566 lines
23 KiB
C#
566 lines
23 KiB
C#
//--------------------------------------------------------------------
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// 此代码由T4模板自动生成 byzhouhang 20210918
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// 生成时间 2023-06-15 15:06:06
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// 对此文件的更改可能会导致不正确的行为，并且如果重新生成代码，这些更改将会丢失。
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//--------------------------------------------------------------------
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using Microsoft.AspNetCore.Mvc;
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using IRaCIS.Core.Application.Interfaces;
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using IRaCIS.Core.Application.ViewModel;
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using IRaCIS.Core.Application.Service.Reading.Dto;
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using IRaCIS.Core.Infra.EFCore.Common;
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using IRaCIS.Core.Domain.Share;
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using MassTransit;
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using IRaCIS.Core.Infrastructure;
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using IRaCIS.Core.Domain.Models;
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using IRaCIS.Core.Infrastructure.Extention;
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namespace IRaCIS.Core.Application.Service
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{
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/// <summary>
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/// 临床答案
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/// </summary>
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[ApiExplorerSettings(GroupName = "Reading")]
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public class ClinicalAnswerService : BaseService
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{
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private readonly IRepository<TrialClinicalQuestion> _trialClinicalQuestionRepository;
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private readonly IRepository<SystemClinicalQuestion> _systemClinicalQuestionRepository;
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private readonly IRepository<SystemClinicalTableQuestion> _systemClinicalTableQuestionRepository;
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private readonly IRepository<TrialClinicalTableQuestion> _trialClinicalTableQuestionRepository;
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private readonly IRepository<ClinicalDataTrialSet> _clinicalDataTrialSetRepository;
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private readonly IRepository<ClinicalForm> _clinicalFormRepository;
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private readonly IRepository<Subject> _subjectRepository;
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private readonly IRepository<ReadModuleCriterionFrom> _readModuleCriterionFromRepository;
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private readonly IRepository<ReadModule> _readModuleRepository;
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private readonly IRepository<ClinicalQuestionAnswer> _clinicalQuestionAnswerRepository;
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private readonly IRepository<ClinicalTableAnswer> _clinicalTableAnswerRepository;
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private readonly IRepository<ClinicalAnswerRowInfo> _clinicalAnswerRowInfoRepository;
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private readonly IRepository<ReadingClinicalData> _readingClinicalDataRepository;
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private readonly IRepository<SubjectVisit> _subjectVisitRepository;
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private readonly IClinicalQuestionService _iClinicalQuestionService;
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public ClinicalAnswerService(IRepository<TrialClinicalQuestion> trialClinicalQuestionRepository,
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IRepository<SystemClinicalTableQuestion> systemClinicalTableQuestionRepository,
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IRepository<TrialClinicalTableQuestion> trialClinicalTableQuestionRepository,
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IRepository<ReadingClinicalData> readingClinicalDataRepository,
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IRepository<ClinicalForm> clinicalFormRepository,
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IRepository<Subject> subjectRepository,
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IRepository<ReadModuleCriterionFrom> readModuleCriterionFromRepository,
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IRepository<ReadModule> readModuleRepository,
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IRepository<SubjectVisit> subjectVisitRepository,
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IRepository<ClinicalTableAnswer> clinicalTableAnswerRepository,
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IRepository<ClinicalQuestionAnswer> clinicalQuestionAnswerRepository,
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IClinicalQuestionService iClinicalQuestionService,
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IRepository<ClinicalAnswerRowInfo> clinicalAnswerRowInfoRepository,
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IRepository<ClinicalDataTrialSet> clinicalDataTrialSetRepository,
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IRepository<SystemClinicalQuestion> systemClinicalQuestionRepository
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)
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{
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_subjectVisitRepository = subjectVisitRepository;
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_readingClinicalDataRepository = readingClinicalDataRepository;
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_clinicalAnswerRowInfoRepository = clinicalAnswerRowInfoRepository;
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_clinicalQuestionAnswerRepository = clinicalQuestionAnswerRepository;
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_systemClinicalTableQuestionRepository = systemClinicalTableQuestionRepository;
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_trialClinicalQuestionRepository = trialClinicalQuestionRepository;
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_trialClinicalTableQuestionRepository = trialClinicalTableQuestionRepository;
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_systemClinicalQuestionRepository = systemClinicalQuestionRepository;
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_clinicalDataTrialSetRepository = clinicalDataTrialSetRepository;
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_clinicalFormRepository = clinicalFormRepository;
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this._subjectRepository = subjectRepository;
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this._readModuleCriterionFromRepository = readModuleCriterionFromRepository;
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this._readModuleRepository = readModuleRepository;
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_clinicalTableAnswerRepository = clinicalTableAnswerRepository;
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_iClinicalQuestionService = iClinicalQuestionService;
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}
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/// <summary>
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/// 自动添加CRC临床数据
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/// </summary>
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/// <param name="inDto"></param>
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/// <returns></returns>
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public async Task AutoAddCRCClinical(AutoAddClinicalInDto inDto)
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{
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var dataTrialSetList = await _clinicalDataTrialSetRepository.Where(x =>x.TrialId == inDto.TrialId && x.UploadRole == UploadRole.CRC && x.IsConfirm)
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.IgnoreAutoIncludes().ToListAsync();
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var baseLine = await _subjectVisitRepository.Where(x => x.TrialId == inDto.TrialId)
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.WhereIf(inDto.SubjectId!=null,x=>x.SubjectId==inDto.SubjectId)
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.Select(x => new
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{
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x.SubjectId,
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VisitId = x.Id,
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x.IsBaseLine,
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}).ToListAsync();
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var clinicalDataList =await _readingClinicalDataRepository.Where(x =>x.TrialId==inDto.TrialId&&x.ClinicalDataTrialSet.UploadRole== UploadRole.CRC).IgnoreAutoIncludes().ToListAsync();
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List<ReadingClinicalData> readingClinicalDatas = new List<ReadingClinicalData>();
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baseLine.Select(x => x.SubjectId).Distinct().ForEach(n =>
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{
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var baseLineVisitId = baseLine.Where(x => x.IsBaseLine && x.SubjectId == n).Select(x => x.VisitId).First();
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readingClinicalDatas.AddRange(
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dataTrialSetList.Where(x => x.ClinicalDataLevel == ClinicalLevel.Subject).Where(x => clinicalDataList.Where(y => y.ClinicalDataTrialSetId == x.Id && y.SubjectId == n).Count() == 0)
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.Select(x => new ReadingClinicalData()
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{
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ClinicalDataTrialSetId = x.Id,
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IsVisit = true,
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SubjectId = n,
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ReadingId = baseLineVisitId,
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TrialId = inDto.TrialId
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}).ToList());
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readingClinicalDatas.AddRange(
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dataTrialSetList.Where(x => x.ClinicalDataLevel == ClinicalLevel.ImageRead).Where(x => clinicalDataList.Where(y => y.ClinicalDataTrialSetId == x.Id && y.SubjectId == n).Count() == 0)
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.Select(x => new ReadingClinicalData()
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{
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ClinicalDataTrialSetId = x.Id,
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IsVisit = false,
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SubjectId = n,
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ReadingId = default(Guid),
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TrialId = inDto.TrialId
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}).ToList());
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readingClinicalDatas.AddRange(
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dataTrialSetList.Where(x => x.ClinicalDataLevel == ClinicalLevel.OncologyRead).Where(x => clinicalDataList.Where(y => y.ClinicalDataTrialSetId == x.Id && y.SubjectId == n).Count() == 0)
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.Select(x => new ReadingClinicalData()
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{
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ClinicalDataTrialSetId = x.Id,
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IsVisit = false,
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SubjectId = n,
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ReadingId = default(Guid),
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TrialId = inDto.TrialId
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}).ToList());
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});
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baseLine.ForEach(n =>
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{
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readingClinicalDatas.AddRange(
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dataTrialSetList.Where(x => x.ClinicalDataLevel == ClinicalLevel.SubjectVisit).Where(x => clinicalDataList.Where(y => y.ClinicalDataTrialSetId == x.Id && y.ReadingId == n.VisitId).Count() == 0)
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.Select(x => new ReadingClinicalData()
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{
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ClinicalDataTrialSetId = x.Id,
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IsVisit = true,
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SubjectId = n.SubjectId,
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ReadingId = n.VisitId,
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TrialId = inDto.TrialId
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}).ToList());
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});
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await _readingClinicalDataRepository.AddRangeAsync(readingClinicalDatas);
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await _readingClinicalDataRepository.SaveChangesAsync();
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}
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/// <summary>
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/// 获取CRC受试者临床数据
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/// </summary>
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/// <param name="inDto"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<List<GetCRCSubjectClinicalOutDto>> GetCRCSubjectClinicalList(GetCRCSubjectClinicalInDto inDto)
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{
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await AutoAddCRCClinical(new AutoAddClinicalInDto()
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{
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TrialId = inDto.TrialId
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}) ;
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var subjects = await _subjectRepository.Where(x => x.TrialId == inDto.TrialId).Select(x => new GetCRCSubjectClinicalResultDto()
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{
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SubjectId = x.Id,
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SubjectCode = x.Code
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}).ToListAsync();
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var clinicalData=await _readingClinicalDataRepository.Where(x=>x.TrialId == inDto.TrialId&&x.ClinicalDataTrialSet.UploadRole==UploadRole.CRC&&x.ClinicalDataTrialSet.ClinicalDataLevel!= ClinicalLevel.SubjectVisit)
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.Where(x=>!x.IsSign)
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.Include(x=>x.ClinicalDataTrialSet).Select(x=>new GetCRCSubjectClinicalOutDto() {
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SubjectId=x.SubjectId,
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SubjectCode=x.Subject.Code,
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TrialId=inDto.TrialId,
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ClinicalDataTrialSetId = x.ClinicalDataTrialSet.Id,
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ClinicalDataSetEnName= x.ClinicalDataTrialSet.ClinicalDataSetEnName,
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ClinicalDataSetName = x.ClinicalDataTrialSet.ClinicalDataSetName,
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}).OrderBy(x=>x.SubjectCode).ToListAsync();
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// 一次查询报错 分两次写
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clinicalData.ForEach(x =>
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{
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x.ClinicalDataSetEnName = x.ClinicalDataSetName.LanguageName(x.ClinicalDataSetEnName, _userInfo.IsEn_Us);
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});
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var clinicalFormData = await _clinicalFormRepository.Where(x => x.TrialId == inDto.TrialId).ToListAsync();
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clinicalData.ForEach(n =>
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{
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n.ClinicalCount = clinicalFormData.Where(y => y.ClinicalDataTrialSetId == n.ClinicalDataTrialSetId && y.SubjectId == n.SubjectId).Count();
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});
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return clinicalData;
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}
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/// <summary>
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/// 获取表单列表
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/// </summary>
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/// <param name="inDto"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<GetClinicalQuestionAnswerListOutDto> GetClinicalQuestionFormList(GetClinicalQuestionAnswerListInDto inDto)
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{
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var result = new GetClinicalQuestionAnswerListOutDto();
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result.AnswerList = new List<Dictionary<string, string>>();
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result.QuestionList=await _trialClinicalQuestionRepository.Where(x=>x.TrialClinicalId==inDto.ClinicalDataTrialSetId
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&&x.ClinicalQuestionType!= ReadingQestionType.Group
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&& x.ClinicalQuestionType != ReadingQestionType.Table).OrderBy(x=>x.ShowOrder)
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.ProjectTo<TrialClinicalQuestionDto>(_mapper.ConfigurationProvider).ToListAsync();
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var answers = await _clinicalQuestionAnswerRepository.Where(x => x.SubjectId == inDto.SubjectId && x.ClinicalDataTrialSetId == inDto.ClinicalDataTrialSetId)
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.Select(x => new
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{
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x.ClinicalFormId,
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x.ClinicalForm.CheckDate,
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x.QuestionId,
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x.Answer
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})
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.ToListAsync();
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var ClinicalFormIds = answers.OrderBy(x=>x.CheckDate).Select(x => x.ClinicalFormId).Distinct().ToList();
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ClinicalFormIds.ForEach(x =>
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{
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var dic = answers.Where(y => y.ClinicalFormId == x).ToDictionary(x => x.QuestionId.ToString(), x => x.Answer);
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dic.Add("clinicalFormId", x.ToString());
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result.AnswerList.Add(dic);
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});
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return result;
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}
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/// <summary>
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/// 获取临床数据表单问题
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/// </summary>
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/// <param name="inDto"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<GetClinicalFormInfoOutDto> GetClinicalFormInfo(GetClinicalFormInfoInDto inDto)
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{
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var formInfo = await _clinicalFormRepository.Where(x => x.Id == inDto.ClinicalFormId).FirstNotNullAsync();
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var questionAnswer = await _clinicalQuestionAnswerRepository.Where(x => x.ClinicalFormId == inDto.ClinicalFormId).Select(x => new ClinicalFormQuestionAnswer
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{
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QuestionId = x.QuestionId,
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Answer = x.Answer
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}).ToListAsync();
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var tableAnswer = await _clinicalTableAnswerRepository.Where(x => x.ClinicalFormId == inDto.ClinicalFormId).Select(x => new ClinicalFormTableQuestionAnswer
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{
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TableQuestionId = x.TableQuestionId,
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Answer = x.Answer,
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QuestionId = x.QuestionId,
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RowIndex = x.ClinicalAnswerRowInfo.RowIndex
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}).ToListAsync();
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var questions = await _trialClinicalQuestionRepository.Where(x => x.TrialClinicalId == formInfo.ClinicalDataTrialSetId)
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.ProjectTo<ClinicalQuestionPreviewDto>(_mapper.ConfigurationProvider).ToListAsync();
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var tableQuestions = await _trialClinicalQuestionRepository.Where(x => x.TrialClinicalId == formInfo.ClinicalDataTrialSetId)
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.ProjectTo<ClinicalTablePreviewDto>(_mapper.ConfigurationProvider).ToListAsync();
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var result = questions.Where(x => x.ClinicalQuestionType == ReadingQestionType.Group).ToList();
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result.ForEach(x =>
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{
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_iClinicalQuestionService.FindChildQuestion(x, questions, tableQuestions, questionAnswer, tableAnswer);
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});
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return new GetClinicalFormInfoOutDto()
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{
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Question = result
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};
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}
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/// <summary>
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/// 提交临床数据表单
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/// </summary>
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/// <param name="inDto"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<IResponseOutput> SubmitClinicalForm(SubmitClinicalFormInDto inDto)
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{
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ClinicalForm clinicalForm = new ClinicalForm() { };
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clinicalForm = new ClinicalForm()
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{
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ClinicalDataTrialSetId = inDto.ClinicalDataTrialSetId,
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SubjectId = inDto.SubjectId,
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TrialId= inDto.TrialId,
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Id = inDto.ClinicalFormId ?? NewId.NextGuid(),
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ReadingId = inDto.ReadingId,
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VisitId = inDto.VisitId,
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};
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try
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{
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var checkDateQuestionId = await _trialClinicalQuestionRepository.Where(x => x.TrialClinicalId == inDto.ClinicalDataTrialSetId && x.IsCheckDate).Select(x => x.Id).FirstNotNullAsync();
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clinicalForm.CheckDate = DateTime.Parse(inDto.QuestionAnswers.Where(x => x.QuestionId == checkDateQuestionId).Select(x => x.Answer).First());
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}
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catch (Exception)
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{
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}
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List<ClinicalQuestionAnswer> clinicalQuestionAnswers = inDto.QuestionAnswers.Select(x => new ClinicalQuestionAnswer()
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{
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Answer=x.Answer,
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ClinicalDataTrialSetId=inDto.ClinicalDataTrialSetId,
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SubjectId=inDto.SubjectId,
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ClinicalFormId= clinicalForm.Id,
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QuestionId=x.QuestionId,
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}).ToList();
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List<ClinicalAnswerRowInfo> clinicalAnswerRowInfos = new List<ClinicalAnswerRowInfo>();
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List<ClinicalTableAnswer> clinicalTableAnswers = new List<ClinicalTableAnswer>();
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inDto.TableQuestionAnswerList.ForEach(x => {
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var questionid = x.QuestionId;
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for (int i = 0; i < x.TableQuestionAnswers.Count(); i++)
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{
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var rowInfo = new ClinicalAnswerRowInfo()
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{
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Id = NewId.NextGuid(),
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SubjectId = inDto.SubjectId,
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ClinicalFormId = clinicalForm.Id,
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QuestionId = questionid,
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RowIndex = i+1,
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};
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clinicalAnswerRowInfos.Add(rowInfo);
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x.TableQuestionAnswers[i].ForEach(y => {
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clinicalTableAnswers.Add(new ClinicalTableAnswer()
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{
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Answer=y.Answer,
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ClinicalFormId= clinicalForm.Id,
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QuestionId= questionid,
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RowId= rowInfo.Id,
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TableQuestionId=y.TableQuestionId,
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SubjectId= inDto.SubjectId,
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});
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});
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}
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});
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if (inDto.ClinicalFormId != null)
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{
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await _clinicalFormRepository.BatchDeleteNoTrackingAsync(x => x.Id == inDto.ClinicalFormId);
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await _clinicalQuestionAnswerRepository.BatchDeleteNoTrackingAsync(x => x.ClinicalFormId == inDto.ClinicalFormId);
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await _clinicalAnswerRowInfoRepository.BatchDeleteNoTrackingAsync(x => x.ClinicalFormId == inDto.ClinicalFormId);
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await _clinicalTableAnswerRepository.BatchDeleteNoTrackingAsync(x => x.ClinicalFormId == inDto.ClinicalFormId);
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}
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await _clinicalFormRepository.AddAsync(clinicalForm);
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await _clinicalQuestionAnswerRepository.AddRangeAsync(clinicalQuestionAnswers);
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await _clinicalAnswerRowInfoRepository.AddRangeAsync(clinicalAnswerRowInfos);
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await _clinicalTableAnswerRepository.AddRangeAsync(clinicalTableAnswers);
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await _clinicalTableAnswerRepository.SaveChangesAsync();
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return ResponseOutput.Ok(true);
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}
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/// <summary>
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/// 获取CRC确认列表
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/// </summary>
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/// <param name="inDto"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<List<GetCRCConfirmListOutDto>> GetCRCConfirmList(GetCRCConfirmListInDto inDto)
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{
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List<GetCRCConfirmListOutDto> result = await _readModuleRepository.Where(x => x.TrialId == inDto.TrialId)
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.Select(x => new GetCRCConfirmListOutDto()
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{
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SubjectId= x.SubjectId,
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IsCRCConfirm = x.IsCRCConfirm,
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LatestScanDate = x.SubjectVisit.LatestScanDate,
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ReadingSetType = x.ReadingSetType,
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IsPMConfirm = x.IsPMConfirm,
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ReadModuleId = x.Id,
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}).OrderBy(x => x.LatestScanDate).ToListAsync();
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var formList = await _clinicalFormRepository.Where(x => x.TrialId == inDto.TrialId)
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.Where(x => x.ClinicalDataTrialSet.UploadRole == UploadRole.CRC)
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.Where(x => x.ClinicalDataTrialSet.ClinicalDataLevel == ClinicalLevel.ImageRead || x.ClinicalDataTrialSet.ClinicalDataLevel == ClinicalLevel.OncologyRead)
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.Select(x => new CRCClinicalForm
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{
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CkeckDate = x.CheckDate,
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ClinicalDataLevel = x.ClinicalDataTrialSet.ClinicalDataLevel,
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ClinicalFormId = x.Id,
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}).ToListAsync();
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var confirmList = await _readModuleCriterionFromRepository.Where(x => x.TrialId == inDto.TrialId).ToListAsync();
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result.ForEach(x =>
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{
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if (x.IsCRCConfirm)
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{
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x.ClinicalFormIdList = confirmList.Where(y => y.ReadModuleId == x.ReadModuleId).Select(y=>y.ClinicalFormId).ToList();
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}
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else
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{
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if (x.ReadingSetType == ReadingSetType.ImageReading)
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{
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x.ClinicalFormIdList = formList.Where(y => y.ClinicalDataLevel == ClinicalLevel.ImageRead&&y.CkeckDate<=x.LatestScanDate).Select(y => y.ClinicalFormId).ToList();
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}
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else
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{
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x.ClinicalFormIdList = formList.Where(y => y.ClinicalDataLevel == ClinicalLevel.OncologyRead&&y.CkeckDate <= x.LatestScanDate).Select(y => y.ClinicalFormId).ToList();
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}
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}
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});
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return result;
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}
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/// <summary>
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/// CRC 确认临床数据
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/// </summary>
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/// <param name="inDto"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<IResponseOutput> CRCConfirmClinical(CRCConfirmClinicalInDto inDto)
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{
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var dataList =await this.GetCRCConfirmList(new GetCRCConfirmListInDto()
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{
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TrialId = inDto.TrialId
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});
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var presentData = dataList.Where(x => x.ReadModuleId == inDto.ReadModuleId).First();
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var confirmlist= dataList.Where(x =>(x.LatestScanDate < presentData.LatestScanDate && x.ReadingSetType == presentData.ReadingSetType)
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|| x.ReadModuleId == presentData.ReadModuleId).Where(x => !x.IsCRCConfirm).ToList();
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List<ReadModuleCriterionFrom> needAddList = new List<ReadModuleCriterionFrom>()
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{
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|
|
};
|
|
confirmlist.ForEach(x =>
|
|
{
|
|
x.ClinicalFormIdList.ForEach(y =>
|
|
{
|
|
needAddList.Add(new ReadModuleCriterionFrom()
|
|
{
|
|
ClinicalFormId = y,
|
|
ReadModuleId = x.ReadModuleId,
|
|
SubjectId = x.SubjectId,
|
|
TrialId = inDto.TrialId,
|
|
});
|
|
});
|
|
});
|
|
|
|
var readModuleIds = confirmlist.Select(x => x.ReadModuleId).ToList();
|
|
|
|
await _readModuleRepository.UpdatePartialFromQueryAsync(x => readModuleIds.Contains(x.Id),x=>new ReadModule() {
|
|
IsCRCConfirm=true
|
|
});
|
|
await _readModuleCriterionFromRepository.AddRangeAsync(needAddList);
|
|
|
|
await _readModuleCriterionFromRepository.SaveChangesAsync();
|
|
|
|
return ResponseOutput.Ok(true);
|
|
}
|
|
|
|
/// <summary>
|
|
/// CRC 取消确认
|
|
/// </summary>
|
|
/// <param name="inDto"></param>
|
|
/// <returns></returns>
|
|
[HttpPost]
|
|
public async Task<IResponseOutput> CRCCancelConfirmClinical(CRCCancelConfirmClinicalInDto inDto)
|
|
{
|
|
var dataList = await this.GetCRCConfirmList(new GetCRCConfirmListInDto()
|
|
{
|
|
TrialId = inDto.TrialId
|
|
});
|
|
|
|
var presentData = dataList.Where(x => x.ReadModuleId == inDto.ReadModuleId).First();
|
|
|
|
if (dataList.Any(x => x.IsPMConfirm && x.LatestScanDate > presentData.LatestScanDate && x.ReadingSetType == presentData.ReadingSetType))
|
|
{
|
|
throw new BusinessValidationFailedException("当前数据并非最后一条确认信息,无法取消！");
|
|
}
|
|
|
|
if(presentData.IsPMConfirm)
|
|
{
|
|
throw new BusinessValidationFailedException("PM已确认,无法取消！");
|
|
}
|
|
|
|
|
|
await _readModuleRepository.UpdatePartialFromQueryAsync(x => presentData.ReadModuleId==x.Id, x => new ReadModule()
|
|
{
|
|
IsCRCConfirm = false
|
|
});
|
|
|
|
await _readModuleCriterionFromRepository.BatchDeleteNoTrackingAsync(x=>x.ReadModuleId== presentData.ReadModuleId);
|
|
|
|
await _readModuleCriterionFromRepository.SaveChangesAsync();
|
|
|
|
return ResponseOutput.Ok(true);
|
|
}
|
|
|
|
/// <summary>
|
|
/// PM确认临床数据
|
|
/// </summary>
|
|
/// <param name="inDto"></param>
|
|
/// <returns></returns>
|
|
/// <exception cref="BusinessValidationFailedException"></exception>
|
|
[HttpPost]
|
|
public async Task<IResponseOutput> PMConfirmClinical(CRCConfirmClinicalInDto inDto)
|
|
{
|
|
var readModuleData = await _readModuleRepository.Where(x => x.Id == inDto.ReadModuleId).FirstNotNullAsync();
|
|
if (!readModuleData.IsCRCConfirm)
|
|
{
|
|
throw new BusinessValidationFailedException("CRC还未确认数据,PM无法确认");
|
|
}
|
|
|
|
await _readModuleRepository.UpdatePartialFromQueryAsync(x => inDto.ReadModuleId == x.Id, x => new ReadModule()
|
|
{
|
|
IsPMConfirm = false
|
|
});
|
|
|
|
await _readModuleRepository.SaveChangesAsync();
|
|
|
|
return ResponseOutput.Ok(true);
|
|
}
|
|
|
|
}
|
|
}
|