diff --git a/src/api/trials.js b/src/api/trials.js
index 3c367114..717ce7c0 100644
--- a/src/api/trials.js
+++ b/src/api/trials.js
@@ -4457,4 +4457,13 @@ export function amendmentPatientInfo(data) {
     method: 'post',
     data
   })
+}
+
+//修改临床数据后 将签名状态变更为未签名
+export function updateReadModuleClinicalData(data) {
+  return request({
+    url: `/ReadingClinicalData/updateReadModuleClinicalData`,
+    method: 'post',
+    data
+  })
 }
\ No newline at end of file
diff --git a/src/components/Dicom/DicomViewer.vue b/src/components/Dicom/DicomViewer.vue
index 8eefb5dd..9b916af2 100644
--- a/src/components/Dicom/DicomViewer.vue
+++ b/src/components/Dicom/DicomViewer.vue
@@ -1218,7 +1218,7 @@ export default {
 
 
 
-.btnBox {
+.dicom-tools .btnBox {
   display: inline-block;
   width: 80px;
   text-align: center;
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/StudyList.vue b/src/views/trials/trials-panel/reading/dicoms/components/StudyList.vue
index ba349335..20fb8faf 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/StudyList.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/StudyList.vue
@@ -17,7 +17,7 @@
             <div
               v-else
               class="dicom-desc"
-              style="width: 150px;white-space: nowrap;overflow: hidden;text-overflow: ellipsis;"
+              style="width: 135px;white-space: nowrap;overflow: hidden;text-overflow: ellipsis;"
             >
                 <div>
                   <div style="text-overflow: ellipsis;overflow: hidden;" v-if="!study.StudyName">
@@ -32,7 +32,37 @@
                     <div>{{ study.Modalities }} ({{ study.SeriesCount }})</div>
                   </div>
                   <div style="text-overflow: ellipsis;overflow: hidden;" :title="study.Description">{{ study.Description }}</div>
-                  
+                  <div class="patient-info" v-if="['PT、CT', 'CT、PT', 'PET-CT'].includes(study.Modalities)">
+                    <el-popover placement="right-start" trigger="hover" popper-class="patient-info-popper">
+                      <h4>{{ $t('trials:ptData:title') }}</h4>
+                      <div class="patient-info-row">
+                        <label>{{ $t('trials:ptData:label:patientSex') }}</label>
+                        <span>{{ study.PatientSex }}</span>
+                      </div>
+                      <div class="patient-info-row">
+                        <label>{{ $t('trials:ptData:label:patientWeight') }}</label>
+                        <span>{{ study.PatientWeight }}</span>
+                      </div>
+                      <div class="patient-info-row">
+                        <label>{{ $t('trials:ptData:label:totalDose') }}</label>
+                        <span>{{ study.RadionuclideTotalDose }}</span>
+                      </div>
+                      <div class="patient-info-row">
+                        <label>{{ $t('trials:ptData:label:halfLife') }}</label>
+                        <span>{{ study.RadionuclideHalfLife }}</span>
+                      </div>
+                      <div class="patient-info-row">
+                        <label>{{ $t('trials:ptData:label:injectTime') }}</label>
+                        <span>{{ study.RadiopharmaceuticalStartTime }}</span>
+                      </div>
+                      <div class="patient-info-row">
+                        <label>{{ $t('trials:ptData:label:acquisitionTime') }}</label>
+                        <span>{{ study.AcquisitionTime }}</span>
+                      </div>
+                      <i slot="reference" class="el-icon-document"
+                        style="font-size: 15px;cursor: pointer;color: #f5f7fa;" />
+                    </el-popover>
+                  </div>
                 </div>
 
             </div>
@@ -99,37 +129,7 @@
                     <el-tooltip class="item" effect="dark" :content="series.description" placement="right">
                       <div style="">{{ series.description }}</div>
                     </el-tooltip>
-                    <div class="patient-info" style="position: absolute;right: 0;top: 30px;" v-if="['PT','PET'].includes(series.modality)">
-                      <el-popover placement="right" trigger="hover" popper-class="patient-info-popper">
-                        <h4>{{ $t('trials:ptData:title') }}</h4>
-                        <div class="patient-info-row">
-                          <label>{{ $t('trials:ptData:label:patientSex') }}</label>
-                          <span>{{ study.PatientSex }}</span>
-                        </div>
-                        <div class="patient-info-row">
-                          <label>{{ $t('trials:ptData:label:patientWeight') }}</label>
-                          <span>{{ study.PatientWeight }}</span>
-                        </div>
-                        <div class="patient-info-row">
-                          <label>{{ $t('trials:ptData:label:totalDose') }}</label>
-                          <span>{{ study.RadionuclideTotalDose }}</span>
-                        </div>
-                        <div class="patient-info-row">
-                          <label>{{ $t('trials:ptData:label:halfLife') }}</label>
-                          <span>{{ study.RadionuclideHalfLife }}</span>
-                        </div>
-                        <div class="patient-info-row">
-                          <label>{{ $t('trials:ptData:label:injectTime') }}</label>
-                          <span>{{ study.RadiopharmaceuticalStartTime }}</span>
-                        </div>
-                        <div class="patient-info-row">
-                          <label>{{ $t('trials:ptData:label:acquisitionTime') }}</label>
-                          <span>{{ study.AcquisitionTime }}</span>
-                        </div>
-                        <i slot="reference" class="el-icon-document"
-                          style="font-size: 15px;cursor: pointer;color: #f5f7fa;" />
-                      </el-popover>
-                    </div>
+                    
                   </p>
 
                   <p v-show="series.sliceThickness && !study.IsCriticalSequence">
@@ -1140,6 +1140,10 @@ export default {
 }
 </style>
 <style lang="scss">
+.patient-info {
+  // display: inline-block;
+  text-align: right;
+}
 .patient-info-popper {
   font-size: 12px;
   color: #ddd;
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/SegmentForm.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/SegmentForm.vue
index ccc374fe..f06ada47 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/SegmentForm.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/SegmentForm.vue
@@ -145,6 +145,7 @@ export default {
             }
         },
         async handleChange(e, key) {
+            this.handleClear(e, key)
             if (key === 'study') {
                 this.seriesList = this.studyList.find(item => item.StudyId === this.form.studyId).SeriesArr
                 this.form.seriesId = null
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue
index d5b2b0c1..1778aa3f 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue
@@ -127,7 +127,7 @@
                         </el-switch>
                         <span style="margin-left: 5px;">{{
                             $t('trials:reading:Segmentations:title:InactiveSegmentationsShow')
-                        }}</span>
+                            }}</span>
                     </div>
                 </div>
                 <template v-if="segmentList.length > 0">
@@ -163,7 +163,8 @@
                             <i class="el-icon-warning-outline" style="color:red;margin-right: 5px;"
                                 :title="$t('trials:reading:Segmentations:tip:segmentationIsNotSave')"
                                 v-if="!curSegmentGroup.isSaved"></i>
-                            <el-button type="success" size="small" :disabled="saveLoading || isMPR"
+                            <el-button type="success" size="small"
+                                :disabled="saveLoading || isMPR || curSegmentGroup.isSaved"
                                 @click="saveSegmentGroup([curSegmentGroup])">
                                 {{ $t("trials:reading:Segmentations:button:save") }}
                             </el-button>
@@ -186,21 +187,39 @@
                             <div class="messageBox">
                                 <el-popover placement="left" :title="item.SegmentLabel" width="200" trigger="hover">
                                     <div class="Bidirectionalbox">
-                                        <div class="BidirectionalBtn" @click.stop="addTip(item)"
+                                        <!-- <div class="BidirectionalBtn" @click.stop="addTip(item)"
                                             v-if="!item.bidirectional">
                                             {{ $t('trials:reading:Segmentations:button:getBidirectional') }}
-                                        </div>
-                                        <template v-else>
+                                        </div> -->
+                                        <template>
                                             <div class="num">
-                                                <span>L:{{ Number(item.bidirectional.maxMajor).toFixed(2) }} mm</span>
-                                                <span>S:{{ Number(item.bidirectional.maxMinor).toFixed(2) }} mm</span>
+                                                <span>L: {{
+                                                    item.bidirectional && item.bidirectional.maxMajor
+                                                        ? Number(item.bidirectional.maxMajor).toFixed(2) : ' '
+                                                }} mm</span>
+                                                <span>S: {{
+                                                    item.bidirectional && item.bidirectional.maxMinor
+                                                        ? Number(item.bidirectional.maxMinor).toFixed(2) : ' '
+                                                }} mm</span>
                                             </div>
                                             <div class="btnBox">
-                                                <svg-icon :icon-class="!item.bidirectionalView ? 'eye' : 'eye-open'"
-                                                    style="color:#000;margin-right: 5px;cursor: pointer;"
-                                                    @click.stop="viewBidirectional([item], !item.bidirectionalView)" />
-                                                <svg-icon icon-class="jumpto" style="color:#000;cursor: pointer;"
-                                                    @click.stop="jumpBidirectional(item)" />
+                                                <div
+                                                    :title="!item.bidirectionalView ? $t('trials:reading:Segmentations:button:eye') : $t('trials:reading:Segmentations:button:eye-open')">
+                                                    <svg-icon :icon-class="!item.bidirectionalView ? 'eye' : 'eye-open'"
+                                                        style="color:#000;margin-right: 5px;cursor: pointer;"
+                                                        @click.stop="viewBidirectional([item], !item.bidirectionalView)"
+                                                        v-if="item.bidirectional" />
+                                                </div>
+                                                <div :title="$t('trials:reading:Segmentations:button:jumpto')">
+                                                    <svg-icon icon-class="jumpto" style="color:#000;cursor: pointer;"
+                                                        @click.stop="jumpBidirectional(item)"
+                                                        v-if="item.bidirectional" />
+                                                </div>
+
+                                                <i class="el-icon-plus" style="color:#000;cursor: pointer;"
+                                                    v-if="!item.bidirectional"
+                                                    :title="$t('trials:reading:Segmentations:button:getBidirectional')"
+                                                    @click.stop="addTip(item)" />
                                             </div>
                                         </template>
                                     </div>
@@ -253,7 +272,8 @@
             </el-collapse-item>
         </el-collapse>
         <div class="saveBtnBox" v-if="readingTaskState < 2 && segmentList && segmentList.length > 1">
-            <el-button type="success" size="small" :disabled="saveLoading || isMPR" @click="saveSegmentGroup()">
+            <el-button type="success" size="small" :disabled="saveLoading || isMPR || curSegmentGroup.isSaved"
+                @click="saveSegmentGroup()">
                 {{ $t("trials:reading:Segmentations:button:saveAll") }}
             </el-button>
         </div>
@@ -746,7 +766,7 @@ export default {
             return name
         },
         getSegmentName(arr, num = 1) {
-            let defaultSegmentName = arr[0].SegmentLabel
+            let defaultSegmentName = this.trialCriterion && this.trialCriterion.DefaultSegmentName && this.trialCriterion.DefaultSegmentName.SegmentNameList && this.trialCriterion.DefaultSegmentName.SegmentNameList.length > 0 ? this.trialCriterion.DefaultSegmentName.SegmentNameList[0] : arr[0].SegmentLabel
             let name = defaultSegmentName + num
             let has = arr.find(item => item.SegmentLabel === name)
             num++
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/StudyList.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/StudyList.vue
index b5595516..c11a3d07 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/StudyList.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/StudyList.vue
@@ -32,6 +32,37 @@
                     <span :title="study.Modalities">{{ `${study.Modalities} (${study.SeriesCount})` }}</span>
                   </div>
                 </template>
+                <div class="patient-info" v-if="['PT、CT', 'CT、PT', 'PET-CT'].includes(study.Modalities)">
+                  <el-popover placement="right-start" trigger="hover" popper-class="patient-info-popper">
+                    <h4>{{ $t('trials:ptData:title') }}</h4>
+                    <div class="patient-info-row">
+                      <label>{{ $t('trials:ptData:label:patientSex') }}</label>
+                      <span>{{ study.PatientSex }}</span>
+                    </div>
+                    <div class="patient-info-row">
+                      <label>{{ $t('trials:ptData:label:patientWeight') }}</label>
+                      <span>{{ study.PatientWeight }}</span>
+                    </div>
+                    <div class="patient-info-row">
+                      <label>{{ $t('trials:ptData:label:totalDose') }}</label>
+                      <span>{{ study.RadionuclideTotalDose }}</span>
+                    </div>
+                    <div class="patient-info-row">
+                      <label>{{ $t('trials:ptData:label:halfLife') }}</label>
+                      <span>{{ study.RadionuclideHalfLife }}</span>
+                    </div>
+                    <div class="patient-info-row">
+                      <label>{{ $t('trials:ptData:label:injectTime') }}</label>
+                      <span>{{ study.RadiopharmaceuticalStartTime }}</span>
+                    </div>
+                    <div class="patient-info-row">
+                      <label>{{ $t('trials:ptData:label:acquisitionTime') }}</label>
+                      <span>{{ study.AcquisitionTime }}</span>
+                    </div>
+                    <i slot="reference" class="el-icon-document"
+                      style="font-size: 15px;cursor: pointer;color: #f5f7fa;" />
+                  </el-popover>
+                </div>
 
               </div>
               <div v-else>
@@ -74,39 +105,9 @@
                       #{{ series.SeriesNumber }}
 
                     </div>
-                    <div v-if="series.Description" class="text-desc" :title="series.Description" style="position: relative;">
+                    <div v-if="series.Description" class="text-desc" :title="series.Description">
                       {{ series.Description }}
-                      <div class="patient-info" style="position: absolute;right: 0;top: 0;" v-if="['PT','PET'].includes(series.Modality)">
-                        <el-popover placement="right" trigger="hover" popper-class="patient-info-popper">
-                          <h4>{{ $t('trials:ptData:title') }}</h4>
-                          <div class="patient-info-row">
-                            <label>{{ $t('trials:ptData:label:patientSex') }}</label>
-                            <span>{{ study.PatientSex }}</span>
-                          </div>
-                          <div class="patient-info-row">
-                            <label>{{ $t('trials:ptData:label:patientWeight') }}</label>
-                            <span>{{ study.PatientWeight }}</span>
-                          </div>
-                          <div class="patient-info-row">
-                            <label>{{ $t('trials:ptData:label:totalDose') }}</label>
-                            <span>{{ study.RadionuclideTotalDose }}</span>
-                          </div>
-                          <div class="patient-info-row">
-                            <label>{{ $t('trials:ptData:label:halfLife') }}</label>
-                            <span>{{ study.RadionuclideHalfLife }}</span>
-                          </div>
-                          <div class="patient-info-row">
-                            <label>{{ $t('trials:ptData:label:injectTime') }}</label>
-                            <span>{{ study.RadiopharmaceuticalStartTime }}</span>
-                          </div>
-                          <div class="patient-info-row">
-                            <label>{{ $t('trials:ptData:label:acquisitionTime') }}</label>
-                            <span>{{ study.AcquisitionTime }}</span>
-                          </div>
-                          <i slot="reference" class="el-icon-document"
-                            style="font-size: 15px;cursor: pointer;color: #f5f7fa;" />
-                        </el-popover>
-                      </div>
+                      
                     </div>
                     <div v-if="series.SliceThickness && !study.IsCriticalSequence" class="text-desc">
                       T: {{ parseFloat(series.SliceThickness).toFixed(digitPlaces) }}
@@ -262,6 +263,10 @@ export default {
 }
 </script>
 <style lang="scss">
+.patient-info {
+  // display: inline-block;
+  text-align: right;
+}
 .patient-info-popper {
   font-size: 12px;
   color: #ddd;
@@ -294,6 +299,7 @@ export default {
   color: #bbb;
   // font-weight: 600;
   white-space: nowrap;
+  // text-align: right;
 }
 
 .patient-info-popper span {
diff --git a/src/views/trials/trials-panel/subject/reading-period/components/AddSubjectRP.vue b/src/views/trials/trials-panel/subject/reading-period/components/AddSubjectRP.vue
index c2fe98bf..52875a57 100644
--- a/src/views/trials/trials-panel/subject/reading-period/components/AddSubjectRP.vue
+++ b/src/views/trials/trials-panel/subject/reading-period/components/AddSubjectRP.vue
@@ -138,7 +138,7 @@ export default {
           addReadModule(this.form).then(res => {
             this.btnLoading = false
             this.$emit('getList')
-            this.$emit('close')
+            this.$emit('close', {visitStageId: this.form.VisitStageId})
             this.form.Name = null
             this.form.VisitStageId = null
             this.$message.success(this.$t('common:message:savedSuccessfully'))
diff --git a/src/views/trials/trials-panel/subject/reading-period/components/ClinicalData.vue b/src/views/trials/trials-panel/subject/reading-period/components/ClinicalData.vue
index 7c2a0024..97d6ea6e 100644
--- a/src/views/trials/trials-panel/subject/reading-period/components/ClinicalData.vue
+++ b/src/views/trials/trials-panel/subject/reading-period/components/ClinicalData.vue
@@ -143,6 +143,15 @@
                   scope.row.IsSign ||
                   scope.row.UploadRole === 0
                   " @click="handleDelete(scope.row)" />
+              <!-- 更新 临床数据已签名，阅片状态待阅片 -->
+              <el-button
+                v-hasPermi="['trials:trials-panel:subject:readingPeriod:edit']" 
+                circle
+                :title="$t('trials:readingPeriod:cd:action:update')" icon="el-icon-refresh" 
+                :disabled="
+                  !scope.row.IsSign ||
+                  scope.row.UploadRole === 0 || data.ReadingStatus > 4" 
+                @click="handleUpdateStatus(scope.row)" />
             </template>
           </el-table-column>
         </el-table>
@@ -285,6 +294,15 @@
                   scope.row.IsSign ||
                   scope.row.UploadRole === 0
                   " @click="handleDelete(scope.row)" />
+              <!-- 更新 临床数据已签名，阅片状态待阅片 -->
+              <el-button
+                v-hasPermi="['trials:trials-panel:subject:readingPeriod:edit']" 
+                circle
+                :title="$t('trials:readingPeriod:cd:action:update')" icon="el-icon-refresh" 
+                :disabled="
+                  !scope.row.IsSign ||
+                  scope.row.UploadRole === 0 || data.ReadingStatus > 4" 
+                @click="handleUpdateStatus(scope.row)" />
             </template>
           </el-table-column>
         </el-table>
@@ -328,6 +346,7 @@ import {
   getTrialClinicalDataSelect,
   getConsistencyAnalysisReadingClinicalDataList,
   signConsistencyAnalysisReadingClinicalData,
+  updateReadModuleClinicalData
 } from '@/api/trials'
 import AddOrEditCD from './AddOrEditCD'
 import Verification from './Verification'
@@ -658,6 +677,28 @@ export default {
         })
         .catch(() => { })
     },
+    async handleUpdateStatus(row) {
+      try {
+        const confirm = await this.$confirm(this.$t('trials:readingPeriod:cd:message:updateCDStatus'), {
+          type: 'warning',
+          distinguishCancelAndClose: true,
+        })
+        if (confirm === 'confirm') {
+          this.loading = true
+          let res = await updateReadModuleClinicalData({readingClinicalDataId: row.Id})
+          this.loading = false
+          if (res.IsSuccess) {
+            this.getList()
+            this.$message.success(this.$t('common:message:savedSuccessfully'))
+          }
+        } else {
+          this.subjectPeriod.visible = true
+        }
+      } catch(e) {
+        this.loading = false
+        console.log(e)
+      }
+    },
     handleSign(from) {
       // this.currentData = { ...row }
       this.currentData.IsBlind = from.IsBlind
diff --git a/src/views/trials/trials-panel/subject/reading-period/index.vue b/src/views/trials/trials-panel/subject/reading-period/index.vue
index 8fa374b5..b3d03a84 100644
--- a/src/views/trials/trials-panel/subject/reading-period/index.vue
+++ b/src/views/trials/trials-panel/subject/reading-period/index.vue
@@ -382,7 +382,7 @@
             <el-dialog v-if="subjectPeriod.visible" :title="subjectPeriod.title" :visible.sync="subjectPeriod.visible"
               width="500px" custom-class="base-dialog-wrapper" :close-on-click-modal="false">
               <SubjectPR :trial-reading-criterion-id="TrialReadingCriterionId" :trial-id="trialId" :data="param"
-                @close="() => { subjectPeriod.visible = false }" @getList="getList" />
+                @close="subjectPeriodClose" @getList="getList" />
             </el-dialog>
             <!-- 编辑受试者阅片期 -->
             <el-dialog v-if="subjectPeriodEdit.visible" :title="subjectPeriodEdit.title"
@@ -527,6 +527,29 @@ export default {
           ? this.$t('trials:readingPeriod:dialogTitle:addSubjectPR')
           : this.$t('trials:readingPeriod:dialogTitle:addSubjectTumorPR')
     },
+    async subjectPeriodClose(obj) {
+      this.subjectPeriod.visible = false
+      if (typeof obj !== 'object' || obj === null) return
+      
+      if (this.param.ReadingSetType === 0 && this.isClinicalReading) {
+        try {
+          const res = await this.$confirm(this.$t('trials:readingPeriod:message:msg1'), {
+            type: 'warning',
+            distinguishCancelAndClose: true,
+          })
+          if (res === 'confirm') {
+            this.param.ReadingSetType = 1
+            this.param.VisitStageId = obj.visitStageId
+            this.subjectPeriod = { visible: true, title: this.$t('trials:readingPeriod:dialogTitle:addSubjectTumorPR') }
+          } else {
+            this.subjectPeriod.visible = true
+          }
+        } catch(e) {
+          console.log(e)
+        }
+      }
+      
+    },
     handleEdit(row, type) {
       this.param = { ...type }
       this.param.VisitStageId = this.param.CutOffVisitId