460 lines
23 KiB
C#
460 lines
23 KiB
C#
using IRaCIS.Application.Interfaces;
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using IRaCIS.Application.Contracts;
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using IRaCIS.Core.Domain.Share;
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using EasyCaching.Core;
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using IRaCIS.Core.Application.Filter;
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using Microsoft.AspNetCore.Mvc;
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using Panda.DynamicWebApi.Attributes;
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using IRaCIS.Core.Infrastructure;
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using Microsoft.Extensions.Options;
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using static IRaCIS.Core.Domain.Share.StaticData;
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using Microsoft.AspNetCore.Authorization;
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using System.Linq.Expressions;
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using System.Linq;
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namespace IRaCIS.Application.Services
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{
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[ApiExplorerSettings(GroupName = "Trial")]
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public class TrialService : BaseService, ITrialService
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{
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private readonly IEasyCachingProvider _provider;
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private readonly IRepository<Trial> _trialRepository;
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private readonly IRepository<TrialUser> _trialUserRepository;
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private readonly IOptionsMonitor<ServiceVerifyConfigOption> _verifyConfig;
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private readonly IOptionsMonitor<SystemEmailSendConfig> _systemEmailSendConfig;
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public bool TrialExpeditedChange { get; set; } = false;
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public TrialService(IEasyCachingProvider provider, IRepository<Trial> trialRepository,
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IRepository<TrialUser> trialUserRepository, IOptionsMonitor<ServiceVerifyConfigOption> verifyConfig
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, IOptionsMonitor<SystemEmailSendConfig> systemEmailSendConfig
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)
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{
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_systemEmailSendConfig = systemEmailSendConfig;
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_verifyConfig = verifyConfig;
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_provider = provider;
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_trialRepository = trialRepository;
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this._trialUserRepository = trialUserRepository;
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}
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/// <summary>
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/// 分页获取临床项目列表 默认后台加急状态为3 查所有的
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/// </summary>
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/// <param name="searchParam"></param>
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/// <returns></returns>
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[HttpPost]
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public async Task<PageOutput<TrialDetailDTO>> GetTrialList(TrialQueryDTO searchParam)
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{
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var multiModalityIdSelectCount = searchParam.ModalityIds.Count;
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var multiCriteriaSelectCount = searchParam.CriterionIds.Count;
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var multiReviewTypeSelectCount = searchParam.ReviewTypeIds.Count;
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Expression<Func<Trial, bool>> trialDeclarationTypeExpression = x => true;
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foreach (var item in searchParam.DeclarationTypeEnumList)
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{
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trialDeclarationTypeExpression = trialDeclarationTypeExpression.And(t => t.DeclarationTypes.Contains($"|{item}|"));
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}
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Expression<Func<Trial, bool>> trialAttendedReviewerTypeExpression = x => true;
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foreach (var item in searchParam.AttendedReviewerTypeEnumList)
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{
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trialAttendedReviewerTypeExpression = trialAttendedReviewerTypeExpression.And(t => t.AttendedReviewerTypes.Contains($"|{item}|"));
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}
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var query = _trialRepository.AsQueryable().IgnoreQueryFilters()
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.WhereIf(!string.IsNullOrEmpty(searchParam.TrialStatusStr), o => o.TrialStatusStr.Contains(searchParam.TrialStatusStr))
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.WhereIf(searchParam.SponsorId != null, o => o.SponsorId == searchParam.SponsorId)
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.WhereIf(searchParam.Expedited != null, o => o.Expedited == searchParam.Expedited)
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.WhereIf(!string.IsNullOrEmpty(searchParam.Code), o => o.TrialCode.Contains(searchParam.Code))
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.WhereIf(!string.IsNullOrWhiteSpace(searchParam.Indication), o => o.Indication.Contains(searchParam.Indication))
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.WhereIf(!string.IsNullOrEmpty(searchParam.ResearchProgramNo), o => o.ResearchProgramNo.Contains(searchParam.ResearchProgramNo))
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.WhereIf(!string.IsNullOrWhiteSpace(searchParam.ExperimentName), o => o.ExperimentName.Contains(searchParam.ExperimentName))
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.WhereIf(searchParam.PhaseId != null, o => o.PhaseId == searchParam.PhaseId)
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.WhereIf(searchParam.DeclarationTypeEnumList.Count > 0, trialDeclarationTypeExpression)
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.WhereIf(searchParam.AttendedReviewerTypeEnumList.Count > 0, trialAttendedReviewerTypeExpression)
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//.WhereIf(searchParam.AttendedReviewerType != null, o => o.AttendedReviewerType == searchParam.AttendedReviewerType)
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.WhereIf(searchParam.IndicationTypeId != null, o => o.IndicationTypeId == searchParam.IndicationTypeId)
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.WhereIf(searchParam.CROId != null, o => o.CROId == searchParam.CROId)
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.WhereIf(searchParam.BeginDate != null, o => o.CreateTime >= searchParam.BeginDate)
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.WhereIf(searchParam.EndDate != null, o => o.CreateTime <= searchParam.EndDate)
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.WhereIf(multiModalityIdSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.Modality) == multiModalityIdSelectCount)
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.WhereIf(multiCriteriaSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.Criterion) == multiCriteriaSelectCount)
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.WhereIf(multiReviewTypeSelectCount > 0, t => t.TrialDicList.Count(t => t.KeyName == StaticData.ReviewType) == multiReviewTypeSelectCount)
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.WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.Admin
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&& _userInfo.UserTypeEnumInt != (int)UserTypeEnum.OP, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id && t.IsDeleted == false) && t.IsDeleted == false)
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.ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new { userTypeEnumInt = _userInfo.UserTypeEnumInt, userId = _userInfo.Id , isEn_Us= _userInfo.IsEn_Us });
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return await query.ToPagedListAsync(searchParam.PageIndex, searchParam.PageSize, string.IsNullOrWhiteSpace(searchParam.SortField) ? "CreateTime" : searchParam.SortField, searchParam.Asc);
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}
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//过滤废除的项目
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public async Task<List<TrialSelectDTO>> GetTrialSelect()
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{
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return await _trialRepository.AsQueryable().IgnoreQueryFilters()
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.WhereIf(_userInfo.UserTypeEnumInt != (int)UserTypeEnum.SuperAdmin && _userInfo.UserTypeEnumInt !=(int)UserTypeEnum.Admin && _userInfo.UserTypeEnumInt != (int)UserTypeEnum.OP
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, t => t.TrialUserList.Any(t => t.UserId == _userInfo.Id) && t.IsDeleted == false)
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.ProjectTo<TrialSelectDTO>(_mapper.ConfigurationProvider).ToListAsync();
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}
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/// <summary>
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/// 获取项目基本信息
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/// </summary>
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/// <param name="projectId"></param>
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/// <returns></returns>
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[HttpGet("{projectId:guid}")]
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public async Task<TrialDetailDTO> GetTrialInfoAndLockState(Guid projectId)
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{
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return (await _trialRepository.Where(o => o.Id == projectId).IgnoreQueryFilters().ProjectTo<TrialDetailDTO>(_mapper.ConfigurationProvider, new {isEn_Us = _userInfo.IsEn_Us }).FirstOrDefaultAsync()).IfNullThrowException();
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}
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[HttpGet("{trialId:guid}")]
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public async Task<TrialAndTrialStateVieModel> GetTrialInfoAndMaxTrialState(Guid trialId)
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{
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return new TrialAndTrialStateVieModel()
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{
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TrialView = await GetTrialInfoAndLockState(trialId),
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};
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}
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[HttpGet("{trialId:guid}")]
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public async Task<int> GetTrialExpeditedState(Guid trialId)
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{
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var trial = (await _trialRepository.FirstOrDefaultAsync(u => u.Id == trialId)).IfNullThrowException();
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return trial.Expedited;
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}
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/// <summary>
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/// 添加项目
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/// </summary>
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/// <param name="trialAddModel"></param>
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/// <returns></returns>
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[NonDynamicMethod]
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public virtual async Task<IResponseOutput<Trial>> AddOrUpdateTrial(TrialCommand trialAddModel)
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{
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//测试用户 只能创建非正式项目
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if (_userInfo.IsTestUser && trialAddModel.TrialType != TrialType.NoneOfficial)
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{
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//---测试用户 只能创建非正式项目
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throw new BusinessValidationFailedException(_localizer["Trial_TestUserCreateOnlyNonFormal"]);
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}
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if (trialAddModel.Id == Guid.Empty || trialAddModel.Id == null)
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{
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if (await _trialRepository.AnyAsync(u => u.TrialCode == trialAddModel.TrialCode))
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{
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//---已经存在相同的项目编号。
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throw new BusinessValidationFailedException(_localizer["Trial_DuplicateProjectNumber"]);
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}
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var dbMaxCode = await _trialRepository.Where(t => t.CreateTime.Year == DateTime.Now.Year && t.TrialType == trialAddModel.TrialType).Select(t => t.Code).DefaultIfEmpty().MaxAsync();
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var currentYearMaxCodeNext = dbMaxCode + 1;
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//var test = _trialRepository.Where(t => t.CreateTime.Year == DateTime.Now.Year + 1).Select(t => t.Code).DefaultIfEmpty(1).ToList();
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var trial = _mapper.Map<Trial>(trialAddModel);
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//trial.Id = NewId.NextGuid();
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var yearStr = DateTime.Now.Year.ToString();
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trial.Code = currentYearMaxCodeNext;
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trial.TrialCode = (trial.TrialType == TrialType.NoneOfficial ? "T0" : yearStr.Substring(yearStr.Length - 2)) + trial.TrialCode + currentYearMaxCodeNext.ToString("D3");
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trial.DeclarationTypes = $"|{string.Join('|', trialAddModel.DeclarationTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";
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trial.AttendedReviewerTypes = $"|{string.Join('|', trialAddModel.AttendedReviewerTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";
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//多选信息
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trialAddModel.ModalityIds.ForEach(modalityId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = modalityId, KeyName = StaticData.Modality, TrialId = trial.Id }));
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trialAddModel.CriterionIds.ForEach(criterionId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = criterionId, KeyName = StaticData.Criterion, TrialId = trial.Id }));
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trialAddModel.ReviewTypeIds.ForEach(ReviewTypeId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = ReviewTypeId, KeyName = StaticData.ReviewType, TrialId = trial.Id }));
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//添加项目后 项目状态变更为申请下载简历
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trial.TrialEnrollStatus = (int)TrialEnrollStatus.ChooseDoctor;
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//trial.TrialStatusStr = StaticData.TrialInitializing;
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//状态变更详细表
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trial.ClinicalTrialProjectDetails.Add(new TrialStatusDetail() { TrialId = trial.Id, TrialStatus = (int)TrialEnrollStatus.ChooseDoctor });
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trial = await _trialRepository.AddAsync(trial);
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//如果是PM， 则需要将该人员添加到 运维人员表
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//添加运维人员PM
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await _repository.AddAsync(new TrialUser() { TrialId = trial.Id, UserId = _userInfo.Id, JoinTime = DateTime.Now });
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//添加访视
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await _repository.AddAsync(new VisitStage { TrialId = trial.Id, VisitNum = 0, BlindName = "B" + 0.ToString("D3"), VisitDay = 0, VisitName = "Baseline", IsBaseLine = true });
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await _repository.AddAsync(new VisitStage { TrialId = trial.Id, VisitNum = 1, BlindName = "B" + 10.ToString("D3"), VisitDay = 30, VisitName = "Visit 1" });
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//默认采用系统邮件
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trial.EmailAuthorizationCode = _systemEmailSendConfig.CurrentValue.AuthorizationCode;
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trial.EmailFromEmail = _systemEmailSendConfig.CurrentValue.FromEmail;
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trial.EmailFromName = _systemEmailSendConfig.CurrentValue.FromName;
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trial.EmailSMTPServerAddress = _systemEmailSendConfig.CurrentValue.Host;
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trial.EmailSMTPServerPort = _systemEmailSendConfig.CurrentValue.Port;
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trial.IsConfigureEmail = true;
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var success = await _repository.SaveChangesAsync();
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_provider.Set(trial.Id.ToString(), StaticData.TrialState.TrialInitializing, TimeSpan.FromDays(7));
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return ResponseOutput.Ok(trial);
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}
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else
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{
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var updateModel = trialAddModel;
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if (!await _repository.AnyAsync<Trial>(u => u.Id == trialAddModel.Id && (u.TrialStatusStr == StaticData.TrialState.TrialInitializing || u.TrialStatusStr == StaticData.TrialState.TrialOngoing)))
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{
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//---项目状态只有处于：初始化或者进行中时，才允许操作。
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throw new BusinessValidationFailedException(_localizer["Trial_InvalidProjectStatus"]);
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}
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// 判断项目Id 是否已经存在
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if (await _repository.AnyAsync<Trial>(u => u.TrialCode == updateModel.TrialCode && u.Id != updateModel.Id))
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{
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//---已经存在相同的项目编号。
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throw new BusinessValidationFailedException(_localizer["Trial_DuplicateProjectNumber"]);
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}
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var trial = await _repository.FirstOrDefaultAsync<Trial>(t => t.Id == updateModel.Id);
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//删除中间表 Title对应的记录
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await _repository.BatchDeleteAsync<TrialDictionary>(t => t.TrialId == updateModel.Id);
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//重新插入新的 Title记录
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updateModel.ModalityIds.ForEach(modalityId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = modalityId, KeyName = StaticData.Modality, TrialId = trial.Id }));
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updateModel.CriterionIds.ForEach(criterionId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = criterionId, KeyName = StaticData.Criterion, TrialId = trial.Id }));
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updateModel.ReviewTypeIds.ForEach(ReviewTypeId => trial.TrialDicList.Add(new TrialDictionary() { DictionaryId = ReviewTypeId, KeyName = StaticData.ReviewType, TrialId = trial.Id }));
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if (updateModel.Expedited != trial.Expedited && updateModel.Expedited != null)
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{
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TrialExpeditedChange = true;
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}
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_mapper.Map(updateModel, trial);
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trial.DeclarationTypes = $"|{string.Join('|', updateModel.DeclarationTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";
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trial.AttendedReviewerTypes = $"|{string.Join('|', updateModel.AttendedReviewerTypeEnumList.Select(x => ((int)x).ToString()).ToList())}|";
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var success = await _repository.SaveChangesAsync();
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return ResponseOutput.Ok(trial);
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}
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}
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/// <summary> 真删除项目 方便清理测试数据 </summary>
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/// <param name="trialId">临床试验项目Id</param>
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[AllowAnonymous]
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[HttpDelete, Route("{trialId:guid}")]
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public async Task<IResponseOutput> DeleteTrial(Guid trialId)
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{
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if (_verifyConfig.CurrentValue.OpenTrialRelationDelete)
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{
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await _repository.BatchDeleteAsync<CheckChallengeDialog>(o => o.SubjectVisit.TrialId == trialId);
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await _repository.BatchDeleteAsync<ClinicalDataTrialSet>(o => o.TrialId == trialId);
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await _repository.BatchDeleteAsync<ClinicalQuestionAnswer>(o => o.ClinicalForm.TrialId == trialId);
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await _repository.BatchDeleteAsync<ClinicalQuestionAnswer>(o => o.ClinicalForm.TrialId == trialId);
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await _repository.BatchDeleteAsync<ClinicalForm>(o => o.TrialId == trialId);
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await _repository.BatchDeleteAsync<CriterionNidusSystem>(o => o.TrialReadingCriterion.TrialId == trialId);
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await _repository.BatchDeleteAsync<CriterionNidusTrial>(o => o.TrialReadingCriterion.TrialId == trialId);
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await _repository.BatchDeleteAsync<CheckChallengeDialog>(o => o.SubjectVisit.TrialId == trialId);
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await _repository.BatchDeleteAsync<ClinicalDataTrialSet>(o => o.TrialId == trialId);
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await _repository.BatchDeleteAsync<InspectionFile>(o => o.TrialId == trialId);
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await _repository.BatchDeleteAsync<CriterionNidusSystem>(o => o.TrialReadingCriterion.TrialId == trialId);
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await _repository.BatchDeleteAsync<DataInspection>(o => o.TrialId == trialId);
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await _repository.BatchDeleteAsync<DicomStudy>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<StudyMonitor>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<DicomSeries>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<DicomInstance>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<NoneDicomStudyFile>(t => t.NoneDicomStudy.TrialId == trialId);
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await _repository.BatchDeleteAsync<NoneDicomStudy>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<OrganTrialInfo>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<PreviousHistory>(t => t.SubjectVisit.TrialId == trialId);
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await _repository.BatchDeleteAsync<PreviousOther>(t => t.SubjectVisit.TrialId == trialId);
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await _repository.BatchDeleteAsync<PreviousPDF>(t => t.SubjectVisit.TrialId == trialId);
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await _repository.BatchDeleteAsync<QCChallengeDialog>(t => t.QCChallenge.TrialId == trialId);
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await _repository.BatchDeleteAsync<QCChallenge>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingClinicalDataPDF>(t => t.ReadingClinicalData.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingClinicalData>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingGlobalTaskInfo>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingJudgeInfo>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingMedicalReviewDialog>(t => t.TaskMedicalReview.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingMedicineQuestionAnswer>(t => t.TaskMedicalReview.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingMedicineTrialQuestion>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingOncologyTaskInfo>(t => t.VisitTask.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingPeriodPlan>(t => t.ReadingPeriodSet.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingPeriodSet>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingQuestionTrial>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingTableAnswerRowInfo>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingTableQuestionAnswer>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingTableQuestionTrial>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingTaskQuestionAnswer>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingTaskRelation>(t => t.VisitTask.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadModule>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingTaskQuestionAnswer>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<Subject>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<SubjectVisit>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TaskInfluence>(t => t.InfluenceTask.TrialId == trialId);
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await _repository.BatchDeleteAsync<TaskMedicalReview>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TaskMedicalReviewRule>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialStateChange>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<Trial>(o => o.Id == trialId);
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await _repository.BatchDeleteAsync<TrialClinicalDataSetCriterion>(t => t.TrialReadingCriterion.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialCriterionDictionaryCode>(t => t.TrialReadingCriterion.TrialId == trialId);
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await _repository.BatchDeleteAsync<ReadingQuestionCriterionTrial>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialDictionary>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialDocConfirmedUser>(t => t.TrialDocument.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialDocument>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialDocNeedConfirmedUserType>(t => t.TrialDocument.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialEmailNoticeUser>(t => t.TrialEmailNoticeConfig.TrialId == trialId);
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//await _repository.BatchDeleteAsync<TrialExperience>(t => t.TrialId == trialId) ;
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await _repository.BatchDeleteAsync<TrialEmailNoticeUser>(t => t.TrialEmailNoticeConfig.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialEmailNoticeConfig>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialExternalUser>(t => t.TrialId == trialId);
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await _repository.BatchDeleteAsync<TrialQCQuestion>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<TrialQCQuestionAnswer>(t => t.TrialId == trialId);
|
||
|
||
|
||
|
||
|
||
await _repository.BatchDeleteAsync<TrialSign>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<TrialSite>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<TrialSiteSurvey>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<TrialSiteUserSurvey>(t => t.TrialSiteSurvey.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<TrialSiteEquipmentSurvey>(t => t.TrialSiteSurvey.TrialId == trialId);
|
||
|
||
await _repository.BatchDeleteAsync<TrialUser>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<TrialSiteUser>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<VisitStage>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<VisitPlanInfluenceStat>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<VisitPlanInfluenceStudy>(t => t.TrialId == trialId);
|
||
|
||
await _repository.BatchDeleteAsync<VisitTaskReReading>(t => t.OriginalReReadingTask.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<VisitTask>(t => t.TrialId == trialId);
|
||
await _repository.BatchDeleteAsync<TrialStateChange>(t => t.TrialId == trialId) ;
|
||
|
||
return ResponseOutput.Ok();
|
||
|
||
}
|
||
|
||
else
|
||
{
|
||
//---当前运行环境下，不允许删除项目数据。
|
||
return ResponseOutput.NotOk(_localizer["Trial_CannotDeleteProject"]);
|
||
}
|
||
|
||
|
||
}
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
#region 医生用户接口
|
||
|
||
|
||
|
||
|
||
|
||
#endregion
|
||
|
||
|
||
|
||
|
||
|
||
|
||
}
|
||
|
||
}
|