diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue
index 3374aeb2..0a1ebb29 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue
@@ -33,12 +33,12 @@
               </template>
             </el-input>
             <!-- 测量 -->
-            <el-button v-if="!questionForm[question.Id] && readingTaskState!== 2" size="mini" type="text" @click="addAnnotation(question)">{{ $t('trials:lugano:button:addAnnotation') }}</el-button>
+            <el-button v-if="(!questionForm[question.Id] && ((question.QuestionType === 51 && liverIsInsideVolume) || (question.QuestionType === 52 && lungIsInsideVolume)) && readingTaskState!== 2)" size="mini" type="text" @click="addAnnotation(question)">{{ $t('trials:lugano:button:addAnnotation') }}</el-button>
             <!-- 清除标记 -->
-            <el-button v-if="questionForm[question.Id] && readingTaskState!== 2" size="mini" type="text" style="padding: 7px 5px;" @click="removeAnnotation(question)">{{ $t('trials:lugano:button:clearAnnotation') }}</el-button>
+            <el-button v-if="(questionForm[question.Id] || (question.QuestionType === 51 && !liverIsInsideVolume) || (question.QuestionType === 52 && !lungIsInsideVolume)) && readingTaskState!== 2" size="mini" type="text" style="padding: 7px 5px;" @click="removeAnnotation(question)">{{ $t('trials:lugano:button:clearAnnotation') }}</el-button>
             <!-- 定位 -->
             <el-button
-              v-if="questionForm[question.Id]"
+              v-if="(questionForm[question.Id] || (question.QuestionType === 51 && !liverIsInsideVolume) || (question.QuestionType === 52 && !lungIsInsideVolume))"
               size="mini"
               type="text"
               style="margin-left: -5px;padding: 7px 5px;"
@@ -224,6 +224,8 @@
         :reading-task-state="readingTaskState"
         :question-form="questionForm"
         :visit-task-id="visitTaskId"
+        :lung-is-inside-volume="lungIsInsideVolume"
+        :liver-is-inside-volume="liverIsInsideVolume"
         @setFormItemData="setFormItemData"
         @resetFormItemData="resetFormItemData"
         @addAnnotation="addAnnotation"
@@ -258,6 +260,14 @@ export default {
     visitTaskId: {
       type: String,
       default: ''
+    },
+    lungIsInsideVolume: {
+      type: Boolean,
+      default: true
+    },
+    liverIsInsideVolume: {
+      type: Boolean,
+      default: true
     }
   },
   data() {
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
index 1419ed08..1b6eabbc 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
@@ -14,6 +14,8 @@
           :question-form="questionForm"
           :reading-task-state="readingTaskState"
           :visit-task-id="visitTaskId"
+          :lung-is-inside-volume="lungIsInsideVolume"
+          :liver-is-inside-volume="liverIsInsideVolume"
           @setFormItemData="setFormItemData"
           @resetFormItemData="resetFormItemData"
           @addAnnotation="addAnnotation"
@@ -287,7 +289,6 @@ export default {
     },
 
     removeAnnotation(obj) {
-      console.log('question_removeAnnotation')
       const { Id } = obj
       var idx = this.measurements.findIndex(i => i.QuestionId === Id)
       if (idx === -1) return
@@ -297,6 +298,8 @@ export default {
       this.calculatePet5PS = pet5PS
       this.setPet5PSCommentDisplay()
       FusionEvent.$emit('removeAnnotation', { otherMeasureData: this.measurements[idx].OtherMeasureData, type: 'clear' })
+      var remark = this.measurements[idx].OtherMeasureData.data.remark
+      remark === 'Liver' ? this.liverIsInsideVolume = true : remark === 'Mediastinum' ? this.lungIsInsideVolume = true : ''
       this.measurements.splice(idx, 1)
     },
     locateAnnotation(obj) {
@@ -400,6 +403,7 @@ export default {
       this.currentQsId = this.measurements[idx].QuestionId
       // const { QuestionId, QuestionType } = this.measurements[idx]
       this.questionFormChangeState = true
+      remark === 'Liver' ? this.liverIsInsideVolume = true : remark === 'Mediastinum' ? this.lungIsInsideVolume = true : ''
     },
     resetFormItemData(v) {
       this.questionForm[v] = null
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/TableQuestionItem.vue b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/TableQuestionItem.vue
index 68fc9234..faeba76e 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/TableQuestionItem.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/TableQuestionItem.vue
@@ -627,7 +627,7 @@ export default {
       } else {
         this.$set(this.questionForm, 'saveTypeEnum', 0)
       }
-      this.$set(this.questionForm, 'OtherMeasureData', measureData)
+      this.$set(this.questionForm, 'OtherMeasureData', measureData.data)
       var isLymph = this.getQuestionVal(2)
       isLymph = !isNaN(parseInt(isLymph)) ? parseInt(isLymph) : null
       const lesionPart = this.getQuestionVal(8)
@@ -725,20 +725,24 @@ export default {
     handleSave() {
       this.$refs.measurementForm.validate(async valid => {
         if (!valid) return
+        const loading = this.$loading({ fullscreen: true })
         if (!this.isInsideVolume) {
-          this.$alert('当前标记在图像外，不允许保存！', '提示', {
-            callback: action => {
-              this.$message({
-                type: 'info',
-                message: `action: ${action}`
-              })
-            }
+          // this.$alert('当前标记在图像外，不允许保存！', '提示', {
+          //   callback: action => {}
+          // })
+          loading.close()
+          this.$confirm(this.$t('当前标记在图像外，不允许保存！'), {
+            type: 'warning',
+            showCancelButton: false,
+            callback: action => {}
           })
+
           return
         }
         // 消失、无法评估状态的病灶限制不能测量SUV值
         var lesionState = this.getQuestionVal(7)
         if ((lesionState === 2 || lesionState === 3) && this.questionForm.OtherMeasureData) {
+          loading.close()
           this.$confirm(this.$t('评估状态为无法评估或消失的病灶不能测量SUV值！'), {
             type: 'warning',
             showCancelButton: false,
@@ -750,6 +754,7 @@ export default {
         if (this.questionForm.OtherMeasureData) {
           var suvmax = this.getQuestionVal(20)
           if (suvmax === 0) {
+            loading.close()
             this.$confirm(this.$t('当前病灶suv测量值为0，不允许保存！'), {
               type: 'warning',
               showCancelButton: false,
@@ -759,7 +764,6 @@ export default {
           }
         }
 
-        const loading = this.$loading({ fullscreen: true })
         var otherMeasureData = this.questionForm.OtherMeasureData ? Object.assign({}, this.questionForm.OtherMeasureData) : null
         if (otherMeasureData) {
           for (const k in otherMeasureData.data.cachedStats) {
@@ -876,6 +880,7 @@ export default {
           }
           var suvMax = this.getQuestionVal(20)
           this.$emit('resetQuestions', { isLymphLesion, lesionPart, lesionOrgan, suvMax, saveTypeEnum: this.questionForm.saveTypeEnum, rowIndex: this.rowIndex, questionId: this.parentQsId, anwsers: anwsers })
+          this.isInsideVolume = true
         })
         .catch(() => {})
     },
@@ -911,6 +916,7 @@ export default {
       }
       var suvMax = this.getQuestionVal(20)
       this.$emit('resetQuestions', { isLymphLesion, lesionPart, lesionOrgan, suvMax, saveTypeEnum: this.questionForm.saveTypeEnum, rowIndex: this.rowIndex, questionId: this.parentQsId, anwsers: anwsers })
+      this.isInsideVolume = true
     },
     handleDelete() {
       // 是否确认删除？