diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue
index 7336fc8d..d620d7d8 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/QuestionItem.vue
@@ -45,7 +45,7 @@
               @click="locateAnnotation(question)"
             >{{ $t('trials:lugano:button:locateAnnotation') }}</el-button>
             <!-- 保存 -->
-            <el-button v-if="questionForm[question.Id] && readingTaskState!== 2 && question.SaveEnum === 1" size="mini" type="text" style="padding: '7px 5px';margin-left:-5px;" @click="saveAnnotation(question)">
+            <el-button v-if="readingTaskState!== 2 && question.SaveEnum === 1" size="mini" type="text" style="padding: '7px 5px';margin-left:-5px;" @click="saveAnnotation(question)">
               <!-- 未保存 -->
               <el-tooltip class="item" effect="dark" :content="$t('trials:reading:button:unsaved')" placement="bottom">
                 <i class="el-icon-warning" style="color:red" />
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
index 40daaef4..ef4f0f3f 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Fusion/Questions.vue
@@ -328,6 +328,10 @@ export default {
       var idx = this.measurements.findIndex(i => i.QuestionId === Id)
       if (idx === -1) return
       this.$set(this.questionForm, Id, '')
+
+      if (!this.questionForm[this.liverSuvmaxId] && !this.questionForm[this.lungSuvmaxId]) {
+        this.clearPet5PS()
+      }
       // var pet5PS = this.setpet5PS()
       // this.questionForm[this.pet5PSId] = pet5PS
       // this.calculatePet5PS = pet5PS
@@ -336,6 +340,7 @@ export default {
       FusionEvent.$emit('removeAnnotation', { otherMeasureData: this.measurements[idx].OtherMeasureData, type: 'clear' })
       var remark = this.measurements[idx].OtherMeasureData.data.remark
       remark === 'Liver' ? this.liverIsInsideVolume = true : remark === 'Mediastinum' ? this.lungIsInsideVolume = true : ''
+      this.setQuestionStatus(this.questions, this.measurements[idx].QuestionType)
       this.measurements.splice(idx, 1)
     },
     locateAnnotation(obj) {
@@ -347,6 +352,18 @@ export default {
 
       FusionEvent.$emit('imageLocation', { otherMeasureData: otherMeasureData })
     },
+    clearPet5PS() {
+      this.questionForm[this.pet5PSId] = ''
+      this.questionForm[this.uptakeFromBaselineId] = ''
+      for (let i = 0; i < this.questions[0].Childrens[0].Childrens.length; i++) {
+        if (this.questions[0].Childrens[0].Childrens[i].QuestionType === 59) {
+          this.questions[0].Childrens[0].Childrens[i].ShowQuestion = 2
+          this.questions[0].Childrens[0].Childrens[i].IsRequired = 3
+          this.questionForm[this.pet5PSCommentsId] = ''
+          break
+        }
+      }
+    },
     saveAnnotation(question) {
       if ((question.QuestionType === 51 && !this.liverIsInsideVolume) || (question.QuestionType === 52 && !this.lungIsInsideVolume)) {
         // 当前标记在图像外
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/QuestionItem.vue b/src/views/trials/trials-panel/reading/dicoms/components/QuestionItem.vue
index 021f4fb1..2e6fdb8f 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/QuestionItem.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/QuestionItem.vue
@@ -46,7 +46,7 @@
             <!-- 定位 -->
             <el-button v-if="questionForm[question.Id]" size="mini" type="text" @click="locateAnnotation(question)">{{ $t('trials:lugano:button:locateAnnotation') }}</el-button>
             <!-- 保存 -->
-            <el-button v-if="questionForm[question.Id] && readingTaskState!== 2 && question.SaveEnum === 1" size="mini" type="text" @click="saveAnnotation(question)">
+            <el-button v-if="readingTaskState!== 2 && question.SaveEnum === 1" size="mini" type="text" @click="saveAnnotation(question)">
               <!-- 未保存 -->
               <el-tooltip class="item" effect="dark" :content="$t('trials:reading:button:unsaved')" placement="bottom">
                 <i class="el-icon-warning" style="color:red" />
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue b/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue
index a60bf11b..84e3efad 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Questions.vue
@@ -505,17 +505,33 @@ export default {
       var idx = this.measurements.findIndex(i => i.QuestionId === Id)
       if (idx === -1) return
       this.$set(this.questionForm, Id, '')
+      if (!this.questionForm[this.spleenTopId] && !this.questionForm[this.spleenBottomId]) {
+        this.clearSpleenStatus()
+      }
       // if (obj.QuestionType === 60 || obj.QuestionType === 61) {
       //   this.$set(this.questionForm, this.spleenStatusId, '')
       //   this.$set(this.questionForm, this.spleenLengthId, '')
       // }
       await store.dispatch('reading/removeNonTargetMeasuredData', { visitTaskId: this.visitTaskId, measureData: this.measurements[idx].MeasureData, questionId: Id })
+      this.setQuestionStatus(this.questions, this.measurements[idx].QuestionType)
       this.measurements.splice(idx, 1)
       DicomEvent.$emit('getMeasureData')
       // this.calculateSpleenStatus = ''
       // this.setSpleenCommentDisplay()
       this.formChanged = true
     },
+    clearSpleenStatus() {
+      this.$set(this.questionForm, this.spleenStatusId, '')
+      this.$set(this.questionForm, this.spleenLengthId, '')
+      for (let i = 0; i < this.questions[0].Childrens.length; i++) {
+        if (this.questions[0].Childrens[i].QuestionType === 58) {
+          this.questions[0].Childrens[i].ShowQuestion = 2
+          this.questions[0].Childrens[i].IsRequired = 3
+          this.questionForm[this.spleenCommentsId] = ''
+          break
+        }
+      }
+    },
     saveAnnotation(question) {
       this.loading = true
       // 获取截图