using DocumentFormat.OpenXml.EMMA;
using DocumentFormat.OpenXml.Spreadsheet;
using IRaCIS.Application.Contracts;
using IRaCIS.Application.Interfaces;
using IRaCIS.Core.Application.Contracts;
using IRaCIS.Core.Application.Helper;
using IRaCIS.Core.Application.Service.Reading.Dto;
using IRaCIS.Core.Domain.Models;
using IRaCIS.Core.Domain.Share;
using IRaCIS.Core.Infrastructure;
using MailKit;
using Microsoft.Extensions.Options;
using Microsoft.VisualBasic;
using MimeKit;
using System;
using System.Collections.Generic;
using System.Linq;
using System.Net.Mail;
using System.Text;
using System.Threading.Tasks;

namespace IRaCIS.Core.Application.Service
{

    public interface IEmailSendService
    {
        Task SendEnrollOrPdEmail(Guid visitTaskId, bool? isEnrollment, bool? isPDConfirm);
        Task SendClinicalDataQuestionAsync(Guid visitTaskId, string content);
        Task SendTrialImageQCTaskEmailAsync(Guid trialId);

        Task SendTrialQCQuestionEmailAsync(Guid trialId);
        Task SendTrialImageQuestionAsync(Guid trialId);
        Task SendPIAuditResultAsync(Guid visitTaskId);

        Task<(TrialEmailNoticeConfig?, SMTPEmailConfig?)> BuildEmailConfig(Guid trialId, EmailBusinessScenario businessScenario, Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc, Guid? siteId = null, Guid? trialReadingCriterionId = null);
    }

    public class EmailSendService : BaseService, IEmailSendService
    {
        private readonly IRepository<TrialEmailNoticeConfig> _trialEmailNoticeConfigRepository;

        private readonly IRepository<EmailNoticeConfig> _emailNoticeConfigRepository;

        private readonly IRepository<Trial> _trialRepository;

        private readonly IOptionsMonitor<SystemEmailSendConfig> _SystemEmailSendConfig;

        public readonly static string EmailNamePlaceholder = "EmailNamePlaceholder";

        private readonly IRepository<Dictionary> _dictionaryRepository;

        public EmailSendService(IRepository<TrialEmailNoticeConfig> trialEmailNoticeConfigRepository, IRepository<EmailNoticeConfig> emailNoticeConfigRepository, IRepository<Trial> trialRepository, IOptionsMonitor<SystemEmailSendConfig> systemEmailSendConfig,IRepository<Dictionary> dictionaryRepository)
        {
            _trialEmailNoticeConfigRepository = trialEmailNoticeConfigRepository;
            _emailNoticeConfigRepository = emailNoticeConfigRepository;
            _trialRepository = trialRepository;
            _SystemEmailSendConfig = systemEmailSendConfig;
            _dictionaryRepository=dictionaryRepository;
        }

        //入组确认/PD确认

        public async Task SendEnrollOrPdEmail(Guid visitTaskId, bool? isEnrollment, bool? isPDConfirm)
        {
            EmailBusinessScenario businessScenarioEnum;

            bool? result = null;

            if (isEnrollment != null && isPDConfirm == null)
            {
                businessScenarioEnum = EmailBusinessScenario.EnrollConfirmed;

                result = isEnrollment;
            }
            else
            {
                businessScenarioEnum = EmailBusinessScenario.PDConfirmed;

                result = isPDConfirm;
            }

            var taskInfo = await _repository.Where<VisitTask>(t => t.Id == visitTaskId).Select(t => new
            {
                t.Subject.SiteId,
                t.Trial.ResearchProgramNo,
                t.Subject.TrialSite.TrialSiteCode,
                SubjectCode = t.Subject.Code,
                t.Trial.Sponsor.SponsorName,
                t.SourceSubjectVisit.VisitName,
                t.TrialId,

            }).FirstNotNullAsync();

            var isEn_us = _userInfo.IsEn_Us;

            var resultStr = isEn_us ? (result == true ? "Yes" : "No") : (result == true ? "是" : "否");

            if (isEnrollment == true)
            {
                Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc = trialEmailConfig =>
                {
                    var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, taskInfo.ResearchProgramNo, taskInfo.SubjectCode);

                    var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN,
                       EmailNamePlaceholder, taskInfo.ResearchProgramNo, taskInfo.SubjectCode, resultStr);
                    return (topicStr, htmlBodyStr, isEn_us, null);
                };

                await SendTrialEmailAsync(taskInfo.TrialId, businessScenarioEnum, topicAndHtmlFunc, taskInfo.SiteId);
            }
            else
            {
                Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc = trialEmailConfig =>
                {
                    var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, taskInfo.ResearchProgramNo, taskInfo.SubjectCode, taskInfo.VisitName);

                    var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN,
                       EmailNamePlaceholder, taskInfo.ResearchProgramNo, taskInfo.SubjectCode, taskInfo.VisitName, resultStr);

                    return (topicStr, htmlBodyStr, isEn_us, null);
                };

                await SendTrialEmailAsync(taskInfo.TrialId, businessScenarioEnum, topicAndHtmlFunc, taskInfo.SiteId);
            }


        }

        /// <summary>
        /// 影像质控
        /// </summary>
        /// <param name="trialId"></param>
        /// <returns></returns>
        public async Task SendTrialImageQCTaskEmailAsync(Guid trialId)
        {
            var isEn_us = false;
            var trialInfo = await _repository.Where<Trial>(t => t.Id == trialId).Select(t => new { t.ResearchProgramNo, t.ExperimentName, t.TrialCode, t.TrialStatusStr }).FirstNotNullAsync();

            //找到 该项目的IQC 用户Id
            var userList = await _repository.Where<TrialUser>(t => t.TrialId == trialId).Where(t => t.User.UserTypeEnum == UserTypeEnum.IQC).Select(t => new { t.UserId, t.User.FullName }).ToListAsync();

            //判断是否任务可以领取 ，可以的话 发送邮件
            var userIdList = userList.Select(t => t.UserId).ToList();

            foreach (var user in userList)
            {
                var userId = user.UserId;

                //过滤项目  并且 将 _userInfo.Id 换位 当前发送邮件的Id
                var query = _trialRepository.Where(t => t.Id == trialId)
                .Where(t => t.QCProcessEnum != TrialQCProcess.NotAudit)
                .Select(t => new
                {
                    //待领取量
                    ToBeClaimedCount = t.SubjectVisitList.Where(u => u.SubmitState == SubmitStateEnum.Submitted && u.CurrentActionUserId == null && (u.PreliminaryAuditUserId == null || (u.PreliminaryAuditUserId != userId && u.ReviewAuditUserId == null))).Count(),

                    //待审核通过，统计从已领取到QC提交之间的      已领取 待审核 审核中   (审核完成  领取人就会清理 所以只用查询当前领取人是自己的就好了)
                    ToBeReviewedCount = t.SubjectVisitList.Where(u => u.CurrentActionUserId == userId).Count()

                });

                var sendStat = await query.FirstOrDefaultAsync();

                //当前人 有待领取的或者有待审核的才发邮件
                if (sendStat != null && (sendStat.ToBeClaimedCount > 0 || sendStat.ToBeReviewedCount > 0))
                {

                    Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc = trialEmailConfig =>
                    {
                        var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, trialInfo.ResearchProgramNo);
                        var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN,
                            user.FullName, DateTime.Now, sendStat.ToBeClaimedCount, sendStat.ToBeReviewedCount, _SystemEmailSendConfig.CurrentValue.SiteUrl);
                        return (topicStr, htmlBodyStr, false, userId);
                    };

                    await SendTrialEmailAsync(trialId, EmailBusinessScenario.QCTask, topicAndHtmlFunc);
                }
            }
        }

        /// <summary>
        /// QC质疑
        /// </summary>
        /// <param name="trialId"></param>
        /// <returns></returns>
        public async Task SendTrialQCQuestionEmailAsync(Guid trialId)
        {
            var isEn_us = false;
            var trialInfo = _repository.Where<Trial>(t => t.Id == trialId).Select(t => new { t.ResearchProgramNo, t.ExperimentName, t.TrialCode, t.TrialStatusStr, t.DeclarationTypeEnumList }).FirstOrDefault();

            //找到 该项目的IQC 用户Id
            var userList = await _repository.Where<TrialUser>(t => t.TrialId == trialId).Where(t => t.User.UserTypeEnum == UserTypeEnum.IQC).Select(t => new { t.UserId, t.User.FullName }).ToListAsync();

            //判断是否任务可以领取 ，可以的话 发送邮件

            foreach (var user in userList)
            {
                var userId = user.UserId;

                //过滤项目  并且 将 _userInfo.Id 换位 当前发送邮件的Id
                var query = _trialRepository
                    .Where(t => t.Id == trialId)
                 .Select(t => new
                 {
                     ReUploadTobeDealedCount = t.SubjectVisitList.SelectMany(c => c.QCChallengeList)
                     .Where(u => u.CreateUserId == userId && u.IsClosed == false && u.LatestReplyUser.UserTypeEnum == UserTypeEnum.ClinicalResearchCoordinator && u.ReuploadEnum == QCChanllengeReuploadEnum.CRCRequestReupload).Count(),

                     //质疑待处理  发送邮件的时候 需要减去ReUploadTobeDealedCount  
                     ToBeDealedCount = t.SubjectVisitList.SelectMany(c => c.QCChallengeList)
                     .Where(u => u.CreateUserId == userId && u.IsClosed == false && u.LatestReplyUser.UserTypeEnum == UserTypeEnum.ClinicalResearchCoordinator).Count(),
                 });

                var sendStat = await query.FirstOrDefaultAsync();

                //当前人 
                if (sendStat != null && (sendStat.ToBeDealedCount > 0 || sendStat.ReUploadTobeDealedCount > 0))
                {

                    Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc = trialEmailConfig =>
                    {
                        var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, trialInfo.ResearchProgramNo);
                        var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN,

                            user.FullName, DateTime.Now, sendStat.ToBeDealedCount - sendStat.ReUploadTobeDealedCount, sendStat.ReUploadTobeDealedCount, _SystemEmailSendConfig.CurrentValue.SiteUrl);
                        return (topicStr, htmlBodyStr, false, userId);
                    };

                    await SendTrialEmailAsync(trialId, EmailBusinessScenario.QCQuestion, topicAndHtmlFunc);
                }
            }
        }

        /// <summary>
        /// 影像质疑
        /// </summary>
        /// <param name="trialId"></param>
        /// <returns></returns>
        public async Task SendTrialImageQuestionAsync(Guid trialId)
        {
            var isEn_us = false;

            var trialInfo = _repository.Where<Trial>(t => t.Id == trialId).Select(t => new { t.ResearchProgramNo, t.ExperimentName, t.TrialCode, t.TrialStatusStr }).FirstOrDefault();

            //找到 该项目的CRC 用户Id
            var userList = await _repository.Where<TrialUser>(t => t.TrialId == trialId).Where(t => t.User.UserTypeEnum == UserTypeEnum.ClinicalResearchCoordinator).Select(t => new { t.UserId, t.User.FullName }).ToListAsync();

            //判断是否任务可以领取 ，可以的话 发送邮件

            foreach (var user in userList)
            {
                var userId = user.UserId;
                //过滤项目  并且 将 _userInfo.Id 换位 当前发送邮件的Id
                var query = _trialRepository.Where(t => t.Id == trialId)

                 .Select(t => new
                 {
                     //质疑待处理
                     ToBeDealedCount = t.SubjectVisitList.Where(t => t.TrialSite.CRCUserList.Any(t => t.UserId == userId)).SelectMany(c => c.QCChallengeList)
                     .Where(u => u.IsClosed == false && (u.LatestReplyUser.UserTypeEnum == UserTypeEnum.IQC || u.LatestReplyUserId == null)).Count(),

                 });

                var sendStat = await query.FirstOrDefaultAsync();

                //当前人 
                if (sendStat != null && (sendStat.ToBeDealedCount > 0))
                {

                    Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc = trialEmailConfig =>
                    {
                        var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, trialInfo.ResearchProgramNo);
                        var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN,
                            user.FullName, DateTime.Now, sendStat.ToBeDealedCount, _SystemEmailSendConfig.CurrentValue.SiteUrl);
                        return (topicStr, htmlBodyStr, isEn_us, userId);
                    };

                    await SendTrialEmailAsync(trialId, EmailBusinessScenario.ImageQuestion, topicAndHtmlFunc);
                }
            }
        }


        //临床数据质询
        public async Task SendClinicalDataQuestionAsync(Guid visitTaskId, string content)
        {

            var isEn_us = _userInfo.IsEn_Us;

            var info = await _repository.Where<VisitTask>(t => t.Id == visitTaskId, ignoreQueryFilters: true).Select(t => new { t.TrialId, t.Trial.ResearchProgramNo, t.Trial.TrialCode, t.SourceSubjectVisit.VisitName, t.Subject.SiteId, t.Subject.Code }).FirstOrDefaultAsync();


            Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc = trialEmailConfig =>
            {
                var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, info.ResearchProgramNo, info.Code, info.VisitName);
                var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN,
                  EmailNamePlaceholder, info.ResearchProgramNo, info.Code, info.VisitName, _userInfo.UserName, content, _SystemEmailSendConfig.CurrentValue.SiteUrl);
                return (topicStr, htmlBodyStr, isEn_us, null);
            };

            await SendTrialEmailAsync(info.TrialId, EmailBusinessScenario.ClinicalDataQuestion, topicAndHtmlFunc, info.SiteId);
        }


        public async Task SendPIAuditResultAsync(Guid visitTaskId)
        {
            var isEn_us = _userInfo.IsEn_Us;

            var info = await _repository.Where<VisitTask>(t => t.Id == visitTaskId, ignoreQueryFilters: true).Select(t => new { t.TrialId, t.Trial.ResearchProgramNo, t.Trial.TrialCode, t.SourceSubjectVisit.VisitName, t.Subject.SiteId, t.Subject.Code }).FirstOrDefaultAsync();
            var answerList = await _repository.Where<VisitTask>(t => t.Id == visitTaskId, ignoreQueryFilters: true).SelectMany(t => t.ReadingTaskQuestionAnswerList).Where(t => t.ReadingQuestionTrial.IsJudgeQuestion == true).Select(t => new { QuestionName = isEn_us ? t.ReadingQuestionTrial.QuestionEnName : t.ReadingQuestionTrial.QuestionName, t.ReadingQuestionTrial.DictionaryCode, t.Answer }).ToListAsync();

            var template = " <div style=\"margin-left: 2ch;\"> {0}: {1} </div>";

            var needTranslateDicNameList = answerList.Where(t => !string.IsNullOrEmpty(t.DictionaryCode)).Select(t => t.DictionaryCode).ToList();


            var searchList = await _dictionaryRepository.Where(t => needTranslateDicNameList.ToArray().Contains(t.Parent.Code) && t.ParentId != null && t.IsEnable).ProjectTo<BasicDicSelectCopy>(_mapper.ConfigurationProvider, new { isEn_Us = _userInfo.IsEn_Us }).ToListAsync();

            var translateDataList = searchList.GroupBy(t => t.ParentCode).ToDictionary(g => g.Key, g => g.OrderBy(t => t.ShowOrder).ToList());



            Func<bool, string, string, string> transFunc = (bool isNeedTranslate, string dicCode, string answer) =>
            {
                if (isNeedTranslate && translateDataList.ContainsKey(dicCode))
                {
                    var result = translateDataList[dicCode].Where(t => t.Code.ToLower() == answer.ToLower()).Select(t => isEn_us ? t.Value : t.ValueCN).FirstOrDefault() ?? answer;
                    return result;

                }
                else
                {
                    return answer;
                }

            };

            var piResult = string.Join(' ', answerList.Select(t => string.Format(template, t.QuestionName, transFunc(!string.IsNullOrEmpty(t.DictionaryCode), t.DictionaryCode, t.Answer))));

            Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc = trialEmailConfig =>
            {
                var topicStr = string.Format(isEn_us ? trialEmailConfig.EmailTopic : trialEmailConfig.EmailTopicCN, info.ResearchProgramNo, info.Code, info.VisitName);
                var htmlBodyStr = string.Format(isEn_us ? trialEmailConfig.EmailHtmlContent : trialEmailConfig.EmailHtmlContentCN,
                  EmailNamePlaceholder, info.ResearchProgramNo, info.Code, info.VisitName, _userInfo.UserName, piResult, _SystemEmailSendConfig.CurrentValue.SiteUrl);
                return (topicStr, htmlBodyStr, isEn_us, null);
            };

            await SendTrialEmailAsync(info.TrialId, EmailBusinessScenario.PIAuditResutl, topicAndHtmlFunc, info.SiteId);
        }



        public async Task SendTrialEmailAsync(Guid trialId, EmailBusinessScenario businessScenario, Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc, Guid? siteId = null, Guid? trialReadingCriterionId = null)
        {
            //找到配置
            var trialEmailConfig = await _trialEmailNoticeConfigRepository.Where(t => t.TrialId == trialId && t.TrialReadingCriterionId == trialReadingCriterionId && t.BusinessScenarioEnum == businessScenario, ignoreQueryFilters: true)
           .Include(t => t.TrialEmailNoticeUserList).Include(t => t.TrialEmailBlackUserList).FirstOrDefaultAsync();


            if (trialEmailConfig == null || trialEmailConfig.IsAutoSend == false || trialEmailConfig.IsEnable==false)
            {
                return;
            }
            else
            {
                var sendEmailConfig = new SMTPEmailConfig();

                var (topicStr, htmlBodyStr, isEn_us, onlyToUserId) = topicAndHtmlFunc(trialEmailConfig);


                sendEmailConfig.TopicDescription = topicStr;
                sendEmailConfig.HtmlBodyStr = htmlBodyStr;


                var blackUserIdList = trialEmailConfig.TrialEmailBlackUserList.Select(t => t.UserId).ToList();


                var toUserTypeEnumList = trialEmailConfig.TrialEmailNoticeUserList.Where(t => t.EmailUserType == EmailUserType.To).Select(c => c.UserType).ToList();

                var copyUserTypeEnumList = trialEmailConfig.TrialEmailNoticeUserList.Where(t => t.EmailUserType == EmailUserType.Copy).Select(c => c.UserType).ToList();

                var allUserTypeEnumList = toUserTypeEnumList.Union(copyUserTypeEnumList).Distinct().ToList();

                var allUserList = await _repository.Where<TrialUser>(t => t.TrialId == trialId && allUserTypeEnumList.Contains(t.User.UserTypeEnum)).Select(t => new { t.UserId, t.User.EMail, t.User.FullName, t.User.UserTypeEnum }).ToListAsync();


                var toUserList = allUserList.Where(t => toUserTypeEnumList.Contains(t.UserTypeEnum))
                   .ToList();

                //收件人 有CRC  CRA  ， CRC  CRA的账户要按照中心发送
                if (siteId == null && toUserTypeEnumList.Any(t => t == UserTypeEnum.ClinicalResearchCoordinator || t == UserTypeEnum.CRA) && onlyToUserId == null)
                {
                    throw new BusinessValidationFailedException("当前场景收件人包含CRC CRA,但是没有siteId,请联系后端开发");
                }
                if (siteId != null && toUserTypeEnumList.Any(t => t == UserTypeEnum.ClinicalResearchCoordinator || t == UserTypeEnum.CRA))
                {
                    var curentSiteUserIdList = _repository.Where<TrialSiteUser>(t => t.TrialId == trialId && t.SiteId == siteId).Select(t => t.UserId).ToList();

                    toUserList = toUserList.Where(t => (t.UserTypeEnum != UserTypeEnum.CRA && t.UserTypeEnum != UserTypeEnum.ClinicalResearchCoordinator) || curentSiteUserIdList.Contains(t.UserId)).ToList();
                }


                //去除黑名单
                toUserList = toUserList.Where(t => !blackUserIdList.Contains(t.UserId)).ToList();

                var copyUserList = allUserList.Where(t => copyUserTypeEnumList.Contains(t.UserTypeEnum))
                    .Where(t => !blackUserIdList.Contains(t.UserId)).ToList();

                if (siteId != null && copyUserTypeEnumList.Any(t => t == UserTypeEnum.ClinicalResearchCoordinator || t == UserTypeEnum.CRA))
                {
                    var curentSiteUserIdList = _repository.Where<TrialSiteUser>(t => t.TrialId == trialId && t.SiteId == siteId).Select(t => t.UserId).ToList();

                    copyUserList = copyUserList.Where(t => (t.UserTypeEnum != UserTypeEnum.CRA && t.UserTypeEnum != UserTypeEnum.ClinicalResearchCoordinator) || curentSiteUserIdList.Contains(t.UserId)).ToList();
                }

                if (onlyToUserId != null)
                {
                    toUserList = toUserList.Where(t => t.UserId == onlyToUserId).ToList();
                }
                else
                {
                    sendEmailConfig.HtmlBodyStr = htmlBodyStr.Replace(EmailNamePlaceholder, string.Join(isEn_us ? ", " : "、", toUserList.Select(t => t.FullName).ToList()));
                }

                if (toUserList.Count == 0)
                {
                    //---没有收件人，无法发送邮件
                    throw new BusinessValidationFailedException(_localizer["TrialEmailN_NoRecipient"]);
                }


                if (trialEmailConfig.FromEmail.Contains("@") && !string.IsNullOrEmpty(trialEmailConfig.FromEmail))
                {

                    sendEmailConfig.FromEmailAddress = new MimeKit.MailboxAddress(trialEmailConfig.FromName, trialEmailConfig.FromEmail);
                    sendEmailConfig.AuthorizationCode = trialEmailConfig.AuthorizationCode;
                    sendEmailConfig.UserName = trialEmailConfig.FromEmail;

                    sendEmailConfig.Host = trialEmailConfig.SMTPServerAddress;
                    sendEmailConfig.Port = trialEmailConfig.SMTPServerPort;
                }
                else
                {
                    //---项目发件邮箱配置有误，请核实
                    throw new BusinessValidationFailedException(_localizer["TrialEmailN_InvalidEmailConfig"]);
                }

                foreach (var item in toUserList)
                {

                    if (item.EMail.Contains("@") && !string.IsNullOrEmpty(item.EMail))
                    {

                        sendEmailConfig.ToMailAddressList.Add(new MimeKit.MailboxAddress(item.FullName, item.EMail));

                    }
                }
                foreach (var item in copyUserList)
                {

                    if (item.EMail.Contains("@") && !string.IsNullOrEmpty(item.EMail))
                    {

                        sendEmailConfig.CopyToMailAddressList.Add(new MimeKit.MailboxAddress(item.FullName, item.EMail));

                    }
                }

                await SendEmailHelper.SendEmailAsync(sendEmailConfig);

            }
        }

        public async Task<(TrialEmailNoticeConfig?, SMTPEmailConfig?)> BuildEmailConfig(Guid trialId, EmailBusinessScenario businessScenario, Func<TrialEmailNoticeConfig, (string topicStr, string htmlBodyStr, bool isEn_us, Guid? onlyToUserId)> topicAndHtmlFunc, Guid? siteId = null, Guid? trialReadingCriterionId = null)
        {
            //找到配置
            var trialEmailConfig = await _trialEmailNoticeConfigRepository.Where(t => t.TrialId == trialId && t.TrialReadingCriterionId == trialReadingCriterionId && t.BusinessScenarioEnum == businessScenario, ignoreQueryFilters: true)
           .Include(t => t.TrialEmailNoticeUserList).Include(t => t.TrialEmailBlackUserList).FirstOrDefaultAsync();


            if (trialEmailConfig == null || trialEmailConfig.IsAutoSend == false || trialEmailConfig.IsEnable==false)
            {
                return (null, null);
            }
            else
            {
                var sendEmailConfig = new SMTPEmailConfig();

                var (topicStr, htmlBodyStr, isEn_us, onlyToUserId) = topicAndHtmlFunc(trialEmailConfig);


                sendEmailConfig.TopicDescription = topicStr;
                sendEmailConfig.HtmlBodyStr = htmlBodyStr;


                var blackUserIdList = trialEmailConfig.TrialEmailBlackUserList.Select(t => t.UserId).ToList();


                var toUserTypeEnumList = trialEmailConfig.TrialEmailNoticeUserList.Where(t => t.EmailUserType == EmailUserType.To).Select(c => c.UserType).ToList();

                var copyUserTypeEnumList = trialEmailConfig.TrialEmailNoticeUserList.Where(t => t.EmailUserType == EmailUserType.Copy).Select(c => c.UserType).ToList();

                var allUserTypeEnumList = toUserTypeEnumList.Union(copyUserTypeEnumList).Distinct().ToList();

                var allUserList = await _repository.Where<TrialUser>(t => t.TrialId == trialId && allUserTypeEnumList.Contains(t.User.UserTypeEnum)).Select(t => new { t.UserId, t.User.EMail, t.User.FullName, t.User.UserTypeEnum }).ToListAsync();


                var toUserList = allUserList.Where(t => toUserTypeEnumList.Contains(t.UserTypeEnum))
                   .ToList();

                //收件人 有CRC  CRA  ， CRC  CRA的账户要按照中心发送
                if (siteId == null && toUserTypeEnumList.Any(t => t == UserTypeEnum.ClinicalResearchCoordinator || t == UserTypeEnum.CRA) && onlyToUserId == null)
                {
                    throw new BusinessValidationFailedException("当前场景收件人包含CRC CRA,但是没有siteId,请联系后端开发");
                }
                if (siteId != null && toUserTypeEnumList.Any(t => t == UserTypeEnum.ClinicalResearchCoordinator || t == UserTypeEnum.CRA))
                {
                    var curentSiteUserIdList = _repository.Where<TrialSiteUser>(t => t.TrialId == trialId && t.SiteId == siteId).Select(t => t.UserId).ToList();

                    toUserList = toUserList.Where(t => (t.UserTypeEnum != UserTypeEnum.CRA && t.UserTypeEnum != UserTypeEnum.ClinicalResearchCoordinator) || curentSiteUserIdList.Contains(t.UserId)).ToList();
                }


                //去除黑名单
                toUserList = toUserList.Where(t => !blackUserIdList.Contains(t.UserId)).ToList();

                var copyUserList = allUserList.Where(t => copyUserTypeEnumList.Contains(t.UserTypeEnum))
                    .Where(t => !blackUserIdList.Contains(t.UserId)).ToList();

                if (siteId != null && copyUserTypeEnumList.Any(t => t == UserTypeEnum.ClinicalResearchCoordinator || t == UserTypeEnum.CRA))
                {
                    var curentSiteUserIdList = _repository.Where<TrialSiteUser>(t => t.TrialId == trialId && t.SiteId == siteId).Select(t => t.UserId).ToList();

                    copyUserList = copyUserList.Where(t => (t.UserTypeEnum != UserTypeEnum.CRA && t.UserTypeEnum != UserTypeEnum.ClinicalResearchCoordinator) || curentSiteUserIdList.Contains(t.UserId)).ToList();
                }

                if (onlyToUserId != null)
                {
                    toUserList = toUserList.Where(t => t.UserId == onlyToUserId).ToList();
                }
                else
                {
                    sendEmailConfig.HtmlBodyStr = htmlBodyStr.Replace(EmailNamePlaceholder, string.Join(isEn_us ? ", " : "、", toUserList.Select(t => t.FullName).ToList()));
                }

                if (toUserList.Count == 0)
                {
                    //---没有收件人，无法发送邮件
                    throw new BusinessValidationFailedException(_localizer["TrialEmailN_NoRecipient"]);
                }


                if (trialEmailConfig.FromEmail.Contains("@") && !string.IsNullOrEmpty(trialEmailConfig.FromEmail))
                {

                    sendEmailConfig.FromEmailAddress = new MimeKit.MailboxAddress(trialEmailConfig.FromName, trialEmailConfig.FromEmail);
                    sendEmailConfig.AuthorizationCode = trialEmailConfig.AuthorizationCode;
                    sendEmailConfig.UserName = trialEmailConfig.FromEmail;

                    sendEmailConfig.Host = trialEmailConfig.SMTPServerAddress;
                    sendEmailConfig.Port = trialEmailConfig.SMTPServerPort;
                }
                else
                {
                    //---项目发件邮箱配置有误，请核实
                    throw new BusinessValidationFailedException(_localizer["TrialEmailN_InvalidEmailConfig"]);
                }

                foreach (var item in toUserList)
                {

                    if (item.EMail.Contains("@") && !string.IsNullOrEmpty(item.EMail))
                    {

                        sendEmailConfig.ToMailAddressList.Add(new MimeKit.MailboxAddress(item.FullName, item.EMail));

                    }
                }
                foreach (var item in copyUserList)
                {

                    if (item.EMail.Contains("@") && !string.IsNullOrEmpty(item.EMail))
                    {

                        sendEmailConfig.CopyToMailAddressList.Add(new MimeKit.MailboxAddress(item.FullName, item.EMail));

                    }
                }

                //邮件附件  这里是原格式发送，不是PDF

                //if (trialEmailConfig.AttachCNPath != string.Empty && trialEmailConfig.AttachPath != string.Empty)
                //{
                //    var phyPath = FileStoreHelper.GetPhysicalFilePath(_hostEnvironment, isEn_us? trialEmailConfig.AttachName: trialEmailConfig.AttachNameCN);

                //    //先预先生成了邮件，发送预先生成的邮件
                //    sendEmailConfig.EmailAttachMentConfigList.Add(new EmailAttachMentConfig()
                //    {
                //        FileName = $"{attachPrefix}_{Path.GetFileName(_userInfo.IsEn_Us ? trialEmailConfig.AttachName : trialEmailConfig.AttachNameCN)}",

                //        FileStream = File.OpenRead(phyPath),
                //    });
                //}

                return (trialEmailConfig, sendEmailConfig);


            }
        }

    }
}