506 lines
24 KiB
C#
506 lines
24 KiB
C#
using IRaCIS.Application.Interfaces;
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using IRaCIS.Application.Contracts;
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using IRaCIS.Core.Domain.Share;
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using EasyCaching.Core;
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using IRaCIS.Core.Application.Filter;
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using IRaCIS.Core.Infra.EFCore;
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using MassTransit;
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using Microsoft.AspNetCore.Mvc;
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using Panda.DynamicWebApi.Attributes;
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using IRaCIS.Core.Infrastructure;
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namespace IRaCIS.Application.Services
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{
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[ApiExplorerSettings(GroupName = "Trial")]
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public class TrialService : BaseService, ITrialService
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{
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private readonly IEasyCachingProvider _provider;
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private readonly IRepository<Trial> _trialRepository;
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private readonly IRepository<TrialUser> _trialUserRepository;
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public bool TrialExpeditedChange { get; set; } = false;
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public TrialService(IEasyCachingProvider provider,IRepository<Trial> trialRepository,
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IRepository<TrialUser> trialUserRepository
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)
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{
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_provider = provider;
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_trialRepository = trialRepository;
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this._trialUserRepository = trialUserRepository;
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}
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/// <summary>
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/// 分页获取临床项目列表 默认后台加急状态为3 查所有的
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/// </summary>
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/// <param name="searchParam"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<PageOutput<TrialDetailDTO>> GetTrialList(TrialQueryDTO searchParam)
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{
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var multiModalityIdSelectCount = searchParam.ModalityIds.Count;
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var multiCriteriaSelectCount = searchParam.CriterionIds.Count;
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var multiReviewTypeSelectCount = searchParam.ReviewTypeIds.Count;
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var query = _trialRepository.AsQueryable().IgnoreQueryFilters()
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.WhereIf(!string.IsNullOrEmpty(searchParam.TrialStatusStr), o => o.TrialStatusStr.Contains(searchParam.TrialStatusStr))
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.WhereIf(searchParam.SponsorId != null, o => o.SponsorId == searchParam.SponsorId)
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.WhereIf(searchParam.Expedited != null, o => o.Expedited == searchParam.Expedited)
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.WhereIf(!string.IsNullOrEmpty(searchParam.Code), o => o.TrialCode.Contains(searchParam.Code))
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.WhereIf(!string.IsNullOrWhiteSpace(searchParam.Indication), o => o.Indication.Contains(searchParam.Indication))
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.WhereIf(!string.IsNullOrEmpty(searchParam.ResearchProgramNo), o => o.ResearchProgramNo.Contains(searchParam.ResearchProgramNo))
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.WhereIf(!string.IsNullOrWhiteSpace(searchParam.ExperimentName), o => o.ExperimentName.Contains(searchParam.ExperimentName))
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.WhereIf(searchParam.PhaseId != null, o => o.PhaseId == searchParam.PhaseId)
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.WhereIf(searchParam.DeclarationTypeId != null, o => o.PhaseId == searchParam.DeclarationTypeId)
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.WhereIf(searchParam.IndicationTypeId != null, o => o.PhaseId == searchParam.IndicationTypeId)
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.WhereIf(searchParam.CROId != null, o => o.CROId == searchParam.CROId)
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.WhereIf(searchParam.BeginDate != null, o => o.CreateTime >= searchParam.BeginDate)
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.WhereIf(searchParam.EndDate != null, o => o.CreateTime <= searchParam.EndDate)
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.WhereIf(searchParam.AttendedReviewerType != null, o => o.AttendedReviewerType == searchParam.AttendedReviewerType)
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.WhereIf(multiModalityIdSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.Modality) == multiModalityIdSelectCount)
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.WhereIf(multiCriteriaSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.Criterion) == multiCriteriaSelectCount)
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.WhereIf(multiReviewTypeSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.ReviewType) == multiReviewTypeSelectCount)
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.WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id))
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.WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.ProjectManager && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.APM, t => t.IsDeleted == false)
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.ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { userTypeEnumInt = _userInfo.UserTypeEnumInt, userId = _userInfo.Id });
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return await query.ToPagedListAsync(searchParam.PageIndex, searchParam.PageSize, string.IsNullOrWhiteSpace(searchParam.SortField) ? "CreateTime" : searchParam.SortField, searchParam.Asc);
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}
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//过滤废除的项目
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public async Task<List<TrialSelectDTO>> GetTrialSelect()
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{
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return await _trialRepository.AsQueryable()
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.WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id))
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.WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.ProjectManager && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.APM, t => t.IsDeleted == false)
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.ProjectTo<TrialSelectDTO>(_mapper.ConfigurationProvider).ToListAsync();
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}
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/// <summary>
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/// 获取项目基本信息
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/// </summary>
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/// <param name="projectId"></param>
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/// <returns></returns>
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[HttpGet("{projectId:guid}")]
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public async Task<TrialDetailDTO> GetTrialInfoAndLockState(Guid projectId)
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{
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return (await _trialRepository.Where(o => o.Id == projectId).IgnoreQueryFilters().ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider).FirstOrDefaultAsync()).IfNullThrowException();
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}
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[NonDynamicMethod]
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public async Task<int> GetTrialMaxState(Guid trialId)
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{
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return await _repository.Where<EnrollDetail>(t => t.TrialId == trialId).MaxAsync(u => (int?)u.EnrollStatus) ?? 0;
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}
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[HttpGet("{trialId:guid}")]
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public async Task<TrialAndTrialStateVieModel> GetTrialInfoAndMaxTrialState(Guid trialId)
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{
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return new TrialAndTrialStateVieModel()
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{
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TrialView = await GetTrialInfoAndLockState(trialId),
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TrialMaxState = await GetTrialMaxState(trialId)
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};
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}
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[HttpGet("{trialId:guid}")]
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public async Task<int> GetTrialExpeditedState(Guid trialId)
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{
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var trial = await _trialRepository.FirstOrDefaultAsync(u => u.Id == trialId).IfNullThrowConvertException();
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return trial.Expedited;
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}
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/// <summary>
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/// 添加项目
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/// </summary>
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/// <param name="trialAddModel"></param>
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/// <returns></returns>
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[NonDynamicMethod]
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public virtual async Task<IResponseOutput<Trial>> AddOrUpdateTrial(TrialCommand trialAddModel)
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{
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// 到时候 策略授权 统一改 归类
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if (!(_userInfo.UserTypeEnumInt == (int)UserTypeEnum.APM || _userInfo.UserTypeEnumInt == (int)UserTypeEnum.ProjectManager || _userInfo.UserTypeEnumInt == (int)UserTypeEnum.SuperAdmin))
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{
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throw new BusinessValidationFailedException("仅PM/APM可以操作!");
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}
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if (trialAddModel.Id == Guid.Empty || trialAddModel.Id == null)
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{
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if (await _trialRepository.AnyAsync(u => u.TrialCode == trialAddModel.TrialCode))
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{
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throw new BusinessValidationFailedException("Same Trial ID already exists.");
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}
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var dbMaxCode = await _trialRepository.Where(t => t.CreateTime.Year == DateTime.Now.Year && t.TrialType == trialAddModel.TrialType).Select(t => t.Code).DefaultIfEmpty().MaxAsync();
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var currentYearMaxCodeNext = dbMaxCode + 1;
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//var test = _trialRepository.Where(t => t.CreateTime.Year == DateTime.Now.Year + 1).Select(t => t.Code).DefaultIfEmpty(1).ToList();
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var trial = _mapper.Map<Trial>(trialAddModel);
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//trial.Id = NewId.NextGuid();
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var yearStr = DateTime.Now.Year.ToString();
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trial.Code = currentYearMaxCodeNext;
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trial.TrialCode = (trial.TrialType == 1 ? yearStr.Substring(yearStr.Length - 2) : "T0") + trial.TrialCode + currentYearMaxCodeNext.ToString("D3");
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//多选信息
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trialAddModel.ModalityIds.ForEach(modalityId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = modalityId, KeyName = StaticData.Modality, TrialId = trial.Id }));
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trialAddModel.CriterionIds.ForEach(criterionId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = criterionId, KeyName = StaticData.Criterion, TrialId = trial.Id }));
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trialAddModel.ReviewTypeIds.ForEach(ReviewTypeId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = ReviewTypeId, KeyName = StaticData.ReviewType, TrialId = trial.Id }));
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//添加项目后 项目状态变更为申请下载简历
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trial.TrialEnrollStatus = (int)TrialEnrollStatus.ChooseDoctor;
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//trial.TrialStatusStr = StaticData.TrialInitializing;
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//状态变更详细表
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trial.ClinicalTrialProjectDetails.Add(new TrialStatusDetail() { TrialId = trial.Id, TrialStatus = (int)TrialEnrollStatus.ChooseDoctor });
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trial = await _trialRepository.AddAsync(trial);
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//如果是PM， 则需要将该人员添加到 运维人员表
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//添加运维人员PM
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await _repository.AddAsync(new TrialUser() { TrialId = trial.Id, UserId = _userInfo.Id ,JoinTime = DateTime.Now});
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// 添加扩展信息表记录
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await _repository.AddAsync(new TrialPaymentPrice() { TrialId = trial.Id });
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//添加访视
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await _repository.AddAsync(new VisitStage { TrialId = trial.Id, VisitNum = 0, BlindName = "B" + 0.ToString("D3"), VisitDay = 1, VisitName = "Baseline", IsBaseLine = true });
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await _repository.AddAsync(new VisitStage { TrialId = trial.Id, VisitNum = 1, BlindName = "B" + 10.ToString("D3"), VisitDay = 30, VisitName = "Visit 1" });
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var success = await _repository.SaveChangesAsync();
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_provider.Set(trial.Id.ToString(), StaticData.TrialInitializing, TimeSpan.FromDays(7));
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return ResponseOutput.Ok(trial);
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}
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else
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{
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var updateModel = trialAddModel;
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if (!await _repository.AnyAsync<Trial>(u => u.Id == trialAddModel.Id && (u.TrialStatusStr == StaticData.TrialInitializing || u.TrialStatusStr == StaticData.TrialOngoing)))
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{
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throw new BusinessValidationFailedException("项目初始化或者进行中时 才允许操作");
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}
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// 判断项目Id 是否已经存在
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if (await _repository.AnyAsync<Trial>(u => u.TrialCode == updateModel.TrialCode && u.Id != updateModel.Id))
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{
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throw new BusinessValidationFailedException("Same Trial ID already exists.");
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}
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var trial = await _repository.FirstOrDefaultAsync<Trial>(t => t.Id == updateModel.Id);
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//删除中间表 Title对应的记录
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await _repository.BatchDeleteAsync<TrialDictionary>(t => t.TrialId == updateModel.Id);
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//重新插入新的 Title记录
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updateModel.ModalityIds.ForEach(modalityId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = modalityId, KeyName = StaticData.Modality, TrialId = trial.Id }));
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updateModel.CriterionIds.ForEach(criterionId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = criterionId, KeyName = StaticData.Criterion, TrialId = trial.Id }));
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updateModel.ReviewTypeIds.ForEach(ReviewTypeId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = ReviewTypeId, KeyName = StaticData.ReviewType, TrialId = trial.Id }));
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if (updateModel.Expedited != trial.Expedited && updateModel.Expedited != null)
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{
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TrialExpeditedChange = true;
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await TrialExpeditedStatusChange(trial.Id, trial.Expedited, (int)updateModel.Expedited);
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}
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_mapper.Map(updateModel, trial);
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var success = await _repository.SaveChangesAsync();
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return ResponseOutput.Ok(trial);
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}
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}
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// TODO: 需要优化，嵌套两层 switch case ？
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[NonDynamicMethod]
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private async Task TrialExpeditedStatusChange(Guid trialId, int oldState, int newState)
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{
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switch (oldState)
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{
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case (int)TrialExpedited.None:
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switch (newState)
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{
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case (int)TrialExpedited.ExpeditedIn24H:
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await _repository.BatchUpdateAsync<Workload>(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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{
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TimepointIn24H = u.Timepoint,
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AdjudicationIn24H = u.Adjudication,
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Timepoint = 0,
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Adjudication = 0
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});
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break;
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case (int)TrialExpedited.ExpeditedIn48H:
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await _repository.BatchUpdateAsync<Workload>(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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{
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TimepointIn48H = u.Timepoint,
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AdjudicationIn48H = u.Adjudication,
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Timepoint = 0,
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Adjudication = 0
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});
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break;
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}
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//_workloadRepository.Update(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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//{
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// Timepoint = 0,
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// Adjudication = 0
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//});
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break;
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case (int)TrialExpedited.ExpeditedIn24H:
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switch (newState)
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{
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case (int)TrialExpedited.None:
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await _repository.BatchUpdateAsync<Workload>(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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{
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Timepoint = u.TimepointIn24H,
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Adjudication = u.AdjudicationIn24H,
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TimepointIn24H = 0,
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AdjudicationIn24H = 0
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});
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break;
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case (int)TrialExpedited.ExpeditedIn48H:
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await _repository.BatchUpdateAsync<Workload>(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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{
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TimepointIn48H = u.TimepointIn24H,
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AdjudicationIn48H = u.AdjudicationIn24H,
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TimepointIn24H = 0,
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AdjudicationIn24H = 0
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});
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break;
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}
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//_workloadRepository.Update(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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//{
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// TimepointIn24H = 0,
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// AdjudicationIn24H = 0
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//});
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break;
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case (int)TrialExpedited.ExpeditedIn48H:
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switch (newState)
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{
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case (int)TrialExpedited.None:
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await _repository.BatchUpdateAsync<Workload>(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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{
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Timepoint = u.TimepointIn48H,
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Adjudication = u.AdjudicationIn48H,
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TimepointIn48H = 0,
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AdjudicationIn48H = 0
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});
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break;
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case (int)TrialExpedited.ExpeditedIn24H:
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await _repository.BatchUpdateAsync<Workload>(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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{
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TimepointIn24H = u.TimepointIn48H,
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AdjudicationIn24H = u.AdjudicationIn48H,
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TimepointIn48H = 0,
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AdjudicationIn48H = 0
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});
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break;
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}
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//_workloadRepository.Update(t => t.IsLock == false && t.TrialId == trialId, u => new Workload()
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//{
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// TimepointIn48H = 0,
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// AdjudicationIn48H = 0
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//});
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break;
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}
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}
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/// <summary> 删除临床项目 </summary>
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/// <param name="trialId">临床试验项目Id</param>
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[HttpDelete, Route("{trialId:guid}")]
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[TypeFilter(typeof(TrialResourceFilter))]
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public async Task<IResponseOutput> DeleteTrial(Guid trialId)
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{
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var trial = await _trialRepository.FirstOrDefaultAsync(u => u.Id == trialId);
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if (trial == null) return Null404NotFound(trial);
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if (trial.VisitPlanConfirmed)
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{
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return ResponseOutput.NotOk("Trial访视计划已经确认，无法删除");
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}
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if (await _repository.AnyAsync<Enroll>(u => u.TrialId == trialId))
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{
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return ResponseOutput.NotOk("该Trial有医生入组或在入组流程中，无法删除");
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}
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if (await _repository.AnyAsync<TrialSite>(u => u.TrialId == trialId))
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{
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return ResponseOutput.NotOk("该Trial下面有Site，无法删除");
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}
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//PM 可以删除项目 仅仅在没有site 参与者只有他自己的时候
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if (_userInfo.UserTypeEnumInt == (int)UserTypeEnum.ProjectManager)
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{
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//参与者仅有他自己时，可以删除
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if (await _trialUserRepository.CountAsync(t => t.TrialId == trialId) == 1)
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{
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var success1 = await _repository.BatchDeleteAsync<Trial>(o => o.Id == trialId) ||
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await _repository.BatchDeleteAsync<TrialUser>(t => t.TrialId == trialId) ||
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await _repository.BatchDeleteAsync<TrialDictionary>(t => t.TrialId == trialId);
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return ResponseOutput.Result(success1);
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}
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}
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if (await _repository.AnyAsync<TrialUser>(u => u.TrialId == trialId))
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{
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return ResponseOutput.NotOk("该Trial下面有参与者，无法删除");
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}
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var success = await _repository.BatchDeleteAsync<Trial>(o => o.Id == trialId) ||
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await _repository.BatchDeleteAsync<TrialUser>(t => t.TrialId == trialId) ||
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await _repository.BatchDeleteAsync<TrialDictionary>(t => t.TrialId == trialId) ||
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await _repository.BatchDeleteAsync<TrialSiteUser>(t => t.TrialId == trialId);
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return ResponseOutput.Result(success);
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}
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[HttpPost]
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public async Task<PageOutput<TrialDetailDTO>> GetReviewerTrialListByEnrollmentStatus(TrialByStatusQueryDTO param)
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{
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var query = _trialRepository.AsQueryable()
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.WhereIf(param.Status == 5, t => t.EnrollList.Any(u => u.EnrollStatus == (int)EnrollStatus.HasCommittedToCRO))
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.WhereIf(param.Status == 8, t => t.EnrollList.Any(u => u.EnrollStatus == (int)EnrollStatus.InviteIntoGroup))
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.WhereIf(param.Status == 10, t => t.EnrollList.Any(u => u.EnrollStatus == (int)EnrollStatus.DoctorReading))
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.WhereIf(param.Status == 14, t => t.EnrollList.Any(u => u.EnrollStatus == (int)EnrollStatus.Finished))
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.ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { userTypeEnumInt = _userInfo.UserTypeEnumInt, userId = _userInfo.Id });
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return await query.ToPagedListAsync(param.PageIndex, param.PageSize, string.IsNullOrWhiteSpace(param.SortField) ? "CreateTime" : param.SortField, param.Asc);
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}
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/// <summary>
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/// 根据项目Id 获取医生Id，用于出发计算费用
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/// </summary>
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public async Task<List<Guid>> GetTrialEnrollmentReviewerIds(Guid trialId)
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{
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return await _repository.Where<Enroll>(u => u.TrialId == trialId &&
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u.EnrollStatus >= (int)EnrollStatus.DoctorReading).Select(u => u.DoctorId).Distinct().ToListAsync();
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}
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[HttpPost("{trialId:guid}/{confirmOrCancel:bool}")]
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[TrialAudit(AuditType.TrialAudit, AuditOptType.ConfirmTrialVisitPlan)]
|
||
[TypeFilter(typeof(TrialResourceFilter))]
|
||
public async Task<IResponseOutput> ConfirmTrialVisitPlan(Guid trialId, bool confirmOrCancel = true)
|
||
{
|
||
|
||
//取消的时候要做验证 确认的话，前端操作多次也没关系
|
||
if (!confirmOrCancel)
|
||
{
|
||
if (await _repository.AnyAsync<Subject>(t => t.TrialId == trialId))
|
||
{
|
||
return ResponseOutput.NotOk("VisitPlan has been generated for some subjects,can not revert editable state");
|
||
}
|
||
}
|
||
|
||
await _trialRepository.BatchUpdateNoTrackingAsync(u => u.Id == trialId, t => new Trial() { VisitPlanConfirmed = confirmOrCancel });
|
||
|
||
await _repository.BatchUpdateAsync<VisitStage>(u => u.Id == trialId, t => new VisitStage() { IsConfirmed = true });
|
||
|
||
|
||
return ResponseOutput.Ok();
|
||
}
|
||
|
||
|
||
#region 医生用户接口
|
||
|
||
/// <summary> 分页获取医生参与的临床实验项目列表（查询条件）</summary>
|
||
/// <returns></returns>
|
||
[HttpPost]
|
||
public async Task<PageOutput<TrialDetailDTO>> GetTrialListByReviewer(ReviewerTrialQueryDTO searchModel)
|
||
{
|
||
var query = _trialRepository
|
||
.WhereIf(searchModel.EnrollStatus != null, o => (int)searchModel.EnrollStatus! == 10 ? o.EnrollList.Any(o => o.EnrollStatus >= 10 && o.EnrollStatus <= 13 && o.DoctorId == _userInfo.Id) : o.EnrollList.Any(o => o.EnrollStatus == searchModel.EnrollStatus && o.DoctorId == _userInfo.Id))
|
||
.WhereIf(searchModel.Expedited != null, o => o.Expedited == searchModel.Expedited)
|
||
.WhereIf(!string.IsNullOrEmpty(searchModel.Code), o => o.TrialCode.Contains(searchModel.Code))
|
||
.WhereIf(!string.IsNullOrWhiteSpace(searchModel.Indication), o => o.Indication.Contains(searchModel.Indication))
|
||
.WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id))
|
||
.ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { userTypeEnumInt = _userInfo.UserTypeEnumInt, userId = _userInfo.Id });
|
||
|
||
|
||
return await query.ToPagedListAsync(searchModel.PageIndex, searchModel.PageSize, string.IsNullOrWhiteSpace(searchModel.SortField) ? "CreateTime" : searchModel.SortField, searchModel.Asc);
|
||
|
||
|
||
|
||
}
|
||
|
||
|
||
/// <summary>
|
||
/// 医生确认入组或拒绝入组
|
||
/// </summary>
|
||
/// <param name="trialId">项目Id</param>
|
||
/// <param name="status">9-拒绝入组，10-确认入组</param>
|
||
/// <returns></returns>
|
||
[HttpPost("{trialId:guid}/{status:int}")]
|
||
|
||
[TypeFilter(typeof(TrialResourceFilter))]
|
||
public async Task<IResponseOutput> UpdateEnrollStatus(Guid trialId, int status)
|
||
{
|
||
await _repository.AddAsync(new EnrollDetail()
|
||
{
|
||
DoctorId = _userInfo.Id,
|
||
TrialId = trialId,
|
||
EnrollStatus = status,
|
||
OptUserType = (int)SystemUserType.DoctorUser,
|
||
});
|
||
return ResponseOutput.Result(await _repository.BatchUpdateAsync<Enroll>(u => u.TrialId == trialId && u.DoctorId == _userInfo.Id, e => new Enroll
|
||
{
|
||
EnrollStatus = status
|
||
}));
|
||
}
|
||
|
||
#endregion
|
||
|
||
|
||
|
||
|
||
|
||
|
||
}
|
||
|
||
} |