using IRaCIS.Application.Contracts;
using IRaCIS.Application.Interfaces;
using IRaCIS.Core.Application.Filter;
using IRaCIS.Core.Application.Helper;
using IRaCIS.Core.Domain.Share;
using IRaCIS.Core.Infrastructure;
using Microsoft.AspNetCore.Authorization;
using Microsoft.AspNetCore.Mvc;
using Microsoft.Extensions.Options;
using Panda.DynamicWebApi.Attributes;
using ZiggyCreatures.Caching.Fusion;

namespace IRaCIS.Core.Application.Service
{

    [ApiExplorerSettings(GroupName = "Trial")]

    public class TrialService(IRepository<Trial> _trialRepository,
        IRepository<TrialUser> _trialUserRepository,
        IRepository<CRO> _croRepository,
        IRepository<EnrollDetail> _enrollDetailRepository,
        IRepository<Dictionary> _dictionaryRepository,
        IRepository<Enroll> _enrollRepository,
        IRepository<Workload> _workloadRepository,
        IRepository<Sponsor> _sponsorRepository,
        IRepository<VisitStage> _visitStageRepository,
        IRepository<TrialPaymentPrice> _trialPaymentPriceRepository,
        IRepository<TrialDictionary> _trialDictionaryRepository,
        IRepository<TrialBodyPart> _trialBodyPartRepository,
        IOptionsMonitor<ServiceVerifyConfigOption> _verifyConfig,
        IMapper _mapper, IUserInfo _userInfo, IStringLocalizer _localizer, IFusionCache _fusionCache) : BaseService, ITrialService
    {



        public bool TrialExpeditedChange { get; set; } = false;



        /// <summary>
        /// 分页获取临床项目列表  默认后台加急状态为3 查所有的   
        /// </summary>
        /// <param name="inQuery"></param>
        /// <returns></returns>
        [HttpPost]
        public async Task<PageOutput<TrialDetailDTO>> GetTrialList(TrialQueryDTO inQuery)
        {

            var multiModalityIdSelectCount = inQuery.ModalityIds.Count;
            var multiCriteriaSelectCount = inQuery.CriterionIds.Count;
            var multiReviewTypeSelectCount = inQuery.ReviewTypeIds.Count;

            Expression<Func<Trial, bool>> trialDeclarationTypeExpression = x => true;



            foreach (var item in inQuery.DeclarationTypeEnumList)
            {
                trialDeclarationTypeExpression = trialDeclarationTypeExpression.And(t => t.DeclarationTypes.Contains($"|{item}|"));
            }

            Expression<Func<Trial, bool>> trialAttendedReviewerTypeExpression = x => true;

            foreach (var item in inQuery.AttendedReviewerTypeEnumList)
            {
                trialAttendedReviewerTypeExpression = trialAttendedReviewerTypeExpression.And(t => t.AttendedReviewerTypes.Contains($"|{item}|"));
            }


            var query = _trialRepository.AsQueryable()
                .WhereIf(!string.IsNullOrEmpty(inQuery.TrialStatusStr), o => o.TrialStatusStr.Contains(inQuery.TrialStatusStr))
                .WhereIf(inQuery.SponsorId != null, o => o.SponsorId == inQuery.SponsorId)
                .WhereIf(inQuery.Expedited != null, o => o.Expedited == inQuery.Expedited)
                .WhereIf(!string.IsNullOrEmpty(inQuery.Code), o => o.TrialCode.Contains(inQuery.Code))
                .WhereIf(!string.IsNullOrWhiteSpace(inQuery.Indication), o => o.Indication.Contains(inQuery.Indication))
                .WhereIf(!string.IsNullOrEmpty(inQuery.ResearchProgramNo), o => o.ResearchProgramNo.Contains(inQuery.ResearchProgramNo))
                .WhereIf(!string.IsNullOrWhiteSpace(inQuery.ExperimentName), o => o.ExperimentName.Contains(inQuery.ExperimentName))
                .WhereIf(inQuery.PhaseId != null, o => o.PhaseId == inQuery.PhaseId)

                .WhereIf(inQuery.DeclarationTypeEnumList.Count > 0, trialDeclarationTypeExpression)
                .WhereIf(inQuery.AttendedReviewerTypeEnumList.Count > 0, trialAttendedReviewerTypeExpression)

                //.WhereIf(searchParam.AttendedReviewerType != null, o => o.AttendedReviewerType == searchParam.AttendedReviewerType)

                .WhereIf(inQuery.IndicationTypeId != null, o => o.IndicationTypeId == inQuery.IndicationTypeId)
                .WhereIf(inQuery.CROId != null, o => o.CROId == inQuery.CROId)
                .WhereIf(inQuery.BeginDate != null, o => o.CreateTime >= inQuery.BeginDate)
                .WhereIf(inQuery.EndDate != null, o => o.CreateTime <= inQuery.EndDate)

                .WhereIf(multiModalityIdSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.Modality) == multiModalityIdSelectCount)
                .WhereIf(multiCriteriaSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.Criterion) == multiCriteriaSelectCount)
                .WhereIf(multiReviewTypeSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.ReviewType) == multiReviewTypeSelectCount)
                .WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id && t.IsDeleted == false) && t.IsDeleted == false)
                .ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { userTypeEnumInt = _userInfo.UserTypeEnumInt, userId = _userInfo.Id, isEn_Us = _userInfo.IsEn_Us });

            return await query.ToPagedListAsync(inQuery);


        }

        //过滤废除的项目
        public async Task<List<TrialSelectDTO>> GetTrialSelect()
        {
            return await _trialRepository.AsQueryable()
                .WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.Admin && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.OP, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id) && t.IsDeleted == false)

                .ProjectTo<TrialSelectDTO>(_mapper.ConfigurationProvider).ToListAsync();
        }



        /// <summary>
        /// 获取项目基本信息
        /// </summary>
        /// <param name="projectId"></param>
        /// <returns></returns>
        [HttpGet("{projectId:guid}")]
        public async Task<TrialDetailDTO> GetTrialInfoAndLockState(Guid projectId)
        {
            return (await _trialRepository.Where(o => o.Id == projectId).ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { isEn_Us = _userInfo.IsEn_Us }).FirstOrDefaultAsync()).IfNullThrowException();

        }


        [NonDynamicMethod]
        public async Task<int> GetTrialMaxState(Guid trialId)
        {
            return await _enrollDetailRepository.Where(t => t.TrialId == trialId).MaxAsync(u => (int?)u.EnrollStatus) ?? 0;
        }

        [HttpGet("{trialId:guid}")]
        public async Task<TrialAndTrialStateVieModel> GetTrialInfoAndMaxTrialState(Guid trialId)
        {
            return new TrialAndTrialStateVieModel()
            {
                TrialView = await GetTrialInfoAndLockState(trialId),
                TrialMaxState = await GetTrialMaxState(trialId)
            };
        }


        [HttpGet("{trialId:guid}")]
        public async Task<int> GetTrialExpeditedState(Guid trialId)
        {
            var trial = (await _trialRepository.FirstOrDefaultAsync(u => u.Id == trialId)).IfNullThrowException();

            return trial.Expedited;
        }



        /// <summary>
        /// 添加项目
        /// </summary>
        /// <param name="trialAddModel"></param>
        /// <returns></returns>
        [NonDynamicMethod]
        public virtual async Task<IResponseOutput<Trial>> AddOrUpdateTrial(TrialCommand trialAddModel)
        {



            //测试用户 只能创建非正式项目
            if (_userInfo.IsTestUser && trialAddModel.TrialType != TrialType.NoneOfficial)
            {
                //---测试用户 只能创建非正式项目
                throw new BusinessValidationFailedException(_localizer["Trial_TestUserCreateOnlyNonFormal"]);
            }

            if (trialAddModel.Id == Guid.Empty || trialAddModel.Id == null)
            {
                if (await _trialRepository.AnyAsync(u => u.TrialCode == trialAddModel.TrialCode))
                {
                    //---已经存在相同的项目编号。
                    throw new BusinessValidationFailedException(_localizer["Trial_DuplicateProjectNumber"]);
                }

                var dbMaxCode = await _trialRepository.Where(t => t.CreateTime.Year == DateTime.Now.Year && t.TrialType == trialAddModel.TrialType).Select(t => t.Code).DefaultIfEmpty().MaxAsync();

                var currentYearMaxCodeNext = dbMaxCode + 1;

                //var test = _trialRepository.Where(t => t.CreateTime.Year == DateTime.Now.Year + 1).Select(t => t.Code).DefaultIfEmpty(1).ToList();

                var trial = _mapper.Map<Trial>(trialAddModel);
                //trial.Id = NewId.NextGuid();
                var yearStr = DateTime.Now.Year.ToString();

                trial.Code = currentYearMaxCodeNext;
                trial.TrialCode = (trial.TrialType == TrialType.NoneOfficial ? "T0" : yearStr.Substring(yearStr.Length - 2)) + trial.TrialCode + currentYearMaxCodeNext.ToString("D3");


                trial.DeclarationTypes = $"|{string.Join('|', trialAddModel.DeclarationTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";
                trial.AttendedReviewerTypes = $"|{string.Join('|', trialAddModel.AttendedReviewerTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";

                //多选信息
                trialAddModel.ModalityIds.ForEach(modalityId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = modalityId, KeyName = StaticData.Modality, TrialId = trial.Id }));
                trialAddModel.CriterionIds.ForEach(criterionId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = criterionId, KeyName = StaticData.Criterion, TrialId = trial.Id }));
                trialAddModel.ReviewTypeIds.ForEach(ReviewTypeId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = ReviewTypeId, KeyName = StaticData.ReviewType, TrialId = trial.Id }));

                //添加项目后 项目状态变更为申请下载简历
                trial.TrialEnrollStatus = (int)TrialEnrollStatus.ChooseDoctor;
                //trial.TrialStatusStr = StaticData.TrialInitializing;

                //状态变更详细表
                trial.ClinicalTrialProjectDetails.Add(new TrialStatusDetail() { TrialId = trial.Id, TrialStatus = (int)TrialEnrollStatus.ChooseDoctor });

                trial = await _trialRepository.AddAsync(trial);

                //如果是PM， 则需要将该人员添加到 运维人员表
                //添加运维人员PM 
                await _trialUserRepository.AddAsync(new TrialUser() { TrialId = trial.Id, UserId = _userInfo.Id, JoinTime = DateTime.Now });

                // 添加扩展信息表记录
                await _trialPaymentPriceRepository.AddAsync(new TrialPaymentPrice() { TrialId = trial.Id });

                //添加访视
                await _visitStageRepository.AddAsync(new VisitStage { TrialId = trial.Id, VisitNum = 0, BlindName = "B" + 0.ToString("D3"), VisitDay = 0, VisitName = "Baseline", IsBaseLine = true, VisitWindowLeft = -28, VisitWindowRight = 0 });
                await _visitStageRepository.AddAsync(new VisitStage { TrialId = trial.Id, VisitNum = 1, BlindName = "B" + 10.ToString("D3"), VisitDay = 30, VisitName = "Visit 1", VisitWindowLeft = -5, VisitWindowRight = 5 });


                var success = await _trialRepository.SaveChangesAsync();

                //维护CRO Sponsor
                await DealSponsorAndCROAsync(trial);

                //维护部位到项目表
                var searchList = await _dictionaryRepository.Where(t => t.Parent.Code == "BodyPart" && t.ParentId != null && t.IsEnable).ProjectTo<BasicDicSelect>(_mapper.ConfigurationProvider).ToListAsync();

                var needAddBodyPartList = searchList.Select(t => new TrialBodyPart() { Code = t.Code, Name = t.Value, NameCN = t.ValueCN }).ToList();

                foreach (var item in needAddBodyPartList)
                {
                    item.TrialId = trial.Id;
                }


                await _trialBodyPartRepository.AddRangeAsync(needAddBodyPartList, true);

                await _fusionCache.SetAsync(CacheKeys.Trial(trial.Id.ToString()), StaticData.TrialState.TrialInitializing, TimeSpan.FromDays(7));

                return ResponseOutput.Ok(trial);
            }
            else
            {
                var updateModel = trialAddModel;

                if (!await _trialRepository.AnyAsync(u => u.Id == trialAddModel.Id && (u.TrialStatusStr == StaticData.TrialState.TrialInitializing || u.TrialStatusStr == StaticData.TrialState.TrialOngoing)))
                {
                    //---项目状态只有处于：初始化或者进行中时，才允许操作。
                    throw new BusinessValidationFailedException(_localizer["Trial_InvalidProjectStatus"]);

                }
                // 判断项目Id 是否已经存在
                if (await _trialRepository.AnyAsync(u => u.TrialCode == updateModel.TrialCode && u.Id != updateModel.Id))
                {
                    //---已经存在相同的项目编号。
                    throw new BusinessValidationFailedException(_localizer["Trial_DuplicateProjectNumber"]);
                }



                var trial = await _trialRepository.FirstOrDefaultAsync(t => t.Id == updateModel.Id);


                //删除中间表  Title对应的记录
                await _trialDictionaryRepository.BatchDeleteNoTrackingAsync(t => t.TrialId == updateModel.Id);

                //重新插入新的 Title记录

                updateModel.ModalityIds.ForEach(modalityId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = modalityId, KeyName = StaticData.Modality, TrialId = trial.Id }));
                updateModel.CriterionIds.ForEach(criterionId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = criterionId, KeyName = StaticData.Criterion, TrialId = trial.Id }));
                updateModel.ReviewTypeIds.ForEach(ReviewTypeId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = ReviewTypeId, KeyName = StaticData.ReviewType, TrialId = trial.Id }));


                if (updateModel.Expedited != trial.Expedited && updateModel.Expedited != null)
                {
                    TrialExpeditedChange = true;
                    await TrialExpeditedStatusChange(trial.Id, trial.Expedited, (int)updateModel.Expedited);
                }
                _mapper.Map(updateModel, trial);

                trial.DeclarationTypes = $"|{string.Join('|', updateModel.DeclarationTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";
                trial.AttendedReviewerTypes = $"|{string.Join('|', updateModel.AttendedReviewerTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";

                var success = await _trialRepository.SaveChangesAsync();

                //维护CRO Sponsor
                await DealSponsorAndCROAsync(trial);

                return ResponseOutput.Ok(trial);

            }
        }


        private async Task DealSponsorAndCROAsync(Trial trial)
        {
            if (trial.SponsorId != null)
            {
                if (await _sponsorRepository.AnyAsync(t => t.Id == trial.SponsorId && t.IsTrialLevel))
                {
                    await _sponsorRepository.BatchUpdateNoTrackingAsync(t => t.Id == trial.SponsorId, u => new Sponsor() { TrialId = trial.Id });
                }
            }

            if (trial.CROId != null)
            {
                if (await _croRepository.AnyAsync(t => t.Id == trial.CROId && t.IsTrialLevel))
                {
                    await _croRepository.BatchUpdateNoTrackingAsync(t => t.Id == trial.CROId, u => new CRO() { TrialId = trial.Id });
                }
            }
        }

        // TODO: 需要优化，嵌套两层 switch case ？
        [NonDynamicMethod]
        private async Task TrialExpeditedStatusChange(Guid trialId, int oldState, int newState)
        {
            switch (oldState)
            {
                case (int)TrialExpedited.None:
                    switch (newState)
                    {
                        case (int)TrialExpedited.ExpeditedIn24H:
                            await _workloadRepository.BatchUpdateNoTrackingAsync(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                            {
                                TimepointIn24H = u.Timepoint,
                                AdjudicationIn24H = u.Adjudication,
                                Timepoint = 0,
                                Adjudication = 0
                            });
                            break;
                        case (int)TrialExpedited.ExpeditedIn48H:
                            await _workloadRepository.BatchUpdateNoTrackingAsync(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                            {
                                TimepointIn48H = u.Timepoint,
                                AdjudicationIn48H = u.Adjudication,
                                Timepoint = 0,
                                Adjudication = 0
                            });
                            break;
                    }
                    //_workloadRepository.Update(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                    //{
                    //    Timepoint = 0,
                    //    Adjudication = 0
                    //});

                    break;
                case (int)TrialExpedited.ExpeditedIn24H:

                    switch (newState)
                    {
                        case (int)TrialExpedited.None:
                            await _workloadRepository.BatchUpdateNoTrackingAsync(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                            {
                                Timepoint = u.TimepointIn24H,
                                Adjudication = u.AdjudicationIn24H,
                                TimepointIn24H = 0,
                                AdjudicationIn24H = 0
                            });
                            break;
                        case (int)TrialExpedited.ExpeditedIn48H:
                            await _workloadRepository.BatchUpdateNoTrackingAsync(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                            {
                                TimepointIn48H = u.TimepointIn24H,
                                AdjudicationIn48H = u.AdjudicationIn24H,
                                TimepointIn24H = 0,
                                AdjudicationIn24H = 0
                            });

                            break;
                    }

                    //_workloadRepository.Update(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                    //{
                    //    TimepointIn24H = 0,
                    //    AdjudicationIn24H = 0
                    //});

                    break;
                case (int)TrialExpedited.ExpeditedIn48H:
                    switch (newState)
                    {
                        case (int)TrialExpedited.None:
                            await _workloadRepository.BatchUpdateNoTrackingAsync(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                            {
                                Timepoint = u.TimepointIn48H,
                                Adjudication = u.AdjudicationIn48H,
                                TimepointIn48H = 0,
                                AdjudicationIn48H = 0
                            });
                            break;
                        case (int)TrialExpedited.ExpeditedIn24H:
                            await _workloadRepository.BatchUpdateNoTrackingAsync(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                            {
                                TimepointIn24H = u.TimepointIn48H,
                                AdjudicationIn24H = u.AdjudicationIn48H,
                                TimepointIn48H = 0,
                                AdjudicationIn48H = 0
                            });
                            break;
                    }

                    //_workloadRepository.Update(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
                    //{
                    //    TimepointIn48H = 0,
                    //    AdjudicationIn48H = 0
                    //});
                    break;
            }
        }

        /// <summary>
        /// 标记项目删除
        /// </summary>
        /// <param name="trialId"></param>
        /// <returns></returns>
        [HttpDelete, Route("{trialId:guid}")]
        public async Task<IResponseOutput> MarkTrialDelete(Guid trialId)
        {
            await _trialRepository.BatchUpdateNoTrackingAsync(t => t.Id == trialId, u => new Trial() { IsDeleted = true });

            return ResponseOutput.Ok();
        }

        /// <summary> 真删除项目  方便清理测试数据 </summary>
        /// <param name="trialId">临床试验项目Id</param>
        [AllowAnonymous]
        [HttpDelete, Route("{trialId:guid}")]
        public async Task<IResponseOutput> DeleteTrial(Guid trialId, [FromServices] IRepository _repository)
        {


            var trial = (await _trialRepository.FirstOrDefaultAsync(u => u.Id == trialId, true)).IfNullThrowException();


            if (_verifyConfig.CurrentValue.OpenTrialRelationDelete)
            {


                #region 真项目删除
                await _repository.BatchDeleteNoTrackingAsync<CheckChallengeDialog>(o => o.SubjectVisit.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ClinicalDataTrialSet>(o => o.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<InspectionFile>(o => o.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<CriterionNidusSystem>(o => o.TrialReadingCriterion.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<DataInspection>(o => o.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<DicomStudy>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<StudyMonitor>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<DicomSeries>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<DicomInstance>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<EnrollReadingCategory>(t => t.Enroll.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<Enroll>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<EnrollDetail>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<NoneDicomStudyFile>(t => t.NoneDicomStudy.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<NoneDicomStudy>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<OrganTrialInfo>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<PaymentAdjustment>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<PaymentDetail>(t => t.TrialId == trialId);




                await _repository.BatchDeleteNoTrackingAsync<PreviousHistory>(t => t.SubjectVisit.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<PreviousOther>(t => t.SubjectVisit.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<PreviousPDF>(t => t.SubjectVisit.TrialId == trialId);


                await _repository.BatchDeleteNoTrackingAsync<QCChallengeDialog>(t => t.QCChallenge.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<QCChallenge>(t => t.TrialId == trialId);



                await _repository.BatchDeleteNoTrackingAsync<ReadingClinicalDataPDF>(t => t.ReadingClinicalData.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingClinicalData>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingGlobalTaskInfo>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingJudgeInfo>(t => t.TrialId == trialId);


                await _repository.BatchDeleteNoTrackingAsync<ReadingMedicalReviewDialog>(t => t.TaskMedicalReview.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingMedicineQuestionAnswer>(t => t.TaskMedicalReview.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingMedicineTrialQuestion>(t => t.TrialId == trialId);


                await _repository.BatchDeleteNoTrackingAsync<ReadingOncologyTaskInfo>(t => t.VisitTask.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingPeriodPlan>(t => t.ReadingPeriodSet.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingPeriodSet>(t => t.TrialId == trialId);


                await _repository.BatchDeleteNoTrackingAsync<ReadingQuestionTrial>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingTableAnswerRowInfo>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<ReadingTableQuestionAnswer>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingTableQuestionTrial>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingTaskQuestionAnswer>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<ReadingTaskRelation>(t => t.VisitTask.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadModule>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingTaskQuestionAnswer>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<SubjectCanceDoctor>(t => t.Subject.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<SubjectUser>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<Subject>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<SubjectVisit>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TaskAllocationRule>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TaskConsistentRule>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TaskInfluence>(t => t.InfluenceTask.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TaskMedicalReview>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TaskMedicalReviewRule>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TrialStateChange>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialPaymentPrice>(t => t.TrialId == trialId);


                await _repository.BatchDeleteNoTrackingAsync<Trial>(o => o.Id == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialClinicalDataSetCriterion>(t => t.TrialReadingCriterion.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialCriterionDictionaryCode>(t => t.TrialReadingCriterion.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<ReadingQuestionCriterionTrial>(t => t.TrialId == trialId);
                await _trialDictionaryRepository.BatchDeleteNoTrackingAsync(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialDocConfirmedUser>(t => t.TrialDocument.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TrialDocument>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialDocNeedConfirmedUserType>(t => t.TrialDocument.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TrialEmailNoticeUser>(t => t.TrialEmailNoticeConfig.TrialId == trialId);


                await _repository.BatchDeleteNoTrackingAsync<TrialEmailNoticeConfig>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TrialExternalUser>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TrialPaymentPrice>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TrialQCQuestion>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialQCQuestionAnswer>(t => t.TrialId == trialId);


                await _repository.BatchDeleteNoTrackingAsync<TrialRevenuesPrice>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialRevenuesPriceVerification>(t => t.TrialId == trialId);



                await _repository.BatchDeleteNoTrackingAsync<TrialSign>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialSite>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialSiteSurvey>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialSiteUserSurvey>(t => t.TrialSiteSurvey.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialSiteEquipmentSurvey>(t => t.TrialSiteSurvey.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<TrialUser>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialSiteUser>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<VisitStage>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<VisitPlanInfluenceStat>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<VisitPlanInfluenceStudy>(t => t.TrialId == trialId);

                await _repository.BatchDeleteNoTrackingAsync<VisitTaskReReading>(t => t.OriginalReReadingTask.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<VisitTask>(t => t.TrialId == trialId);
                await _repository.BatchDeleteNoTrackingAsync<TrialStateChange>(t => t.TrialId == trialId);
                #endregion




                return ResponseOutput.Ok();

            }

            else
            {
                //---当前运行环境下，不允许删除项目数据。
                return ResponseOutput.NotOk(_localizer["Trial_CannotDeleteProject"]);
            }


        }



        [HttpPost]
        public async Task<PageOutput<TrialDetailDTO>> GetReviewerTrialListByEnrollmentStatus(TrialByStatusQueryDTO inQuery)
        {

            var query = _trialRepository.AsQueryable()
                .WhereIf(inQuery.Status == 5, t => t.EnrollList.Any(u => u.EnrollStatus == EnrollStatus.HasCommittedToCRO))
                .WhereIf(inQuery.Status == 8, t => t.EnrollList.Any(u => u.EnrollStatus == EnrollStatus.InviteIntoGroup))
                .WhereIf(inQuery.Status == 10, t => t.EnrollList.Any(u => u.EnrollStatus == EnrollStatus.DoctorReading))
                .WhereIf(inQuery.Status == 14, t => t.EnrollList.Any(u => u.EnrollStatus == EnrollStatus.Finished))
               .ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { userTypeEnumInt = _userInfo.UserTypeEnumInt, userId = _userInfo.Id, isEn_Us = _userInfo.IsEn_Us });

            return await query.ToPagedListAsync(inQuery, nameof(TrialDetailDTO.CreateTime));

        }



        /// <summary>
        /// 根据项目Id 获取医生Id，用于触发计算费用
        /// </summary>
        public async Task<List<Guid>> GetTrialEnrollmentReviewerIds(Guid trialId)
        {
            return await _enrollRepository.Where(u => u.TrialId == trialId &&
            u.EnrollStatus >= EnrollStatus.DoctorReading).Select(u => u.DoctorId).Distinct().ToListAsync();
        }




        #region 医生用户接口

        /// <summary> 分页获取医生参与的临床实验项目列表（查询条件）</summary>
        /// <returns></returns>
        [HttpPost]
        public async Task<PageOutput<TrialDetailDTO>> GetTrialListByReviewer(ReviewerTrialQueryDTO inQuery)
        {
            var query = _trialRepository
               .WhereIf(inQuery.EnrollStatus != null, o => (int)inQuery.EnrollStatus! == 10 ?
               o.EnrollList.Any(o => o.EnrollStatus >= EnrollStatus.ConfirmIntoGroup && o.EnrollStatus <= EnrollStatus.DoctorReading && o.DoctorId == _userInfo.Id) :
               o.EnrollList.Any(o => o.EnrollStatus == inQuery.EnrollStatus && o.DoctorId == _userInfo.Id))
               .WhereIf(inQuery.Expedited != null, o => o.Expedited == inQuery.Expedited)
               .WhereIf(!string.IsNullOrEmpty(inQuery.Code), o => o.TrialCode.Contains(inQuery.Code))
               .WhereIf(!string.IsNullOrWhiteSpace(inQuery.Indication), o => o.Indication.Contains(inQuery.Indication))
               .WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id))
               .ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { userTypeEnumInt = _userInfo.UserTypeEnumInt, userId = _userInfo.Id, isEn_Us = _userInfo.IsEn_Us });


            return await query.ToPagedListAsync(inQuery, nameof(TrialDetailDTO.CreateTime));



        }


        /// <summary>
        /// 医生确认入组或拒绝入组
        /// </summary>
        /// <param name="trialId">项目Id</param>
        /// <param name="status">9-拒绝入组，10-确认入组</param>
        /// <returns></returns>
        [HttpPost("{trialId:guid}/{status:int}")]

        [TrialGlobalLimit("AfterStopCannNotOpt")]
        public async Task<IResponseOutput> UpdateEnrollStatus(Guid trialId, EnrollStatus status)
        {
            await _enrollDetailRepository.AddAsync(new EnrollDetail()
            {
                DoctorId = _userInfo.Id,
                TrialId = trialId,
                EnrollStatus = status,
                OptUserType = (int)SystemUserType.DoctorUser,
            });
            return ResponseOutput.Result(await _enrollRepository.BatchUpdateNoTrackingAsync(u => u.TrialId == trialId && u.DoctorId == _userInfo.Id, e => new Enroll
            {
                EnrollStatus = status
            }));
        }

        #endregion






    }

}