diff --git a/src/views/trials/trials-panel/reading/dicoms/components/IRecist/QuestionForm.vue b/src/views/trials/trials-panel/reading/dicoms/components/IRecist/QuestionForm.vue
index 626b9349..601cddcc 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/IRecist/QuestionForm.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/IRecist/QuestionForm.vue
@@ -1,4 +1,4 @@
-<template>
+<template>
   <el-form v-if="isRender" ref="measurementForm" v-loading="loading" :model="questionForm" size="mini"
     class="measurement-form">
     <div class="base-dialog-body">
@@ -240,7 +240,8 @@ export default {
       deleteInfo: null,
       pictureBaseStr: '',
       currentMarkTool: '',
-      saveLoading: false
+      saveLoading: false,
+      validationDialogVisible: false
     }
   },
   mounted() {
@@ -257,6 +258,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },
     async initForm() {
       const loading = this.$loading({ fullscreen: true })
       const closeLoading = loading.close.bind(loading)
@@ -854,12 +873,25 @@ export default {
         return
       }
       const loading = this.$loading({ fullscreen: true })
+      const closeLoading = loading.close.bind(loading)
+      let loadingClosed = false
+      loading.close = () => {
+        if (loadingClosed) return
+        loadingClosed = true
+        closeLoading()
+      }
+      const resetSaveState = () => {
+        loading.close()
+        this.saveLoading = false
+      }
+      let canSubmit = false
       var measureData = this.questionForm.MeasureData
       var lesionState = this.getQuestionVal(7)
       var lesionLength = this.getQuestionVal(0)
       var lesionShort = this.getQuestionVal(1)
       var lymphNodes = this.getQuestionVal(2)
-      if (this.isBaseLineTask) {
+      try {
+        if (this.isBaseLineTask) {
         // 基线
         // 靶病灶且状态为存在（0）
         if (this.lesionType === 0 && lesionState === 0) {
@@ -867,24 +899,14 @@ export default {
             //  淋巴结靶病灶 必须使用长短径测量工具,短径大于等于15mm
             if (!(measureData && measureData.type === 'Bidirectional' && lesionShort >= 15)) {
               // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记，且短径须大于15mm！
-              this.$confirm(this.$t('trials:reading:warnning:msg19'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg19'))
               return
             }
           } else {
             // 非淋巴结靶病灶 直径测量工具 长径须大于等于10mm且不小于2倍层厚
             if (!(measureData && measureData.type === 'Length' && lesionLength >= 10 && (measureData.thick && lesionLength >= 2 * measureData.thick || !measureData.thick))) {
               // 评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记，长径须大于10mm且不小于2倍层厚！
-              this.$confirm(this.$t('trials:reading:warnning:msg20'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg20'))
               return
             }
           }
@@ -896,24 +918,14 @@ export default {
             // 淋巴结非靶病灶 必须使用长短径测量工具或箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-              this.$confirm(this.$t('trials:reading:warnning:msg21'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg21'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具或箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg22'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg22'))
               return
             }
           }
@@ -926,24 +938,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具
             if (!(measureData && measureData.type === 'Bidirectional' && lesionShort >= 10)) {
               // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg23'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg23'))
               return
             }
           } else {
             // 非淋巴结靶病灶 直径测量工具
             if (!(measureData && measureData.type === 'Length')) {
               // `评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg24'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg24'))
               return
             }
           }
@@ -954,12 +956,7 @@ export default {
             // 淋巴结靶病灶 必须使用箭头工具，短径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg25'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg25'))
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
               const shortId = this.getQuestionId(1)
@@ -970,12 +967,7 @@ export default {
             // 非淋巴结靶病灶 箭头工具，长径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的非淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg26'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg26'))
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
               const lengthId = this.getQuestionId(0)
@@ -991,24 +983,14 @@ export default {
             // 淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg27'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg27'))
               return
             }
           } else {
             // 非淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 状态为无法评估的非淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg28'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg28'))
               return
             }
           }
@@ -1019,24 +1001,14 @@ export default {
           if (lymphNodes === 1) {
             if (!(measureData && (measureData.type === 'Bidirectional' && lesionShort < 10))) {
               // `评估状态为消失的淋巴结靶病灶需使用长短径工具添加标记,且短径需小于10mm！`
-              this.$confirm(this.$t('trials:reading:warnning:msg29'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg29'))
               return
             }
           } else {
             // 非淋巴结靶病灶 箭头工具
             if (!(measureData && measureData.type === 'ArrowAnnotate')) {
               // 评估状态为消失的非淋巴结靶病灶只能使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg30'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg30'))
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
               const lId = this.getQuestionId(0)
@@ -1052,24 +1024,14 @@ export default {
             // 淋巴结非靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg31'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg31'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg32'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg32'))
               return
             }
           }
@@ -1081,24 +1043,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // `评估状态为显著增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg33'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg33'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为显著增大的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg34'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg34'))
               return
             }
           }
@@ -1110,24 +1062,14 @@ export default {
             // 淋巴结靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg35'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg35'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的非淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg36'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg36'))
               return
             }
           }
@@ -1139,24 +1081,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionShort < 10)))) {
               // 评估状态为消失的淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg37'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg37'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg38'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg38'))
               return
             }
           }
@@ -1168,24 +1100,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // `评估状态为显著增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg33'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg33'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为显著增大的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg34'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg34'))
               return
             }
           }
@@ -1197,24 +1119,14 @@ export default {
             // 淋巴结非靶病灶 必须使用长短径测量工具、矩形工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // `评估状态为进一步增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-              this.$confirm(this.$t('trials:iRecist:warnning:msg50'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg50'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为进一步增大的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-              this.$confirm(this.$t('trials:iRecist:warnning:msg51'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg51'))
               return
             }
           }
@@ -1226,24 +1138,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg39'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg39'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg40'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg40'))
               return
             }
           }
@@ -1255,24 +1157,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为疑似的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg41'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg41'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
               // `评估状态为疑似的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg42'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg42'))
               return
             }
           }
@@ -1284,24 +1176,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (measureData) {
               // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg43'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg43'))
               return
             }
           } else {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (measureData) {
               // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg44'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg44'))
               return
             }
           }
@@ -1313,24 +1195,14 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionShort < 10)))) {
               // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg45'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg45'))
               return
             }
           } else {
             // 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg46'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
-              loading.close()
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg46'))
               return
             }
           }
@@ -1345,24 +1217,14 @@ export default {
                 //  淋巴结新靶病灶 必须使用长短径测量工具,短径大于等于15mm
                 if (!(measureData && measureData.type === 'Bidirectional' && lesionShort >= 15)) {
                   // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记，且短径须大于15mm！
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg31'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg31'))
                   return
                 }
               } else {
                 // 非淋巴结新靶病灶 直径测量工具 长径须大于等于10mm且不小于2倍层厚
                 if (!(measureData && measureData.type === 'Length' && lesionLength >= 10 && (measureData.thick && lesionLength >= 2 * measureData.thick || !measureData.thick))) {
                   // 评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记，长径须大于10mm且不小于2倍层厚！
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg32'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg32'))
                   return
                 }
               }
@@ -1374,24 +1236,14 @@ export default {
                 // 淋巴结靶病灶 必须使用长短径测量工具
                 if (!(measureData && measureData.type === 'Bidirectional' && lesionShort >= 10)) {
                   // 评估状态为存在的淋巴结新靶病灶需使用长短径测量工具添加标记！ 短径应不小于10mm
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg1'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg1'))
                   return
                 }
               } else {
                 // 非淋巴结靶病灶 直径测量工具
                 if (!(measureData && measureData.type === 'Length')) {
                   // `评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记！`
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg2'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg2'))
                   return
                 }
               }
@@ -1401,24 +1253,14 @@ export default {
               if (lymphNodes === 1) {
                 if (!(measureData && (measureData.type === 'Bidirectional' && lesionShort < 10))) {
                   // `评估状态为消失的淋巴结靶病灶需使用长短径工具添加标记,且短径需小于10mm！`
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg3'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg3'))
                   return
                 }
               } else {
                 // 非淋巴结靶病灶 箭头工具
                 if (!(measureData && measureData.type === 'ArrowAnnotate')) {
                   // 评估状态为消失的非淋巴结靶病灶只能使用箭头工具添加标记！
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg4'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg4'))
                   return
                 } else if (measureData && measureData.type === 'ArrowAnnotate') {
                   const lId = this.getQuestionId(0)
@@ -1434,24 +1276,14 @@ export default {
                 // 淋巴结新靶病灶 不需要添加标记
                 if (measureData) {
                   // 评估状态为无法评估的淋巴结新靶病灶不需要添加标记！
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg5'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg5'))
                   return
                 }
               } else {
                 // 非淋巴结靶病灶 不需要添加标记
                 if (measureData) {
                   // 状态为无法评估的非淋巴结新靶病灶不需要添加标记！
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg6'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg6'))
                   return
                 }
               }
@@ -1463,12 +1295,7 @@ export default {
                 // 淋巴结靶病灶 必须使用箭头工具，短径记录为5mm
                 if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                   // 评估状态为太小的淋巴结靶病灶需使用箭头工具添加标记！
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg33'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg33'))
                   return
                 } else if (measureData && measureData.type === 'ArrowAnnotate') {
                   const shortId = this.getQuestionId(1)
@@ -1479,12 +1306,7 @@ export default {
                 // 非淋巴结靶病灶 箭头工具，长径记录为5mm
                 if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                   // 评估状态为太小的非淋巴结靶病灶需使用箭头工具添加标记！
-                  this.$confirm(this.$t('trials:iRecist:warnning:msg34'), {
-                    type: 'warning',
-                    showCancelButton: false,
-                    callback: action => { }
-                  })
-                  loading.close()
+                  await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg34'))
                   return
                 } else if (measureData && measureData.type === 'ArrowAnnotate') {
                   const lengthId = this.getQuestionId(0)
@@ -1536,24 +1358,14 @@ export default {
               // 淋巴结非靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
                 // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg7'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg7'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
                 // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg8'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg8'))
                 return
               }
             }
@@ -1564,24 +1376,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
                 // `评估状态为增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-                this.$confirm(this.$t('trials:iRecist:warnning:msg9'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg9'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
                 // 评估状态为增大的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg10'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg10'))
                 return
               }
             }
@@ -1592,24 +1394,14 @@ export default {
               // 淋巴结靶病灶 无标记
               if (measureData) {
                 // 评估状态为无法评估的淋巴结非靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg11'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg11'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 无标记
               if (measureData) {
                 // 评估状态为无法评估的非淋巴结非靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg12'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg12'))
                 return
               }
             }
@@ -1620,24 +1412,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为消失的淋巴结非靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg13'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg13'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 箭头工具
               if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为消失的非淋巴结非靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg14'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg14'))
                 return
               }
             }
@@ -1652,24 +1434,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为明确的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg15'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg15'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为明确的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg16'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg16'))
                 return
               }
             }
@@ -1681,24 +1453,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为疑似的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg17'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg17'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
                 // `评估状态为疑似的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！`
-                this.$confirm(this.$t('trials:iRecist:warnning:msg18'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg18'))
                 return
               }
             }
@@ -1710,24 +1472,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (measureData) {
                 // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-                this.$confirm(this.$t('trials:iRecist:warnning:msg19'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg19'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (measureData) {
                 // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg20'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg20'))
                 return
               }
             }
@@ -1739,24 +1491,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg21'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg21'))
                 return
               }
             } else {
               // 箭头工具
               if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg22'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg22'))
                 return
               }
             }
@@ -1770,24 +1512,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为明确的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg23'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg23'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为存在的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg24'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg24'))
                 return
               }
             }
@@ -1799,24 +1531,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为疑似的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg25'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg25'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
                 // `评估状态为疑似的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！`
-                this.$confirm(this.$t('trials:iRecist:warnning:msg26'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg26'))
                 return
               }
             }
@@ -1827,24 +1549,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg27'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg27'))
                 return
               }
             } else {
               // 箭头工具
               if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
                 // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg28'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg28'))
                 return
               }
             }
@@ -1855,107 +1567,100 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (measureData) {
                 // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-                this.$confirm(this.$t('trials:iRecist:warnning:msg29'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg29'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (measureData) {
                 // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-                this.$confirm(this.$t('trials:iRecist:warnning:msg30'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:iRecist:warnning:msg30'))
                 return
               }
             }
           }
         }
+        }
+        canSubmit = true
+      } finally {
+        if (!canSubmit) {
+          resetSaveState()
+        }
       }
-
-      DicomEvent.$emit('getScreenshots', { questionId: this.parentQsId, rowIndex: this.questionForm.RowIndex, visitTaskId: this.visitTaskId, lesionName: this.lesionMark, lesionType: this.lesionType, isMarked: !!measureData }, async val => {
-        // 靶病灶状态为0（存在）时，一定存在长径或者长短径（长径、十字线 ）
-        // 普通靶病灶：长径大于10mm且不小于2倍层厚（基线校验）
-        // 淋巴结靶病灶：短径大于15mm且不小于2倍层厚（基线校验）
-        try {
-          var picturePath = ''
-          if (val && measureData && this.questionForm.IsDicomReading) {
-            var pictureObj = await this.uploadScreenshots(`${new Date().getTime()}`, val)
-            picturePath = pictureObj.isSuccess ? this.$getObjectName(pictureObj.result.url) : ''
-          }
-          var answers = []
-          var reg = new RegExp(/^[0-9a-zA-Z]{8}-[0-9a-zA-Z]{4}-[0-9a-zA-Z]{4}-[0-9a-zA-Z]{4}-[0-9a-zA-Z]{12}$/)
-          for (const k in this.questionForm) {
-            if (reg.test(k)) {
-              if (answers.findIndex(i => i.tableQuestionId === k) === -1) {
-                answers.push({ tableQuestionId: k, answer: this.questionForm[k] })
-              }
+      try {
+        const screenshot = await new Promise(resolve => {
+          DicomEvent.$emit('getScreenshots', { questionId: this.parentQsId, rowIndex: this.questionForm.RowIndex, visitTaskId: this.visitTaskId, lesionName: this.lesionMark, lesionType: this.lesionType, isMarked: !!measureData }, resolve)
+        })
+        var picturePath = ''
+        if (screenshot && measureData && this.questionForm.IsDicomReading) {
+          var pictureObj = await this.uploadScreenshots(`${new Date().getTime()}`, screenshot)
+          picturePath = pictureObj.isSuccess ? this.$getObjectName(pictureObj.result.url) : ''
+        }
+        var answers = []
+        var reg = new RegExp(/^[0-9a-zA-Z]{8}-[0-9a-zA-Z]{4}-[0-9a-zA-Z]{4}-[0-9a-zA-Z]{4}-[0-9a-zA-Z]{12}$/)
+        for (const k in this.questionForm) {
+          if (reg.test(k)) {
+            if (answers.findIndex(i => i.tableQuestionId === k) === -1) {
+              answers.push({ tableQuestionId: k, answer: this.questionForm[k] })
             }
           }
-
-          var params = {
-            questionId: this.parentQsId,
-            rowId: this.questionForm.RowId,
-            rowIndex: this.answers.RowIndex,
-            visitTaskId: this.visitTaskId,
-            trialId: this.trialId,
-            measureData: measureData ? JSON.stringify(measureData) : '',
-            answerList: answers,
-            isCanEditPosition: this.questionForm.IsCanEditPosition,
-            studyId: measureData ? this.questionForm.MeasureData.studyId : '',
-            seriesId: measureData ? this.questionForm.MeasureData.seriesId : '',
-            instanceId: measureData ? this.questionForm.MeasureData.instanceId : '',
-            numberOfFrames: measureData && !isNaN(parseInt(this.questionForm.MeasureData.frame)) ? parseInt(this.questionForm.MeasureData.frame) : 0,
-            picturePath: picturePath,
-            organInfoId: this.questionForm.OrganInfoId,
-            markTool: measureData ? measureData.type : '',
-            fromMark: this.answers.FromMark,
-            reportMark: this.answers.FromMark
-          }
-          if (this.questionForm.IsDicomReading === false) {
-            params.isDicomReading = false
-          }
-          if (this.deleteInfo) {
-            await this.deleteOldLesion(this.deleteInfo.rowId)
-            this.deleteInfo = null
-            params.rowId = ''
-          }
-          const res = await submitTableQuestion(params)
-          if (res.IsSuccess) {
-            // 保存成功！
-            this.$message.success(this.$t('common:message:savedSuccessfully'))
-            this.currentMarkTool = measureData ? measureData.type : ''
-            // saveTypeEnum 0：未保存过（新建病灶）；1：已保存，信息不完整（随访初始化病灶/分裂病灶，通过状态判断）；2：已保存，信息完整
-            this.$set(this.questionForm, 'saveTypeEnum', 2)
-            this.originalQuestionForm = { ...this.questionForm }
-            var isLymphLesion = this.getQuestionVal(2)
-            var lesionOrgan = this.getQuestionVal(6)
-            this.$set(this.questionForm, 'RowId', res.Result.RowId)
-            const lesionPart = this.getQuestionVal(8)
-            const lesionState = this.getQuestionVal(7)
-            this.$emit('resetQuestions', { isLymphLesion, lesionPart, lesionOrgan, lesionShort, saveTypeEnum: this.questionForm.saveTypeEnum, lesionLength, lesionState, rowIndex: this.rowIndex, rowId: res.Result.RowId, questionId: this.parentQsId, anwsers: this.questionForm })
-
-            // await store.dispatch('reading/refreshMeasuredData', this.visitTaskId)
-            // DicomEvent.$emit('getMeasureData')
-            this.$emit('close')
-            DicomEvent.$emit('getReportInfo', true)
-            DicomEvent.$emit('setMeasuredToolsPassive')
-          }
-          loading.close()
-          this.saveLoading = false
-        } catch (e) {
-          console.log(e)
-          loading.close()
-          this.saveLoading = false
         }
-      })
+
+        var params = {
+          questionId: this.parentQsId,
+          rowId: this.questionForm.RowId,
+          rowIndex: this.answers.RowIndex,
+          visitTaskId: this.visitTaskId,
+          trialId: this.trialId,
+          measureData: measureData ? JSON.stringify(measureData) : '',
+          answerList: answers,
+          isCanEditPosition: this.questionForm.IsCanEditPosition,
+          studyId: measureData ? this.questionForm.MeasureData.studyId : '',
+          seriesId: measureData ? this.questionForm.MeasureData.seriesId : '',
+          instanceId: measureData ? this.questionForm.MeasureData.instanceId : '',
+          numberOfFrames: measureData && !isNaN(parseInt(this.questionForm.MeasureData.frame)) ? parseInt(this.questionForm.MeasureData.frame) : 0,
+          picturePath: picturePath,
+          organInfoId: this.questionForm.OrganInfoId,
+          markTool: measureData ? measureData.type : '',
+          fromMark: this.answers.FromMark,
+          reportMark: this.answers.FromMark
+        }
+        if (this.questionForm.IsDicomReading === false) {
+          params.isDicomReading = false
+        }
+        if (this.deleteInfo) {
+          await this.deleteOldLesion(this.deleteInfo.rowId)
+          this.deleteInfo = null
+          params.rowId = ''
+        }
+        const res = await submitTableQuestion(params)
+        if (res.IsSuccess) {
+          // 保存成功！
+          this.$message.success(this.$t('common:message:savedSuccessfully'))
+          this.currentMarkTool = measureData ? measureData.type : ''
+          // saveTypeEnum 0：未保存过（新建病灶）；1：已保存，信息不完整（随访初始化病灶/分裂病灶，通过状态判断）；2：已保存，信息完整
+          this.$set(this.questionForm, 'saveTypeEnum', 2)
+          this.originalQuestionForm = { ...this.questionForm }
+          var isLymphLesion = this.getQuestionVal(2)
+          var lesionOrgan = this.getQuestionVal(6)
+          this.$set(this.questionForm, 'RowId', res.Result.RowId)
+          const lesionPart = this.getQuestionVal(8)
+          const lesionState = this.getQuestionVal(7)
+          this.$emit('resetQuestions', { isLymphLesion, lesionPart, lesionOrgan, lesionShort, saveTypeEnum: this.questionForm.saveTypeEnum, lesionLength, lesionState, rowIndex: this.rowIndex, rowId: res.Result.RowId, questionId: this.parentQsId, anwsers: this.questionForm })
+
+          // await store.dispatch('reading/refreshMeasuredData', this.visitTaskId)
+          // DicomEvent.$emit('getMeasureData')
+          this.$emit('close')
+          DicomEvent.$emit('getReportInfo', true)
+          DicomEvent.$emit('setMeasuredToolsPassive')
+        }
+        return !!res.IsSuccess
+      } catch (e) {
+        console.log(e)
+        return false
+      } finally {
+        resetSaveState()
+      }
     },
     async handleDeleteMeasureData() {
       // 是否确认清除标记？
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Lugano/QuestionForm.vue b/src/views/trials/trials-panel/reading/dicoms/components/Lugano/QuestionForm.vue
index 3ce18e68..dcb6076a 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Lugano/QuestionForm.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Lugano/QuestionForm.vue
@@ -1,4 +1,4 @@
-<template>
+<template>
   <el-form v-if="isRender" ref="measurementForm" v-loading="loading" :model="questionForm" size="mini"
     class="measurement-form">
     <div class="base-dialog-body">
@@ -277,7 +277,8 @@ export default {
       splitLesionTargetPPD: null,
       splitLesionTargetLDi: null,
       splitLesionTargetSDi: null,
-      saveLoading: false
+      saveLoading: false,
+      validationDialogVisible: false
     }
   },
   mounted() {
@@ -300,7 +301,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
-    scrollHandle() {
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },    scrollHandle() {
       for (const k in this.$refs) {
         if (k.indexOf('select_') === -1) continue
         if (this.$refs[k] instanceof Array) {
@@ -1065,22 +1083,16 @@ export default {
           if (lymphNodes === 1) {
             //  评估状态为“存在”的淋巴结靶病灶，长径应大于15 mm，请使用长短径测量工具添加标记。
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 15 && lesionLength >= 2 * measureData.thick)) {
-              this.$confirm(this.$t('trials:lugano:message:validState1'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState1'))
+
               loading.close()
               return
             }
           } else {
             // 评估状态为“存在”的非淋巴结靶病灶，长径应大于10 mm，请使用长短径测量工具添加标记。
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 10 && lesionLength >= 2 * measureData.thick)) {
-              this.$confirm(this.$t('trials:lugano:message:validState2'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState2'))
+
               loading.close()
               return
             }
@@ -1092,22 +1104,16 @@ export default {
           if (lymphNodes === 1) {
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-              this.$confirm(this.$t('trials:reading:warnning:msg21'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg21'))
+
               loading.close()
               return
             }
           } else {
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-              this.$confirm(this.$t('trials:lugano:message:validState12'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState12'))
+
               loading.close()
               return
             }
@@ -1120,11 +1126,8 @@ export default {
           if (lymphNodes === 1) {
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 15)) {
               // 状态为“存在”的淋巴结靶病灶，长径应大于15 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState3'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState3'))
+
               loading.close()
               return
             }
@@ -1132,11 +1135,8 @@ export default {
             // 非淋巴结靶病灶 长短径测量工具
             if (!(measureData && measureData.type === 'Bidirectional')) {
               // 状态为“存在”的非淋巴结靶病灶，长径应大于10 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState4'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState4'))
+
               loading.close()
               return
             }
@@ -1148,11 +1148,8 @@ export default {
             // 淋巴结靶病灶 必须使用箭头工具，长径、短径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg25'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg25'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -1167,11 +1164,8 @@ export default {
             // 非淋巴结靶病灶 箭头工具，长径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的非淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg26'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg26'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -1191,11 +1185,8 @@ export default {
             // 淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg27'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg27'))
+
               loading.close()
               return
             }
@@ -1203,11 +1194,8 @@ export default {
             // 非淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 状态为无法评估的非淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg28'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg28'))
+
               loading.close()
               return
             }
@@ -1220,20 +1208,14 @@ export default {
             // 淋巴结靶病灶 使用箭头工具 measureData.type === 'ArrowAnnotate' ||
             if (!(measureData && (measureData.type === 'Bidirectional'))) {
               // 评估状态为消失的淋巴结靶病灶需使用箭头工具或长短径工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState5'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState5'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'Bidirectional' && lesionLength > 15) {
               // 评估状态为消失的淋巴结靶病灶,短径应不大于15mm！
-              this.$confirm(this.$t('trials:lugano:message:validState6'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState6'))
+
               loading.close()
               return
             }
@@ -1251,11 +1233,8 @@ export default {
             // 非淋巴结靶病灶 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结靶病灶只能使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:lugano:warnning:validState7'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:warnning:validState7'))
+
               loading.close()
               return
             }
@@ -1280,11 +1259,8 @@ export default {
           if (lymphNodes === 1) {
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 15)) {
               // 状态为“疾病进展”的淋巴结靶病灶，长径应大于15 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState7'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState7'))
+
               loading.close()
               return
             }
@@ -1292,11 +1268,8 @@ export default {
             // 非淋巴结靶病灶 直径测量工具
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 10)) {
               // 状态为“疾病进展”的非淋巴结靶病灶，长径应大于10 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState8'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState8'))
+
               loading.close()
               return
             }
@@ -1309,11 +1282,8 @@ export default {
             // 淋巴结非靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg31'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg31'))
+
               loading.close()
               return
             }
@@ -1321,11 +1291,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState9'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState9'))
+
               loading.close()
               return
             }
@@ -1338,11 +1305,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // `评估状态为显著增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg33'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg33'))
+
               loading.close()
               return
             }
@@ -1350,11 +1314,8 @@ export default {
             // 非淋巴结非靶病灶 矩形工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为显著增大的非淋巴结非靶病灶需使用矩形工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState10'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState10'))
+
               loading.close()
               return
             }
@@ -1367,11 +1328,8 @@ export default {
             // 淋巴结靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg35'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg35'))
+
               loading.close()
               return
             }
@@ -1379,11 +1337,8 @@ export default {
             // 非淋巴结非靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的非淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg36'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg36'))
+
               loading.close()
               return
             }
@@ -1396,11 +1351,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionLength < 15)))) {
               // 评估状态为消失的淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:lgmsg37'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:lgmsg37'))
+
               loading.close()
               return
             }
@@ -1408,11 +1360,8 @@ export default {
             // 非淋巴结非靶病灶 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg38'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg38'))
+
               loading.close()
               return
             }
@@ -1425,11 +1374,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg39'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg39'))
+
               loading.close()
               return
             }
@@ -1437,11 +1383,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的非淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState11'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState11'))
+
               loading.close()
               return
             }
@@ -1483,11 +1426,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (measureData) {
               // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg43'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg43'))
+
               loading.close()
               return
             }
@@ -1495,11 +1435,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (measureData) {
               // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg44'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg44'))
+
               loading.close()
               return
             }
@@ -1512,11 +1449,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionLength < 15)))) {
               // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:lgmsg45'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:lgmsg45'))
+
               loading.close()
               return
             }
@@ -1524,11 +1458,8 @@ export default {
             // 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg46'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg46'))
+
               loading.close()
               return
             }
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/LuganoWithoutPET/QuestionForm.vue b/src/views/trials/trials-panel/reading/dicoms/components/LuganoWithoutPET/QuestionForm.vue
index 3ce18e68..dcb6076a 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/LuganoWithoutPET/QuestionForm.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/LuganoWithoutPET/QuestionForm.vue
@@ -1,4 +1,4 @@
-<template>
+<template>
   <el-form v-if="isRender" ref="measurementForm" v-loading="loading" :model="questionForm" size="mini"
     class="measurement-form">
     <div class="base-dialog-body">
@@ -277,7 +277,8 @@ export default {
       splitLesionTargetPPD: null,
       splitLesionTargetLDi: null,
       splitLesionTargetSDi: null,
-      saveLoading: false
+      saveLoading: false,
+      validationDialogVisible: false
     }
   },
   mounted() {
@@ -300,7 +301,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
-    scrollHandle() {
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },    scrollHandle() {
       for (const k in this.$refs) {
         if (k.indexOf('select_') === -1) continue
         if (this.$refs[k] instanceof Array) {
@@ -1065,22 +1083,16 @@ export default {
           if (lymphNodes === 1) {
             //  评估状态为“存在”的淋巴结靶病灶，长径应大于15 mm，请使用长短径测量工具添加标记。
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 15 && lesionLength >= 2 * measureData.thick)) {
-              this.$confirm(this.$t('trials:lugano:message:validState1'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState1'))
+
               loading.close()
               return
             }
           } else {
             // 评估状态为“存在”的非淋巴结靶病灶，长径应大于10 mm，请使用长短径测量工具添加标记。
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 10 && lesionLength >= 2 * measureData.thick)) {
-              this.$confirm(this.$t('trials:lugano:message:validState2'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState2'))
+
               loading.close()
               return
             }
@@ -1092,22 +1104,16 @@ export default {
           if (lymphNodes === 1) {
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-              this.$confirm(this.$t('trials:reading:warnning:msg21'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg21'))
+
               loading.close()
               return
             }
           } else {
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-              this.$confirm(this.$t('trials:lugano:message:validState12'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState12'))
+
               loading.close()
               return
             }
@@ -1120,11 +1126,8 @@ export default {
           if (lymphNodes === 1) {
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 15)) {
               // 状态为“存在”的淋巴结靶病灶，长径应大于15 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState3'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState3'))
+
               loading.close()
               return
             }
@@ -1132,11 +1135,8 @@ export default {
             // 非淋巴结靶病灶 长短径测量工具
             if (!(measureData && measureData.type === 'Bidirectional')) {
               // 状态为“存在”的非淋巴结靶病灶，长径应大于10 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState4'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState4'))
+
               loading.close()
               return
             }
@@ -1148,11 +1148,8 @@ export default {
             // 淋巴结靶病灶 必须使用箭头工具，长径、短径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg25'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg25'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -1167,11 +1164,8 @@ export default {
             // 非淋巴结靶病灶 箭头工具，长径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的非淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg26'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg26'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -1191,11 +1185,8 @@ export default {
             // 淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg27'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg27'))
+
               loading.close()
               return
             }
@@ -1203,11 +1194,8 @@ export default {
             // 非淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 状态为无法评估的非淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg28'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg28'))
+
               loading.close()
               return
             }
@@ -1220,20 +1208,14 @@ export default {
             // 淋巴结靶病灶 使用箭头工具 measureData.type === 'ArrowAnnotate' ||
             if (!(measureData && (measureData.type === 'Bidirectional'))) {
               // 评估状态为消失的淋巴结靶病灶需使用箭头工具或长短径工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState5'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState5'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'Bidirectional' && lesionLength > 15) {
               // 评估状态为消失的淋巴结靶病灶,短径应不大于15mm！
-              this.$confirm(this.$t('trials:lugano:message:validState6'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState6'))
+
               loading.close()
               return
             }
@@ -1251,11 +1233,8 @@ export default {
             // 非淋巴结靶病灶 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结靶病灶只能使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:lugano:warnning:validState7'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:warnning:validState7'))
+
               loading.close()
               return
             }
@@ -1280,11 +1259,8 @@ export default {
           if (lymphNodes === 1) {
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 15)) {
               // 状态为“疾病进展”的淋巴结靶病灶，长径应大于15 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState7'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState7'))
+
               loading.close()
               return
             }
@@ -1292,11 +1268,8 @@ export default {
             // 非淋巴结靶病灶 直径测量工具
             if (!(measureData && measureData.type === 'Bidirectional' && lesionLength > 10)) {
               // 状态为“疾病进展”的非淋巴结靶病灶，长径应大于10 mm，请使用长短径测量工具添加标记。
-              this.$confirm(this.$t('trials:lugano:message:validState8'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState8'))
+
               loading.close()
               return
             }
@@ -1309,11 +1282,8 @@ export default {
             // 淋巴结非靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg31'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg31'))
+
               loading.close()
               return
             }
@@ -1321,11 +1291,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState9'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState9'))
+
               loading.close()
               return
             }
@@ -1338,11 +1305,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // `评估状态为显著增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg33'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg33'))
+
               loading.close()
               return
             }
@@ -1350,11 +1314,8 @@ export default {
             // 非淋巴结非靶病灶 矩形工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为显著增大的非淋巴结非靶病灶需使用矩形工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState10'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState10'))
+
               loading.close()
               return
             }
@@ -1367,11 +1328,8 @@ export default {
             // 淋巴结靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg35'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg35'))
+
               loading.close()
               return
             }
@@ -1379,11 +1337,8 @@ export default {
             // 非淋巴结非靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的非淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg36'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg36'))
+
               loading.close()
               return
             }
@@ -1396,11 +1351,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionLength < 15)))) {
               // 评估状态为消失的淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:lgmsg37'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:lgmsg37'))
+
               loading.close()
               return
             }
@@ -1408,11 +1360,8 @@ export default {
             // 非淋巴结非靶病灶 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg38'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg38'))
+
               loading.close()
               return
             }
@@ -1425,11 +1374,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg39'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg39'))
+
               loading.close()
               return
             }
@@ -1437,11 +1383,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的非淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:lugano:message:validState11'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:lugano:message:validState11'))
+
               loading.close()
               return
             }
@@ -1483,11 +1426,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (measureData) {
               // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg43'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg43'))
+
               loading.close()
               return
             }
@@ -1495,11 +1435,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (measureData) {
               // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg44'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg44'))
+
               loading.close()
               return
             }
@@ -1512,11 +1449,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionLength < 15)))) {
               // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:lgmsg45'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:lgmsg45'))
+
               loading.close()
               return
             }
@@ -1524,11 +1458,8 @@ export default {
             // 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg46'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg46'))
+
               loading.close()
               return
             }
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/PCWG/QuestionForm.vue b/src/views/trials/trials-panel/reading/dicoms/components/PCWG/QuestionForm.vue
index 69fe2a93..f3706bd4 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/PCWG/QuestionForm.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/PCWG/QuestionForm.vue
@@ -1,4 +1,4 @@
-<template>
+<template>
   <el-form v-if="isRender" ref="measurementForm" v-loading="loading" :model="questionForm" size="mini"
     class="measurement-form">
     <div class="base-dialog-body">
@@ -199,7 +199,8 @@ export default {
       digitPlaces: 0,
       focusQs: null,
       currentMarkTool: '',
-      saveLoading: false
+      saveLoading: false,
+      validationDialogVisible: false
     }
   },
 
@@ -217,7 +218,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
-    validateLesionCount(rule, value, callback) {
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },    validateLesionCount(rule, value, callback) {
       // const reg = /^[1-9][0-9]?$|^100$/
       // const reg = /^(0+)|[^\d]+/g
       const reg = /^(?:[1-9]|[1-9][0-9])$/
@@ -586,11 +604,8 @@ export default {
         // 病灶状态为“存在”的新病灶，请使用箭头工具添加标记2
         if (this.lesionType === 2 && lesionState === 2) {
           if (!(measureData && measureData.type === 'ArrowAnnotate')) {
-            this.$confirm(this.$t('trials:readingPGWC:warnning:msg2'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingPGWC:warnning:msg2'))
+
             this.saveLoading = false
             return
           }
@@ -599,11 +614,8 @@ export default {
         // 病灶状态为“存在”的既往新病灶，请使用箭头工具添加标记2
         if (this.lesionType === 3 && lesionState === 2) {
           if (!(measureData && measureData.type === 'ArrowAnnotate')) {
-            this.$confirm(this.$t('trials:readingPGWC:warnning:msg3'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingPGWC:warnning:msg3'))
+
             this.saveLoading = false
             return
           }
@@ -611,11 +623,8 @@ export default {
         // 病灶状态为“良性”的既往新病灶，请使用箭头工具添加标记3
         if (this.lesionType === 3 && lesionState === 3) {
           if (!(measureData && measureData.type === 'ArrowAnnotate')) {
-            this.$confirm(this.$t('trials:readingPGWC:warnning:msg4'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingPGWC:warnning:msg4'))
+
             this.saveLoading = false
             return
           }
@@ -623,11 +632,8 @@ export default {
         // 病灶状态为“消失”的既往新病灶，请使用箭头工具添加标记1
         if (this.lesionType === 3 && lesionState === 1) {
           if (!(measureData && measureData.type === 'ArrowAnnotate')) {
-            this.$confirm(this.$t('trials:readingPGWC:warnning:msg5'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingPGWC:warnning:msg5'))
+
             this.saveLoading = false
             return
           }
@@ -635,11 +641,8 @@ export default {
         // 病灶状态为“不可评估”的既往新病灶，不需要添加标记4
         if (this.lesionType === 3 && lesionState === 4) {
           if (measureData) {
-            this.$confirm(this.$t('trials:readingPGWC:warnning:msg6'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingPGWC:warnning:msg6'))
+
             this.saveLoading = false
             return
           }
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Recist/QuestionForm.vue b/src/views/trials/trials-panel/reading/dicoms/components/Recist/QuestionForm.vue
index 188e38b8..4e8e8e55 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Recist/QuestionForm.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Recist/QuestionForm.vue
@@ -1,4 +1,4 @@
-<template>
+<template>
   <el-form v-if="isRender" ref="measurementForm" v-loading="loading" :model="questionForm" size="mini"
     class="measurement-form">
     <div class="base-dialog-body">
@@ -218,7 +218,8 @@ export default {
       deleteInfo: null,
       pictureBaseStr: '',
       currentMarkTool: '',
-      saveLoading: false
+      saveLoading: false,
+      validationDialogVisible: false
     }
   },
   mounted() {
@@ -235,7 +236,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
-    async initForm() {
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },    async initForm() {
       const loading = this.$loading({ fullscreen: true })
       const closeLoading = loading.close.bind(loading)
       loading.close = () => {
@@ -797,11 +815,8 @@ export default {
             //  淋巴结靶病灶 必须使用长短径测量工具,短径大于等于15mm
             if (!(measureData && measureData.type === 'Bidirectional' && lesionShort >= 15)) {
               // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记，且短径须大于15mm！
-              this.$confirm(this.$t('trials:reading:warnning:msg19'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg19'))
+
               loading.close()
               return
             }
@@ -809,11 +824,8 @@ export default {
             // 非淋巴结靶病灶 直径测量工具 长径须大于等于10mm且不小于2倍层厚
             if (!(measureData && measureData.type === 'Length' && lesionLength >= 10 && (measureData.thick && lesionLength >= 2 * measureData.thick || !measureData.thick))) {
               // 评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记，长径须大于10mm且不小于2倍层厚！
-              this.$confirm(this.$t('trials:reading:warnning:msg20'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg20'))
+
               loading.close()
               return
             }
@@ -826,11 +838,8 @@ export default {
             // 淋巴结非靶病灶 必须使用长短径测量工具或箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-              this.$confirm(this.$t('trials:reading:warnning:msg21'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg21'))
+
               loading.close()
               return
             }
@@ -838,11 +847,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具或箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg22'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg22'))
+
               loading.close()
               return
             }
@@ -856,11 +862,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具
             if (!(measureData && measureData.type === 'Bidirectional' && lesionShort >= 10)) {
               // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg23'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg23'))
+
               loading.close()
               return
             }
@@ -868,11 +871,8 @@ export default {
             // 非淋巴结靶病灶 直径测量工具
             if (!(measureData && measureData.type === 'Length')) {
               // `评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg24'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg24'))
+
               loading.close()
               return
             }
@@ -884,11 +884,8 @@ export default {
             // 淋巴结靶病灶 必须使用箭头工具，短径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg25'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg25'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -900,11 +897,8 @@ export default {
             // 非淋巴结靶病灶 箭头工具，长径记录为5mm
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为太小的非淋巴结靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg26'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg26'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -921,11 +915,8 @@ export default {
             // 淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg27'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg27'))
+
               loading.close()
               return
             }
@@ -933,11 +924,8 @@ export default {
             // 非淋巴结靶病灶 不需要添加标记
             if (measureData) {
               // 状态为无法评估的非淋巴结靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg28'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg28'))
+
               loading.close()
               return
             }
@@ -968,11 +956,8 @@ export default {
             // }
             if (!(measureData && (measureData.type === 'Bidirectional' && lesionShort < 10))) {
               // `评估状态为消失的淋巴结靶病灶需使用长短径工具添加标记,且短径需小于10mm！`
-              this.$confirm(this.$t('trials:reading:warnning:msg29'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg29'))
+
               loading.close()
               return
             }
@@ -980,11 +965,8 @@ export default {
             // 非淋巴结靶病灶 箭头工具
             if (!(measureData && measureData.type === 'ArrowAnnotate')) {
               // 评估状态为消失的非淋巴结靶病灶只能使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg30'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg30'))
+
               loading.close()
               return
             } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -1001,11 +983,8 @@ export default {
             // 淋巴结非靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg31'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg31'))
+
               loading.close()
               return
             }
@@ -1013,11 +992,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg32'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg32'))
+
               loading.close()
               return
             }
@@ -1030,11 +1006,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'RectangleRoi'))) {
               // `评估状态为显著增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg33'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg33'))
+
               loading.close()
               return
             }
@@ -1042,11 +1015,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
               // 评估状态为显著增大的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg34'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg34'))
+
               loading.close()
               return
             }
@@ -1059,11 +1029,8 @@ export default {
             // 淋巴结靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg35'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg35'))
+
               loading.close()
               return
             }
@@ -1071,11 +1038,8 @@ export default {
             // 非淋巴结非靶病灶 无标记
             if (measureData) {
               // 评估状态为无法评估的非淋巴结非靶病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg36'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg36'))
+
               loading.close()
               return
             }
@@ -1088,11 +1052,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionShort < 10)))) {
               // 评估状态为消失的淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg37'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg37'))
+
               loading.close()
               return
             }
@@ -1100,11 +1061,8 @@ export default {
             // 非淋巴结非靶病灶 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结非靶病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg38'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg38'))
+
               loading.close()
               return
             }
@@ -1117,11 +1075,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg39'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg39'))
+
               loading.close()
               return
             }
@@ -1129,11 +1084,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为存在的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg40'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg40'))
+
               loading.close()
               return
             }
@@ -1146,11 +1098,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Bidirectional' || measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为疑似的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg41'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg41'))
+
               loading.close()
               return
             }
@@ -1158,11 +1107,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
               // `评估状态为疑似的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg42'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg42'))
+
               loading.close()
               return
             }
@@ -1175,11 +1121,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (measureData) {
               // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-              this.$confirm(this.$t('trials:reading:warnning:msg43'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg43'))
+
               loading.close()
               return
             }
@@ -1187,11 +1130,8 @@ export default {
             // 非淋巴结非靶病灶 直径测量工具、箭头工具
             if (measureData) {
               // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg44'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg44'))
+
               loading.close()
               return
             }
@@ -1204,11 +1144,8 @@ export default {
             // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate' || (measureData.type === 'Bidirectional' && lesionShort < 10)))) {
               // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg45'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg45'))
+
               loading.close()
               return
             }
@@ -1216,11 +1153,8 @@ export default {
             // 箭头工具
             if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
               // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-              this.$confirm(this.$t('trials:reading:warnning:msg46'), {
-                type: 'warning',
-                showCancelButton: false,
-                callback: action => { }
-              })
+              await this.showValidationDialog(this.$t('trials:reading:warnning:msg46'))
+
               loading.close()
               return
             }
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/RecistBM/QuestionForm.vue b/src/views/trials/trials-panel/reading/dicoms/components/RecistBM/QuestionForm.vue
index d3ea7a1f..0039032b 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/RecistBM/QuestionForm.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/RecistBM/QuestionForm.vue
@@ -1,4 +1,4 @@
-<template>
+<template>
   <el-form v-if="isRender" ref="measurementForm" v-loading="loading" :model="questionForm" size="mini"
     class="measurement-form">
     <div class="base-dialog-body">
@@ -209,7 +209,8 @@ export default {
       deleteInfo: null,
       pictureBaseStr: '',
       currentMarkTool: '',
-      saveLoading: false
+      saveLoading: false,
+      validationDialogVisible: false
     }
   },
   mounted() {
@@ -226,7 +227,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
-    async initForm() {
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },    async initForm() {
       const loading = this.$loading({ fullscreen: true })
       const closeLoading = loading.close.bind(loading)
       loading.close = () => {
@@ -722,11 +740,8 @@ export default {
           // 靶病灶 直径测量工具 长径须大于等于10mm且不小于2倍层厚
           if (!(measureData && measureData.type === 'Length' && lesionLength >= 10 && (measureData.thick && lesionLength >= 2 * measureData.thick || !measureData.thick))) {
             // 病灶状态为“存在”的靶病灶，长径应大于10mm且不小于2倍层厚。请使用直径测量工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg06'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg06'))
+
             loading.close()
             return
           }
@@ -736,11 +751,8 @@ export default {
         if (this.lesionType === 1 && lesionState === 0) {
           if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
             // 病灶状态为“存在”的非靶病灶，请使用直径测量工具或矩形工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg07'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg07'))
+
             loading.close()
             return
           }
@@ -751,11 +763,8 @@ export default {
         if (this.lesionType === 0 && lesionState === 0) {
           if (!(measureData && measureData.type === 'Length')) {
             // `病灶状态为“存在”的靶病灶，请使用直径测量工具添加标记。`
-            this.$confirm(this.$t('trials:readingBM:warnning:msg08'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg08'))
+
             loading.close()
             return
           }
@@ -764,11 +773,8 @@ export default {
         if (this.lesionType === 0 && lesionState === 1) {
           if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
             // 病灶状态为“太小”的靶病灶，请使用箭头工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg09'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg09'))
+
             loading.close()
             return
           } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -782,11 +788,8 @@ export default {
         if (this.lesionType === 0 && lesionState === 2) {
           if (measureData) {
             // 病灶状态为“无法评估”的靶病灶，不需要添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg10'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg10'))
+
             loading.close()
             return
           }
@@ -796,11 +799,8 @@ export default {
         if (this.lesionType === 0 && lesionState === 3) {
           if (!(measureData && measureData.type === 'ArrowAnnotate')) {
             // 病灶状态为“消失”的靶病灶，请使用箭头工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg11'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg11'))
+
             loading.close()
             return
           } else if (measureData && measureData.type === 'ArrowAnnotate') {
@@ -814,11 +814,8 @@ export default {
         if (this.lesionType === 1 && lesionState === 0) {
           if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
             // 病灶状态为“存在”的非靶病灶，请使用直径测量工具或矩形工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg12'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg12'))
+
             loading.close()
             return
           }
@@ -828,11 +825,8 @@ export default {
         if (this.lesionType === 1 && lesionState === 1) {
           if (!(measureData && (measureData.type === 'Length' || measureData.type === 'RectangleRoi'))) {
             // 病灶状态为“显著增大”的非靶病灶，请使用直径测量工具或矩形工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg13'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg13'))
+
             loading.close()
             return
           }
@@ -842,11 +836,8 @@ export default {
         if (this.lesionType === 1 && lesionState === 2) {
           if (measureData) {
             // 病灶状态为“无法评估”的非靶病灶，不需要添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg14'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg14'))
+
             loading.close()
             return
           }
@@ -856,11 +847,8 @@ export default {
         if (this.lesionType === 1 && lesionState === 3) {
           if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
             // 病灶状态为“消失”的非靶病灶，请使用箭头工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg15'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg15'))
+
             loading.close()
             return
           }
@@ -870,11 +858,8 @@ export default {
         if (this.lesionType === 2 && lesionState === 0) {
           if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
             // 病灶状态为“明确”的新病灶，请使用直径测量工具或箭头工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg16'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg16'))
+
             loading.close()
             return
           }
@@ -884,11 +869,8 @@ export default {
         if (this.lesionType === 2 && lesionState === 1) {
           if (!(measureData && (measureData.type === 'Length' || measureData.type === 'ArrowAnnotate'))) {
             // 病灶状态为“疑似”的新病灶，请使用直径测量工具或箭头工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg17'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg17'))
+
             loading.close()
             return
           }
@@ -898,11 +880,8 @@ export default {
         if (this.lesionType === 2 && lesionState === 2) {
           if (measureData) {
             // 病灶状态为“无法评估”的新病灶，不需要添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg18'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg18'))
+
             loading.close()
             return
           }
@@ -912,11 +891,8 @@ export default {
         if (this.lesionType === 2 && lesionState === 3) {
           if (!(measureData && (measureData.type === 'ArrowAnnotate'))) {
             // 病灶状态为“消失”的新病灶，请使用箭头工具添加标记。
-            this.$confirm(this.$t('trials:readingBM:warnning:msg19'), {
-              type: 'warning',
-              showCancelButton: false,
-              callback: action => { }
-            })
+            await this.showValidationDialog(this.$t('trials:readingBM:warnning:msg19'))
+
             loading.close()
             return
           }
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/Recist/QuestionList.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/Recist/QuestionList.vue
index 0f3a3059..a05ef00d 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/Recist/QuestionList.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/Recist/QuestionList.vue
@@ -283,6 +283,7 @@ export default {
       imageQualityIssuesId: '',
       outerSaveLoading: false,
       rowSaveLoadingMap: {},
+      validationDialogVisible: false,
 
 
       merge: { visible: false, loading: false },
@@ -325,6 +326,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },
     // 融合
     async handleMerge(answers, questionId, orderMark) {
       this.lesionData = []
@@ -994,24 +1013,14 @@ export default {
               //  淋巴结靶病灶 必须使用长短径测量工具,短径大于等于15mm
               if (!(measureData && measureData.markTool === 'Bidirectional' && lesionShort >= 15)) {
                 // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记，且短径须大于15mm！
-                this.$confirm(this.$t('trials:reading:warnning:msg19'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg19'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 直径测量工具 长径须大于等于10mm且不小于2倍层厚
               if (!(measureData && measureData.markTool === 'Length' && lesionLength >= 10 && (measureData.sliceThickness && lesionLength >= 2 * measureData.sliceThickness || !measureData.sliceThickness))) {
                 // 评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记，长径须大于10mm且不小于2倍层厚！
-                this.$confirm(this.$t('trials:reading:warnning:msg20'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg20'))
                 return
               }
             }
@@ -1023,12 +1032,7 @@ export default {
               // 淋巴结非靶病灶 必须使用长短径测量工具或箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'RectangleROI' || measureData.markTool === "RectangleRoi"))) {
                 // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-                this.$confirm(this.$t('trials:reading:warnning:msg21'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg21'))
                 return
               }
             } else {
@@ -1036,12 +1040,7 @@ export default {
               console.log(measureData, 'measureData')
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'RectangleROI' || measureData.markTool === "RectangleRoi"))) {
                 // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg22'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg22'))
                 return
               }
             }
@@ -1054,24 +1053,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具
               if (!(measureData && measureData.markTool === 'Bidirectional' && lesionShort >= 10)) {
                 // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg23'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg23'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 直径测量工具
               if (!(measureData && measureData.markTool === 'Length')) {
                 // `评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg24'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg24'))
                 return
               }
             }
@@ -1082,12 +1071,7 @@ export default {
               // 淋巴结靶病灶 必须使用箭头工具，短径记录为5mm
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为太小的淋巴结靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg25'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg25'))
                 return
               } else if (measureData && measureData.markTool === 'ArrowAnnotate') {
                 const shortId = this.getQuestionId(1, table.TableQuestions.Questions)
@@ -1099,12 +1083,7 @@ export default {
               // 非淋巴结靶病灶 箭头工具，长径记录为5mm
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为太小的非淋巴结靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg26'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg26'))
                 return
               } else if (measureData && measureData.markTool === 'ArrowAnnotate') {
                 const lengthId = this.getQuestionId(0, table.TableQuestions.Questions)
@@ -1121,24 +1100,14 @@ export default {
               // 淋巴结靶病灶 不需要添加标记
               if (measureData) {
                 // 评估状态为无法评估的淋巴结靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg27'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg27'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 不需要添加标记
               if (measureData) {
                 // 状态为无法评估的非淋巴结靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg28'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg28'))
                 return
               }
             }
@@ -1149,24 +1118,14 @@ export default {
             if (lymphNodes === 1) {
               if (!(measureData && (measureData.markTool === 'Bidirectional' && lesionShort < 10))) {
                 // `评估状态为消失的淋巴结靶病灶需使用长短径工具添加标记,且短径需小于10mm！`
-                this.$confirm(this.$t('trials:reading:warnning:msg29'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg29'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 箭头工具
               if (!(measureData && measureData.markTool === 'ArrowAnnotate')) {
                 // 评估状态为消失的非淋巴结靶病灶只能使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg30'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg30'))
                 return
               } else if (measureData && measureData.markTool === 'ArrowAnnotate') {
                 const lengthId = this.getQuestionId(0, table.TableQuestions.Questions)
@@ -1183,24 +1142,14 @@ export default {
               // 淋巴结非靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'RectangleROI' || measureData.markTool === "RectangleRoi"))) {
                 // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg31'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg31'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'RectangleROI' || measureData.markTool === "RectangleRoi"))) {
                 // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg32'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg32'))
                 return
               }
             }
@@ -1212,24 +1161,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'RectangleROI' || measureData.markTool === "RectangleRoi"))) {
                 // `评估状态为显著增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg33'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg33'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'RectangleROI' || measureData.markTool === "RectangleRoi"))) {
                 // 评估状态为显著增大的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg34'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg34'))
                 return
               }
             }
@@ -1241,24 +1180,14 @@ export default {
               // 淋巴结靶病灶 无标记
               if (measureData) {
                 // 评估状态为无法评估的淋巴结非靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg35'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg35'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 无标记
               if (measureData) {
                 // 评估状态为无法评估的非淋巴结非靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg36'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg36'))
                 return
               }
             }
@@ -1270,24 +1199,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate' || (measureData.markTool === 'Bidirectional' && lesionShort < 10)))) {
                 // 评估状态为消失的淋巴结非靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg37'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg37'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为消失的非淋巴结非靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg38'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg38'))
                 return
               }
             }
@@ -1299,24 +1218,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为存在的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg39'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg39'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为存在的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg40'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg40'))
                 return
               }
             }
@@ -1328,24 +1237,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为疑似的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg41'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg41'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'ArrowAnnotate'))) {
                 // `评估状态为疑似的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg42'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg42'))
                 return
               }
             }
@@ -1357,24 +1256,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (measureData) {
                 // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg43'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg43'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (measureData) {
                 // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg44'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg44'))
                 return
               }
             }
@@ -1386,24 +1275,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate' || (measureData.markTool === 'Bidirectional' && lesionShort < 10)))) {
                 // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg45'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg45'))
                 return
               }
             } else {
               // 箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg46'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg46'))
                 return
               }
             }
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/mRecist/QuestionList.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/mRecist/QuestionList.vue
index e5b17c5c..b634b06b 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/mRecist/QuestionList.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/mRecist/QuestionList.vue
@@ -281,6 +281,7 @@ export default {
       imageQualityIssuesId: '',
       outerSaveLoading: false,
       rowSaveLoadingMap: {},
+      validationDialogVisible: false,
 
       merge: { visible: false, loading: false },
       lesionData: [],
@@ -321,6 +322,24 @@ export default {
     handleReadingChart(e) {
       this.$emit('handleReadingChart', e)
     },
+    async showValidationDialog(msg) {
+      if (this.validationDialogVisible) {
+        return false
+      }
+      this.validationDialogVisible = true
+      try {
+        await this.$confirm(msg, {
+          type: 'warning',
+          showCancelButton: false,
+          closeOnClickModal: false,
+          closeOnPressEscape: false
+        })
+      } catch (e) {
+      } finally {
+        this.validationDialogVisible = false
+      }
+      return false
+    },
     // 融合
     async handleMerge(answers, questionId, orderMark) {
       this.lesionData = []
@@ -1002,34 +1021,19 @@ export default {
               //  淋巴结靶病灶 必须使用长短径测量工具,短径大于等于15mm
               if (!(measureData && measureData.markTool === 'Bidirectional' && lesionShort >= 15)) {
                 // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记，且短径须大于15mm！
-                this.$confirm(this.$t('trials:reading:warnning:msg19'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg19'))
                 return
               }
               if ((lesionPart === '肝门淋巴结' || lesionPart === 'Lymph node-hilum of liver') && !(measureData && measureData.markTool === 'Bidirectional' && lesionShort >= 20)) {
                 // 靶病灶部位为肝门淋巴结时，选择要求时短轴≥2cm
-                this.$confirm(this.$t('trials:mRecist:warnning:msg2'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:mRecist:warnning:msg2'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 直径测量工具 长径须大于等于10mm且不小于2倍层厚
               if (!(measureData && measureData.markTool === 'Length' && lesionLength >= 10 && (measureData.sliceThickness && lesionLength >= 2 * measureData.sliceThickness || !measureData.sliceThickness))) {
                 // 评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记，长径须大于10mm且不小于2倍层厚！
-                this.$confirm(this.$t('trials:reading:warnning:msg20'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg20'))
                 return
               }
             }
@@ -1041,24 +1045,14 @@ export default {
               // 淋巴结非靶病灶 必须使用长短径测量工具或箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'RectangleROI'))) {
                 // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记
-                this.$confirm(this.$t('trials:reading:warnning:msg21'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg21'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具或箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'RectangleROI'))) {
                 // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg22'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg22'))
                 return
               }
             }
@@ -1071,24 +1065,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具
               if (!(measureData && measureData.markTool === 'Bidirectional' && lesionShort >= 10)) {
                 // 评估状态为存在的淋巴结靶病灶需使用长短径测量工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg23'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg23'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 直径测量工具
               if (!(measureData && measureData.markTool === 'Length')) {
                 // `评估状态为存在的非淋巴结靶病灶需使用直径测量工具添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg24'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg24'))
                 return
               }
             }
@@ -1099,12 +1083,7 @@ export default {
               // 淋巴结靶病灶 必须使用箭头工具，短径记录为5mm
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为太小的淋巴结靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg25'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg25'))
                 return
               } else if (measureData && measureData.markTool === 'ArrowAnnotate') {
                 const shortId = this.getQuestionId(1, table.TableQuestions.Questions)
@@ -1116,12 +1095,7 @@ export default {
               // 非淋巴结靶病灶 箭头工具，长径记录为5mm
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为太小的非淋巴结靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg26'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg26'))
                 return
               } else if (measureData && measureData.markTool === 'ArrowAnnotate') {
                 const lengthId = this.getQuestionId(0, table.TableQuestions.Questions)
@@ -1138,24 +1112,14 @@ export default {
               // 淋巴结靶病灶 不需要添加标记
               if (measureData) {
                 // 评估状态为无法评估的淋巴结靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg27'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg27'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 不需要添加标记
               if (measureData) {
                 // 状态为无法评估的非淋巴结靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg28'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg28'))
                 return
               }
             }
@@ -1166,24 +1130,14 @@ export default {
             if (lymphNodes === 1) {
               if (!(measureData && (measureData.markTool === 'Bidirectional' && lesionShort < 10))) {
                 // `评估状态为消失的淋巴结靶病灶需使用长短径工具添加标记,且短径需小于10mm！`
-                this.$confirm(this.$t('trials:reading:warnning:msg29'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg29'))
                 return
               }
             } else {
               // 非淋巴结靶病灶 箭头工具
               if (!(measureData && measureData.markTool === 'ArrowAnnotate')) {
                 // 评估状态为消失的非淋巴结靶病灶只能使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg30'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg30'))
                 return
               } else if (measureData && measureData.markTool === 'ArrowAnnotate') {
                 const lengthId = this.getQuestionId(0, table.TableQuestions.Questions)
@@ -1200,24 +1154,14 @@ export default {
               // 淋巴结非靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'RectangleROI'))) {
                 // 评估状态为存在的淋巴结非靶病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg31'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg31'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'RectangleROI'))) {
                 // 评估状态为存在的非淋巴结非靶病灶需使用直径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg32'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg32'))
                 return
               }
             }
@@ -1229,24 +1173,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'RectangleROI'))) {
                 // `评估状态为显著增大的淋巴结非靶病灶需使用长短径测量工具或矩形工具添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg33'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg33'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'RectangleROI'))) {
                 // 评估状态为显著增大的非淋巴结非靶病灶需使用直径测量工具或矩形工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg34'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg34'))
                 return
               }
             }
@@ -1258,24 +1192,14 @@ export default {
               // 淋巴结靶病灶 无标记
               if (measureData) {
                 // 评估状态为无法评估的淋巴结非靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg35'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg35'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 无标记
               if (measureData) {
                 // 评估状态为无法评估的非淋巴结非靶病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg36'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg36'))
                 return
               }
             }
@@ -1287,24 +1211,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate' || measureData.markTool === 'Bidirectional'))) {
                 // 评估状态为消失的淋巴结非靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg37'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg37'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为消失的非淋巴结非靶病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg38'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg38'))
                 return
               }
             }
@@ -1316,44 +1230,24 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为存在的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg39'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg39'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (intrahepaticLesion && !(measureData && measureData.markTool === 'Length')) {
                 // 评估状态为存在的非淋巴结新病灶需使用直径测量工具添加标记！
-                this.$confirm(this.$t('trials:mRecist:warnning:msg6'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:mRecist:warnning:msg6'))
                 return
               }
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为存在的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg40'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg40'))
                 return
               }
               if (measureData && measureData.markTool === 'Length' && innerForm.IntrahepaticLesion && lesionLength < 10) {
                 // 病灶状态为“明确”的典型肝内病灶，长径应不小于10mm。
-                this.$confirm(this.$t('trials:mRecist:warnning:msg3'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:mRecist:warnning:msg3'))
                 return
               }
             }
@@ -1365,44 +1259,24 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Bidirectional' || measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为疑似的淋巴结新病灶需使用长短径测量工具或箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg41'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg41'))
                 return
               }
             } else {
               if (innerForm.IntrahepaticLesion && !(measureData && (measureData.markTool === 'Length'))) {
                 // `评估状态为疑似的非淋巴结新病灶需使用直径测量工具添加标记！`
-                this.$confirm(this.$t('trials:mRecist:warnning:msg6'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:mRecist:warnning:msg6'))
                 return
               }
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'Length' || measureData.markTool === 'ArrowAnnotate'))) {
                 // `评估状态为疑似的非淋巴结新病灶需使用直径测量工具或箭头工具添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg42'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg42'))
                 return
               }
               if (measureData && measureData.markTool === 'Length' && innerForm.IntrahepaticLesion && lesionLength >= 10) {
                 // 病灶状态为“疑似”的典型肝内病灶，长径应小于10mm。
-                this.$confirm(this.$t('trials:mRecist:warnning:msg4'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:mRecist:warnning:msg4'))
                 return
               }
             }
@@ -1414,24 +1288,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (measureData) {
                 // `评估状态为无法评估的淋巴结新病灶不需要添加标记！`
-                this.$confirm(this.$t('trials:reading:warnning:msg43'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg43'))
                 return
               }
             } else {
               // 非淋巴结非靶病灶 直径测量工具、箭头工具
               if (measureData) {
                 // 评估状态为无法评估的非淋巴结新病灶不需要添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg44'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg44'))
                 return
               }
             }
@@ -1443,24 +1307,14 @@ export default {
               // 淋巴结靶病灶 必须使用长短径测量工具、箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate' || measureData.markTool === 'Bidirectional'))) {
                 // 评估状态为消失的淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg45'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg45'))
                 return
               }
             } else {
               // 箭头工具
               if (!(measureData && (measureData.markTool === 'ArrowAnnotate'))) {
                 // 评估状态为消失的非淋巴结新病灶需使用箭头工具添加标记！
-                this.$confirm(this.$t('trials:reading:warnning:msg46'), {
-                  type: 'warning',
-                  showCancelButton: false,
-                  callback: action => { }
-                })
-                loading.close()
+                await this.showValidationDialog(this.$t('trials:reading:warnning:msg46'))
                 return
               }
             }
@@ -1533,6 +1387,9 @@ export default {
         }
       } finally {
         this.$set(this.rowSaveLoadingMap, rowKey, false)
+        if (loading) {
+          loading.close()
+        }
       }
     },
     // 上传截图