diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue
index 61d76bc6..830f44b1 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue
@@ -486,6 +486,11 @@ export default {
 
         }
       }
+    },
+    'addOrEdit.visible': {
+      handler() {
+        DicomEvent.$emit('opentableCol', { visible: this.addOrEdit.visible })
+      }
     }
   },
 
@@ -1077,7 +1082,7 @@ export default {
             }
           })
         }
-        
+
       }
       // this.$emit('formItemNumberChange')
     },
@@ -1336,7 +1341,7 @@ export default {
           }
         }
         const val = this.getAnnotationProp(item.MeasureData, item.ImageToolAttribute)
-        this.setFormTableItemData({key: item.TableQuestionId, val})
+        this.setFormTableItemData({ key: item.TableQuestionId, val })
         // this.$set(this.QuestionsForm, item.TableQuestionId, val)
         this.formItemTableNumberChange()
       })
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue
index 1db2a526..0f12415a 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue
@@ -26,13 +26,15 @@
 
         <el-form-item v-if="readingTaskState < 2">
           <div style="text-align:center;">
-            <el-button v-if="taskInfo && taskInfo.IseCRFShowInDicomReading" type="primary" @click="skipTask">
+            <el-button v-if="taskInfo && taskInfo.IseCRFShowInDicomReading" :disabled="isTableVisible" type="primary"
+              @click="skipTask">
               {{ $t('trials:readingReport:button:skip') }}
             </el-button>
-            <el-button type="primary" @click="handleSave">
+            <el-button type="primary" :disabled="isTableVisible" @click="handleSave">
               {{ $t('common:button:save') }}
             </el-button>
-            <el-button v-if="taskInfo && taskInfo.IseCRFShowInDicomReading" type="primary" @click="handleSubmit">
+            <el-button v-if="taskInfo && taskInfo.IseCRFShowInDicomReading" :disabled="isTableVisible" type="primary"
+              @click="handleSubmit">
               {{ $t('common:button:submit') }}
             </el-button>
           </div>
@@ -115,7 +117,8 @@ export default {
       questionsMarkStatus: {},
       digitPlaces: 2,
       questionImageToolAttributeInfo: {},
-      unSaveTargets: []
+      unSaveTargets: [],
+      isTableVisible: false
     }
   },
   mounted() {
@@ -129,6 +132,10 @@ export default {
     this.digitPlaces = digitPlaces === -1 ? this.digitPlaces : digitPlaces
     this.getQuestionCalculateRelation()
     this.getQuestions(true)
+    DicomEvent.$on('opentableCol', (data) => {
+      let { visible } = data
+      this.isTableVisible = visible
+    })
   },
   methods: {
     handleReadingChart(e) {
@@ -241,6 +248,13 @@ export default {
     async handleSave(isMsg) {
       const valid = await this.$refs['questions'].validate()
       if (!valid) return
+      let isSaved = this.verifyAnnotationIsSave()
+      if (isSaved) {
+        let confirm = this.$confirm(this.$t('trials:reading:confirm:AnnotationNotSave'), this.$t('system:menu:confirm:title:warning'), {
+          type: 'warning'
+        })
+        if (!confirm) return false
+      }
       this.loading = true
       try {
         var answers = []
@@ -271,6 +285,13 @@ export default {
     async handleSubmit() {
       const valid = await this.$refs['questions'].validate()
       if (!valid) return
+      let isSaved = this.verifyAnnotationIsSave()
+      if (isSaved) {
+        let confirm = this.$confirm(this.$t('trials:reading:confirm:AnnotationNotSave'), this.$t('system:menu:confirm:title:warning'), {
+          type: 'warning'
+        })
+        if (!confirm) return false
+      }
       await this.handleSave(false)
       await verifyVisitTaskQuestions({ visitTaskId: this.visitTaskId })
       const { ImageAssessmentReportConfirmation } = const_.processSignature
@@ -334,6 +355,13 @@ export default {
     },
     async skipTask() {
       try {
+        let isSaved = this.verifyAnnotationIsSave()
+        if (isSaved) {
+          let confirm = this.$confirm(this.$t('trials:reading:confirm:AnnotationNotSave'), this.$t('system:menu:confirm:title:warning'), {
+            type: 'warning'
+          })
+          if (!confirm) return false
+        }
         // 是否确认跳过？
         const confirm = await this.$confirm(
           this.$t('trials:readingReport:message:skipConfirm'),