

            if (allExists.Count > 0)
            {
                errorMassage += _localizer["ReadingCalculate_NoMarkerEmpty", string.Join(',', stateIsNullList)] + ",";
            }

            // 判断是否有pet
            if (await _readingTaskQuestionAnswerRepository.AnyAsync(x => x.ReadingQuestionTrial.QuestionType == QuestionType.ExistPET && x.VisitTaskId == inDto.VisitTaskId && x.Answer == ReadingYesOrNo.Yes.GetEnumInt()))
            {

                List<QuestionType?> required = new List<QuestionType?>() {
                QuestionType.LiverSUVmax,
                QuestionType.MediastinumSUVmax,
                QuestionType.SUVmax,
                QuestionType.SUVmaxLesion,
                QuestionType.PET5PS,
                };
                if (taskinfo.VisitTaskNum != 0m)
                {
                    required.Add(QuestionType.UptakeChange);
                    required.Add(QuestionType.EvidenceFocalFDG);
                }

                if ((await _readingTaskQuestionAnswerRepository.CountAsync(x => required.Contains(x.ReadingQuestionTrial.QuestionType) && x.VisitTaskId == inDto.VisitTaskId && x.Answer != string.Empty)) != required.Count())
                {
                    if (taskinfo.VisitTaskNum != 0m)
                    {
                        errorMassage += _localizer["ReadingCalculate_LuganoPetVerification"];
                    }
                    else
                    {
                        errorMassage += _localizer["ReadingCalculate_LuganoBaseLinePetVerification"];
                    }

                }
            }


            if (errorMassage != string.Empty)
            {
                //errorMassage = errorMassage;
                throw new BusinessValidationFailedException(errorMassage);
            }


        }

        /// <summary>
        /// 计算融合靶病灶的状态
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task CalculateMergeTargetLesionStatus(CalculateTargetLesionStatusInDto inDto)
        {
			var taskInfo = await _visitTaskRepository.Where(x => x.Id == inDto.VisitTaskId).FirstNotNullAsync();

			// 找到靶病灶问题
			var targetQuestion = await _readingQuestionTrialRepository.Where(x => x.ReadingQuestionCriterionTrialId == taskInfo.TrialReadingCriterionId && x.LesionType == LesionType.TargetLesion).FirstOrDefaultAsync();
			if (targetQuestion != null)
			{
				// 找到状态问题
				var stateQuestion = await _readingTableQuestionTrialRepository.Where(x => x.ReadingQuestionId == targetQuestion.Id && x.QuestionMark == QuestionMark.State).FirstOrDefaultAsync();
				if (stateQuestion != null)
				{

					//// 找到主病灶的状态
					//var state = await _readingTableQuestionAnswerRepository.Where(x => x.VisitTaskId == inDto.VisitTaskId && x.RowIndex == (int)Math.Floor(inDto.RowNumber) && x.TableQuestionId == stateQuestion.Id).Select(x => x.Answer).FirstOrDefaultAsync();

					// 长径
					var majorAxis = (await _readingTableQuestionAnswerRepository.Where(x =>
					x.VisitTaskId == inDto.VisitTaskId &&
					x.RowIndex == inDto.RowNumber &&
					x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.MajorAxis &&
					x.QuestionId == targetQuestion.Id
					).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();

					// 短径
					var shortAxis = (await _readingTableQuestionAnswerRepository.Where(x =>
					x.VisitTaskId == inDto.VisitTaskId &&
					x.RowIndex == inDto.RowNumber &&
					x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.ShortAxis &&
					x.QuestionId == targetQuestion.Id
					).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();

					// 找到ppd问题
					var ppdQuestion = await _readingTableQuestionTrialRepository.Where(x => x.ReadingQuestionId == targetQuestion.Id && x.QuestionMark == QuestionMark.PPD).FirstOrDefaultAsync();

					if (ppdQuestion != null)
					{
						var pPdAnswer = (await _readingTableQuestionAnswerRepository.Where(x =>
						   x.VisitTaskId == inDto.VisitTaskId &&
						   x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.PPD &&
						   x.QuestionId == targetQuestion.Id &&
						   x.RowIndex == inDto.RowNumber
						   ).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();


						// 是否符合疾病进展
						var accord = false;

						var lowPPDInfo = await GetLowPPDInfo(new GetPPDInfoInDto()
						{
							RowIndex = inDto.RowNumber,
							VisitTaskId = inDto.VisitTaskId,
							QuestionId = inDto.QuestionId,
						});


						if (lowPPDInfo.NadirPPD != 0)
						{
							//当前融合靶病灶LDi>15 mm  &&
							//(当前融合靶病灶的ppd-最低点PPD)/最低点PPD ≥50 %

							if (majorAxis >= 15 &&
								(pPdAnswer - lowPPDInfo.NadirPPD) * 100 / lowPPDInfo.NadirPPD >= 50)
							{
								accord = true;
							}
						}

						// 符合疾病进展
						if (accord)
						{
							await _readingTableQuestionAnswerRepository.UpdatePartialFromQueryAsync(x =>
							x.VisitTaskId == inDto.VisitTaskId &&
							x.RowIndex == inDto.RowNumber &&
							x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State &&
							x.QuestionId == targetQuestion.Id, x => new ReadingTableQuestionAnswer()
							{
								Answer = TargetState.DiseaseProgression.GetEnumInt()
							}
							);
						}
						//else if (state == TargetState.DiseaseProgression.GetEnumInt())
						//{
						//	//await _readingTableQuestionAnswerRepository.UpdatePartialFromQueryAsync(x =>
						//	//	x.VisitTaskId == inDto.VisitTaskId &&
						//	//	x.RowIndex == inDto.RowNumber &&
						//	//	x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State &&
						//	//	x.QuestionId == targetQuestion.Id, x => new ReadingTableQuestionAnswer()
						//	//	{
						//	//		Answer = TargetState.Exist.GetEnumInt()
						//	//	}
						//	//	);
						//}


					}
				}

			}
		}

		/// <summary>
		/// 计算分裂靶病灶状态
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task CalculateTargetLesionStatus(CalculateTargetLesionStatusInDto inDto)
        {
            if (inDto.RowNumber % 1 != 0)
            {
                var taskInfo = await _visitTaskRepository.Where(x => x.Id == inDto.VisitTaskId).FirstNotNullAsync();

                // 找到靶病灶问题
                var targetQuestion = await _readingQuestionTrialRepository.Where(x => x.ReadingQuestionCriterionTrialId == taskInfo.TrialReadingCriterionId && x.LesionType == LesionType.TargetLesion).FirstOrDefaultAsync();
                if(targetQuestion!=null)
                {
                    // 找到状态问题
                    var stateQuestion = await _readingTableQuestionTrialRepository.Where(x => x.ReadingQuestionId == targetQuestion.Id && x.QuestionMark == QuestionMark.State).FirstOrDefaultAsync();
                    if (stateQuestion != null)
                    { 

                        // 找到主病灶的状态
                        var state =await _readingTableQuestionAnswerRepository.Where(x=>x.VisitTaskId==inDto.VisitTaskId&&x.RowIndex== (int)Math.Floor(inDto.RowNumber)&&x.TableQuestionId== stateQuestion.Id).Select(x=>x.Answer).FirstOrDefaultAsync();

                        // 长径
						var majorAxis = (await _readingTableQuestionAnswerRepository.Where(x => 
                        x.VisitTaskId == inDto.VisitTaskId &&
						 x.RowIndex >= (int)Math.Floor(inDto.RowNumber) && x.RowIndex < ((int)Math.Floor(inDto.RowNumber) + 1) &&
						x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.MajorAxis &&
                        x.QuestionId== targetQuestion.Id
						).Select(x => x.Answer).ToListAsync()).Select(x => x.IsNullOrEmptyReturn0()).Sum();

						// 短径
						var shortAxis = (await _readingTableQuestionAnswerRepository.Where(x =>
						x.VisitTaskId == inDto.VisitTaskId &&
					    x.RowIndex >= (int)Math.Floor(inDto.RowNumber) && x.RowIndex < ((int)Math.Floor(inDto.RowNumber) + 1) &&
						x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.ShortAxis &&
						x.QuestionId == targetQuestion.Id
						).Select(x => x.Answer).ToListAsync()).Select(x => x.IsNullOrEmptyReturn0()).Sum();

						// 找到ppd问题
						var ppdQuestion = await _readingTableQuestionTrialRepository.Where(x => x.ReadingQuestionId == targetQuestion.Id && x.QuestionMark == QuestionMark.PPD).FirstOrDefaultAsync();

                        if(ppdQuestion!=null)
                        {
                            var ppdAnswerList= await _readingTableQuestionAnswerRepository.Where(x =>
                               x.VisitTaskId == inDto.VisitTaskId &&
							   x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.PPD &&
						       x.QuestionId == targetQuestion.Id &&
							   x.RowIndex >= (int)Math.Floor(inDto.RowNumber) && x.RowIndex < ((int)Math.Floor(inDto.RowNumber) + 1)
							   ).Select(x => x.Answer).ToListAsync();

                            var allPPd = ppdAnswerList.Select(x => x.IsNullOrEmptyReturn0()).Sum();

                            // 是否符合疾病进展
                            var accord = false;

                            var lowPPDInfo = await GetLowPPDInfo(new GetPPDInfoInDto()
                            {
                                RowIndex = (int)Math.Floor(inDto.RowNumber),
                                VisitTaskId = inDto.VisitTaskId,
                                QuestionId = inDto.QuestionId,
                            });

                         
                            if (lowPPDInfo.NadirPPD != 0)
                            {
                                //15mm < 当前靶病灶LDi≤20mm  &&
                                //&& 相比最低点PPD增加百分比 ≥50％  &&
                                //(相比PPD最低点LDi增加值 ≥5 mm
                                //or相比PPD最低点SDi增加值≥5 mm)
                                if (15 < majorAxis && majorAxis <= 20 &&
                                    (allPPd - lowPPDInfo.NadirPPD) * 100 / lowPPDInfo.NadirPPD >= 50 &&
                                    (majorAxis - lowPPDInfo.LowPPDLDi >= 5 ||
                                    shortAxis - lowPPDInfo.LowPPDSDi >= 5)
                                    )
                                {
                                    accord = true;
								}

								//当前靶病灶LDi>20 mm
								//相比最低点PPD增加百分比 ≥50％
								//	(相比PPD最低点LDi增加值 ≥10 mm
								//  或者相比PPD最低点SDi增加值Sdi ≥10 mm)
								if ( majorAxis > 20 &&
									(allPPd - lowPPDInfo.NadirPPD) * 100 / lowPPDInfo.NadirPPD >= 50 &&
									(majorAxis - lowPPDInfo.LowPPDLDi >= 10 ||
									shortAxis - lowPPDInfo.LowPPDSDi >= 10)
									)
								{
									accord = true;
								}

							}

                            // 符合疾病进展
                            if (accord)
                            {
                                await _readingTableQuestionAnswerRepository.UpdatePartialFromQueryAsync(x =>
                                x.VisitTaskId == inDto.VisitTaskId &&
                                x.RowIndex == (int)Math.Floor(inDto.RowNumber) &&
                                x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State &&
                                x.QuestionId == targetQuestion.Id, x => new ReadingTableQuestionAnswer()
                                {
                                    Answer = TargetState.DiseaseProgression.GetEnumInt()
                                }
                                );
                            }
                            else if (state == TargetState.DiseaseProgression.GetEnumInt())
                            {
								await _readingTableQuestionAnswerRepository.UpdatePartialFromQueryAsync(x =>
									x.VisitTaskId == inDto.VisitTaskId &&
									x.RowIndex == (int)Math.Floor(inDto.RowNumber) &&
									x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State &&
									x.QuestionId == targetQuestion.Id, x => new ReadingTableQuestionAnswer()
									{
										Answer = TargetState.Exist.GetEnumInt()
									}
									);
							}

                            await _readingTableQuestionAnswerRepository.SaveChangesAsync();

						}
					}

                }


			}
        }

       


        

        /// <summary>
        /// 获取分裂病灶的PPd之和 不包括当前的主病灶
        /// </summary>
        /// <returns></returns>
        [HttpPost]
        public async Task<List<GetSplitPPdOutDto>> GetSplitPPdSum(GetSplitPPdInDto inDto)
        {
            List<GetSplitPPdOutDto> result = new List<GetSplitPPdOutDto>();
			var taskInfo = await _visitTaskRepository.Where(x => x.Id == inDto.VisitTaskId).FirstNotNullAsync();
			var targetQuestion = await _readingQuestionTrialRepository.Where(x => x.ReadingQuestionCriterionTrialId == taskInfo.TrialReadingCriterionId && x.LesionType == LesionType.TargetLesion).FirstOrDefaultAsync();
			if (targetQuestion != null)
			{
				var ppdAnswerList = await _readingTableQuestionAnswerRepository.Where(x =>
					  x.VisitTaskId == inDto.VisitTaskId &&
					  //x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.PPD &&
					  x.QuestionId == targetQuestion.Id)
						.Select(x => new {
							x.RowId,
							x.RowIndex,
							x.Answer,
							x.ReadingTableQuestionTrial.QuestionMark,
						}).ToListAsync();
				var answerList = ppdAnswerList.Select(x => new {
					x.RowId,
					x.RowIndex,
					Answer = x.Answer.IsNullOrEmptyReturn0(),
                    x.QuestionMark,
				}).ToList();
				var maxRowIndex = answerList.MaxOrDefault(x => x.RowIndex);
				for (int i = 1; i < maxRowIndex; i++)
				{
					result.Add(new GetSplitPPdOutDto()
					{
						RowId = answerList.Where(x => x.RowIndex == i).Select(x => x.RowId).FirstOrDefault(),
                        RowIndex = answerList.Where(x => x.RowIndex == i).Select(x => x.RowIndex).FirstOrDefault().ToString(),
						AllPPD = answerList.Where(x=>x.QuestionMark== QuestionMark.PPD).Where(x => x.RowIndex > i && x.RowIndex < (i + 1)).Sum(x => x.Answer),
						AllLDi = answerList.Where(x => x.QuestionMark == QuestionMark.MajorAxis).Where(x => x.RowIndex > i && x.RowIndex < (i + 1)).Sum(x => x.Answer),
						AllSDi = answerList.Where(x => x.QuestionMark == QuestionMark.ShortAxis).Where(x => x.RowIndex > i && x.RowIndex < (i + 1)).Sum(x => x.Answer),
					});
				}
			}
			return result;
		}

		#region 将上一次的访视病灶添加到这一次

		/// <summary>
		/// 将上一次的访视病灶添加到这一次
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task<AddTaskLesionAnswerFromLastTaskOutDto> AddTaskLesionAnswerFromLastTask(AddTaskLesionAnswerFromLastTaskInDto inDto)
        {
            var visitTaskId = inDto.VisitTaskId;

            var taskinfo = await _visitTaskRepository.Where(x => x.Id == visitTaskId).FirstNotNullAsync();

            var baseLineVisitId = await _subjectVisitRepository.Where(x => x.SubjectId == taskinfo.SubjectId && x.IsBaseLine).Select(x => x.Id).FirstOrDefaultAsync();


            ReadingCalculateDto readingData = await _generalCalculateService.GetReadingCalculateDto(visitTaskId);

            await ReadingCalculate(readingData, new List<QuestionType>() { QuestionType.ExistPET });


            // 判断当前任务是否是基线
            if (taskinfo.SourceSubjectVisitId != baseLineVisitId)
            {
                // 判断当前任务是是否有表格问题答案
                if (!(await _readingTableQuestionAnswerRepository.AnyAsync(x => x.VisitTaskId == visitTaskId)))
                {

                    var LastVisitTaskId = await _visitTaskRepository.Where(x => x.ReadingCategory == ReadingCategory.Visit &&
                    x.TrialReadingCriterionId == taskinfo.TrialReadingCriterionId &&
                    x.IsAnalysisCreate == taskinfo.IsAnalysisCreate &&
                     x.DoctorUserId == taskinfo.DoctorUserId &&
                     x.IsSelfAnalysis == taskinfo.IsSelfAnalysis &&
                    x.SubjectId == taskinfo.SubjectId && x.ReadingTaskState == ReadingTaskState.HaveSigned && x.VisitTaskNum < taskinfo.VisitTaskNum && x.TaskState == TaskState.Effect && x.ArmEnum == taskinfo.ArmEnum
                    ).OrderByDescending(x => x.VisitTaskNum).Select(x => x.Id).FirstOrDefaultAsync();



                    var copyTableAnswers = await _readingTableQuestionAnswerRepository.Where(x => x.VisitTaskId == LastVisitTaskId).Select(x => new CopyTableAnswerDto()
                    {
                        Answer = x.Answer,
                        QuestionId = x.QuestionId,
                        RowId = x.RowId,
                        QuestionMark = x.ReadingTableQuestionTrial.QuestionMark,
                        TableQuestionId = x.TableQuestionId,
                        RowIndex = x.RowIndex,
                        TrialId = x.TrialId
                    }).ToListAsync();

                    var tableRowAnswers = await _readingTableAnswerRowInfoRepository.Where(x => x.VisitTaskId == LastVisitTaskId).OrderBy(x=>x.RowIndex).ProjectTo<CopyTableAnswerRowInfo>(_mapper.ConfigurationProvider).ToListAsync();


                    tableRowAnswers.ForEach(x =>
                    {

                        switch (x.SplitOrMergeType)
                        {
                            case SplitOrMergeType.Merge:
							case SplitOrMergeType.Merged:
                                x.SplitOrMergeType = SplitOrMergeType.Merged;
                                break;
							case SplitOrMergeType.MergeMain:
							case SplitOrMergeType.MergeMained:
								x.SplitOrMergeType = SplitOrMergeType.MergeMained;
								break;
                            default:
                                x.SplitOrMergeType = null;
                                break;
						}
                        x.VisitTaskId = visitTaskId;
                        x.IsCurrentTaskAdd = false;
                        x.Id = NewId.NextGuid();
                        x.SeriesId = null;
                        x.InstanceId = null;
                        x.MeasureData = string.Empty;
                        x.PicturePath = string.Empty;


					});

                    tableRowAnswers.ForEach(x =>
                    {
                        x.SplitRowId = tableRowAnswers.Where(y => y.OriginalId == x.SplitRowId).FirstOrDefault()?.Id;
                        x.MergeRowId = tableRowAnswers.Where(y => y.OriginalId == x.MergeRowId).FirstOrDefault()?.Id;

                    });

                    List<QuestionMark?> needCopyMarks = new List<QuestionMark?>()
                    {

                         QuestionMark.IsLymph,
                         QuestionMark.Lesion,
                         QuestionMark.Organ,
                         QuestionMark.Location,
                         QuestionMark.Part,
                         QuestionMark.BodyPartDescription,
                         QuestionMark.LowPPDLDi,
                         QuestionMark.LowPPDSDi,
                         QuestionMark.NadirPPD,
                         QuestionMark.LowPPDVisit,
                    };



                    var rowIndexList = copyTableAnswers.Select(x => x.RowIndex).Distinct().ToList();
                    // 找到靶病灶问题Id
                   var  questionId=await _readingQuestionTrialRepository.Where(x => x.ReadingQuestionCriterionTrialId == taskinfo.TrialReadingCriterionId && x.LesionType == LesionType.TargetLesion).Select(x => x.Id).FirstNotNullAsync();

                    foreach (var item in rowIndexList)
                    {
                        var lowPPD =await this.GetLowPPDInfo(new GetPPDInfoInDto() { 
                        
                        VisitTaskId= visitTaskId,
                        QuestionId= questionId,
                        RowIndex=item
                        });

                        copyTableAnswers.Where(x => x.RowIndex == item).ForEach(x =>
                        {


                            switch (x.QuestionMark)
                            {
                                case QuestionMark.LowPPDLDi:
                                    x.Answer = lowPPD.LowPPDLDi==null?string.Empty: lowPPD.LowPPDLDi.Value.ToString();
                                    break;
                                case QuestionMark.LowPPDSDi:
                                    x.Answer = lowPPD.LowPPDSDi == null ? string.Empty : lowPPD.LowPPDSDi.Value.ToString();
                                    break;
                                case QuestionMark.NadirPPD:
                                    x.Answer = lowPPD.NadirPPD == null ? string.Empty : lowPPD.NadirPPD.Value.ToString();
                                    break;
                                case QuestionMark.LowPPDVisit:
                                    x.Answer = lowPPD.LowPPDVisit == null ? string.Empty : lowPPD.LowPPDVisit.ToString();
                                    break;


                            }


                        });
                    }

                    var tableAnswers = new List<ReadingTableQuestionAnswer>();
					// 处理状态

					var mergedRowIds = tableRowAnswers.Where(x => x.SplitOrMergeType == SplitOrMergeType.Merged).Select(x => x.Id).ToList();
                    copyTableAnswers.ForEach(x =>
                    {
                        var tableAnswer = new ReadingTableQuestionAnswer()
                        {
                            Id = NewId.NextGuid(),
                            Answer = needCopyMarks.Contains(x.QuestionMark) ? x.Answer : string.Empty,
                            QuestionId = x.QuestionId,
                            RowIndex = x.RowIndex,
                            RowId = tableRowAnswers.Where(y => y.OriginalId == x.RowId).Select(x => x.Id).FirstOrDefault(),
                            TableQuestionId = x.TableQuestionId,
                            TrialId = x.TrialId,
                            VisitTaskId = visitTaskId,
                        };
                        if (mergedRowIds.Contains(tableAnswer.RowId) && x.QuestionMark == QuestionMark.State)
                        {
                            tableAnswer.Answer = TargetState.Loss.GetEnumInt();

                        }
                        tableAnswers.Add(tableAnswer);
                    });

					 var questionMarkList = await _readingTaskQuestionMarkRepository.Where(x => x.VisitTaskId == LastVisitTaskId).Select(x => new ReadingTaskQuestionMark()
                    {
                        VisitTaskId= visitTaskId,
                        FirstAddTaskId=x.FirstAddTaskId,
                        QuestionId=x.QuestionId,
                        QuestionType=x.QuestionType,
                        OrderMarkName=x.OrderMarkName,

                    }).ToListAsync();
                    questionMarkList.ForEach(x => {
                        x.Id = NewId.NextGuid();
                    });


					var addList = _mapper.Map<List<ReadingTableAnswerRowInfo>>(tableRowAnswers).OrderBy(x => x.RowIndex).ToList();

					await _readingTaskQuestionMarkRepository.AddRangeAsync(questionMarkList);
					await _readingTableAnswerRowInfoRepository.AddRangeAsync(addList);
					await _readingTableQuestionAnswerRepository.AddRangeAsync(tableAnswers);
                    addList.ForEach(x =>
                    {
                        x.MergeRow = null;
                        x.SplitRow = null;

                    });
					await _readingTableQuestionAnswerRepository.SaveChangesAsync();

				}
            }

            return new AddTaskLesionAnswerFromLastTaskOutDto()
            {

                IsBaseLine = taskinfo.SourceSubjectVisitId == baseLineVisitId,
            };

        }
        #endregion

        #region 获取SOD

        /// <summary>
        /// 获取SOD
        /// </summary>
        /// <remarks>
        /// 靶病灶径线之和（SOD）
        /// 非淋巴结的长径 和淋巴结的短径
        /// </remarks>
        /// <returns></returns>
        public async Task<decimal?> GetSODData(ReadingCalculateDto inDto)
        {
            if (sODData != null)
            {
                return sODData.Value;
            }

            var tableQuestion = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).ToList();

            if (tableQuestion.Count() == 0)
            {
                return null;
            }

            decimal result = 0;

            foreach (var item in tableQuestion)
            {
                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.Yes)))
                {
                    // 淋巴结的短径
                    result += (item.TableQuestionList.Where(x => x.QuestionMark == QuestionMark.ShortAxis).Select(x => x.Answer).FirstOrDefault()).IsNullOrEmptyReturn0();
                }

                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.No)))
                {
                    // 非淋巴结的长径
                    result += item.TableQuestionList.Where(x => x.QuestionMark == QuestionMark.MajorAxis).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
                }
            }

            sODData = result;

            return sODData.Value;



        }
        #endregion

        #region 非淋巴结靶病灶长径之和
        /// <summary>
        /// 非淋巴结靶病灶长径之和
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<decimal?> GetSumOfDiameter(ReadingCalculateDto inDto)
        {
            var tableQuestion = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).ToList();

            if (tableQuestion.Count() == 0)
            {
                return null;
            }

            decimal result = 0;

            foreach (var item in tableQuestion)
            {
                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.No)))
                {
                    // 非淋巴结的长径
                    result += item.TableQuestionList.Where(x => x.QuestionMark == QuestionMark.MajorAxis).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
                }
            }


            return result;
        }
        #endregion

        #region  与基线SOD相比变化量（mm）
        /// <summary>
        /// 与基线SOD相比变化量（mm）
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<decimal?> GetSODChange(ReadingCalculateDto inDto)
        {

            var value = await GetSODData(inDto);

            if (value == null || inDto.IsBaseLine)
            {
                return null;
            }
            return value.NullChange0() - await GetBaseLineSOD(inDto);
        }
        #endregion

        #region 与基线访视相比SOD变化百分比
        /// <summary>
        /// 与基线访视相比SOD变化百分比
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<decimal?> GetSODPercent(ReadingCalculateDto inDto)
        {
            var thisSOD = await GetSODData(inDto);

            if (thisSOD == null || inDto.IsBaseLine)
            {
                return null;
            }

            var baseLineSOD = await GetBaseLineSOD(inDto);

            if (baseLineSOD == 0)
            {
                return 100;
            }
            else
            {
                return (thisSOD.NullChange0() - baseLineSOD) * 100 / baseLineSOD;
            }
        }
        #endregion

        #region 与整个访视期间SOD最低点相比增加的值（mm）
        /// <summary>
        /// 与整个访视期间SOD最低点相比增加的值（mm）
        /// </summary>
        /// <param name="inDto"></param>
        /// <remarks>
        /// 要更新之前的
        /// </remarks>
        /// <returns></returns>
        public async Task<decimal?> GetLowestIncrease(ReadingCalculateDto inDto)
        {
            var value = await GetSODData(inDto);
            if (value == null || inDto.IsBaseLine)
            {
                return null;
            }
            var decimalAnswerList = await GetLowSODVisit(inDto);
            var minSOD = decimalAnswerList.OrderBy(x => x.SOD).Select(x => x.SOD).FirstOrDefault();
            return value.NullChange0() - minSOD;
        }
        #endregion

        #region 与整个访视期间SOD最低点相比增加的百分比
        /// <summary>
        /// 与整个访视期间SOD最低点相比增加的百分比
        /// </summary>
        /// <param name="inDto"></param>
        /// <remarks>
        /// 要更新之前的
        /// </remarks>
        /// <returns></returns>
        public async Task<decimal?> GetLowPercent(ReadingCalculateDto inDto)
        {
            var thisSOD = await GetSODData(inDto);
            if (thisSOD == null || inDto.IsBaseLine)
            {
                return null;
            }
            var decimalAnswerList = await GetLowSODVisit(inDto);
            var minSOD = decimalAnswerList.OrderBy(x => x.SOD).Select(x => x.SOD).FirstOrDefault();

            if (minSOD == 0)
            {
                return 100;
            }
            else
            {
                return (thisSOD.NullChange0() - minSOD) * 100 / minSOD;
            }


        }
        #endregion

        #region 整个访视期间SOD最低点访视名称
        /// <summary>
        /// 整个访视期间SOD最低点访视名称
        /// </summary>
        /// <param name="inDto"></param>
        /// <remarks>
        /// 要更新之前的
        /// </remarks>
        /// <returns></returns>
        public async Task<string> GetLowVisit(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return nameof(YesOrNoOrNa.NA);
            }
            var targetCount = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).Count();
            if (targetCount == 0)
            {
                return nameof(YesOrNoOrNa.NA);
            }

            var decimalAnswerList = await GetLowSODVisit(inDto);
            return decimalAnswerList.OrderBy(x => x.SOD).Select(x => x.BlindName).FirstOrDefault() ?? string.Empty;
        }
        #endregion

        #region 是否存在非淋巴结靶病灶
        /// <summary>
        /// 是否存在非淋巴结靶病灶
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetIsLymphTarget(ReadingCalculateDto inDto)
        {
            var result = IsLymph.No.GetEnumInt();
            var tableQuestion = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).ToList();

            foreach (var item in tableQuestion)
            {
                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(IsLymph.No)))
                {
                    result = IsLymph.Yes.GetEnumInt();
                }
            }



            return result;
        }
        #endregion

        #region 是否存在淋巴结靶病灶且该病灶比上一访视短径增加5MM以上
        /// <summary>
        ///  是否存在淋巴结靶病灶且该病灶比上一访视短径增加5MM以上
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetIsAddFive(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return YesOrNoOrNa.NA.GetEnumInt();
            }
            var addFiveList = await GetIsAddFiveRowIndexs(inDto);
            var isExists = addFiveList.Count() > 0 ? true : false;

            return isExists ? YesOrNoOrNa.Yes.GetEnumInt() : YesOrNoOrNa.No.GetEnumInt();

        }

        /// <summary>
        /// 获取存在淋巴结靶病灶且该病灶比上一访视短径增加5MM以上的病灶
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<List<decimal>> GetIsAddFiveRowIndexs(ReadingCalculateDto inDto)
        {
            List<decimal> result = new List<decimal>();
            var LastVisitTaskId = await this.GetLastVisitTaskId(inDto);
            var questionIds = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).Select(x => x.QuestionId).ToList();
            var lastQuestionAsnwer = await _readingTableQuestionAnswerRepository.Where(x => x.VisitTaskId == LastVisitTaskId && questionIds.Contains(x.QuestionId)).Include(x => x.ReadingQuestionTrial).Include(x => x.ReadingTableQuestionTrial).ToListAsync();
            var rowIndexs = lastQuestionAsnwer.Where(x => x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.Yes)).Select(x => x.RowIndex).Distinct().OrderBy(x => x).ToList();
            var thisQuestionAsnwer = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).ToList();
            foreach (var item in rowIndexs)
            {
                var lastValue = lastQuestionAsnwer.Where(x => x.RowIndex == item && x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.ShortAxis).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();

                var thisRowData = thisQuestionAsnwer.Where(x => x.RowIndex == item).SelectMany(x => x.TableQuestionList).ToList();
                var thisValue = thisRowData.Where(x => x.QuestionMark == QuestionMark.ShortAxis).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();

                if (thisValue - lastValue >= 5)
                {
                    result.Add(item);
                }
            }

            return result;
        }
        #endregion

        #region 被评估为NE的单个靶病灶
        /// <summary>
        /// 被评估为NE的单个靶病灶
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetNETarget(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return ExistOrNA.NA.GetEnumInt();
            }

            var result = inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.TargetLesion && x.Answer.EqEnum(TargetAssessment.NE));

            return result ? ExistOrNA.Exist.GetEnumInt() : ExistOrNA.NotExist.GetEnumInt();
        }
        #endregion

        #region 整体肿瘤评估

        /// <summary>
        /// 整体肿瘤评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetTumor(ReadingCalculateDto inDto)
        {

            if (inDto.IsBaseLine)
            {
                return OverallAssessment.NA.GetEnumInt();
            }

            var targetLesion = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.TargetLesion).Select(x => x.Answer).FirstOrDefault();
            var noTargetLesion = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.NoTargetLesion).Select(x => x.Answer).FirstOrDefault();
            var newLesions = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.NewLesions).Select(x => x.Answer).FirstOrDefault();
            var result = await _tumorAssessmentRepository.Where(x =>
            x.TargetLesion == (TargetAssessment)int.Parse(targetLesion.IsNullOrEmpty() ? TargetAssessment.NA.GetEnumInt() : targetLesion) &&
            x.NonTargetLesions == (NoTargetAssessment)int.Parse(noTargetLesion.IsNullOrEmpty() ? NoTargetAssessment.NA.GetEnumInt() : noTargetLesion) &&
            x.NewLesion == (NewLesionAssessment)int.Parse(newLesions.IsNullOrEmpty() ? NewLesionAssessment.NA.GetEnumInt() : newLesions)).Select(x => x.OverallEfficacy).ToListAsync();

            return result.Count == 0 ? OverallAssessment.NE.GetEnumInt() : result[0].GetEnumInt();
        }
        #endregion

        #region 是否存在疾病
        /// <summary>
        /// 是否存在疾病
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetIsExistDisease(ReadingCalculateDto inDto)
        {
            if (!inDto.IsBaseLine)
            {
                return string.Empty;
            }

            var lesionCount = inDto.QuestionInfo.SelectMany(x => x.TableRowInfoList).Count();

            return lesionCount > 0 ? ExistDisease.Yes.GetEnumInt() : ExistDisease.No.GetEnumInt();
        }
        #endregion


        #region 修改其他标准




        #region 修改整个访视期间SOD最低点相比增加的百分比

        /// <summary>
        /// 修改整个访视期间SOD最低点相比增加的百分比
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        //public async Task ChangeAllLowPercent(ChangeAllTaskDto inDto)
        //{
        //    var visitTaskList = await GetVisitTaskAnswerList(inDto.calculateDto);

        //    var lowSod = (await GetLowSODVisit(inDto.calculateDto)).Select(x => x.SOD).OrderBy(x => x).FirstOrDefault();

        //    foreach (var item in visitTaskList.Where(x => x.VisitTaskId != inDto.calculateDto.BaseLineTaskId))
        //    {
        //        decimal percent = 0;
        //        if (lowSod == 0)
        //        {
        //            percent = 100;
        //        }
        //        else
        //        {
        //            percent = decimal.Round((item.SOD - lowSod) * 100 / lowSod, 2);
        //        }

        //        await _readingTaskQuestionAnswerRepository.BatchUpdateNoTrackingAsync(x => x.VisitTaskId == item.VisitTaskId && x.ReadingQuestionTrialId == inDto.QuestionId, x => new ReadingTaskQuestionAnswer()
        //        {
        //            Answer = percent.ToString()
        //        });
        //    }
        //}

        #endregion

        #region 修改最低方式点名称
        /// <summary>
        /// 修改最低方式点名称
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task ChangeAllLowVisitName(ChangeAllTaskDto inDto)
        {
            // 找到所有访视任务的Id

            var visitTaskIds = await _visitTaskRepository.Where(x => x.IsAnalysisCreate == inDto.IsAnalysisCreate &&
            x.ReadingCategory == ReadingCategory.Visit &&
              x.TrialReadingCriterionId == inDto.calculateDto.TrialReadingCriterionId &&
              x.TaskState == TaskState.Effect && x.ReadingTaskState == ReadingTaskState.HaveSigned && x.ArmEnum == inDto.calculateDto.ArmEnum).Select(x => x.Id).ToListAsync();

            var answer = (await GetLowSODVisit(inDto.calculateDto)).OrderBy(x => x.SOD).Select(x => x.BlindName).FirstOrDefault();
            visitTaskIds = visitTaskIds.Where(x => x != inDto.calculateDto.BaseLineTaskId).ToList();
            await this.ChangeAllVisitTaskAnswer(visitTaskIds, inDto.QuestionId, answer);

        }
        #endregion


        #endregion

        #region 通用方法

        #region 修改所有访视任务的答案
        /// <summary>
        /// 修改所有访视任务的答案
        /// </summary>
        /// <param name="visitTaskGuids"></param>
        /// <param name="questionId"></param>
        /// <param name="answer"></param>
        /// <returns></returns>
        private async Task ChangeAllVisitTaskAnswer(List<Guid> visitTaskGuids, Guid questionId, string answer)
        {
            await _readingTaskQuestionAnswerRepository.BatchUpdateNoTrackingAsync(x => visitTaskGuids.Contains(x.VisitTaskId) && x.ReadingQuestionTrialId == questionId, x => new ReadingTaskQuestionAnswer()
            {
                Answer = answer
            });
        }
        #endregion


        #region 获取基线任务ID

        /// <summary>
        /// 获取基线任务的Id
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        private async Task<Guid> GetBaseLineTaskId(ReadingCalculateDto inDto)
        {
            if (this.BaseLineTaskId == null)
            {
                this.BaseLineTaskId = await _visitTaskRepository.Where(x => x.SubjectId == inDto.SubjectId && x.ReadingCategory == ReadingCategory.Visit
                                                                && x.TrialReadingCriterionId == inDto.TrialReadingCriterionId &&

                                                                x.SourceSubjectVisit.IsBaseLine && x.TaskState == TaskState.Effect &&
                                                                x.IsAnalysisCreate == inDto.IsAnalysisCreate
                                                                && x.DoctorUserId == inDto.DoctorUserId
                                                                && x.IsSelfAnalysis == inDto.IsSelfAnalysis && x.ArmEnum == inDto.ArmEnum)
                                                                 .Select(x => x.Id).FirstOrDefaultAsync();
            }

            return this.BaseLineTaskId.Value;

        }
        #endregion

        #region 获取基线SOD
        /// <summary>
        /// 获取基线SOD
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        private async Task<decimal> GetBaseLineSOD(ReadingCalculateDto inDto)
        {
            if (await _visitTaskRepository.AnyAsync(x => x.Id == inDto.VisitTaskId && x.SourceSubjectVisit.IsBaseLine && x.IsAnalysisCreate == inDto.IsAnalysisCreate && x.ArmEnum == inDto.ArmEnum))
            {
                return 0;
            }

            // 先找到基线的任务
            var baseLineTaskId = await _visitTaskRepository.Where(x => x.SubjectId == inDto.SubjectId && x.ReadingCategory == ReadingCategory.Visit
                                                                  && x.TrialReadingCriterionId == inDto.TrialReadingCriterionId &&

                                                                  x.SourceSubjectVisit.IsBaseLine && x.TaskState == TaskState.Effect &&
                                                                  x.IsAnalysisCreate == inDto.IsAnalysisCreate
                                                                  && x.DoctorUserId == inDto.DoctorUserId
                                                                  && x.IsSelfAnalysis == inDto.IsSelfAnalysis && x.ArmEnum == inDto.ArmEnum)
                                                                   .Select(x => x.Id).FirstOrDefaultAsync();


            var baseLineSOD = (await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SOD).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();
            return baseLineSOD;
        }
        #endregion


        /// <summary>
        /// 获取最低方式
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<List<VisitTaskAnswerInfo>> GetLowSODVisit(ReadingCalculateDto inDto)
        {
            var taskAnswerList = await GetVisitTaskAnswerList(inDto);

            taskAnswerList = taskAnswerList.Where(x => x.VisitTaskId != inDto.VisitTaskId).ToList();

            var taskIds = taskAnswerList.Select(x => x.VisitTaskId).ToList();

            // 排除无法评估
            var unableEvaluateTaskIds = await _readingTableQuestionAnswerRepository.Where(x => taskIds.Contains(x.VisitTaskId) &&
            x.ReadingTableQuestionTrial.QuestionMark == QuestionMark.State
            && x.ReadingQuestionTrial.LesionType == LesionType.TargetLesion
            && x.Answer == TargetState.UnableEvaluate.GetEnumInt()
            )
             .Select(x => x.VisitTaskId).Distinct().ToListAsync();

            taskAnswerList = taskAnswerList.Where(x => !unableEvaluateTaskIds.Contains(x.VisitTaskId)).ToList();
            return taskAnswerList.OrderBy(x => x.SOD).ToList();
        }

        #region 获取访视任务信息
        /// <summary>
        /// 获取访视任务信息
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<List<VisitTaskAnswerInfo>> GetVisitTaskAnswerList(ReadingCalculateDto inDto)
        {
            if (visitTaskAnswerList == null)
            {
                // 查询的时候要把自己排除 因为查询出来的可能不是计算出的最新的
                visitTaskAnswerList = await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId != inDto.VisitTaskId && x.VisitTask.ReadingCategory == ReadingCategory.Visit
                && x.VisitTask.IsAnalysisCreate == inDto.IsAnalysisCreate
                && x.VisitTask.IsSelfAnalysis == inDto.IsSelfAnalysis
                && x.VisitTask.VisitTaskNum < inDto.VisitTaskNum
                && x.ReadingQuestionCriterionTrialId == inDto.TrialReadingCriterionId
                && x.SubjectId == inDto.SubjectId && x.VisitTask.ReadingTaskState == ReadingTaskState.HaveSigned && x.VisitTask.ArmEnum == inDto.ArmEnum && x.VisitTask.TaskState == TaskState.Effect && x.ReadingQuestionTrial.QuestionType == QuestionType.SpleenLength)
                .Select(x => new VisitTaskAnswerInfo
                {
                    VisitTaskId = x.VisitTaskId,
                    QuestionId = x.ReadingQuestionTrialId,
                    VisitName = x.VisitTask.SourceSubjectVisit.VisitName,
                    BlindName = x.VisitTask.TaskBlindName,

                    SpleenLength = x.Answer.IsNullOrEmptyReturn0(),
                }).ToListAsync();

                //// 这里是需要加上自己的 基线不用管
                //if (visitTaskAnswerList.Count > 0)
                //{
                //    visitTaskAnswerList.Add(new VisitTaskAnswerInfo()
                //    {
                //        VisitTaskId = inDto.VisitTaskId,
                //        BlindName = inDto.TaskBlindName,
                //        QuestionId = visitTaskAnswerList[0].QuestionId,
                //        VisitName = inDto.VisitName,
                //        SOD = (await GetSODData(inDto)).ToString().IsNullOrEmptyReturn0(),
                //    });
                //}


            }

            return visitTaskAnswerList;
        }
        #endregion

        /// <summary>
        /// 获取上一个访视任务Id
        /// </summary>
        /// <returns></returns>
        private async Task<Guid> GetLastVisitTaskId(ReadingCalculateDto inDto)
        {
            // 拿到这一个访视
            var thisNum = await _subjectVisitRepository.Where(x => x.Id == inDto.SubjectVisitId).Select(x => x.VisitNum).FirstOrDefaultAsync();

            // 先找到上一个访视
            var lastVisitId = await _subjectVisitRepository.Where(x => x.SubjectId == inDto.SubjectId && !x.IsLostVisit && x.VisitNum < thisNum).OrderByDescending(x => x.VisitNum).Select(x => x.Id).FirstOrDefaultAsync();

            // 找到访视任务Id

            var LastVisitTaskId = await _visitTaskRepository.Where(x => x.ReadingCategory == ReadingCategory.Visit &&
            x.TrialReadingCriterionId == inDto.TrialReadingCriterionId &&
            x.TaskState == TaskState.Effect &&
            x.IsAnalysisCreate == inDto.IsAnalysisCreate
            && x.SourceSubjectVisitId == lastVisitId && x.ArmEnum == inDto.ArmEnum).Select(x => x.Id).FirstOrDefaultAsync();

            return LastVisitTaskId;
        }
        #endregion

        #region 计算阅片问题  外层问题

        #region 获取SPD

        /// <summary>
        /// 获取SPD
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<decimal> GetSPD(ReadingCalculateDto inDto)
        {
            decimal result = 0;
            var rowInfo = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).ToList();

            var tableQuestionList = rowInfo.SelectMany(x => x.TableQuestionList).ToList();

            result = tableQuestionList.Where(x => x.QuestionMark == QuestionMark.PPD).Sum(x => x.Answer.IsNullOrEmptyReturn0());
            return result;

        }

        #endregion

        #region 与基线相比SPD变化的百分比
        /// <summary>
        /// 与基线相比SPD变化的百分比
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> CompareBaselineSPD(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return "NA";
            }
            var baseLineTaskId = await GetBaseLineTaskId(inDto);

            var baseLineSpd = (await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SPD).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();

            var presentSpd = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SPD).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
            if (baseLineSpd != 0)
            {
                return ReserveDecimal((presentSpd - baseLineSpd)*100 / baseLineSpd,inDto.DigitPlaces);
            }
            else
            {
                return "NA";
            }
        }
        #endregion

        #region 与基线相比脾肿大增加的百分比
        /// <summary>
        /// 与基线相比脾肿大增加的百分比
        /// [（当前垂直径-130）-（基线垂直径-130）]/（基线垂直径-130）
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetSplenoncusChange(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return "NA";
            }
           

            var baseLineSpleenLength =  await GetBaseLineSpleenLength(inDto);

            var presentSpleenLength = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SpleenLength).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
            if (baseLineSpleenLength - 130 > 0&& presentSpleenLength>130)
            {
                return ReserveDecimal((presentSpleenLength - 130 - (baseLineSpleenLength - 130))*100 / (baseLineSpleenLength - 130), inDto.DigitPlaces);
            }
            else
            {
                return "NA";
            }
        }
        #endregion

        #region 与最低点相比脾脏垂直径长度的增加值

        /// <summary>
        /// 与最低点相比脾脏垂直径长度的增加值
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetSplenoncusAdd(ReadingCalculateDto inDto)
        {
            var TaskAnswer = await GetVisitTaskAnswerList(inDto);
            if (inDto.IsBaseLine)
            {
                return "NA";
            }
            if (TaskAnswer.Count() == 0)
            {
				return "0";
			}
            var presentSpd = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SpleenLength).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
            var lowSplenoncus = TaskAnswer.OrderBy(x => x.SpleenLength).Select(x => x.SpleenLength).FirstOrDefault();
            return (presentSpd - lowSplenoncus).ToString();


        }
        #endregion


        #region 脾肿垂直径最低点访视

        /// <summary>
        /// 脾肿垂直径最低点访视
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetLowestSplenoncusVisit(ReadingCalculateDto inDto)
        {
            var taskAnswer = await GetVisitTaskAnswerList(inDto);
            if (inDto.IsBaseLine)
            {
                return "NA";
            }
            if (taskAnswer.Count() == 0)
            {
				return "NA";
			}

            var lowSplenoncus = taskAnswer.OrderBy(x => x.SpleenLength).FirstOrDefault();
            return lowSplenoncus.BlindName;


        }
        #endregion

        #region 获取脾脏状态

        /// <summary>
        /// 获取脾脏状态
        /// </summary>
        /// <param name="visitTaskId"></param>
        /// <param name="spleenLength"></param>
        /// <returns></returns>
        [HttpPost]
        public async Task<string> GetSplenicState(Guid visitTaskId,decimal spleenLength)
        {

            var taskinfo = await _visitTaskRepository.Where(x => x.Id == visitTaskId).FirstNotNullAsync();
            ReadingCalculateDto inDto = await _generalCalculateService.GetReadingCalculateDto(visitTaskId);
			var result = SpleenAssessment.NotEvaluable;
            if (spleenLength < 0)
            {
                return SpleenAssessment.NotEvaluable.GetEnumInt();
            }
            else if (0 < spleenLength && spleenLength <= 130)
            {
				return SpleenAssessment.Normal.GetEnumInt();

			}
            else if (inDto.IsBaseLine)
            {
				return SpleenAssessment.Swelling.GetEnumInt();
			}


			var lowSpleenLength = await this.GetLowSpleenLength(taskinfo);


		


            var presentSpd = spleenLength;
            var baseLineSpleenLength = await GetBaseLineSpleenLength(inDto);

            var baseLineTaskId = await GetBaseLineTaskId(inDto);
            var baseLineState = await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SplenicStatus).Select(x => x.Answer).FirstOrDefaultAsync();


            var differenceValue = presentSpd - baseLineSpleenLength;

            var differenceLowValue = presentSpd - lowSpleenLength;
            decimal percentage = 0;
            if (baseLineSpleenLength != 0)
            {
                percentage = differenceValue * 100 / (baseLineSpleenLength-130);
            }

            //  1、基线 垂直径> 130 mm
            //2、与基线相比脾垂直径变化值≥10 mm
            //与基线相比脾肿大增加的百分比 > 50％
            if (baseLineSpleenLength > 130 && differenceValue >= 10 && percentage > 50)
            {
                result = SpleenAssessment.Increase;
            }
            //1、基线垂直径≤130mm
            //2、与基线相比脾垂直径变化值≥20 mm
            //当前垂直径 > 130 mm
            else if (baseLineSpleenLength <= 130 && differenceValue >= 20 && presentSpd > 130)
            {
                result = SpleenAssessment.Increase;
            }
            //1、基线 垂直径> 130 mm
            //2、当前访视的前面访视中 存在垂直径≤130mm
            //3、与最低点相比脾脏垂直径的增加值≥20 mm
            //4、当前垂直径 > 130 mm
            else if (baseLineSpleenLength > 130 && lowSpleenLength <= 130 && differenceLowValue >= 20 && presentSpd > 130)
            {
                result = SpleenAssessment.Increase;
            }
            // 当前垂直径≤130mm
            else if (spleenLength <= 130)
            {
                result = SpleenAssessment.Normal;
            }
            //1、基线期 状态为“肿大”
            //与基线相比脾肿大增加的百分比 < -50％
            else if (baseLineState.EqEnum(SpleenAssessment.Swelling) && percentage < -50)
            {
                result = SpleenAssessment.Remission;
            }
            else
            {
                result = SpleenAssessment.Stabilization;
            }
            return result.GetEnumInt();
        }
        #endregion
        
        /// <summary>
        /// 获取最低垂直径
        /// </summary>
        /// <returns></returns>
        private async Task<decimal> GetLowSpleenLength(VisitTask taskinfo)
        {
			var visitTaskIds = await _visitTaskRepository.Where(x => x.ReadingCategory == ReadingCategory.Visit &&
			x.TrialReadingCriterionId == taskinfo.TrialReadingCriterionId &&
			x.IsAnalysisCreate == taskinfo.IsAnalysisCreate &&
			 x.DoctorUserId == taskinfo.DoctorUserId &&
			 x.IsSelfAnalysis == taskinfo.IsSelfAnalysis &&
			x.SubjectId == taskinfo.SubjectId && x.ReadingTaskState == ReadingTaskState.HaveSigned && x.ArmEnum == taskinfo.ArmEnum
			&& x.VisitTaskNum < taskinfo.VisitTaskNum && x.TaskState == TaskState.Effect
			).OrderByDescending(x => x.VisitTaskNum).Select(x => x.Id).ToListAsync();

			var questionId = await _readingQuestionTrialRepository.Where(x => x.ReadingQuestionCriterionTrialId == taskinfo.TrialReadingCriterionId && x.QuestionType == QuestionType.SpleenLength).Select(x => x.Id).FirstNotNullAsync();
			var answerList = await _readingTaskQuestionAnswerRepository.Where(x => visitTaskIds.Contains(x.VisitTaskId)
			  && x.ReadingQuestionTrialId == questionId)
				  .Select(x => new
				  {
					  x.Answer,
					  x.VisitTaskId,
				  }).ToListAsync();

			var lowSpleenLength = answerList.Select(x => new
			{
				Answer = x.Answer.IsNullOrEmptyReturn0(),
				x.VisitTaskId
			}).OrderBy(x => x.Answer).Select(x => x.Answer).FirstOrDefault();

            return lowSpleenLength;
		}

        /// <summary>
        /// 获取脾脏验证
        /// </summary>
        /// <param name="visitTaskId"></param>
        /// <returns></returns>
        [HttpPost]
		public async Task<object> GetSplenicVerify(Guid visitTaskId)
        {
			
			ReadingCalculateDto inDto = await _generalCalculateService.GetReadingCalculateDto(visitTaskId);

			// 基线垂直径
			var baseLineSpleenLength = await GetBaseLineSpleenLength(inDto);

			var taskinfo = await _visitTaskRepository.Where(x => x.Id == visitTaskId).FirstNotNullAsync();

			var baseLineTaskId = await GetBaseLineTaskId(inDto);

			// 最低垂直经
			var lowSpleenLength= await this.GetLowSpleenLength(taskinfo);

            // 基线状态
			var baseLineState = await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SplenicStatus).Select(x => x.Answer).FirstOrDefaultAsync();

            return new
            {

                //基线垂直径
                BaseLineSpleenLength = baseLineSpleenLength,
                // 最低垂直经
                LowSpleenLength = lowSpleenLength,
                // 基线状态
                BaseLineState = baseLineState,
            };
           
        }


		#region 获取脾脏评估

		/// <summary>
		/// 获取脾脏评估
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task<string> GetSplenicEvaluation(ReadingCalculateDto inDto)
        {

             return inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SplenicStatus).Select(x => x.Answer).FirstIsNullReturnEmpty();

            //if (inDto.IsBaseLine)
            //{
            //    return SpleenAssessment.Stabilization.GetEnumInt();
            //}

            //var result = SpleenAssessment.Stabilization;


            //var presentSpd = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SpleenLength).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
            //var baseLineSpleenLength = await GetBaseLineSpleenLength(inDto);

            //var baseLineTaskId = await GetBaseLineTaskId(inDto);
            //var baseLineState = await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SplenicStatus).Select(x => x.Answer).FirstOrDefaultAsync();


            //var differenceValue = presentSpd - baseLineSpleenLength;
            //decimal percentage = 0;
            //if (baseLineSpleenLength != 0)
            //{
            //    percentage = differenceValue * 100 / baseLineSpleenLength;
            //}

            ////  1、基线 垂直径> 130 mm
            ////2、与基线相比脾垂直径变化值≥10 mm
            ////与基线相比脾肿大增加的百分比 > 50％
            //if (baseLineSpleenLength > 130 && differenceValue >= 10 && percentage > 50)
            //{
            //    result = SpleenAssessment.Increase;
            //}
            ////1、基线垂直径≤130mm
            ////2、与基线相比脾垂直径变化值≥20 mm
            ////当前垂直径 > 130 mm
            //else if (baseLineSpleenLength <= 130 && differenceValue >= 20 && presentSpd > 130)
            //{
            //    result = SpleenAssessment.Increase;
            //}
            ////1、基线 垂直径> 130 mm
            ////2、当前访视的前面访视中 存在垂直径≤130mm
            ////3、与最低点相比脾脏垂直径的增加值≥20 mm
            ////4、当前垂直径 > 130 mm
            //else if (baseLineSpleenLength > 130 && presentSpd <= 130 && differenceValue >= 20 && presentSpd > 130)
            //{
            //    result = SpleenAssessment.Increase;
            //}
            //// 基线垂直径≤130mm
            //else if (baseLineSpleenLength <= 130)
            //{
            //    result = SpleenAssessment.Normal;
            //}
            ////1、基线期 状态为“肿大”
            ////与基线相比脾肿大增加的百分比 > 50％
            //else if (baseLineState.EqEnum(SpleenState.Swelling) && percentage > 50)
            //{
            //    result = SpleenAssessment.Remission;
            //}
            //else
            //{
            //    result = SpleenAssessment.Remission;
            //}
            //return result.GetEnumInt();


        }
        #endregion


        #region PET 5PS

        /// <summary>
        /// 获取PET5PS评分
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetPET5PS(ReadingCalculateDto inDto)
        {
			//if (inDto.IsBaseLine)
			//{
			//    return SpleenAssessment.Stabilization.GetEnumInt();
			//}
		
			if (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.ExistPET && x.Answer == ReadingYesOrNo.No.GetEnumInt()))
            {
                return PET5PSScore.NE.GetEnumInt();
            }


            var existPET = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.ExistPET).Select(x => x.Answer).FirstOrDefault();
            if (existPET.EqEnum(ReadingYesOrNo.No))
            {
                return PET5PSScore.NE.GetEnumInt();
            }


            PET5PSScore result = PET5PSScore.X;

            // 最大Suvmax
            var maxSUVmax = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SUVmax).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();

            // 肝脏血池Suvmax
            var LiverSUVmax = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.LiverSUVmax).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();

            // 纵膈血池
            var MediastinumSUVmax = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.MediastinumSUVmax).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();

        
            if (existPET.EqEnum(ReadingYesOrNo.No))
            {
                result = PET5PSScore.NE;
            }

           // 本访视病灶的 max SUVmax（所有病灶中最大的）> 2 * 肝脏血池SUVmax
           else if (maxSUVmax >2* LiverSUVmax&& LiverSUVmax != 0m)
            {
                result = PET5PSScore.Five;
            }
            //本访视病灶的SUVmax（所有病灶中最大的）>肝脏血池SUVmax
            else if (maxSUVmax > LiverSUVmax && LiverSUVmax != 0)
            {
                result = PET5PSScore.Four;
            }
            //纵隔血池SUVmax<本访视点病灶的max SUVmax（所有病灶中最大的）≤1*肝脏血池SUVmax
            else if (MediastinumSUVmax < maxSUVmax&& maxSUVmax <= LiverSUVmax&& MediastinumSUVmax != 0)
            {
                result = PET5PSScore.Three;
            }
            //本访视点病灶的SUVmax（所有病灶中最大的）<纵隔血池SUVmax
            else if (maxSUVmax < MediastinumSUVmax && maxSUVmax != 0)
            {
                result = PET5PSScore.Two;
            }
            //无需标记，自主选择
            else
            {
				Console.WriteLine("计算了PET5PS,当前接口" + _userInfo.RequestUrl + "当前结果");
				return string.Empty;
            }

			Console.WriteLine("计算了PET5PS,当前接口" + _userInfo.RequestUrl+"当前结果"+ result.GetEnumInt());
			return result.GetEnumInt();
        }
		#endregion

		#region 修改PET 5PS评分备注

		/// <summary>
		/// 获取PET5PS评分备注
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task<string> GetPET5PSRemark(ReadingCalculateDto inDto)
		{
			return string.Empty;
		}
		#endregion


		#region 与基线相比摄取值变化

		/// <summary>
		/// 与基线相比摄取值变化
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task<string> GetUptakeChange(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return SUVChangeVSBaseline.NA.GetEnumInt();
            }

            if (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.ExistPET && x.Answer == ReadingYesOrNo.No.GetEnumInt()))
            {
                return SUVChangeVSBaseline.NotEvaluable.GetEnumInt();
            }

            var result = SUVChangeVSBaseline.NotEvaluable;
            var baseLineTaskId = await GetBaseLineTaskId(inDto);

            var PET5PS = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.PET5PS).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
            var baseLinePET5PS = (await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.PET5PS).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();


            var existPET = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.ExistPET).Select(x => x.Answer).FirstOrDefault();
            //本访视无PET图像
            if (existPET.EqEnum(ReadingYesOrNo.No))
            {
                result = SUVChangeVSBaseline.NotEvaluable;
            }
            //本访视PET评分>基线PET评分
            else if (PET5PS > baseLinePET5PS)
            {
                result = SUVChangeVSBaseline.Increase;
            }

            //本访视PET评分<基线PET评分
            else if (PET5PS < baseLinePET5PS)
            {
                result = SUVChangeVSBaseline.Decrease;
            }

            //访视PET评分  等于 基线PET评分
            else if (PET5PS == baseLinePET5PS)
            {
                return string.Empty;
                //result = SUVChangeVSBaseline.DidNotChange;
            }

            return result.GetEnumInt();

        }
        #endregion

        /// <summary>
        /// 获取上一次FDGPET 评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetLastFDGPETOverallAssessment(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
              return  FDGPETOverallAssessment.NA.GetEnumInt();
            }

            var lastTaskId = await GetLastVisitTaskId(inDto);


            var answer =await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == lastTaskId).Include(x => x.ReadingQuestionTrial).Where(x => x.ReadingQuestionTrial.QuestionType == QuestionType.FDGPET).Select(x => x.Answer).FirstOrDefaultAsync();
            return answer?? string.Empty;
        }

        #region FDG-PET总体评估结果

        /// <summary>
        /// FDG-PET总体评估结果
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetFDGPETOverallAssessment(ReadingCalculateDto inDto)
        {

            if (inDto.IsBaseLine)
            {
                return FDGPETOverallAssessment.NA.GetEnumInt();
            }

            var notExistPET = inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.ExistPET && x.Answer == ReadingYesOrNo.No.GetEnumInt());


           
            if (notExistPET)
            {
                return FDGPETOverallAssessment.NE.GetEnumInt();
            }

            //FDGPETOverallAssessment result = FDGPETOverallAssessment.NA;

            // PET5PS
            var pET5PS = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.PET5PS).Select(x => x.Answer).FirstOrDefault();

            // UptakeChange
            var uptakeChange = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.UptakeChange).Select(x => x.Answer).FirstOrDefault();

            // EvidenceFocalFDG
            var evidenceFocalFDG = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.EvidenceFocalFDG).Select(x => x.Answer).FirstOrDefault();


            return CalculationFDGPETOverallAssessment(pET5PS, uptakeChange, evidenceFocalFDG);
        }


		/// <summary>
		/// 计算FDG-PET总体评估结果【测试】
		/// </summary>
		/// <param name="pET5PS">PET5PS评分</param>
		/// <param name="uptakeChange"> 与基线相比摄取值变化</param>
		/// <param name="evidenceFocalFDG">骨髓中是否存在局灶性 FDG亲和病灶的证据</param>
		/// <returns></returns>
		public string CalculationFDGPETOverallAssessment(string? pET5PS, string uptakeChange,string? evidenceFocalFDG)
        {
			List<CalculationDto> data = new List<CalculationDto>() {

                //NE	NE	NE	NE
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<PET5PSScore>() { PET5PSScore.NE }),
				Column2=ReadingCommon.EnumToString(new List<SUVChangeVSBaseline>() { SUVChangeVSBaseline.NotEvaluable }),
				Column3=ReadingCommon.EnumToString(new List<FDGAffinityFociInBM>() { FDGAffinityFociInBM.NE}),
				Column4=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				},

                  //NE/5分/4分/3分/2分/1分/X	NE/增大/减少/无明显变化	 是，存在新的/复发的FDG高亲和性病灶	PMD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<PET5PSScore>() { PET5PSScore.NE,PET5PSScore.Five,PET5PSScore.Four,PET5PSScore.Three,PET5PSScore.Two,PET5PSScore.One,PET5PSScore.X, }),
				Column2=ReadingCommon.EnumToString(new List<SUVChangeVSBaseline>() { SUVChangeVSBaseline.NotEvaluable,SUVChangeVSBaseline.Increase,SUVChangeVSBaseline.Decrease,SUVChangeVSBaseline.DidNotChange, }),
				Column3=ReadingCommon.EnumToString(new List<FDGAffinityFociInBM>() { FDGAffinityFociInBM.YesHaveNew,}),
				Column4=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMD }),
				},

                  //5分/4分	增大	NE/（是，存在新的/复发的FDG高亲和性病灶）/（是，存在持续的局灶性变化）/否	PMD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<PET5PSScore>() { PET5PSScore.Five,PET5PSScore.Four, }),
				Column2=ReadingCommon.EnumToString(new List<SUVChangeVSBaseline>() { SUVChangeVSBaseline.Increase }),
				Column3=ReadingCommon.EnumToString(new List<FDGAffinityFociInBM>() { FDGAffinityFociInBM.NE, FDGAffinityFociInBM.YesHaveNew, FDGAffinityFociInBM.YesSustain, FDGAffinityFociInBM.No}),
				Column4=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMD }),
				},

                  //3分/2分/1分/X	NE/增大/减少/无明显变化	否	CMR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<PET5PSScore>() { PET5PSScore.Three,PET5PSScore.Two,PET5PSScore.One,PET5PSScore.X, }),
				Column2=ReadingCommon.EnumToString(new List<SUVChangeVSBaseline>() { SUVChangeVSBaseline.NotEvaluable,SUVChangeVSBaseline.Increase,SUVChangeVSBaseline.Decrease,SUVChangeVSBaseline.DidNotChange, }),
				Column3=ReadingCommon.EnumToString(new List<FDGAffinityFociInBM>() { FDGAffinityFociInBM.No}),
				Column4=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.CMR }),
				},

                  //3分/2分/1分/X	NE/增大/减少/无明显变化	是，存在持续的局灶性变化	PMR
                  new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<PET5PSScore>() { PET5PSScore.Three,PET5PSScore.Two,PET5PSScore.One,PET5PSScore.X, }),
				Column2=ReadingCommon.EnumToString(new List<SUVChangeVSBaseline>() { SUVChangeVSBaseline.NotEvaluable,SUVChangeVSBaseline.Increase,SUVChangeVSBaseline.Decrease,SUVChangeVSBaseline.DidNotChange, }),
				Column3=ReadingCommon.EnumToString(new List<FDGAffinityFociInBM>() { FDGAffinityFociInBM.YesSustain }),
				Column4=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMR }),
				},

                  //5分/4分	减少	否/是，存在持续的局灶性变化	PMR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<PET5PSScore>() {  PET5PSScore.Five,PET5PSScore.Four }),
				Column2=ReadingCommon.EnumToString(new List<SUVChangeVSBaseline>() { SUVChangeVSBaseline.Decrease }),
				Column3=ReadingCommon.EnumToString(new List<FDGAffinityFociInBM>() { FDGAffinityFociInBM.No, FDGAffinityFociInBM.YesSustain}),
				Column4=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMR }),
				},

                     //5分/4分	无明显变化	否/是，存在持续的局灶性变化	NMR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<PET5PSScore>() {  PET5PSScore.Five,PET5PSScore.Four }),
				Column2=ReadingCommon.EnumToString(new List<SUVChangeVSBaseline>() { SUVChangeVSBaseline.DidNotChange }),
				Column3=ReadingCommon.EnumToString(new List<FDGAffinityFociInBM>() { FDGAffinityFociInBM.No, FDGAffinityFociInBM.YesSustain}),
				Column4=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NMR }),
				},
			};


			var resultdata = data.Where(x =>
			(x.NotEq.Contains(1) ? !x.Column1.Contains(pET5PS) : x.Column1.Contains(pET5PS) || x.Column1.Count() == 0) &&
			(x.NotEq.Contains(2) ? !x.Column2.Contains(uptakeChange) : x.Column2.Contains(uptakeChange) || x.Column2.Count() == 0) &&
			(x.NotEq.Contains(3) ? !x.Column3.Contains(evidenceFocalFDG) : x.Column3.Contains(evidenceFocalFDG) || x.Column3.Count() == 0))
			.Select(x => x.Column4.FirstOrDefault())
			.FirstOrDefault();
			return resultdata ?? string.Empty;
		}

		#endregion
		#region 骨髓中是否存在局灶性 FDG亲和病灶的证据

		/// <summary>
		/// 骨髓中是否存在局灶性 FDG亲和病灶的证据
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task<string> GetEvidenceFocalFDG(ReadingCalculateDto inDto)
        {
            if (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.ExistPET && x.Answer == ReadingYesOrNo.No.GetEnumInt()))
            {
                return FDGAffinityFociInBM.NE.GetEnumInt();
            }
            else
            {
                return inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.EvidenceFocalFDG).Select(x => x.Answer).FirstOrDefault()??string.Empty;
            }
        }
        #endregion

        #region 肝脏评估
        /// <summary>
        /// 获取肝脏评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetLiverAssessment(ReadingCalculateDto inDto)
        {
            return inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.LiverState).Select(x => x.Answer).FirstIsNullReturnEmpty();
        }
        #endregion

        #region SuvMax所在病灶

        /// <summary>
        /// SuvMax所在病灶
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetSuvMaxFocus(ReadingCalculateDto inDto)
        {
            var rowInfo = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).ToList();

            if (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.ExistPET && x.Answer == ReadingYesOrNo.No.GetEnumInt())
                  || !inDto.QuestionInfo.SelectMany(x => x.TableRowInfoList).Any(x => x.OtherMeasureData != null && x.OtherMeasureData != string.Empty))
            {
                return string.Empty;
            }

            var tableQuestions = rowInfo.SelectMany(x => x.TableQuestionList).ToList();

            var maxSuv = tableQuestions.Where(x => x.QuestionMark == QuestionMark.SUVmax).Select(x =>new { 
            x.RowIndex,
             Answer=  x.Answer.IsNullOrEmptyReturn0(),
            
            
            }).OrderByDescending(x=>x.Answer).FirstOrDefault();
            if (maxSuv == null|| maxSuv.Answer == 0m)
            {
                return "NE";
            }
            else
            {
                var orderMark = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).FirstOrDefault()!.OrderMark;
                return orderMark+ maxSuv.RowIndex.GetLesionMark();
            }

           
        }
        #endregion

        #region SuvMax
        /// <summary>
        /// 最大sum
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<decimal?> GetSuvMax(ReadingCalculateDto inDto)
        {



            if (inDto.QuestionInfo.Any(x => x.QuestionType == QuestionType.ExistPET && x.Answer == ReadingYesOrNo.No.GetEnumInt())
                 || !inDto.QuestionInfo.SelectMany(x => x.TableRowInfoList).Any(x => x.OtherMeasureData != null && x.OtherMeasureData != string.Empty))
            {
                return null;
            }
            var rowInfo = inDto.QuestionInfo.SelectMany(x => x.TableRowInfoList).ToList();
            var tableQuestions = rowInfo.SelectMany(x => x.TableQuestionList).ToList();

            var maxSuv = tableQuestions.Where(x => x.QuestionMark == QuestionMark.SUVmax).Select(x => x.Answer.IsNullOrEmptyReturn0()).MaxOrDefault();
            return maxSuv;
        }
        #endregion

        /// <summary>
        /// 是否存在PET
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetExistPET(ReadingCalculateDto inDto)
        {
            //var studyList = await this._subjectVisitService.GetReadingVisitStudyList(new Contracts.GetReadingVisitStudyListIndto()
            //{
            //    TrialId = inDto.TrialId,
            //    SujectVisitId = inDto.SubjectVisitId,
            //    VisitTaskId=inDto.VisitTaskId,
            //});

            var existPet=await   _dicomStudyRepository.Where(x => x.TrialId == inDto.TrialId && x.SubjectVisitId == inDto.SubjectVisitId).AnyAsync(x => x.Modalities.Contains("PT"));

            return existPet ? ReadingYesOrNo.Yes.GetEnumInt() : ReadingYesOrNo.No.GetEnumInt();
        }

        #region 影像学整体肿瘤评估
        /// <summary>
        /// 影像学整体肿瘤评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetImgOncology(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return ImagingOverallAssessment_Lugano.NA.GetEnumInt();
            }

            //var imageQualityEvaluation = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.ImageQualityAssessment&&x.Answer.EqEnum(ImageQualityEvaluation.Abnormal)).FirstOrDefault();
            //if (imageQualityEvaluation != null)
            //{
            //    return ImagingOverallAssessment_Lugano.NE.GetEnumInt();
            //}

            // CTandMRI
            var cTandMRIData = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.CTandMRI).Select(x => x.Answer).FirstOrDefault();

            // FDGPET
            var fDGPETData = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.FDGPET).Select(x => x.Answer).FirstOrDefault();

            var baseLineTaskId = await GetBaseLineTaskId(inDto);
            // lastFDGPET
            var lastFDGPETData = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.LastFDGPET).Select(x => x.Answer).FirstOrDefault();

            return CalculationGetImgOncology(cTandMRIData, fDGPETData, lastFDGPETData);

		}

		/// <summary>
		/// 计算整体肿瘤评估 【测试】
		/// </summary>
		/// <param name="cTandMRIData"> CT/MRI总体评估</param>
		/// <param name="fDGPETData"> FDG-PET总体评估</param>
		/// <param name="lastFDGPETData">上一次 FDG-PET总体评估</param>
		/// <returns></returns>
		public string CalculationGetImgOncology(string? cTandMRIData,string? fDGPETData,string? lastFDGPETData)
        {
			List<CalculationDto> data = new List<CalculationDto>() {

                //1、ND	NE	NE/NA	ND
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.ND }),
				},
                  //2、ND/PD/CR/NE/PR/SD	PMD	PMD/CMR/PMR/NMR/NE/NA	PMD/PD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.ND, CTMRIOverallAssessment.PD,CTMRIOverallAssessment.CR,CTMRIOverallAssessment.NE,CTMRIOverallAssessment.PR,CTMRIOverallAssessment.SD}),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMD, }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() {FDGPETOverallAssessment.PMD, FDGPETOverallAssessment.CMR,FDGPETOverallAssessment.PMR, FDGPETOverallAssessment.NMR, FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA }),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.PMDPD }),
				},
                  //3、ND/PD/CR/NE/PR/SD	NE	PMD	PMD/PD
                  new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.ND, CTMRIOverallAssessment.PD,CTMRIOverallAssessment.CR,CTMRIOverallAssessment.NE,CTMRIOverallAssessment.PR,CTMRIOverallAssessment.SD}),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() {FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMD, }),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.PMDPD }),
				},
                  //4、PD	NE	CMR/PMR/NMR/NE/NA	PMD/PD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PD}),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE, }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.CMR,FDGPETOverallAssessment.PMR, FDGPETOverallAssessment.NMR, FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA  }),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.PMDPD }),
				},
                  //5、NE	NE	NE/NA	NE
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() {  CTMRIOverallAssessment.NE }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA }),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.NE }),
				},

                  //6、CR、PR、SD、NE、ND、PD	CMR	CMR/PMR/NMR/PMD/NE/NA	CMR/CR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.CR,CTMRIOverallAssessment.PR,CTMRIOverallAssessment.SD,CTMRIOverallAssessment.NE,CTMRIOverallAssessment.ND,CTMRIOverallAssessment.PD }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.CMR }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.CMR,FDGPETOverallAssessment.PMR, FDGPETOverallAssessment.NMR, FDGPETOverallAssessment.PMD, FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA }),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.CMRCR }),
				},
                  //7、CR	NE	NE/NA	CMR/CR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.CR }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA,}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.CMRCR }),
				},

                   //8、CR、PR、SD、NE、ND   	NE	 CMR	CMR/CR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.CR,CTMRIOverallAssessment.PR,CTMRIOverallAssessment.SD,CTMRIOverallAssessment.NE,CTMRIOverallAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.CMR,}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.CMRCR }),
				},




                 //9、ND/PD/CR/NE/PR/SD	PMR	PMD/CMR/PMR/NMR/NE	PMR/PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() {  CTMRIOverallAssessment.ND, CTMRIOverallAssessment.PD,CTMRIOverallAssessment.CR,CTMRIOverallAssessment.NE,CTMRIOverallAssessment.PR,CTMRIOverallAssessment.SD }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMR }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMD, FDGPETOverallAssessment.CMR,FDGPETOverallAssessment.PMR, FDGPETOverallAssessment.NMR, FDGPETOverallAssessment.NE,FDGPETOverallAssessment.NA, }),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.PMRPR }),
				},
                  //10、PR	NE	NE/NA	PMR/PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA,}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.PMRPR }),
				},
                  //11、CR/PR/SD/NE/ND	NE	PMR	PMR/PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.CR,CTMRIOverallAssessment.PR,CTMRIOverallAssessment.SD,CTMRIOverallAssessment.NE,CTMRIOverallAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMR}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.PMRPR }),
				},
                  //12、ND/PD/CR/NE/PR/SD	NMR	PMD/CMR/PMR/NMR/NE	NMR/SD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.ND,CTMRIOverallAssessment.PD,CTMRIOverallAssessment.CR,CTMRIOverallAssessment.NE,CTMRIOverallAssessment.PR,CTMRIOverallAssessment.SD }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NMR }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.PMD, FDGPETOverallAssessment.CMR, FDGPETOverallAssessment.PMR, FDGPETOverallAssessment.NMR, FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA,}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.NMRSD }),
				},
                  //13、CR/PR/SD/ND/NE	NE	NMR	NMR/SD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.CR, CTMRIOverallAssessment.PR, CTMRIOverallAssessment.SD, CTMRIOverallAssessment.ND, CTMRIOverallAssessment.NE }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NMR}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.NMRSD }),
				},
                  //14、SD	NE	NE	NMR/SD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.SD }),
				Column2=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<FDGPETOverallAssessment>() { FDGPETOverallAssessment.NE, FDGPETOverallAssessment.NA,}),
				Column4=ReadingCommon.EnumToString(new List<ImagingOverallAssessment_Lugano>() { ImagingOverallAssessment_Lugano.NMRSD }),
				},
			};

			var resultdata = data.Where(x =>
			  (x.NotEq.Contains(1) ? !x.Column1.Contains(cTandMRIData) : x.Column1.Contains(cTandMRIData) || x.Column1.Count() == 0) &&
			  (x.NotEq.Contains(2) ? !x.Column2.Contains(fDGPETData) : x.Column2.Contains(fDGPETData) || x.Column2.Count() == 0) &&
			  (x.NotEq.Contains(3) ? !x.Column3.Contains(lastFDGPETData) : x.Column3.Contains(lastFDGPETData) || x.Column3.Count() == 0))
			  .Select(x => x.Column4.FirstOrDefault())
			  .FirstOrDefault();
			return resultdata ?? string.Empty;
		}

		#endregion

		#region 获取基线脾脏长度
		/// <summary>
		/// 获取基线脾脏长度
		/// </summary>
		/// <param name="inDto"></param>
		/// <returns></returns>
		public async Task<decimal> GetBaseLineSpleenLength(ReadingCalculateDto inDto)
        {
            var baseLineTaskId = await GetBaseLineTaskId(inDto);

            var baseLineSpleenLength = (await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SpleenLength).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();
            return baseLineSpleenLength;
        }


        #endregion

        #region 与最低点相比脾脏垂直径长度的增加值
        /// <summary>
        /// 与最低点相比脾脏垂直径长度的增加值
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetSplenoncusDiameterChange(ReadingCalculateDto inDto)
        {
        
            if (inDto.IsBaseLine)
            {
                return "NA";
            }

            var baseLineTaskId = await GetBaseLineTaskId(inDto);
            var presentSpleenLength = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SpleenLength).Select(x => x.Answer).FirstOrDefault().IsNullOrEmptyReturn0();
            var baseLineSpleenLength = (await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SpleenLength).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();
   
            return (presentSpleenLength - baseLineSpleenLength).ToString();


        }
        #endregion


        #region 获取靶病灶评估
        /// <summary>
        /// 获取靶病灶评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetTargetLesionEvaluate(ReadingCalculateDto inDto)
        {



            var rowInfo = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.TargetLesion).SelectMany(x => x.TableRowInfoList).ToList();
            if (inDto.IsBaseLine)
            {
                return TargetAssessment.NA.GetEnumInt();
            }
            var tableQuestions = rowInfo.SelectMany(x => x.TableQuestionList).ToList();

            TargetAssessment result = TargetAssessment.SD;

            //或者当前访视非淋巴结靶病灶全部消失；
            //并且  2.当前访视淋巴结靶病灶的状态全部变为“消失”。	

            var eqCR = true;
            //当前访视中，靶病灶的Σ PPD；
            decimal spd = 0;
            foreach (var item in rowInfo)
            {
                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.No)))
                {
                    // 或者当前访视非淋巴结靶病灶全部消失；
                    eqCR = eqCR && item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(TargetState.Loss));
                }
                spd += (item.TableQuestionList.Where(x => x.QuestionMark == QuestionMark.PPD).Select(x => x.Answer).FirstOrDefault()).IsNullOrEmptyReturn0();
                if (item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.IsLymph && x.Answer.EqEnum(YesOrNoOrNa.Yes)))
                {
                    // 当前访视淋巴结靶病灶的状态全部变为“消失”
                    eqCR = eqCR && item.TableQuestionList.Any(x => x.QuestionMark == QuestionMark.State && (x.Answer.EqEnum(TargetState.Loss)|| x.Answer.EqEnum(TargetState.TooSmall)));
                }
            }
            // 1、与基线相比SPD变化的百分比 ≥50%，；
            var eqPR = false;

            if (inDto.IsBaseLine)
            {
                eqPR = false;
            }
            else
            {
                // 先找到基线的任务
                var baseLineTaskId = await _visitTaskRepository.Where(x => x.SubjectId == inDto.SubjectId && x.ReadingCategory == ReadingCategory.Visit
                                                                      && x.TrialReadingCriterionId == inDto.TrialReadingCriterionId &&
                                                                      x.SourceSubjectVisit.IsBaseLine && x.TaskState == TaskState.Effect &&
                                                                      x.IsAnalysisCreate == inDto.IsAnalysisCreate
                                                                      && x.DoctorUserId == inDto.DoctorUserId
                                                                      && x.IsSelfAnalysis == inDto.IsSelfAnalysis && x.ArmEnum == inDto.ArmEnum)
                                                                       .Select(x => x.Id).FirstOrDefaultAsync();

                var baseLineSPD = (await _readingTaskQuestionAnswerRepository.Where(x => x.VisitTaskId == baseLineTaskId && x.ReadingQuestionTrial.QuestionType == QuestionType.SPD).Select(x => x.Answer).FirstOrDefaultAsync()).IsNullOrEmptyReturn0();
                var presentSPD = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SPD).Select(x => x.Answer).FirstIsNullReturnEmpty().IsNullOrEmptyReturn0();

                if (baseLineSPD > 0)
                {
                    eqPR = (presentSPD - baseLineSPD) / baseLineSPD <=- 0.5m;    
                }
            }



            //基线未选择靶病灶
            if (rowInfo.Count() == 0)
            {
                result = TargetAssessment.ND;
            }
            // 任一单个病灶进展即可
            else if (tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(TargetState.DiseaseProgression)))
            {
                result = TargetAssessment.PD;
            }
  
            //当前访视存在至少一个状态为“不可评估”的靶病灶。
            else if (
                tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(TargetState.UnableEvaluate)))
            {
                result = TargetAssessment.NE;
            }
			//当前访视非淋巴结靶病灶全部消失 && （当前访视淋巴结靶病灶的状态全部变为“消失” 或者 "太小" ）
			else if (eqCR)
            {
                result = TargetAssessment.CR;
            }
            // 与基线相比SPD变化的百分比 <=-50%，；
            else if (eqPR)
            {
                result = TargetAssessment.PR;
            }


            return result.GetEnumInt();
        }
        #endregion

        #region 获取非靶病灶评估

        /// <summary>
        /// 获取非靶病灶评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetNoTargetLesionEvaluate(ReadingCalculateDto inDto)
        {

            NoTargetAssessment result = NoTargetAssessment.PD;

            if (inDto.IsBaseLine)
            {
                return NoTargetAssessment.NA.GetEnumInt();
            }

            var tableRows = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.NonTargetLesions).SelectMany(x => x.TableRowInfoList).ToList();

            var tableQuestions = tableRows.SelectMany(x => x.TableQuestionList).ToList();

            //基线未选择非靶病灶
            if (tableQuestions.Count() == 0)
            {
                result = NoTargetAssessment.ND;
            }
            // 随访至少存在一个状态为“显著增大”的非靶病灶
            else if (tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(NoTargetState.Increase)))
            {
                result = NoTargetAssessment.PD;
            }

            // 随访存在至少一个状态为“不可评估”的非靶病灶
            else if (tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(NoTargetState.UnableEvaluate)))
            {
                result = NoTargetAssessment.NE;
            }
            //所有单个病灶/病灶组状态评估状态为“消失”
            else if (tableQuestions.Count(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(NoTargetState.Loss))== tableQuestions.Count(x=> x.QuestionMark == QuestionMark.State) && tableQuestions.Count(x => x.QuestionMark == QuestionMark.State)>0)
            {
                result = NoTargetAssessment.CR;
            }
            else
            {
                result = NoTargetAssessment.PRSD;
            }

            return result.GetEnumInt();

        }

        #endregion

        #region 获取新病灶评估
        /// <summary>
        ///  获取新病灶评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> GetNewLesionEvaluate(ReadingCalculateDto inDto)
        {

            NewLesionAssessment result = NewLesionAssessment.No;
            if (inDto.IsBaseLine)
            {
                return NewLesionAssessment.NA.GetEnumInt();
            }

            var tableRows = inDto.QuestionInfo.Where(x => x.LesionType == LesionType.NewLesions).SelectMany(x => x.TableRowInfoList).ToList();

            var tableQuestions = tableRows.SelectMany(x => x.TableQuestionList).ToList();



            // 当前访视存在至少一个明确新病灶
            if (tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(NewLesionState.Exist)))
            {
                result = NewLesionAssessment.Yes;
            }
            //只要有任何一个新病灶状态为“无法评估”
            else if (tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(NewLesionState.UnableEvaluate)))
            {
                result = NewLesionAssessment.NE;
            }
            //当前访视不存在明确新病灶且存在至少一个疑似新病灶
            else if (!tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(NewLesionState.Exist)) &&
                tableQuestions.Any(x => x.QuestionMark == QuestionMark.State && x.Answer.EqEnum(NewLesionState.Suspected))
                )
            {
                result = NewLesionAssessment.Suspected;
            }

          
            else
            {
                result = NewLesionAssessment.No;
            }
            return result.GetEnumInt();

        }
        #endregion


        #region CTMRI 总体评估

        /// <summary>
        /// CTMRI 总体评估
        /// </summary>
        /// <param name="inDto"></param>
        /// <returns></returns>
        public async Task<string> CTMRIEvaluation(ReadingCalculateDto inDto)
        {
            if (inDto.IsBaseLine)
            {
                return CTMRIOverallAssessment.NA.GetEnumInt();
            }
            // 靶病灶评估
            var targetEvaluation = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.TargetLesion).Select(x => x.Answer).FirstOrDefault();

            // 非靶病灶评估
            var noTargetEvaluation = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.NoTargetLesion).Select(x => x.Answer).FirstOrDefault();

            // 存在新病灶
            var existsNewTarget = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.NewLesionEvaluation).Select(x => x.Answer).FirstOrDefault();

            // 肝脏评估
            var liverEvaluation = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.LiverAssessment).Select(x => x.Answer).FirstOrDefault();

            // 脾脏评估
            var spleenEvaluation = inDto.QuestionInfo.Where(x => x.QuestionType == QuestionType.SplenicEvaluation).Select(x => x.Answer).FirstOrDefault();
          
            return CalculationCTMRIEvaluation(targetEvaluation, noTargetEvaluation, existsNewTarget, liverEvaluation, spleenEvaluation);
        }

        /// <summary>
        /// 计算CTMRI 总体评估 【测试】
        /// </summary>
        /// <param name="targetEvaluation">靶病灶评估</param>
        /// <param name="noTargetEvaluation">非靶病灶评估</param>
        /// <param name="existsNewTarget">存在新病灶</param>
        /// <param name="liverEvaluation">肝脏评估</param>
        /// <param name="spleenEvaluation">脾脏评估</param>
        /// <returns></returns>
        [HttpPost]
		public string CalculationCTMRIEvaluation(string? targetEvaluation,string? noTargetEvaluation,string? existsNewTarget,string? liverEvaluation,string? spleenEvaluation)
        {
			List<CalculationDto> data = new List<CalculationDto>() {

                //ND	ND	否/疑似	 正常	正常	ND
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No, NewLesionAssessment.Suspected }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.ND }),
				},

                //PD  任一结果    任一结果    任一结果    任一结果    PD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.PD }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() {  }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() {  }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PD }),
				},
                //任一结果	PD	任一结果	任一结果	任一结果	PD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() {  }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.PD }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() {}),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() {  }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PD }),
				},
                //任一结果  任一结果    是   任一结果    任一结果    PD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() {  }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.Yes }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() {  }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PD }),
				},
                //任一结果	任一结果	任一结果	显著增大	任一结果	PD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() {  }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() {  }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Increase }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() {  }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PD }),
				},
                //任一结果    任一结果    任一结果    任一结果    显著增大    PD
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() {  }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() {}),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() {  }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Increase }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PD }),
				},
                //CR	CR/ND	否	正常	正常	CR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.CR }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR, NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.CR }),
				},
                //ND  CR  否   正常  正常  CR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.CR }),
				},
                //NE	非PD	否/疑似/无法评估 	 非显著增大	非显著增大	NE
                new CalculationDto(){
				NotEq=new List<int>(){ 2,4,5},
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.NE }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.PD }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No,NewLesionAssessment.Suspected, NewLesionAssessment.NE}),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Increase }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Increase }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.NE }),
				},
                //ND  NE  否/疑似/无法评估（不为是）	正常/稳定/无法评估/部分缓解（非显著增大）	正常/稳定/无法评估/部分缓解（非显著增大）	NE
                new CalculationDto(){
				NotEq=new List<int>(){ 3,4,5},
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.Yes }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Increase }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Increase }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.NE }),
				},
                //ND  ND  无法评估   正常/稳定/无法评估/部分缓解（非显著增大）	正常/稳定/无法评估/部分缓解（非显著增大）	NE
                new CalculationDto(){
				NotEq=new List<int>(){ 4,5},
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.NE }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Increase }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Increase }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.NE }),
				},
                //ND	ND	否/疑似  	无法评估	正常/稳定/无法评估/部分缓解（非显著增大）	NE
                new CalculationDto(){
				NotEq=new List<int>(){ 5},
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No,NewLesionAssessment.Suspected }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.NotEvaluable }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Increase }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.NE }),
				},
                // ND	ND	否/疑似	正常/稳定	NE	NE
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No,NewLesionAssessment.Suspected }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal,LiverAssessment.Stabilization }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.NE }),
				},
                //1 PR  CR或PR/SD或NE或ND  否/疑似/无法评估NE	  正常/稳定/NE    正常/部分缓解/稳定/NE     PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.PR }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR,NoTargetAssessment.PRSD,NoTargetAssessment.NE,NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No,NewLesionAssessment.Suspected,NewLesionAssessment.NE }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal,LiverAssessment.Stabilization,LiverAssessment.NotEvaluable}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal,SpleenAssessment.Remission,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
                //2 CR	（PR/SD）或者NE	 否/疑似/无法评估	正常/稳定/NE	正常/部分缓解/稳定/NE	PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.CR }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.PRSD,NoTargetAssessment.NE }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No,NewLesionAssessment.Suspected ,NewLesionAssessment.NE}),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal,LiverAssessment.Stabilization,LiverAssessment.NotEvaluable}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal,SpleenAssessment.Remission ,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable}),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
                  //3 CR	CR/ND	疑似/无法评估	正常/稳定/NE	正常/部分缓解/稳定/NE	PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.CR }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR,NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.Suspected, NewLesionAssessment.NE  }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal,LiverAssessment.Stabilization,LiverAssessment.NotEvaluable}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal,SpleenAssessment.Remission ,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
                 //4  CR	CR/ND	否	稳定/NE	  正常/部分缓解/稳定/NE  	PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.CR }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR,NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No  }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() {LiverAssessment.Stabilization,LiverAssessment.NotEvaluable}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal,SpleenAssessment.Remission ,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
                 //5  CR	CR/ND	否	正常	 部分缓解/稳定/NE  	PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.CR }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR,NoTargetAssessment.ND }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { NewLesionAssessment.No  }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() {LiverAssessment.Normal}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Remission ,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
                 // 6  ND  CR  疑似/无法评估 正常/稳定/NE   正常/部分缓解/稳定/NE  PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() {  NewLesionAssessment.Suspected, NewLesionAssessment.NE }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { LiverAssessment.Normal,LiverAssessment.Stabilization,LiverAssessment.NotEvaluable}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal,SpleenAssessment.Remission,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
                   // 7  ND  CR  否  稳定/NE   正常/部分缓解/稳定/NE  PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() {  NewLesionAssessment.No }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() {LiverAssessment.Stabilization,LiverAssessment.NotEvaluable}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Normal,SpleenAssessment.Remission,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
                    // 8  ND  CR  否  正常  部分缓解/稳定/NE  PR
                new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() { TargetAssessment.ND }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { NoTargetAssessment.CR }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() {  NewLesionAssessment.No }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() {LiverAssessment.Normal}),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() { SpleenAssessment.Remission,SpleenAssessment.Stabilization,SpleenAssessment.NotEvaluable }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.PR }),
				},
				 new CalculationDto(){
				Column1=ReadingCommon.EnumToString(new List<TargetAssessment>() {  }),
				Column2=ReadingCommon.EnumToString(new List<NoTargetAssessment>() { }),
				Column3=ReadingCommon.EnumToString(new List<NewLesionAssessment>() { }),
				Column4=ReadingCommon.EnumToString(new List<LiverAssessment>() { }),
				Column5=ReadingCommon.EnumToString(new List<SpleenAssessment>() {  }),
				Column6=ReadingCommon.EnumToString(new List<CTMRIOverallAssessment>() { CTMRIOverallAssessment.SD }),
				},
			};

			var index = data.FindIndex(x =>
			 (x.NotEq.Contains(1) ? !x.Column1.Contains(targetEvaluation) : x.Column1.Contains(targetEvaluation) || x.Column1.Count() == 0) &&
			 (x.NotEq.Contains(2) ? !x.Column2.Contains(noTargetEvaluation) : x.Column2.Contains(noTargetEvaluation) || x.Column2.Count() == 0) &&
			 (x.NotEq.Contains(3) ? !x.Column3.Contains(existsNewTarget) : x.Column3.Contains(existsNewTarget) || x.Column3.Count() == 0) &&
			 (x.NotEq.Contains(4) ? !x.Column4.Contains(liverEvaluation) : x.Column4.Contains(liverEvaluation) || x.Column4.Count() == 0) &&
			 (x.NotEq.Contains(5) ? !x.Column5.Contains(spleenEvaluation) : x.Column5.Contains(spleenEvaluation) || x.Column5.Count() == 0))
			 ;
			var result = data.Where(x =>
			 (x.NotEq.Contains(1) ? !x.Column1.Contains(targetEvaluation) : x.Column1.Contains(targetEvaluation) || x.Column1.Count() == 0) &&
			 (x.NotEq.Contains(2) ? !x.Column2.Contains(noTargetEvaluation) : x.Column2.Contains(noTargetEvaluation) || x.Column2.Count() == 0) &&
			 (x.NotEq.Contains(3) ? !x.Column3.Contains(existsNewTarget) : x.Column3.Contains(existsNewTarget) || x.Column3.Count() == 0) &&
			 (x.NotEq.Contains(4) ? !x.Column4.Contains(liverEvaluation) : x.Column4.Contains(liverEvaluation) || x.Column4.Count() == 0) &&
			 (x.NotEq.Contains(5) ? !x.Column5.Contains(spleenEvaluation) : x.Column5.Contains(spleenEvaluation) || x.Column5.Count() == 0))
			 .Select(x => x.Column6.FirstOrDefault())
			 .FirstOrDefault();
			return result ?? string.Empty;
		}

		#endregion

		/// <summary>
		/// 保留小数
		/// </summary>
		/// <param name="answer"></param>
		/// <param name="digitPlaces"></param>
		/// <returns></returns>
		public string ReserveDecimal (decimal answer, int digitPlaces)
        {
            return  decimal.Round(answer, digitPlaces).ToString();
        }

        #region 脾脏评估

            ///// <summary>
            ///// 获取脾脏评估
            ///// </summary>
            ///// <param name="inDto"></param>
            ///// <returns></returns>
            //public async Task<string> GetSplenicEvaluation(ReadingCalculateDto inDto)
            //{

            //}
            #endregion

            #endregion

    }

}