diff --git a/src/api/reading.js b/src/api/reading.js
index 53cdedae..e686f326 100644
--- a/src/api/reading.js
+++ b/src/api/reading.js
@@ -408,6 +408,14 @@ export function changeSegmentationSavedStatus(data) {
     data
   })
 }
+// 修改分割片段锁定状态
+export function lockOrUnLockSegment(data) {
+  return request({
+    url: `/Segmentation/lockOrUnLockSegment`,
+    method: 'post',
+    data
+  })
+}
 // 图像数据匿名
 export function studyMaskImage(data) {
   return request({
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
index a86af6f4..ccc5bb77 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
@@ -708,8 +708,8 @@ export default {
       criterionType: null,
       tools: [],
       rotateOptions: [
-        { label: this.$t('trials:reading:button:rotateDefault'), val: 1, icon: ''},
-        { label: this.$t('trials:reading:button:rotateVertical'), val: 2, icon: 'rotateVertical'  },
+        { label: this.$t('trials:reading:button:rotateDefault'), val: 1, icon: '' },
+        { label: this.$t('trials:reading:button:rotateVertical'), val: 2, icon: 'rotateVertical' },
         { label: this.$t('trials:reading:button:rotateHorizontal'), val: 3, icon: 'rotateHorizontal' },
         { label: this.$t('trials:reading:button:rotateTurnLeft'), val: 4, icon: 'rotateTurnLeft' },
         { label: this.$t('trials:reading:button:rotateTurnRight'), val: 5, icon: 'rotateTurnRight' }
@@ -1004,6 +1004,24 @@ export default {
     this.getSystemInfoReading();
   },
   methods: {
+    changeScreenSave() {
+      return new Promise(async (reslove, reject) => {
+        if (this.$refs.Segmentations.readingTaskState < 2) {
+          let isSaved = this.$refs.Segmentations.segmentList.some(item => !item.isSaved)
+          if (isSaved) {
+            let confirm = await this.$confirm(this.$t("trials:reading:Segmentations:confirm:changeScreenSave"))
+            if (!confirm) reslove(true)
+            this.$refs.Segmentations.saveSegmentGroup(null, true, () => {
+              reslove(true)
+            })
+          } else {
+            reslove(true)
+          }
+        } else {
+          reslove(true)
+        }
+      })
+    },
     resetHistogram() {
       if (!this.histogramVisible) return false
       if (this.timer['histogram']) {
@@ -3043,6 +3061,10 @@ export default {
     },
     // 更改视图布局
     async changeLayout(v) {
+      if (this.readingTool === 3) {
+        let res = await this.changeScreenSave()
+        if (!res) return false
+      }
       this.setToolsPassive()
       this.fullScreenIndex = null
       this.layout = v
@@ -3356,9 +3378,12 @@ export default {
       }, time)
     },
     // 切换全屏
-    toggleFullScreen(e, index) {
+    async toggleFullScreen(e, index) {
       if (this.isDelay && (this.readingTool === 3 || this.isMPR)) return false
-
+      if (this.readingTool === 3) {
+        let res = await this.changeScreenSave()
+        if (!res) return false
+      }
       this.fullScreenIndex = this.fullScreenIndex === index ? null : index
       this.activeViewportIndex = index
       if (this.readingTool === 3 || this.isMPR) {
@@ -3473,14 +3498,14 @@ export default {
         this.setToolsPassive()
         this.rows = 1
         this.cols = 1
-        this.activeViewportIndex = 0
         this.fullScreenIndex = null
         this.isMPR = false
         obj.isChange = false
         return this.$nextTick(() => {
           DicomEvent.$emit('activeSeries', obj)
           DicomEvent.$emit('changeMPR')
-          this.$refs[`${this.viewportKey}-${this.activeViewportIndex}`][0].setSeriesInfo(obj)
+          this.$refs[`${this.viewportKey}-0`][0].setSeriesInfo(obj)
+          this.activeViewportIndex = 0
           const renderingEngine = getRenderingEngine(renderingEngineId)
           renderingEngine.resize(true, false)
           renderingEngine.render()
@@ -3494,6 +3519,7 @@ export default {
       if (!obj.IsDicom) {
         return this.previewNoneDicoms(obj)
       }
+      this.activeViewportIndex = 0
       this.$refs[`${this.viewportKey}-${this.activeViewportIndex}`][0].setSeriesInfo(obj)
       this.clipPlaying = false
       this.fps = 15
@@ -3516,8 +3542,12 @@ export default {
       this.setToolsPassive()
     },
     // 激活视口
-    activeViewport(index) {
+    async activeViewport(index) {
       if (this.activeViewportIndex === index) return
+      if (this.readingTool === 3) {
+        let res = await this.changeScreenSave()
+        if (!res) return false
+      }
       this.activeViewportIndex = index
       // 切换检查列表
       const series = this.$refs[`${this.viewportKey}-${this.activeViewportIndex}`][0].series
@@ -4174,6 +4204,11 @@ export default {
           if (!data) return resolve(false)
           let viewportSeries = this.$refs[`viewport-MPR-0`][0].series
           if (data && viewportSeries.SeriesInstanceUid === data.SeriesInstanceUid) return resolve(true)
+        } else {
+          if (this.readingTool === 3) {
+            let res = await this.changeScreenSave()
+            if (!res) return false
+          }
         }
         if (!data) {
           let { imageOrientationPatient, imagePositionPatient } = this.$refs[`viewport-${this.activeViewportIndex}`][0].imageInfo
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue
index abc852fc..03bd9f6e 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/Segmentations.vue
@@ -133,8 +133,8 @@
                 <template v-if="segmentList.length > 0">
                     <div class="SegmentGroupBox">
                         <div style="display: flex;align-items: center;">
-                            <el-popover placement="left" width="200px" trigger="click" v-if="readingTaskState < 2"
-                                v-model="popoverVisible" :teleported="true">
+                            <el-popover placement="left" width="200px" trigger="click"
+                                v-if="readingTaskState < 2 && !isMPR" v-model="popoverVisible" :teleported="true">
                                 <div class="SegmentGroupBtnBox">
                                     <div class="SegmentGroupBtn" @click.stop="addSegmentGroup">
                                         {{ $t('trials:reading:Segmentations:button:addSegmentGroup') }}
@@ -151,6 +151,7 @@
                                 </div>
                                 <i slot="reference" class="el-icon-more" style="cursor: pointer;color:#fff" />
                             </el-popover>
+                            <i class="el-icon-more" style="cursor: not-allowed;color: #fff;" v-if="isMPR"></i>
                             <el-select v-model="segmentationId" placeholder="" @change="selectSegmentGroup()"
                                 :disabled="saveLoading">
                                 <el-option v-for="item in segmentList" :key="`${item.segmentationId}`"
@@ -162,7 +163,7 @@
                             <i class="el-icon-warning-outline" style="color:red;margin-right: 5px;"
                                 :title="$t('trials:reading:Segmentations:tip:segmentationIsNotSave')"
                                 v-if="!curSegmentGroup.isSaved"></i>
-                            <el-button type="success" size="small" :disabled="saveLoading"
+                            <el-button type="success" size="small" :disabled="saveLoading && isMPR"
                                 @click="saveSegmentGroup([curSegmentGroup])">
                                 {{ $t("trials:reading:Segmentations:button:save") }}
                             </el-button>
@@ -225,7 +226,7 @@
                                 <i class="el-icon-lock" v-if="item.lock" @click.stop="lockSegment(item, false)"></i>
                                 <el-popover placement="bottom" width="40" trigger="click" class="docShow"
                                     :value="popoverId === `popover-${item.segmentationId}_${item.segmentIndex}`"
-                                    @show="handleClickPopover(item)" v-if="readingTaskState < 2">
+                                    @show="handleClickPopover(item)" v-if="readingTaskState < 2 && !isMPR">
                                     <div class="SegmentGroupBtnBox">
                                         <div class="SegmentGroupBtn" @click.stop="rename('segment', item)">
                                             {{ $t('trials:reading:Segmentations:button:renameSegmentGroup') }}
@@ -244,21 +245,22 @@
                                     </div>
                                     <i slot="reference" class="el-icon-more" style="cursor: pointer;color:#fff" />
                                 </el-popover>
+                                <i class="el-icon-more" style="cursor: not-allowed;color: #fff;" v-if="isMPR"></i>
                             </div>
                         </div>
                     </div>
                 </template>
             </el-collapse-item>
         </el-collapse>
-        <div class="saveBtnBox" v-if="readingTaskState < 2">
-            <el-button type="success" size="small" :disabled="saveLoading" @click="saveSegmentGroup()">
+        <div class="saveBtnBox" v-if="readingTaskState < 2 && segmentList && segmentList.length > 1">
+            <el-button type="success" size="small" :disabled="saveLoading && isMPR" @click="saveSegmentGroup()">
                 {{ $t("trials:reading:Segmentations:button:saveAll") }}
             </el-button>
         </div>
     </div>
 </template>
 <script>
-import { changeSegmentationSavedStatus, getSegmentationList, addOrUpdateSegmentation, deleteSegmentation, getSegmentList, addOrUpdateSegment, deleteSegment, getSegmentBindingList, saveSegmentBindingAndAnswer, getReadingTableQuestionTrialById, getReadingQuestionTrialById } from '@/api/reading'
+import { changeSegmentationSavedStatus, getSegmentationList, addOrUpdateSegmentation, deleteSegmentation, getSegmentList, addOrUpdateSegment, deleteSegment, getSegmentBindingList, saveSegmentBindingAndAnswer, getReadingTableQuestionTrialById, getReadingQuestionTrialById, lockOrUnLockSegment } from '@/api/reading'
 import * as cornerstoneTools from '@cornerstonejs/tools';
 import * as cornerstone from "@cornerstonejs/core";
 import dcmjs from '@/utils/dcmUpload/dcmjs'
@@ -418,7 +420,7 @@ export default {
             if (this.isMPR) return false
             if (Id === this.series.Id && TaskInfo.VisitTaskId === this.visitInfo.VisitTaskId) return false
             this.series = series
-            this.$emit("update:curSegSeries", Object.assign(series, {}))
+            this.$emit("update:curSegSeries", Object.assign({}, series))
             this.getSegmentationList()
         })
         DicomEvent.$on('isloaded', (data) => {
@@ -691,9 +693,12 @@ export default {
         },
         lockSegment(item, lock) {
             if (this.readingTaskState >= 2) return false
+            if (this.isMPR) return false
+            this.$emit('setToolsPassive')
             segmentation.segmentLocking.setSegmentIndexLocked(item.segmentationId, item.segmentIndex, lock)
             item.lock = lock
             if (!lock) this.changeSegmentationSavedStatus(item.segmentationId, lock)
+            this.lockOrUnLockSegment(item.id, lock)
         },
         selectSegment(item, isChange = true) {
             if (isChange) {
@@ -787,6 +792,7 @@ export default {
         },
         async addSegment() {
             if (this.saveLoading) return false
+            if (this.isMPR) return false
             if (this.segmentList.length <= 0) {
                 let obj = {
                     name: this.getSegmentationName(),
@@ -831,6 +837,7 @@ export default {
                 // this.readingSegmentByConfig()
 
             } else {
+                this.changeSegmentationSavedStatus(this.segmentationId, false)
                 let item = this.segmentList.find(i => i.segmentationId === this.segmentationId)
                 let arr = item.segments.sort((a, b) => a.segmentIndex - b.segmentIndex)
                 let segmentIndex = arr[item.segments.length - 1].segmentIndex + 1
@@ -1457,7 +1464,7 @@ export default {
             }
         },
         // 保存整个分组
-        async saveSegmentGroup(list = null, saveSegment = true) {
+        async saveSegmentGroup(list = null, saveSegment = true, callback) {
             try {
                 let segmentList = list ? list : this.segmentList
                 if (segmentList.length <= 0) return false
@@ -1516,6 +1523,7 @@ export default {
                     DicomEvent.$emit("IsBeSegment", { StudyId: this.series.StudyId, Id: this.series.Id, IsBeSegment: f })
                 }
                 this.$emit("update:globalLoading", false)
+                if (callback) callback()
             } catch (err) {
                 this.loading = false
                 console.log(err)
@@ -1703,7 +1711,7 @@ export default {
                                     bidirectional: SegmentJson.bidirectional,
                                     bidirectionalView: true,
                                     view: true,
-                                    lock: true,
+                                    lock: s.IsLock,
                                     id: s.Id
                                 }
                                 obj.segments.push(o)
@@ -1823,6 +1831,20 @@ export default {
                 console.log(err)
             }
         },
+        // 修改分割片段锁定状态
+        async lockOrUnLockSegment(SegmentId, IsLock) {
+            try {
+                let data = {
+                    SegmentId,
+                    IsLock
+                }
+                let res = await lockOrUnLockSegment(data)
+                if (res.IsSuccess) return true
+                return false
+            } catch (err) {
+                console.log(err)
+            }
+        },
         hex2Rgb(hexValue, alpha = 1) {
             const rgx = /^#?([a-f\d])([a-f\d])([a-f\d])$/i;
             const hex = hexValue.replace(rgx, (m, r, g, b) => r + r + g + g + b + b);
@@ -2053,6 +2075,7 @@ export default {
 
     .messageBox {
         color: #333;
+        cursor: not-allowed;
     }
 
     .serialNum {
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/helpers/segmentations.js b/src/views/trials/trials-panel/reading/dicoms3D/components/helpers/segmentations.js
index fc75f336..f229a36e 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/helpers/segmentations.js
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/helpers/segmentations.js
@@ -383,7 +383,7 @@ async function renderSegmentation(series, visitInfo, viewportId, SegmentConfig,
                         let SegmentJson = s.SegmentJson ? JSON.parse(s.SegmentJson) : {};
                         segmentation.segmentIndex.setActiveSegmentIndex(s.SegmentationId, s.SegmentNumber);
                         segmentation.config.color.setSegmentIndexColor(viewportId, s.SegmentationId, s.SegmentNumber, hex2Rgb(s.ColorRgb))
-                        segmentation.segmentLocking.setSegmentIndexLocked(s.SegmentationId, s.SegmentNumber, true)
+                        segmentation.segmentLocking.setSegmentIndexLocked(s.SegmentationId, s.SegmentNumber, s.IsLock)
                         if (SegmentJson.bidirectional) {
                             let an = annotation.state.getAllAnnotations().find(i => i.metadata.segmentationId === s.SegmentationId && i.metadata.segmentIndex === SegmentJson.bidirectional.segmentIndex && i.metadata.toolName === "SegmentBidirectional");
                             if (!an) {