using IRaCIS.Core.Application.Filter;
using Microsoft.AspNetCore.Mvc;
using IRaCIS.Core.Application.Contracts.Dicom.DTO;
using Microsoft.AspNetCore.Authorization;
using IRaCIS.Core.Domain.Share;
using IRaCIS.Core.Application.Contracts;
using IRaCIS.Core.Application.Interfaces;
using IRaCIS.Core.Infrastructure;
using IRaCIS.Core.Application.Auth;
using IRaCIS.Core.Infra.EFCore.Common;
using MassTransit;
namespace IRaCIS.Core.Application.Services
{
[ApiExplorerSettings(GroupName = "Trial")]
public class SubjectVisitService : BaseService, ISubjectVisitService
{
private readonly IRepository<SubjectVisit> _subjectVisitRepository;
private readonly IRepository<ClinicalDataTrialSet> _clinicalDataTrialSetRepository;
private readonly IRepository<ReadingClinicalData> _readingClinicalDataRepository;
private readonly IRepository<ReadModule> _readModuleRepository;
private readonly IRepository<Trial> _trialRepository;
private readonly IRepository<ReadingPeriodSet> _readingPeriodSetRepository;
private readonly IRepository<NoneDicomStudy> _noneDicomStudyRepository;
private readonly IRepository<DicomInstance> _dicomInstanceRepository;
private readonly IRepository<VisitTask> _visitTaskRepository;
private readonly IRepository<ReadingTableAnswerRowInfo> _readingTableAnswerRowInfoRepository;
private readonly IRepository<NoneDicomStudyFile> _noneDicomStudyFileRepository;
private readonly IRepository<ReadingPeriodPlan> _readingPeriodPlanRepository;
private readonly IRepository<Subject> _subjectRepository;
private readonly IRepository<ReadingQuestionCriterionTrial> _trialReadingCriterionRepository;
private readonly IRepository<SubjectCriteriaEvaluationVisitStudyFilter> _subjectCriteriaEvaluationVisitStudyFilterRepository;
public SubjectVisitService(IRepository<SubjectVisit> subjectVisitRepository,
IRepository<ClinicalDataTrialSet> clinicalDataTrialSetRepository,
IRepository<ReadingClinicalData> readingClinicalDataRepository,
IRepository<ReadModule> readModuleRepository,
IRepository<Trial> trialRepository,
IRepository<ReadingPeriodSet> readingPeriodSetRepository,
IRepository<NoneDicomStudy> noneDicomStudyRepository,
IRepository<DicomInstance> dicomInstanceRepository,
IRepository<VisitTask> visitTaskRepository,
IRepository<ReadingTableAnswerRowInfo> readingTableAnswerRowInfoRepository,
IRepository<NoneDicomStudyFile> noneDicomStudyFileRepository,
IRepository<ReadingPeriodPlan> readingPeriodPlanRepository,
IRepository<Subject> subjectRepository,
IRepository<ReadingQuestionCriterionTrial> trialReadingCriterionRepository,
IRepository<SubjectCriteriaEvaluationVisitStudyFilter> subjectCriteriaEvaluationVisitStudyFilterRepository
)
{
_subjectVisitRepository = subjectVisitRepository;
this._clinicalDataTrialSetRepository = clinicalDataTrialSetRepository;
this._readingClinicalDataRepository = readingClinicalDataRepository;
this._readModuleRepository = readModuleRepository;
this._trialRepository = trialRepository;
this._readingPeriodSetRepository = readingPeriodSetRepository;
this._noneDicomStudyRepository = noneDicomStudyRepository;
this._dicomInstanceRepository = dicomInstanceRepository;
this._visitTaskRepository = visitTaskRepository;
this._readingTableAnswerRowInfoRepository = readingTableAnswerRowInfoRepository;
this._noneDicomStudyFileRepository = noneDicomStudyFileRepository;
this._readingPeriodPlanRepository = readingPeriodPlanRepository;
_subjectRepository = subjectRepository;
_trialReadingCriterionRepository = trialReadingCriterionRepository;
_subjectCriteriaEvaluationVisitStudyFilterRepository = subjectCriteriaEvaluationVisitStudyFilterRepository;
}
[HttpPost]
[TypeFilter(typeof(TrialResourceFilter), Arguments = new object[] { "AfterStopCannNotOpt" })]
[UnitOfWork]
//[Authorize(Policy = IRaCISPolicy.CRC)]
public async Task<IResponseOutput<string>> AddOrUpdateSV(SubjectVisitCommand svCommand)
{
var verifyExp1 = new EntityVerifyExp<SubjectVisit>()
{
VerifyExp = t => t.VisitNum == svCommand.VisitNum && t.SubjectId == svCommand.SubjectId,
//---该受试者的访视计划中已经包含一个具有相同访视号的访视。
VerifyMsg = _localizer["Visit_DuplicateVisitNo"]
};
var verifyExp2 = new EntityVerifyExp<SubjectVisit>()
{
VerifyExp = t => t.SubjectId == svCommand.SubjectId && t.IsFinalVisit,
//---该受试者已经有访视设置为末次访视，不允许将当前访视设置为末次访视。
VerifyMsg = _localizer["Visit_LastVisitNoChange"],
IsVerify = svCommand.IsFinalVisit
};
var verifyExp3 = new EntityVerifyExp<SubjectVisit>()
{
VerifyExp = t => t.SubjectId == svCommand.SubjectId && t.VisitName == svCommand.VisitName,
//---该受试者的访视计划中已经包含一个具有相同访视名称的访视。
VerifyMsg = _localizer["Visit_DuplicateVisitName"]
};
svCommand.BlindName = "B" + ((int)(svCommand.VisitNum * 10)).ToString("D3");
svCommand.VisitExecuted = svCommand.IsLostVisit ? VisitExecutedEnum.Executed : svCommand.VisitExecuted;
SubjectVisit? dbBeforeEntity = null;
//Add
if (svCommand.Id == null)
{
//设置末次评估后，不允许添加计划外访视
if (svCommand.InPlan == false)
{
if (await _subjectVisitRepository.AnyAsync(t => t.SubjectId == svCommand.SubjectId && t.IsFinalVisit))
{
//---设置末次评估后，不允许添加计划外访视。
throw new BusinessValidationFailedException(_localizer["Visit_NoExtraVisitAfterLast"]);
}
if (await _repository.AnyAsync<VisitTask>(t => t.SubjectId == svCommand.SubjectId && t.TaskState == TaskState.Effect && t.VisitTaskNum > svCommand.VisitNum && t.SignTime != null && t.TrialReadingCriterion.IsReadingTaskViewInOrder))
{
//---该受试者后续访视已有任务完成阅片(有序阅片标准)，不允许在此添加，如果确实需要，请回退
throw new BusinessValidationFailedException(_localizer["Visit_FinishedTasksNoAdd"]);
}
}
dbBeforeEntity = await _subjectVisitRepository.InsertFromDTOAsync(svCommand, false, verifyExp1, verifyExp2, verifyExp3);
//var cRCClinicalDataIds = await _clinicalDataTrialSetRepository.Where(x => x.TrialId == svCommand.TrialId && x.UploadRole == UploadRole.CRC && x.IsConfirm && x.ClinicalDataLevel == ClinicalLevel.SubjectVisit)
//.Select(x => x.Id).ToListAsync();
//List<ReadingClinicalData> readingClinicals = cRCClinicalDataIds.Select(x => new ReadingClinicalData()
//{
// ClinicalDataTrialSetId = x,
// IsVisit = true,
// SubjectId = svCommand.SubjectId,
// ReadingId = dbBeforeEntity.Id,
// TrialId = svCommand.TrialId
//}).ToList();
//await _readingClinicalDataRepository.AddRangeAsync(readingClinicals);
}
else
{
dbBeforeEntity = await _subjectVisitRepository.UpdateFromDTOAsync(svCommand, false, false, verifyExp1, verifyExp2, verifyExp3);
if (svCommand.PDState != dbBeforeEntity.PDState && dbBeforeEntity.SubmitState == SubmitStateEnum.Submitted)
{
//---当前访视影像提交后，不允许修改PD确认状态。
throw new BusinessValidationFailedException(_localizer["Visit_NoPDStatusChangeAfterSubmission"]);
}
if (svCommand.PDState != dbBeforeEntity.PDState && dbBeforeEntity.RequestBackState == RequestBackStateEnum.PM_AgressBack)
{
//---当前访视影像提交后，不允许修改PD确认状态。
throw new BusinessValidationFailedException(_localizer["Visit_NoPDStatusChangeAfterSubmission"]);
}
if (svCommand.IsLostVisit)
{
if (await _subjectVisitRepository.AnyAsync(t => t.Id == svCommand.Id && t.SubmitState == SubmitStateEnum.ToSubmit))
{
//---当前访视已经有影像上传，不允许设置为失访。
throw new BusinessValidationFailedException(_localizer["Visit_UploadedNoLost"]);
}
}
dbBeforeEntity = await _subjectVisitRepository.UpdateFromDTOAsync(svCommand, true, false, verifyExp1, verifyExp2, verifyExp3);
}
//更新受试者 访视基准日期 是否入组确认
if (svCommand.SubjectFirstGiveMedicineTime != null && svCommand.IsBaseLine)
{
await _subjectRepository.UpdatePartialFromQueryAsync(svCommand.SubjectId, t => new Subject()
{
FirstGiveMedicineTime = svCommand.SubjectFirstGiveMedicineTime
});
}
await _subjectVisitRepository.SaveChangesAsync();
return ResponseOutput.Ok(dbBeforeEntity.Id.ToString());
}
[HttpPut("{trialId:guid}/{subjectVisitId:guid}/{isUrgent:bool}")]
[TypeFilter(typeof(TrialResourceFilter), Arguments = new object[] { "AfterStopCannNotOpt" })]
//[Authorize(Policy = IRaCISPolicy.PM_IQC)]
public async Task<IResponseOutput> SetSubjectVisitUrgent(Guid subjectVisitId, bool isUrgent)
{
await _subjectVisitRepository.UpdatePartialFromQueryAsync(subjectVisitId, u => new SubjectVisit() { IsUrgent = isUrgent }, true);
return ResponseOutput.Ok();
}
[HttpDelete, Route("{trialId:guid}/{id:guid}")]
[TypeFilter(typeof(TrialResourceFilter), Arguments = new object[] { "AfterStopCannNotOpt" })]
//[Authorize(Policy = IRaCISPolicy.CRC)]
public async Task<IResponseOutput> DeleteSV(Guid id)
{
if (await _repository.AnyAsync<DicomStudy>(t => t.SubjectVisitId == id))
{
//---当前访视已经有影像上传，不允许删除。
return ResponseOutput.NotOk(_localizer["Visit_UploadedNoDelete"]);
}
if (await _subjectVisitRepository.AnyAsync(t => t.Id == id && t.InPlan))
{
//---计划内的访视不允许删除。
return ResponseOutput.NotOk(_localizer["Visit_PlanVisitNoDelete"]);
}
if (await _subjectVisitRepository.AnyAsync(t => t.OutPlanPreviousVisitId == id))
{
//---当前访视已经被设置为另一访视的上一访视，不允许删除。
return ResponseOutput.NotOk(_localizer["Visit_PreviousVisitNoDelete"]);
}
await _subjectVisitRepository.DeleteFromQueryAsync(s => s.Id == id, true);
return ResponseOutput.Ok();
}
/// <summary>
/// 获取访视下的Dicom 检查信息 分所有的， 阅片的 不阅片 isReading : 0 查询所有 1 查询仅仅阅片的
/// </summary>
/// <param name="trialId"></param>
/// <param name="sujectVisitId"></param>
/// <param name="isReading"></param>
/// <returns></returns>
[HttpGet, Route("{trialId:guid}/{sujectVisitId:guid}/{isReading}")]
[AllowAnonymous]
public async Task<List<VisitStudyDTO>> GetVisitStudyList(Guid trialId, Guid sujectVisitId, int isReading)
{
var studyList = await _repository.Where<DicomStudy>(t => t.TrialId == trialId && t.SubjectVisitId == sujectVisitId).Select(k => new VisitStudyDTO()
{
InstanceCount = k.InstanceCount,
Modalities = k.Modalities,
SeriesCount = k.SeriesCount,
StudyCode = k.StudyCode,
StudyId = k.Id
}).ToListAsync();
var studyIds = studyList.Select(t => t.StudyId).ToList();
var instanceList = await _repository.Where<DicomInstance>(t => studyIds.Contains(t.StudyId))
.Select(t => new { t.SeriesId, t.Id, t.InstanceNumber, t.Path, t.NumberOfFrames }).ToListAsync();
foreach (var t in studyList)
{
t.SeriesList = await _repository.Where<DicomSeries>(s => s.StudyId == t.StudyId)
.WhereIf(isReading == 1, s => s.IsReading).OrderBy(s => s.SeriesNumber).
ThenBy(s => s.SeriesTime)
.ProjectTo<DicomSeriesDTO>(_mapper.ConfigurationProvider).ToListAsync();
t.SeriesList.ForEach(series =>
{
series.InstanceList = instanceList.Where(t => t.SeriesId == series.Id).OrderBy(t => t.InstanceNumber).Select(k => k.Id).ToList();
//series.InstancePathList = instanceList.Where(t => t.SeriesId == series.Id).OrderBy(t => t.InstanceNumber).Select(k => k.Path).ToList();
//处理多帧
series.InstancePathList = instanceList.OrderBy(t => t.InstanceNumber).Where(s => s.SeriesId == series.Id)
.SelectMany(u =>
{
if (u.NumberOfFrames > 1)
{
var pathList = new List<string>();
for (int i = 1; i <= u.NumberOfFrames; i++)
{
pathList.Add(u.Path + "?frame=" + (i - 1));
}
return pathList;
}
else
{
return new List<string> { u.Path };
}
})
.ToList();
}
);
//设置为阅片与否 不更改数据库检查 的instance数量 和 SeriesCount 所以这里要实时统计
t.SeriesCount = t.SeriesList.Count();
t.InstanceCount = t.SeriesList.SelectMany(t => t.InstanceList).Count();
}
return studyList;
//return ResponseOutput.Ok(studyList.Where(t => t.SeriesList.Count > 0).ToList());
}
/// <summary>
/// 获取访视下的Dicom 检查信息 分所有的， 阅片的 不阅片 isReading : 0 查询所有 1 查询仅仅阅片的
/// </summary>
/// <param name="indto"></param>
/// <returns></returns>
[HttpPost]
public async Task<List<VisitStudyDTO>> GetReadingVisitStudyList(GetReadingVisitStudyListIndto indto)
{
var result = new List<VisitStudyDTO>();
var thisRowinfo = await _readingTableAnswerRowInfoRepository.Where(x => x.VisitTaskId == indto.VisitTaskId && x.StudyId != null).OrderBy(x => x.ReadingQuestionTrial.ShowOrder).ThenBy(x => x.RowIndex).Select(x => new
{
x.ReadingQuestionTrial.ShowOrder,
x.RowIndex,
x.SeriesId,
x.StudyId,
x.InstanceId,
}).ToListAsync();
var taskInfo = await _visitTaskRepository.Where(x => x.Id == indto.VisitTaskId).FirstNotNullAsync();
if (taskInfo.ReadingTaskState == ReadingTaskState.HaveSigned)
{
var thisStudyIds = thisRowinfo.OrderBy(x => x.ShowOrder).ThenBy(x => x.RowIndex).Select(x => x.StudyId).Distinct().ToList();
var thisSeriesIdIds = thisRowinfo.Where(x => x.SeriesId != null).OrderBy(x => x.ShowOrder).ThenBy(x => x.RowIndex).Select(x => x.SeriesId).Distinct().ToList();
if (thisRowinfo.Count > 0)
{
var thisVisitTaskStudy = await _repository.Where<DicomStudy>(t => thisStudyIds.Contains(t.Id)).Select(k => new VisitStudyDTO()
{
InstanceCount = k.InstanceCount,
SeriesCount = k.SeriesCount,
StudyId = k.Id,
IsCriticalSequence = true,
}).FirstOrDefaultAsync();
if (thisVisitTaskStudy != null)
{
thisVisitTaskStudy.StudyId = default(Guid);
var item = await _repository.Where<DicomSeries>(s => thisSeriesIdIds.Contains(s.Id)).OrderBy(s => s.SeriesNumber).
ThenBy(s => s.SeriesTime)
.ProjectTo<DicomSeriesDTO>(_mapper.ConfigurationProvider).FirstOrDefaultAsync();
if (item != null)
{
item.SeriesInstanceUid = string.Empty;
item.InstanceList = thisRowinfo.Where(y => y.InstanceId != null).OrderBy(x => x.ShowOrder).ThenBy(x => x.RowIndex).Select(y => y.InstanceId.Value).Distinct().ToList();
var tempInstanceList = await _repository.Where<DicomInstance>(t => item.InstanceList.Contains(t.Id)).OrderBy(t => t.InstanceNumber)
.Select(t => new TempInstance
{
Id = t.Id,
Path = t.Path,
NumberOfFrames = t.NumberOfFrames,
InstanceNumber = t.InstanceNumber
}).ToListAsync();
tempInstanceList.ForEach(x =>
{
var item = thisRowinfo.FirstOrDefault(y => y.InstanceId == x.Id);
if (item != null)
{
x.ShowOrder = item.ShowOrder;
x.RowIndex = item.RowIndex;
}
});
item.InstancePathList = tempInstanceList.OrderBy(x => x.ShowOrder).ThenBy(x => x.RowIndex).SelectMany(u =>
{
if (u.NumberOfFrames > 1)
{
var pathList = new List<string>();
for (int i = 1; i <= u.NumberOfFrames; i++)
{
pathList.Add(u.Path + "?frame=" + (i - 1));
}
return pathList;
}
else
{
return new List<string> { u.Path };
}
})
.ToList();
item.InstanceCount = item.InstanceList.Count();
thisVisitTaskStudy.SeriesList.Add(item);
thisVisitTaskStudy.SeriesCount = thisVisitTaskStudy.SeriesList.Count();
}
result.Add(thisVisitTaskStudy);
}
}
}
//如果是手动生成的标准，需要过滤检查和序列数据
var isManualGenerate = await _trialReadingCriterionRepository.AnyAsync(t => t.Id == taskInfo.TrialReadingCriterionId && t.IsAutoCreate == false);
var studyList = await _repository.Where<DicomStudy>(t => t.TrialId == indto.TrialId && t.SubjectVisitId == indto.SujectVisitId)
.WhereIf(isManualGenerate,t=>t.SubjectCriteriaEvaluationVisitStudyFilterList.Any(t=>t.TrialReadingCriterionId==taskInfo.TrialReadingCriterionId && t.IsConfirmed &&t.IsReading ))
.Select(k => new VisitStudyDTO()
{
InstanceCount = k.InstanceCount,
Modalities = k.Modalities,
SeriesCount = k.SeriesCount,
StudyCode = k.StudyCode,
StudyId = k.Id,
}).ToListAsync();
var studyIds = studyList.Select(t => t.StudyId).ToList();
var instanceList = await _repository.Where<DicomInstance>(t => studyIds.Contains(t.StudyId))
.Select(t => new { t.SeriesId, t.Id, t.InstanceNumber, t.Path, t.NumberOfFrames,t.WindowCenter,t.WindowWidth }).ToListAsync();
List<DicomSeriesDTO> seriesLists = await _repository.Where<DicomSeries>(s => studyIds.Contains(s.StudyId) /*&& s.IsReading*/)
.WhereIf(isManualGenerate==false, t => t.IsReading)
.WhereIf(isManualGenerate, t => t.SubjectCriteriaEvaluationVisitStudyFilterList.Any(t => t.TrialReadingCriterionId == taskInfo.TrialReadingCriterionId && t.IsConfirmed && t.IsReading))
.OrderBy(s => s.SeriesNumber).
ThenBy(s => s.SeriesTime)
.ProjectTo<DicomSeriesDTO>(_mapper.ConfigurationProvider).ToListAsync();
foreach (var t in studyList)
{
t.SeriesList = seriesLists.Where(s => s.StudyId == t.StudyId).OrderBy(s => s.SeriesNumber).
ThenBy(s => s.SeriesTime).ToList();
t.SeriesList.ForEach(series =>
{
series.InstanceList = instanceList.Where(t => t.SeriesId == series.Id).OrderBy(t => t.InstanceNumber).Select(k => k.Id).ToList();
//series.InstancePathList = instanceList.Where(t => t.SeriesId == series.Id).OrderBy(t => t.InstanceNumber).Select(k => k.Path).ToList();
//处理多帧
series.InstancePathList = instanceList.Where(s => s.SeriesId == series.Id).OrderBy(t => t.InstanceNumber)
.SelectMany(u =>
{
if (u.NumberOfFrames > 1)
{
var pathList = new List<string>();
for (int i = 1; i <= u.NumberOfFrames; i++)
{
pathList.Add(u.Path + "?frame=" + (i - 1));
}
return pathList;
}
else
{
return new List<string> { u.Path };
}
})
.ToList();
series.WindowWidth = instanceList.FirstOrDefault()?.WindowWidth;
series.WindowCenter = instanceList.FirstOrDefault()?.WindowCenter;
});
//设置为阅片与否 不更改数据库检查 的instance数量 和 SeriesCount 所以这里要实时统计
t.SeriesCount = t.SeriesList.Count();
t.InstanceCount = t.SeriesList.SelectMany(t => t.InstanceList).Count();
}
// 非Dicom
var noDicomList = await _noneDicomStudyRepository.Where(x => x.TrialId == indto.TrialId && x.SubjectVisitId == indto.SujectVisitId).ToListAsync();
List<VisitStudyDTO> noDicomStudyList = noDicomList.Select(x => new VisitStudyDTO()
{
InstanceCount = x.FileCount,
StudyId = x.Id,
Modalities = x.Modality,
SeriesCount = 1,
StudyCode = x.StudyCode,
IsDicom = false,
}).ToList();
foreach (var item in noDicomStudyList)
{
var nodicom = noDicomList.Where(x => x.Id == item.StudyId).FirstOrDefault();
item.SeriesList = new List<DicomSeriesDTO>()
{
new DicomSeriesDTO (){
IsDicom=false,
Id=item.StudyId,
InstanceCount=await _noneDicomStudyFileRepository.Where(x=>x.NoneDicomStudyId==item.StudyId).CountAsync(),
Modality=item.Modalities,
StudyId=item.StudyId,
TrialId=nodicom.TrialId,
SiteId=nodicom.SiteId,
SubjectVisitId=nodicom.SubjectVisitId,
SubjectId=nodicom.SubjectId,
SeriesNumber=1,
NoneDicomFileFirstFile=await _noneDicomStudyFileRepository.Where(x=>x.NoneDicomStudyId==item.StudyId).Select(x=>x.Path).FirstOrDefaultAsync(),
}
};
}
if (studyList == null || studyList.Count == 0)
{
studyList = new List<VisitStudyDTO>();
}
studyList.AddRange(noDicomStudyList);
studyList.ForEach(x =>
{
x.SeriesList.ForEach(y =>
{
y.IsBeMark = thisRowinfo.Any(z => z.SeriesId == y.Id);
});
});
result.AddRange(studyList);
result = result.Where(x => x.SeriesCount > 0).ToList();
return result;
}
/// <summary>
/// 设置受试者访视已执行 也就是将studyUploaded状态置为true 为了那些没有影像 人工设置准备
/// </summary>
/// <param name="subjectVisitId"></param>
/// <returns></returns>
[HttpPut("{trialId:guid}/{subjectVisitId:guid}")]
[TypeFilter(typeof(TrialResourceFilter), Arguments = new object[] { "AfterStopCannNotOpt" })]
[Obsolete]
public async Task<IResponseOutput> SetSVExecuted(Guid subjectVisitId)
{
await _subjectVisitRepository.UpdatePartialFromQueryAsync(subjectVisitId, u => new SubjectVisit() { VisitExecuted = VisitExecutedEnum.Executed }, true);
return ResponseOutput.Ok();
}
}
}