diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
index fe8a227a..8dbf49ec 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
@@ -105,10 +105,11 @@ export default {
       this.resetSuvQuestions()
     })
     FusionEvent.$on('addAnnotation', obj => {
-      this.$set(obj, 'SaveEnum', 0)
+      this.$set(obj, 'SaveEnum', 1)
       this.addAnnotation(obj)
     })
     FusionEvent.$on('removeAnnotation', obj => {
+      this.$set(obj, 'SaveEnum', 0)
       this.removeAnnotation(obj)
     })
     FusionEvent.$on('locateAnnotation', obj => {
@@ -235,7 +236,12 @@ export default {
     handleSave() {
       this.$refs['questions'].validate((valid) => {
         if (!valid) return
-
+        // 是否有标记未保存
+        var existUnSave = this.checkAnnotationStatus(this.questions)
+        if (existUnSave) {
+          this.$alert(this.$t('trials:lugano:message:saveWarning1'))
+          return
+        }
         // 肝脏血池SUVmax
         const liverSUVmax = !isNaN(parseFloat(this.questionForm[this.liverSuvmaxId])) ? parseFloat(this.questionForm[this.liverSuvmaxId]) : 0
         // 纵膈血池SUVmax
@@ -295,6 +301,18 @@ export default {
         this.loading = false
       })
     },
+    checkAnnotationStatus(obj) {
+      for (let i = 0; i < obj.length; i++) {
+        if (obj[i].SaveEnum === 1) {
+          return true
+        }
+        if (obj[i].Childrens && obj[i].Childrens.length > 0) {
+          if (this.checkAnnotationStatus(obj[i].Childrens)) {
+            return true
+          }
+        }
+      }
+    },
     addAnnotation(obj) {
       const { Id, QuestionType } = obj
       this.currentQsId = Id
@@ -443,19 +461,19 @@ export default {
       }
     },
     setQuestionStatus(obj, questionType) {
-      console.log(obj, questionType)
       for (let i = 0; i < obj.length; i++) {
         if (obj[i].QuestionType === questionType) {
           this.$set(obj[i], 'SaveEnum', 1)
-          break
+          return true
         }
         if (obj[i].Childrens && obj[i].Childrens.length > 0) {
-          this.setQuestionStatus(obj[i].Childrens, questionType)
+          if (this.setQuestionStatus(obj[i].Childrens, questionType)) {
+            return true
+          }
         }
       }
     },
     setOutsideMeasuredData(measurement) {
-      console.log('setOutsideMeasuredData: ', measurement)
       if ((measurement.data.remark === 'Liver' && this.liverIsInsideVolume === false) || (measurement.data.remark === 'Mediastinum' && this.lungIsInsideVolume === false)) {
         return
       }
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue b/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue
index 6705149f..a3948634 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue
@@ -119,6 +119,7 @@ export default {
         this.addAnnotation(obj)
       })
       DicomEvent.$on('removeAnnotation', obj => {
+        this.$set(obj, 'SaveEnum', 0)
         this.removeAnnotation(obj)
       })
       DicomEvent.$on('saveAnnotation', obj => {
@@ -251,8 +252,15 @@ export default {
     handleSave() {
       this.$refs['questions'].validate(async(valid) => {
         if (!valid) return
+
         // lugano标准校验脾脏状态是否符合要求
         if (this.criterionType === 2 && this.groupClassify === 3) {
+          // 是否有标记未保存
+          var existUnSave = this.checkAnnotationStatus(this.questions)
+          if (existUnSave) {
+            this.$alert(this.$t('trials:lugano:message:saveWarning'))
+            return
+          }
           var currentSpleenStatus = this.questionForm[this.spleenStatusId]
           var currentSpleenLength = this.questionForm[this.spleenLengthId]
           currentSpleenStatus = isNaN(parseInt(currentSpleenStatus)) ? null : parseInt(currentSpleenStatus)
@@ -337,6 +345,18 @@ export default {
         this.loading = false
       })
     },
+    checkAnnotationStatus(obj) {
+      for (let i = 0; i < obj.length; i++) {
+        if (obj[i].SaveEnum === 1) {
+          return true
+        }
+        if (obj[i].Childrens && obj[i].Childrens.length > 0) {
+          if (this.checkAnnotationStatus(obj[i].Childrens)) {
+            return true
+          }
+        }
+      }
+    },
     setSpleenCommentDisplay() {
       if (this.spleenCommentsId && this.spleenStatusId) {
         for (let i = 0; i < this.questions[0].Childrens.length; i++) {
@@ -573,10 +593,12 @@ export default {
       for (let i = 0; i < obj.length; i++) {
         if (obj[i].QuestionType === questionType) {
           this.$set(obj[i], 'SaveEnum', 1)
-          break
+          return true
         }
         if (obj[i].Childrens && obj[i].Childrens.length > 0) {
-          this.setQuestionStatus(obj[i].Childrens, questionType)
+          if (this.setQuestionStatus(obj[i].Childrens, questionType)) {
+            return true
+          }
         }
       }
     },