531 lines
24 KiB
C#
531 lines
24 KiB
C#
using IRaCIS.Application.Contracts;
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using IRaCIS.Core.Application.Contracts;
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using IRaCIS.Core.Application.ViewModel;
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using IRaCIS.Core.Domain.Share;
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using IRaCIS.Core.Infra.EFCore.Common;
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using Microsoft.AspNetCore.Mvc;
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using System;
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using System.Collections.Generic;
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using System.Linq;
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using System.Text;
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using System.Threading.Tasks;
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using static IRaCIS.Core.Application.Service.ExcelExportHelper;
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namespace IRaCIS.Core.Application;
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[ApiExplorerSettings(GroupName = "Trial")]
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public class TrialStatService(
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IRepository<Trial> _trialRepository,
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IRepository<ReadingQuestionTrial> _readingQuestionTrialRepository,
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IRepository<SubjectVisit> _subjectVisitRepository,
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IRepository<TrialDocument> _trialDocumentRepository,
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IRepository<SystemDocument> _systemDocumentRepository,
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IRepository<SystemNotice> _systemNoticeRepository,
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IRepository<VisitTask> _visitTaskRepository,
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IRepository<Dictionary> _dictionaryRepository,
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IRepository<ReadingQuestionCriterionTrial> _readingQuestionCriterionTrialRepository,
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IMapper _mapper, IUserInfo _userInfo, IStringLocalizer _localizer) : BaseService
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{
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/// <summary>
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/// 访视完成度
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/// </summary>
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/// <returns></returns>
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[HttpPost]
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public async Task<VisitFinishedStatViewModel> GetTrialVisitFinishedStatList(VisitFinishedStatQuery inQuery)
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{
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var result = await _trialRepository.Where(t => t.Id == inQuery.TrialId).Select(t => new VisitFinishedStatViewModel()
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{
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UploadedCount = t.SubjectVisitList.Where(t => inQuery.TrialSiteId != null ? t.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.SubmitState == SubmitStateEnum.Submitted).Count(),
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QCFinishedCount = t.SubjectVisitList.Where(t => inQuery.TrialSiteId != null ? t.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.AuditState == AuditStateEnum.QCPassed || t.AuditState == AuditStateEnum.QCFailed).Count(),
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CheckFinishedCount = t.SubjectVisitList.Where(t => inQuery.TrialSiteId != null ? t.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.CheckState == CheckStateEnum.CVPassed).Count(),
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CriterionList = t.TrialReadingCriterionList.Where(t => inQuery.TrialReadingCriterionId != null ? t.Id == inQuery.TrialReadingCriterionId : true)
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.Select(t => new VisitReadingCriterionInfo()
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{
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TrialReadingCriterionId = t.Id,
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TrialReadingCriterionName = t.CriterionName,
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ReadingFinishedCount = t.VisitTaskList
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.Where(t => inQuery.TrialSiteId != null ? t.Subject.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.TaskState == TaskState.Effect && t.IsAnalysisCreate == false
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&& t.ReadingTaskState == ReadingTaskState.HaveSigned && t.ReadingCategory == ReadingCategory.Visit)
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.GroupBy(t => t.SourceSubjectVisitId)
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.Where(g => t.ReadingType == ReadingMethod.Double ? g.Count() == 2 : true)
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.Count()
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}).ToList()
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}).FirstOrDefaultAsync();
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return result;
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}
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/// <summary>
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/// 质疑统计列表 --医学审核不区分标准
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/// </summary>
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/// <returns></returns>
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[HttpPost]
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public async Task<VisitQuestionViewModel> GetTrialQuestionStatList(VisitQuestionStatQuery inQuery)
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{
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var result = await _trialRepository.Where(t => t.Id == inQuery.TrialId).Select(t => new VisitQuestionViewModel()
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{
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QCQuestion_ClosedCount = t.SubjectVisitList.Where(t => inQuery.TrialSiteId != null ? t.TrialSiteId == inQuery.TrialSiteId : true)
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.SelectMany(t => t.QCChallengeList).Where(c => c.IsClosed).Count(),
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QCQuestion_IngCount = t.SubjectVisitList.Where(t => inQuery.TrialSiteId != null ? t.TrialSiteId == inQuery.TrialSiteId : true)
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.SelectMany(t => t.QCChallengeList).Where(c => c.IsClosed == false).Count(),
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CheckQuestion_ClosedCount = t.SubjectVisitList.Where(t => inQuery.TrialSiteId != null ? t.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.CheckChallengeState == CheckChanllengeTypeEnum.Closed).Count(),
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CheckQuestion_IngCount = t.SubjectVisitList.Where(t => inQuery.TrialSiteId != null ? t.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.CheckChallengeState != CheckChanllengeTypeEnum.Closed).Count(),
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MedicalReviewQuestion_ClosedCount = t.TaskMedicalReviewList.Where(t => inQuery.TrialSiteId != null ? t.VisitTask.Subject.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.VisitTask.IsAnalysisCreate == false && t.IsClosedDialog).Count(),
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MedicalReviewQuestion_IngCount = t.TaskMedicalReviewList.Where(t => inQuery.TrialSiteId != null ? t.VisitTask.Subject.TrialSiteId == inQuery.TrialSiteId : true)
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.Where(t => t.VisitTask.IsAnalysisCreate == false && t.IsClosedDialog == false).Count(),
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}).FirstOrDefaultAsync();
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return result;
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}
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/// <summary>
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/// 疗效统计表，只针对肿瘤标准 排除基线
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/// </summary>
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/// <param name="inQuery"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<IResponseOutput<List<EfficacyEvaluationStatViewModel>>> GetTrialEfficacyEvaluationStatList(EfficacyEvaluationQuery inQuery)
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{
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var trialReadingCriterionId = inQuery.TrialReadingCriterionId;
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//每次查询必须是单标准的
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var criterion = await _readingQuestionCriterionTrialRepository.Where(t => t.Id == trialReadingCriterionId).Select(t => new { t.CriterionType, t.CriterionGroup, t.IsGlobalReading, t.IsArbitrationReading, t.IsOncologyReading, t.CriterionName, t.ArbitrationRule, t.TrialId }).FirstNotNullAsync();
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if (criterion.CriterionGroup == CriterionGroup.Nontumorous)
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{
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return ResponseOutput.Ok(new List<EfficacyEvaluationStatViewModel>());
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}
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var questionType = QuestionType.Tumor;
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if (criterion.CriterionType == CriterionType.RECIST1Point1 || criterion.CriterionType == CriterionType.RECIST1Pointt1_MB
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|| criterion.CriterionType == CriterionType.IRECIST1Point1 || criterion.CriterionType == CriterionType.mRECISTHCC)
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{
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questionType = QuestionType.Tumor;
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//iresist pfs 是icpd
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}
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else if (criterion.CriterionType == CriterionType.Lugano2014)
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{
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questionType = QuestionType.ImgOncology;
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}
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else if (criterion.CriterionType == CriterionType.Lugano2014WithoutPET)
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{
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questionType = QuestionType.CTandMRI;
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}
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else if (criterion.CriterionType == CriterionType.PCWG3)
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{
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}
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var query = _visitTaskRepository.WhereIf(inQuery.TrialSiteId != null, t => t.Subject.TrialSiteId == inQuery.TrialSiteId)
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.Where(t => t.TrialId == inQuery.TrialId && t.TrialReadingCriterionId == trialReadingCriterionId && t.IsAnalysisCreate == false && (t.TaskState == TaskState.Effect || t.TaskState == TaskState.Freeze))
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//访视和全局查询已签名完成的，裁判可以是未签名，未完成的
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.Where(t => (t.ReadingTaskState == ReadingTaskState.HaveSigned && (t.ReadingCategory == ReadingCategory.Visit || t.ReadingCategory == ReadingCategory.Global)) || t.ReadingCategory == ReadingCategory.Judge)
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.Select(t => new EfficacyEvaluationExport()
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{
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Id = t.Id,
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SubjectId = t.SubjectId,
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SubjectCode = t.Subject.Code,
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VisitTaskNum = t.VisitTaskNum,
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TaskName = t.TaskName,
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TaskBlindName = t.TaskBlindName,
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ReadingTaskState = t.ReadingTaskState,
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ReadingCategory = t.ReadingCategory,
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ArmEnum = t.ArmEnum,
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JudgeArmEnum = t.JudgeResultTask.ArmEnum,
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LatestScanDate = t.SourceSubjectVisit.LatestScanDate,
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EarliestScanDate = t.SourceSubjectVisit.EarliestScanDate,
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IsTrigerJudge = criterion.ArbitrationRule == ArbitrationRule.Visit ? t.JudgeVisitTaskId != null :
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(criterion.ArbitrationRule == ArbitrationRule.Reading ?
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t.Subject.SubjectVisitTaskList.Any(c => c.TaskState == TaskState.Effect && c.IsAnalysisCreate == false && c.ReadingCategory == ReadingCategory.Judge && c.TrialReadingCriterionId == trialReadingCriterionId
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&& t.VisitTaskNum < c.VisitTaskNum) :
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false),
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JudgeNote = t.ReadingCategory == ReadingCategory.Judge ? t.JudgeResultRemark : "",
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SubjectCriterionReadingPeriodVisitNumList = t.Subject.ReadModuleList.Where(t => t.TrialReadingCriterionId == trialReadingCriterionId && t.ReadingSetType == ReadingSetType.ImageReading).Select(c => c.SubjectVisit.VisitNum).ToList(),
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DictionaryCode = t.ReadingTaskQuestionAnswerList.Where(c => c.ReadingQuestionTrial.QuestionType == questionType).Select(t => t.ReadingQuestionTrial.DictionaryCode).FirstOrDefault(),
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//整体肿瘤评估答案
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OverallTumorEvaluation = t.ReadingTaskQuestionAnswerList.Where(c => c.ReadingQuestionTrial.QuestionType == questionType).Select(t => t.IsGlobalChange ? t.GlobalChangeAnswer : t.Answer).FirstOrDefault()
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});
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var list = await query.ToListAsync();
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var dicName = await _readingQuestionTrialRepository.Where(t => t.TrialId == criterion.TrialId)
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.Where(t => t.QuestionType == questionType).Select(t => t.DictionaryCode).FirstOrDefaultAsync();
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if (criterion.IsArbitrationReading)
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{
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//找到只有一个人阅片的受试者 和访视
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var exceptVisit = list.Where(t => t.ReadingCategory == ReadingCategory.Visit)
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.GroupBy(t => new { t.SubjectCode, t.TaskName }).Where(g => g.Count() == 1).Select(g => new { g.Key.SubjectCode, g.Key.TaskName }).ToList();
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list = list.Where(t => !exceptVisit.Any(ev => ev.SubjectCode == t.SubjectCode && ev.TaskName == t.TaskName)).ToList();
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}
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list = list.OrderBy(t => t.SubjectCode).ThenBy(t => t.ArmEnum).ThenBy(t => t.VisitTaskNum).ToList();
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//处理裁判标记
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list = DealJudgeMark(criterion.ArbitrationRule, criterion.IsGlobalReading, list);
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//基线（最晚拍片日期）-首次PD（所有触发PD的病灶的检查的最早拍片日期）的中位数，单位是天
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// 构建字典：SubjectCode -> LatestScanDate
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var baseLineDict = list.Where(t => t.VisitTaskNum == 0).GroupBy(t => t.SubjectCode)
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.ToDictionary(
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g => g.Key,
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g => g.First().LatestScanDate // 如果同一个 SubjectCode 有多条记录，只取第一条
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);
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//一定要两个人做完了，产生了裁判并且有结果的，否则就不算,并且排除基线
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list = list.Where(t => t.IsJudgeSelect == true && t.VisitTaskNum != 0 && t.ReadingCategory==ReadingCategory.Visit)//全局的答案已经放在对应访视上了
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.GroupBy(t => t.SubjectCode).Select(g => g.OrderByDescending(t => t.VisitTaskNum).First()).ToList();
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//总subject 数量
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var totalSubjectCount = list.Select(t => t.SubjectId).Distinct().Count();
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//判断subject的逻辑需要确认，这么多次访视任务，有的符合，有的不符合，准则是什么？
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var resultList = list.GroupBy(t => t.OverallTumorEvaluation).Select(g => new EfficacyEvaluationStatViewModel()
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{
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DictionaryCode = g.FirstOrDefault()?.DictionaryCode,
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OverallTumorEvaluation = g.Key,
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Code = g.Key,
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SubjectCodeList = g.Select(t => t.SubjectCode).Distinct().ToList()
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}).ToList();
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// 先把 resultList 转成内存字典
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var resultDict = resultList.ToDictionary(r => r.OverallTumorEvaluation, r => r.SubjectCodeList);
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// 查询字典表，先把数据拉出来到内存，再合并
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var translateList = _dictionaryRepository
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.Where(t => t.Parent.Code == dicName)
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.Select(t => new
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{
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t.Code,
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t.Value,
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})
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.ToList()
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.Select(t => new EfficacyEvaluationStatViewModel
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{
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DictionaryCode = dicName,
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Code = t.Code, //方便找到首次PD的日期
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OverallTumorEvaluation = t.Value,//翻译后的值
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SubjectCodeList = resultDict.ContainsKey(t.Code) ? resultDict[t.Code] : new List<string>()
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})
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.ToList();
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// （cr +pr） /总人数
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var crAddPr = translateList.Where(t => t.OverallTumorEvaluation == "PR" || t.OverallTumorEvaluation == "CR").Sum(t => t.SubjectCount);
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var orrPercent = totalSubjectCount > 0
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? ((decimal)crAddPr / totalSubjectCount * 100).ToString("0.00") + "%"
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: "0.00%";
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var pdInfo = translateList
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.WhereIf(criterion.CriterionType == CriterionType.IRECIST1Point1, t => t.OverallTumorEvaluation == "ICPD")
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.WhereIf(criterion.CriterionType == CriterionType.IRECIST1Point1, t => t.OverallTumorEvaluation == "PD")
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.FirstOrDefault();
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var firstPdList = new List<FirstPdInfo>();
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if (pdInfo != null)
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{
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firstPdList = list.Where(t => t.OverallTumorEvaluation == pdInfo.Code).GroupBy(t => t.SubjectCode)
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.Select(g => new FirstPdInfo
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{
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SubjectCode = g.Key,
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EarliestScanDate = g.Where(t => t.OverallTumorEvaluation == pdInfo.Code).OrderBy(t => t.VisitTaskNum).First().EarliestScanDate
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})
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.ToList();
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foreach (var item in firstPdList)
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{
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if (baseLineDict.TryGetValue(item.SubjectCode, out var latestScanDate))
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{
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item.BaseLineLatestScanDate = latestScanDate;
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}
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}
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}
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return ResponseOutput.Ok(translateList, new { PDList = firstPdList, ORR = orrPercent });
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}
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public List<T> DealJudgeMark<T>(ArbitrationRule arbitrationRule, bool isGlobalReading, IEnumerable<T> list) where T : EfficacyEvaluationExport
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{
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//处理访视任务的裁判标记
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var resultExceptJudgeList = list.Where(t => t.ReadingCategory != ReadingCategory.Judge).ToList();
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var judegeList = list.Where(t => t.ReadingCategory == ReadingCategory.Judge).ToList();
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if (arbitrationRule == ArbitrationRule.Visit)
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{
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foreach (var item in resultExceptJudgeList)
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{
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var findJudge = judegeList.FirstOrDefault(t => t.SubjectCode == item.SubjectCode
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&& (t.VisitTaskNum - ReadingCommon.TaskNumDic[ReadingCategory.Judge]) == item.VisitTaskNum);
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if (findJudge != null)
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{
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if (findJudge.ReadingTaskState == ReadingTaskState.HaveSigned)
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{
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item.IsJudgeSelect = findJudge.JudgeArmEnum == item.ArmEnum ? true : false;
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item.JudgeNote = findJudge.JudgeArmEnum == item.ArmEnum ? findJudge.JudgeNote : string.Empty;
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}
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else
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{
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//默认也是null 其实不用赋值
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item.IsJudgeSelect = null;
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}
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}
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else
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{
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//两个人都做了
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if (resultExceptJudgeList.Where(t => t.VisitTaskNum == item.VisitTaskNum && t.SubjectCode == item.SubjectCode).Select(t => t.ArmEnum).Distinct().Count() == 2)
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{
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//如果没有产生裁判，默认选择R1
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if (item.ArmEnum == Arm.DoubleReadingArm1)
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{
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item.IsJudgeSelect = true;
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}
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else
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{
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item.IsJudgeSelect = false;
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}
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}
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else
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{
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item.IsJudgeSelect = null;
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item.IsTrigerJudge = null;
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}
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}
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}
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}
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else if (arbitrationRule == ArbitrationRule.Reading)
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{
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//处理访视裁判标记
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foreach (var visitItem in resultExceptJudgeList.Where(t => t.ReadingCategory == ReadingCategory.Visit))
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{
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////默认设置为false 只处理为true 和 空的情况
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//visitItem.IsJudgeSelect = false;
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var subjectJudgeList = judegeList.Where(t => t.SubjectCode == visitItem.SubjectCode).ToList();
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//阅片期访视号
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var subjectReadingPeriondVisitNumList = resultExceptJudgeList.Where(t => t.SubjectCode == visitItem.SubjectCode).FirstOrDefault()?.SubjectCriterionReadingPeriodVisitNumList;
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//两个人完成最大得任务号(访视+全局)
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var subjectMaxFinishedTaskNum = resultExceptJudgeList.Where(t => t.SubjectCode == visitItem.SubjectCode)
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.GroupBy(t => t.VisitTaskNum).Where(g => g.Count() == 2).Select(g => g.Key).DefaultIfEmpty().Max();
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var addReadingPeriodNum = isGlobalReading ? ReadingCommon.TaskNumDic[ReadingCategory.Global] : 0;
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var finishedGlobalCount = 0;
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//没有配置阅片期
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if (subjectReadingPeriondVisitNumList == null)
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{
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finishedGlobalCount = 0;
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}
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else
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{
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//已完成的全局数量
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finishedGlobalCount = resultExceptJudgeList.Where(t => t.SubjectCode == visitItem.SubjectCode && subjectReadingPeriondVisitNumList.Any(c => (c + addReadingPeriodNum) == t.VisitTaskNum)
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/*&& t.ReadingCategory == ReadingCategory.Global*/)
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.Select(t => new { t.VisitTaskNum, t.ArmEnum }).Distinct()
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.GroupBy(t => t.VisitTaskNum).Where(g => g.Count() == 2).Select(g => g.Key).Count();
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}
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visitItem.IsJudgeSelect = null;
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visitItem.IsTrigerJudge = null;
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if (finishedGlobalCount != 0)
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{
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//最大的全局是否产生裁判
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var subjectMaxFinishedGlobalTaskNum = resultExceptJudgeList.Where(t => t.SubjectCode == visitItem.SubjectCode && subjectReadingPeriondVisitNumList.Any(c => (c + addReadingPeriodNum) == t.VisitTaskNum)
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/*&& t.ReadingCategory == ReadingCategory.Global*/)
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.Select(t => new { t.VisitTaskNum, t.ArmEnum }).Distinct()
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.GroupBy(t => t.VisitTaskNum).Where(g => g.Count() == 2).Select(g => g.Key).DefaultIfEmpty().Max();
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//最大的完成的全局是否产生裁判
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if (subjectJudgeList.Any(t => t.VisitTaskNum == (subjectMaxFinishedGlobalTaskNum + ReadingCommon.TaskNumDic[ReadingCategory.Judge])))
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{
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var maxJudge = subjectJudgeList.FirstOrDefault(t => t.VisitTaskNum == (subjectMaxFinishedGlobalTaskNum + ReadingCommon.TaskNumDic[ReadingCategory.Judge]));
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//最大裁判完成了
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if (maxJudge.ReadingTaskState == ReadingTaskState.HaveSigned)
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{
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if (visitItem.VisitTaskNum < maxJudge.VisitTaskNum)
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{
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//触发裁判
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visitItem.IsTrigerJudge = true;
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if (visitItem.ArmEnum == maxJudge.JudgeArmEnum)
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{
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visitItem.IsJudgeSelect = true;
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visitItem.JudgeNote = maxJudge.JudgeNote;
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}
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//裁判没选择的人设置为false
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||
else
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||
{
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visitItem.IsJudgeSelect = false;
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||
}
|
||
}
|
||
else
|
||
{
|
||
//后续访视 未知 默认都是null
|
||
|
||
}
|
||
}
|
||
else
|
||
{
|
||
//找到当前未阅最大裁判之前的已完成的最大裁判任务
|
||
var maxFinishedJudge = subjectJudgeList.Where(t => t.ReadingTaskState == ReadingTaskState.HaveSigned).OrderByDescending(t => t.VisitTaskNum).FirstOrDefault();
|
||
|
||
if (maxFinishedJudge == null)
|
||
{
|
||
// 为空 裁判选择标记默认就是null 不用处理
|
||
|
||
if (visitItem.VisitTaskNum < maxJudge.VisitTaskNum)
|
||
{
|
||
visitItem.IsTrigerJudge = true;
|
||
}
|
||
|
||
}
|
||
else
|
||
{
|
||
if (visitItem.VisitTaskNum < maxFinishedJudge.VisitTaskNum)
|
||
{
|
||
visitItem.IsTrigerJudge = true;
|
||
|
||
if (visitItem.ArmEnum == maxFinishedJudge.JudgeArmEnum)
|
||
{
|
||
visitItem.IsJudgeSelect = true;
|
||
visitItem.JudgeNote = maxFinishedJudge.JudgeNote;
|
||
}
|
||
//裁判没选择的人设置为false
|
||
else
|
||
{
|
||
visitItem.IsJudgeSelect = false;
|
||
}
|
||
}
|
||
else if (visitItem.VisitTaskNum > maxFinishedJudge.VisitTaskNum && visitItem.VisitTaskNum < maxJudge.VisitTaskNum)
|
||
{
|
||
//完成裁判 和未完成裁判之间的 裁判选择标记默认是null
|
||
|
||
visitItem.IsTrigerJudge = true;
|
||
}
|
||
else
|
||
{
|
||
//在未完成全局裁判之后的访视 未知 默认都是null
|
||
|
||
|
||
}
|
||
|
||
}
|
||
|
||
}
|
||
|
||
|
||
}
|
||
else
|
||
{
|
||
//最大的完成的全局未产生裁判
|
||
|
||
if (visitItem.VisitTaskNum <= subjectMaxFinishedGlobalTaskNum)
|
||
{
|
||
visitItem.IsTrigerJudge = false;
|
||
|
||
if (visitItem.ArmEnum == Arm.DoubleReadingArm1)
|
||
{
|
||
visitItem.IsJudgeSelect = true;
|
||
|
||
}
|
||
else
|
||
{
|
||
visitItem.IsJudgeSelect = false;
|
||
}
|
||
}
|
||
else
|
||
{
|
||
//未产生裁判的全局之后的访视 两个标记都是null (后续可能还有全局，但是全局两个人没做完)
|
||
}
|
||
|
||
|
||
}
|
||
|
||
|
||
}
|
||
|
||
|
||
|
||
}
|
||
}
|
||
else
|
||
{
|
||
foreach (var visitItem in resultExceptJudgeList.Where(t => t.ReadingCategory == ReadingCategory.Visit))
|
||
{
|
||
visitItem.IsJudgeSelect = null;
|
||
visitItem.IsTrigerJudge = null;
|
||
}
|
||
|
||
}
|
||
return resultExceptJudgeList;
|
||
}
|
||
} |