diff --git a/src/api/trials.js b/src/api/trials.js
index 6bb5711e..c8e8d53b 100644
--- a/src/api/trials.js
+++ b/src/api/trials.js
@@ -4366,4 +4366,20 @@ export function updateTrialExtralConfig(params, data) {
     params,
     data
   })
+}
+// 获取项目标准阅片关键点列表
+export function getTrialCriterionKeyFileList(data) {
+  return request({
+    url: `/TrialCriterionKeyFile/getTrialCriterionKeyFileList`,
+    method: 'post',
+    data
+  })
+}
+// 设置已阅读关键文件
+export function setReadKeyFile(data) {
+  return request({
+    url: `/ReadingImageTask/setReadKeyFile`,
+    method: 'post',
+    data
+  })
 }
\ No newline at end of file
diff --git a/src/views/dictionary/template/components/KeyDocument.vue b/src/views/dictionary/template/components/KeyDocument.vue
index c52c256a..83cc9ba0 100644
--- a/src/views/dictionary/template/components/KeyDocument.vue
+++ b/src/views/dictionary/template/components/KeyDocument.vue
@@ -60,6 +60,7 @@ import { Upload } from '@/api/dictionary'
 import BaseContainer from '@/components/BaseContainer'
 import Pagination from '@/components/Pagination'
 import { getSystemCriterionKeyFileList, addOrUpdateSystemCriterionKeyFile, deleteSystemCriterionKeyFile } from '@/api/dictionary'
+import { readEntry } from '@/utils/index'
 const searchDataDefault = () => {
     return {
         FileName: '',
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/DicomViewer.vue b/src/views/trials/trials-panel/reading/dicoms/components/DicomViewer.vue
index 2331140f..91da05e1 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/DicomViewer.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/DicomViewer.vue
@@ -399,9 +399,9 @@
           <div style="padding:5px;display: flex;">
             <!-- 手册 -->
             <el-tooltip class="item" effect="dark" :content="$t('trials:reading:button:handbooks')" placement="bottom"
-              v-if="isExistsManual">
+              v-if="isExistsManual || isHaveKeyFile">
               <div class="tool-wrapper">
-                <div class="icon" @click.prevent="previewManuals">
+                <div class="icon" @click.prevent="previewManuals(false)">
                   <svg-icon icon-class="constitution" class="svg-icon" />
                 </div>
                 <div class="text">{{ $t('trials:reading:button:handbooks') }}</div>
@@ -548,8 +548,14 @@
         </span>
       </span>
       <div style="height: 100%;margin:0;">
-        <Manuals :trial-id="trialId" />
+        <Manuals :trial-id="trialId" :justKeyDoc="manualsDialog.justKeyDoc" />
+        <div slot="footer" style="text-align:right;" v-if="openManuals">
+          <!-- 确认 -->
+          <el-button type="primary" size="mini" @click="handleSubmitKeyDoc">
+            {{ $t('common:button:confirm') }}</el-button>
+        </div>
       </div>
+
     </el-dialog>
 
     <el-dialog v-if="fusionSeries.visible" :visible.sync="fusionSeries.visible" :close-on-click-modal="false"
@@ -683,7 +689,7 @@ import html2canvas from 'html2canvas'
 import uploadDicomAndNonedicom from '@/components/uploadDicomAndNonedicom'
 import downloadDicomAndNonedicom from '@/components/downloadDicomAndNonedicom'
 import SignForm from '@/views/trials/components/newSignForm'
-import { getCriterionReadingInfo, verifyVisitTaskQuestions, submitDicomVisitTask } from '@/api/trials'
+import { getCriterionReadingInfo, verifyVisitTaskQuestions, submitDicomVisitTask, setReadKeyFile } from '@/api/trials'
 import { setSkipReadingCache } from '@/api/reading'
 import { getAutoCutNextTask } from '@/api/user'
 import const_ from '@/const/sign-code'
@@ -736,6 +742,14 @@ export default {
       type: Boolean,
       required: true
     },
+    isReadKeyFile: {
+      type: Boolean,
+      required: true
+    },
+    isHaveKeyFile: {
+      type: Boolean,
+      required: false
+    },
     iseCRFShowInDicomReading: {
       type: Boolean,
       required: true
@@ -838,7 +852,7 @@ export default {
       activeName: '1',
       customWwcTpl: [],
       isFullscreen: false,
-      manualsDialog: { visible: false },
+      manualsDialog: { visible: false, justKeyDoc: false },
       petct: { visible: false },
       fusionSeries: { visible: false },
       fusionForm: {
@@ -886,9 +900,18 @@ export default {
   },
 
   computed: {
-    ...mapGetters(['visitTaskList', 'currentReadingTaskState', 'lastCanvasTaskId', 'imageQualityIssues'])
+    ...mapGetters(['visitTaskList', 'currentReadingTaskState', 'lastCanvasTaskId', 'imageQualityIssues']),
+    openManuals() {
+      return !this.isReadKeyFile && this.isHaveKeyFile
+    }
   },
   watch: {
+    openManuals: {
+      handler() {
+        if (this.openManuals) this.previewManuals(true)
+      },
+      immediate: true
+    },
     currentReadingTaskState: {
       immediate: true,
       handler(val) {
@@ -1126,6 +1149,19 @@ export default {
     })
   },
   methods: {
+    async handleSubmitKeyDoc() {
+      try {
+        let data = {
+          TrialCriterionId: this.$router.currentRoute.query.TrialReadingCriterionId,
+        }
+        let res = await setReadKeyFile(data)
+        if (res.IsSuccess) {
+          this.manualsDialog.visible = false
+        }
+      } catch (err) {
+        console.log(err)
+      }
+    },
     showPanel(e, toolName) {
       if (toolName === 'layout') return false
       e.currentTarget.firstChild.lastChild.style.display = 'block'
@@ -2206,9 +2242,10 @@ export default {
     previewNoneDicoms() {
       this.$emit('previewNoneDicoms')
     },
-    previewManuals() {
+    previewManuals(justKeyDoc = false) {
       this.isFullscreen = false
       this.manualsDialog.visible = true
+      this.manualsDialog.justKeyDoc = justKeyDoc
     },
     async skipTask() {
       // 是否确认跳过？
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/Manuals.vue b/src/views/trials/trials-panel/reading/dicoms/components/Manuals.vue
index 847b30be..9f63da6d 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/Manuals.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/Manuals.vue
@@ -1,14 +1,9 @@
 <template>
   <div v-loading="loading" class="manuals-wrapper">
     <div class="left-wrapper">
-      <div v-if="fileList.length>0" class="basic-content">
-        <div
-          v-for="file in fileList"
-          :key="file.Id"
-          class="file-item"
-          :class="{activeItem:file.Id === selected.id}"
-          @click.prevent="preview(file)"
-        >
+      <div v-if="fileList.length > 0" class="basic-content">
+        <div v-for="file in fileList" :key="file.Id" class="file-item" :class="{ activeItem: file.Id === selected.id }"
+          @click.prevent="preview(file)">
           <!-- {{ file.Name }} -->
           <el-tooltip class="item" :content="file.Name" placement="bottom">
             <span>{{ file.Name }} </span>
@@ -21,19 +16,25 @@
     </div>
     <div class="right-wrapper">
       <div class="right-content">
-        <iframe v-if="selected.filePath" :src="`/static/pdfjs/web/viewer.html?file=${OSSclientConfig.basePath}${selected.filePath}?userName=${currentUser}&COMPANY=${COMPANY}`" width="100%" height="100%" frameborder="0" />
+        <iframe v-if="selected.filePath"
+          :src="`/static/pdfjs/web/viewer.html?file=${OSSclientConfig.basePath}${selected.filePath}?userName=${currentUser}&COMPANY=${COMPANY}`"
+          width="100%" height="100%" frameborder="0" />
       </div>
     </div>
   </div>
 </template>
 <script>
-import { getManualList } from '@/api/trials'
+import { getManualList, getTrialCriterionKeyFileList } from '@/api/trials'
 export default {
   name: 'Manuals',
   props: {
     trialId: {
       type: String,
       required: true
+    },
+    justKeyDoc: {
+      type: Boolean,
+      default: false
     }
   },
   data() {
@@ -45,7 +46,7 @@ export default {
       fileList: [],
       loading: false,
       currentUser: zzSessionStorage.getItem('userName'),
-      COMPANY:process.env.VUE_APP_COMPANY_NAME
+      COMPANY: process.env.VUE_APP_COMPANY_NAME
     }
   },
   mounted() {
@@ -54,16 +55,35 @@ export default {
   methods: {
     async getList() {
       this.loading = true
+      this.fileList = []
       try {
         var param = {
-          trialId: this.trialId
+          TrialCriterionId: this.$router.currentRoute.query.TrialReadingCriterionId,
+          PageIndex: 1,
+          PageSize: 1000
         }
-        const res = await getManualList(param)
+        const res = await getTrialCriterionKeyFileList(param)
         if (res.IsSuccess) {
-          this.fileList = res.Result
-          if (this.fileList.length > 0) {
-            this.preview(this.fileList[0])
+          let list = res.Result.CurrentPageData.map(item => {
+            return {
+              Id: item.Id,
+              Name: item.FileName,
+              Path: item.FilePath
+            }
+          })
+          this.fileList = [...this.fileList, ...list]
+        }
+        if (!this.justKeyDoc) {
+          var param = {
+            trialId: this.trialId
           }
+          const res = await getManualList(param)
+          if (res.IsSuccess) {
+            this.fileList = [...this.fileList, ...res.Result]
+          }
+        }
+        if (this.fileList.length > 0) {
+          this.preview(this.fileList[0])
         }
         this.loading = false
       } catch (e) {
@@ -77,38 +97,43 @@ export default {
   }
 }
 </script>
-<style lang="scss">
-.manuals-wrapper{
+<style lang="scss" scoped>
+.manuals-wrapper {
   display: flex;
   flex-direction: row !important;
   width: 100%;
-  height: 100%;
+  height: 95%;
   padding: 5px;
   overflow: hidden;
+
   ::-webkit-scrollbar {
     width: 7px;
     height: 7px;
   }
+
   ::-webkit-scrollbar-thumb {
     border-radius: 10px;
     background: #d0d0d0;
   }
-  .left-wrapper{
+
+  .left-wrapper {
     box-sizing: border-box;
     margin-right: 10px;
     height: 100%;
     width: 300px;
     border: 1px solid #ddd;
 
-    .basic-content{
+    .basic-content {
       height: 100%;
       overflow: auto;
     }
-    .basic-content-empty{
+
+    .basic-content-empty {
       padding: 5px;
       font-size: 16px;
     }
-    .file-item{
+
+    .file-item {
       box-sizing: border-box;
       border-bottom: 1px solid #f3f3f3;
       height: 50px;
@@ -121,18 +146,21 @@ export default {
       text-overflow: ellipsis;
       width: 100%;
     }
-    .activeItem{
+
+    .activeItem {
       color: #428bca !important;
       border-bottom: 1px solid #f3f3f3 !important;
     }
   }
-  .right-wrapper{
+
+  .right-wrapper {
     flex: 1;
     height: 100%;
     border: 1px solid #ddd;
   }
-  .right-content{
-    height:100%;
+
+  .right-content {
+    height: 100%;
   }
 
 }
diff --git a/src/views/trials/trials-panel/reading/dicoms/components/ReadPage.vue b/src/views/trials/trials-panel/reading/dicoms/components/ReadPage.vue
index 78bd94bc..3a07458c 100644
--- a/src/views/trials/trials-panel/reading/dicoms/components/ReadPage.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/components/ReadPage.vue
@@ -43,6 +43,7 @@
           :is-exists-clinical-data="isExistsClinicalData" :is-exists-no-dicom-file="isExistsNoDicomFile"
           :is-reading-show-subject-info="isReadingShowSubjectInfo" :studyShow="studyShow"
           :is-reading-task-view-in-order="isReadingTaskViewInOrder" :is-exists-manual="isExistsManual"
+          :isReadKeyFile="isReadKeyFile" :isHaveKeyFile="isHaveKeyFile"
           :iseCRFShowInDicomReading="iseCRFShowInDicomReading" @previewCD="previewCD" />
       </div>
 
@@ -124,6 +125,14 @@ export default {
       type: Boolean,
       required: true
     },
+    isReadKeyFile: {
+      type: Boolean,
+      required: true
+    },
+    isHaveKeyFile: {
+      type: Boolean,
+      required: false
+    },
     iseCRFShowInDicomReading: {
       type: Boolean,
       required: true
diff --git a/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeDicomViewer.vue b/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeDicomViewer.vue
index e0368720..9d03a965 100644
--- a/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeDicomViewer.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeDicomViewer.vue
@@ -340,9 +340,9 @@
         <div style="margin-left: auto">
           <div style="padding: 5px">
             <el-tooltip class="item" effect="dark" :content="$t('trials:reading:button:handbooks')" placement="bottom"
-              v-if="isExistsManual">
+              v-if="isExistsManual || isHaveKeyFile">
               <div class="tool-wrapper">
-                <div class="icon" @click.prevent="previewManuals">
+                <div class="icon" @click.prevent="previewManuals()">
                   <svg-icon icon-class="constitution" class="svg-icon" />
                 </div>
                 <div class="text">{{ $t('trials:reading:button:handbooks') }}</div>
@@ -428,7 +428,12 @@
         </span>
       </span>
       <div style="height: 100%; margin: 0">
-        <Manuals :trial-id="trialId" />
+        <Manuals :trial-id="trialId" :justKeyDoc="manualsDialog.justKeyDoc" />
+        <div slot="footer" style="text-align:right;" v-if="openManuals">
+          <!-- 确认 -->
+          <el-button type="primary" size="mini" @click="handleSubmitKeyDoc">
+            {{ $t('common:button:confirm') }}</el-button>
+        </div>
       </div>
     </el-dialog>
     <!--    <button :title="$t('trials:dicom-show:Eraser')" class="btn-link" data-tool="Eraser" @click="setToolActive($event,'Eraser')">-->
@@ -472,7 +477,7 @@ import store from '@/store'
 import { getDoctorShortcutKey, getUserWLTemplateList } from '@/api/user'
 import uploadDicomAndNonedicom from '@/components/uploadDicomAndNonedicom'
 import downloadDicomAndNonedicom from '@/components/downloadDicomAndNonedicom'
-import { getCriterionReadingInfo } from '@/api/trials'
+import { getCriterionReadingInfo, setReadKeyFile } from '@/api/trials'
 export default {
   name: 'DicomViewer',
   components: {
@@ -499,6 +504,14 @@ export default {
       type: Boolean,
       required: true,
     },
+    isReadKeyFile: {
+      type: Boolean,
+      required: true
+    },
+    isHaveKeyFile: {
+      type: Boolean,
+      required: false
+    },
     isReadingShowSubjectInfo: {
       type: Boolean,
       required: true,
@@ -654,7 +667,7 @@ export default {
       activeName: '1',
       customWwcTpl: [],
       isFullscreen: false,
-      manualsDialog: { visible: false },
+      manualsDialog: { visible: false, justKeyDoc: false },
       clipPlaying: false,
       fps: 15,
       trialCriterion: {},
@@ -674,8 +687,17 @@ export default {
 
   computed: {
     ...mapGetters(['visitTaskList', 'currentReadingTaskState']),
+    openManuals() {
+      return !this.isReadKeyFile && this.isHaveKeyFile
+    }
   },
   watch: {
+    openManuals: {
+      handler() {
+        if (this.openManuals) this.previewManuals(true)
+      },
+      immediate: true
+    },
     currentReadingTaskState: {
       immediate: true,
       handler(val) {
@@ -842,6 +864,19 @@ export default {
     DicomEvent.$off('loadLinkedImageStack')
   },
   methods: {
+    async handleSubmitKeyDoc() {
+      try {
+        let data = {
+          TrialCriterionId: this.$router.currentRoute.query.TrialReadingCriterionId,
+        }
+        let res = await setReadKeyFile(data)
+        if (res.IsSuccess) {
+          this.manualsDialog.visible = false
+        }
+      } catch (err) {
+        console.log(err)
+      }
+    },
     getTrialCriterion() {
       getCriterionReadingInfo({
         TrialId: this.trialId,
@@ -2113,9 +2148,10 @@ export default {
     previewNoneDicoms() {
       this.$emit('previewNoneDicoms')
     },
-    previewManuals() {
+    previewManuals(justKeyDoc = false) {
       this.isFullscreen = false
       this.manualsDialog.visible = true
+      this.manualsDialog.justKeyDoc = justKeyDoc
     },
   },
 }
diff --git a/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeReadPage.vue b/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeReadPage.vue
index f51d3978..313c6b5e 100644
--- a/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeReadPage.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/customize/CustomizeReadPage.vue
@@ -33,6 +33,7 @@
           :is-exists-clinical-data="isExistsClinicalData" :is-exists-no-dicom-file="isExistsNoDicomFile"
           :is-reading-show-subject-info="isReadingShowSubjectInfo"
           :is-reading-task-view-in-order="isReadingTaskViewInOrder" :isExistsManual="isExistsManual"
+          :isReadKeyFile="isReadKeyFile" :isHaveKeyFile="isHaveKeyFile"
           :IseCRFShowInDicomReading="IseCRFShowInDicomReading" @previewCD="previewCD" />
       </div>
     </div>
@@ -108,6 +109,14 @@ export default {
       type: Boolean,
       required: true,
     },
+    isReadKeyFile: {
+      type: Boolean,
+      required: true
+    },
+    isHaveKeyFile: {
+      type: Boolean,
+      required: false
+    },
     isExistsNoDicomFile: {
       type: Boolean,
       required: true,
@@ -656,7 +665,7 @@ export default {
     },
     cornerstoneimageloadprogress(e) {
       const imageId = e.detail.imageId
-      console.log(imageId,'imageId')
+      console.log(imageId, 'imageId')
       const params = {}
       const searchParams = new URLSearchParams(imageId.split('?')[1])
       for (const [key, value] of searchParams.entries()) {
diff --git a/src/views/trials/trials-panel/reading/dicoms/customize/Manuals.vue b/src/views/trials/trials-panel/reading/dicoms/customize/Manuals.vue
index fd4babe4..9f63da6d 100644
--- a/src/views/trials/trials-panel/reading/dicoms/customize/Manuals.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/customize/Manuals.vue
@@ -1,14 +1,9 @@
 <template>
   <div v-loading="loading" class="manuals-wrapper">
     <div class="left-wrapper">
-      <div v-if="fileList.length>0" class="basic-content">
-        <div
-          v-for="file in fileList"
-          :key="file.Id"
-          class="file-item"
-          :class="{activeItem:file.Id === selected.id}"
-          @click.prevent="preview(file)"
-        >
+      <div v-if="fileList.length > 0" class="basic-content">
+        <div v-for="file in fileList" :key="file.Id" class="file-item" :class="{ activeItem: file.Id === selected.id }"
+          @click.prevent="preview(file)">
           <!-- {{ file.Name }} -->
           <el-tooltip class="item" :content="file.Name" placement="bottom">
             <span>{{ file.Name }} </span>
@@ -21,19 +16,25 @@
     </div>
     <div class="right-wrapper">
       <div class="right-content">
-        <iframe v-if="selected.filePath" :src="`/static/pdfjs/web/viewer.html?file=${OSSclientConfig.basePath}${selected.filePath}?userName=${currentUser}&COMPANY=${COMPANY}`" width="100%" height="100%" frameborder="0" />
+        <iframe v-if="selected.filePath"
+          :src="`/static/pdfjs/web/viewer.html?file=${OSSclientConfig.basePath}${selected.filePath}?userName=${currentUser}&COMPANY=${COMPANY}`"
+          width="100%" height="100%" frameborder="0" />
       </div>
     </div>
   </div>
 </template>
 <script>
-import { getManualList } from '@/api/trials'
+import { getManualList, getTrialCriterionKeyFileList } from '@/api/trials'
 export default {
   name: 'Manuals',
   props: {
     trialId: {
       type: String,
       required: true
+    },
+    justKeyDoc: {
+      type: Boolean,
+      default: false
     }
   },
   data() {
@@ -45,7 +46,7 @@ export default {
       fileList: [],
       loading: false,
       currentUser: zzSessionStorage.getItem('userName'),
-      COMPANY:process.env.VUE_APP_COMPANY_NAME
+      COMPANY: process.env.VUE_APP_COMPANY_NAME
     }
   },
   mounted() {
@@ -54,18 +55,38 @@ export default {
   methods: {
     async getList() {
       this.loading = true
-      var param = {
-        trialId: this.trialId
-      }
-      try{
-        let res = await getManualList(param)
-        this.fileList = res.Result
-
+      this.fileList = []
+      try {
+        var param = {
+          TrialCriterionId: this.$router.currentRoute.query.TrialReadingCriterionId,
+          PageIndex: 1,
+          PageSize: 1000
+        }
+        const res = await getTrialCriterionKeyFileList(param)
+        if (res.IsSuccess) {
+          let list = res.Result.CurrentPageData.map(item => {
+            return {
+              Id: item.Id,
+              Name: item.FileName,
+              Path: item.FilePath
+            }
+          })
+          this.fileList = [...this.fileList, ...list]
+        }
+        if (!this.justKeyDoc) {
+          var param = {
+            trialId: this.trialId
+          }
+          const res = await getManualList(param)
+          if (res.IsSuccess) {
+            this.fileList = [...this.fileList, ...res.Result]
+          }
+        }
         if (this.fileList.length > 0) {
           this.preview(this.fileList[0])
         }
         this.loading = false
-      }catch(e){
+      } catch (e) {
         this.loading = false
       }
     },
@@ -76,38 +97,43 @@ export default {
   }
 }
 </script>
-<style lang="scss">
-.manuals-wrapper{
+<style lang="scss" scoped>
+.manuals-wrapper {
   display: flex;
   flex-direction: row !important;
   width: 100%;
-  height: 100%;
+  height: 95%;
   padding: 5px;
   overflow: hidden;
+
   ::-webkit-scrollbar {
     width: 7px;
     height: 7px;
   }
+
   ::-webkit-scrollbar-thumb {
     border-radius: 10px;
     background: #d0d0d0;
   }
-  .left-wrapper{
+
+  .left-wrapper {
     box-sizing: border-box;
     margin-right: 10px;
     height: 100%;
     width: 300px;
     border: 1px solid #ddd;
 
-    .basic-content{
+    .basic-content {
       height: 100%;
       overflow: auto;
     }
-    .basic-content-empty{
+
+    .basic-content-empty {
       padding: 5px;
       font-size: 16px;
     }
-    .file-item{
+
+    .file-item {
       box-sizing: border-box;
       border-bottom: 1px solid #f3f3f3;
       height: 50px;
@@ -120,18 +146,21 @@ export default {
       text-overflow: ellipsis;
       width: 100%;
     }
-    .activeItem{
+
+    .activeItem {
       color: #428bca !important;
       border-bottom: 1px solid #f3f3f3 !important;
     }
   }
-  .right-wrapper{
+
+  .right-wrapper {
     flex: 1;
     height: 100%;
     border: 1px solid #ddd;
   }
-  .right-content{
-    height:100%;
+
+  .right-content {
+    height: 100%;
   }
 
 }
diff --git a/src/views/trials/trials-panel/reading/dicoms/index.vue b/src/views/trials/trials-panel/reading/dicoms/index.vue
index 1c930608..23cc8b0d 100644
--- a/src/views/trials/trials-panel/reading/dicoms/index.vue
+++ b/src/views/trials/trials-panel/reading/dicoms/index.vue
@@ -18,6 +18,7 @@
             :is-reading-show-subject-info="isReadingShowSubjectInfo"
             :is-reading-task-view-in-order="isReadingTaskViewInOrder" :is-exists-clinical-data="isExistsClinicalData"
             :is-exists-no-dicom-file="isExistsNoDicomFile" :is-exists-manual="isExistsManual"
+            :isReadKeyFile="isReadKeyFile" :isHaveKeyFile="isHaveKeyFile"
             :ise-c-r-f-show-in-dicom-reading="IseCRFShowInDicomReading" @previewCD="previewCD" />
         </el-tab-pane>
         <!-- 报告 -->
@@ -38,7 +39,8 @@
             :subject-code="subjectCode" :is-show="isShow" :is-reading-show-subject-info="isReadingShowSubjectInfo"
             :is-reading-task-view-in-order="isReadingTaskViewInOrder"
             :ise-c-r-f-show-in-dicom-reading="IseCRFShowInDicomReading" :is-exists-clinical-data="isExistsClinicalData"
-            :is-exists-no-dicom-file="isExistsNoDicomFile" :is-exists-manual="isExistsManual" @previewCD="previewCD" />
+            :is-exists-no-dicom-file="isExistsNoDicomFile" :is-exists-manual="isExistsManual"
+            :isReadKeyFile="isReadKeyFile" :isHaveKeyFile="isHaveKeyFile" @previewCD="previewCD" />
         </el-tab-pane>
         <!-- 报告 -->
         <el-tab-pane v-if="!IseCRFShowInDicomReading" :label="$t('trials:reading:tabTitle:report')" name="report">
@@ -219,7 +221,9 @@ export default {
       closeCDVisible: false,
       cdVisitTaskId: '',
       readingVersionEnum: null,
-      dialogBodyPartVisible: false
+      dialogBodyPartVisible: false,
+      isReadKeyFile: true,
+      isHaveKeyFile: false
     }
   },
   computed: {
@@ -327,6 +331,8 @@ export default {
         this.isExistsNoDicomFile = res.Result.IsExistsNoDicomFile
         this.isExistsClinicalData = res.Result.IsExistsClinicalData
         this.isExistsManual = res.Result.ExistsManual
+        this.isReadKeyFile = res.Result.IsReadKeyFile
+        this.isHaveKeyFile = res.Result.IsHaveKeyFile
         this.isReadClinicalData = res.Result.IsReadClinicalData
         this.IsViewStudyPart = res.Result.IsViewStudyPart
         this.isNeedReadClinicalData = res.Result.IsNeedReadClinicalData
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
index ba9bc8f2..4e864c1a 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
@@ -270,7 +270,7 @@
           <div style="display: flex;">
             <!-- 手册 -->
             <div class="tool-item" :title="$t('trials:reading:button:handbooks')"
-              v-if="taskInfo && taskInfo.ExistsManual" @click.prevent="previewManuals">
+              v-if="taskInfo && (taskInfo.ExistsManual || taskInfo.IsHaveKeyFile)" @click.prevent="previewManuals()">
               <svg-icon icon-class="constitution" class="svg-icon" />
             </div>
             <!-- 临床数据 -->
@@ -370,7 +370,12 @@
         </span>
       </span>
       <div style="height: 100%;margin:0;">
-        <Manuals :trial-id="trialId" />
+        <Manuals :trial-id="trialId" :justKeyDoc="manualsDialog.justKeyDoc" />
+        <div slot="footer" style="text-align:right;" v-if="openManuals">
+          <!-- 确认 -->
+          <el-button type="primary" size="mini" @click="handleSubmitKeyDoc">
+            {{ $t('common:button:confirm') }}</el-button>
+        </div>
       </div>
     </el-dialog>
     <!-- 个性化配置 -->
@@ -425,7 +430,7 @@
   </div>
 </template>
 <script>
-import { getRelatedVisitTask, getReadingVisitStudyList, getTableAnswerRowInfoList, deleteCustomTag, getCriterionReadingInfo } from '@/api/trials'
+import { getRelatedVisitTask, getReadingVisitStudyList, getTableAnswerRowInfoList, deleteCustomTag, getCriterionReadingInfo, setReadKeyFile } from '@/api/trials'
 import { getDoctorShortcutKey, getUserWLTemplateList } from '@/api/user'
 import { getCustomTag, submitCustomTag } from '@/api/reading'
 import { getToken } from '@/utils/auth'
@@ -596,7 +601,7 @@ export default {
       activeViewportWC: null,
       clipPlaying: false,
       fps: 15,
-      manualsDialog: { visible: false, isFullscreen: false },
+      manualsDialog: { visible: false, isFullscreen: false, justKeyDoc: false },
       hotKeyList: [],
       forceFitToWindow: false,
       isShowAnnotations: true,
@@ -661,8 +666,17 @@ export default {
     viewportKey() {
       return this.isFusion ? 'viewport-fusion' : 'viewport'
     },
+    openManuals() {
+      return !this.taskInfo.IsReadKeyFile && this.taskInfo.IsHaveKeyFile
+    }
   },
   watch: {
+    openManuals: {
+      handler() {
+        if (this.openManuals) this.previewManuals(true)
+      },
+      immediate: true
+    },
     currentReadingTaskState() { console.log(this.currentReadingTaskState, 'currentReadingTaskState') },
     activeTaskId: {
       immediate: true,
@@ -751,6 +765,19 @@ export default {
     })
   },
   methods: {
+    async handleSubmitKeyDoc() {
+      try {
+        let data = {
+          TrialCriterionId: this.$router.currentRoute.query.TrialReadingCriterionId,
+        }
+        let res = await setReadKeyFile(data)
+        if (res.IsSuccess) {
+          this.manualsDialog.visible = false
+        }
+      } catch (err) {
+        console.log(err)
+      }
+    },
     // 加载当前任务关联的任务信息
     async loadRelatedTasks() {
       this.loading = true
@@ -2792,9 +2819,10 @@ export default {
       return a < b ? (a < c ? a : c) : (b < c ? b : c)
     },
     // 手册
-    previewManuals() {
+    previewManuals(justKeyDoc = false) {
       this.manualsDialog.isFullscreen = false
       this.manualsDialog.visible = true
+      this.manualsDialog.justKeyDoc = justKeyDoc
     },
     // 临床数据
     previewCD(taskId) {
diff --git a/src/views/trials/trials-panel/reading/visit-review/components/FileViewer.vue b/src/views/trials/trials-panel/reading/visit-review/components/FileViewer.vue
index 578fd92b..a07305d5 100644
--- a/src/views/trials/trials-panel/reading/visit-review/components/FileViewer.vue
+++ b/src/views/trials/trials-panel/reading/visit-review/components/FileViewer.vue
@@ -116,8 +116,8 @@
 
       <div style="display: flex;">
         <!-- 手册 -->
-        <div class="tool-item" :title="$t('trials:reading:button:handbooks')" v-if="taskInfo && taskInfo.ExistsManual"
-          @click.prevent="previewManuals">
+        <div class="tool-item" :title="$t('trials:reading:button:handbooks')"
+          v-if="taskInfo && (taskInfo.ExistsManual || taskInfo.IsHaveKeyFile)" @click.prevent="previewManuals">
           <svg-icon icon-class="constitution" class="svg-icon" />
         </div>
         <!-- 个性化配置 -->
@@ -254,7 +254,12 @@
         </span>
       </span>
       <div style="height: 100%;margin:0;">
-        <Manuals :trial-id="trialId" />
+        <Manuals :trial-id="trialId" :justKeyDoc="manualsDialog.justKeyDoc" />
+        <div slot="footer" style="text-align:right;" v-if="openManuals">
+          <!-- 确认 -->
+          <el-button type="primary" size="mini" @click="handleSubmitKeyDoc">
+            {{ $t('common:button:confirm') }}</el-button>
+        </div>
       </div>
     </el-dialog>
   </div>
@@ -410,9 +415,18 @@ export default {
     cells() {
       return Array(this.rows * this.cols).fill(0)
     },
-    ...mapGetters(['lastViewportTaskId', 'currentTaskState'])
+    ...mapGetters(['lastViewportTaskId', 'currentTaskState']),
+    openManuals() {
+      return !this.taskInfo.IsReadKeyFile && this.taskInfo.IsHaveKeyFile
+    }
   },
   watch: {
+    openManuals: {
+      handler() {
+        if (this.openManuals) this.previewManuals(true)
+      },
+      immediate: true
+    },
     relatedStudyInfo: {
       immediate: true,
       handler(obj) {
@@ -477,10 +491,24 @@ export default {
     window.removeEventListener('message', this.handleIframeMessage)
   },
   methods: {
+    async handleSubmitKeyDoc() {
+      try {
+        let data = {
+          TrialCriterionId: this.$router.currentRoute.query.TrialReadingCriterionId,
+        }
+        let res = await setReadKeyFile(data)
+        if (res.IsSuccess) {
+          this.manualsDialog.visible = false
+        }
+      } catch (err) {
+        console.log(err)
+      }
+    },
     // 手册
-    previewManuals() {
+    previewManuals(justKeyDoc = false) {
       this.manualsDialog.isFullscreen = false
       this.manualsDialog.visible = true
+      this.manualsDialog.justKeyDoc = justKeyDoc
     },
     getTrialCriterion() {
       getCriterionReadingInfo({
diff --git a/src/views/trials/trials-panel/setting/reading-unit/components/ReadingRules.vue b/src/views/trials/trials-panel/setting/reading-unit/components/ReadingRules.vue
index 56a4e131..f4825871 100644
--- a/src/views/trials/trials-panel/setting/reading-unit/components/ReadingRules.vue
+++ b/src/views/trials/trials-panel/setting/reading-unit/components/ReadingRules.vue
@@ -288,6 +288,15 @@
           </el-radio>
         </el-radio-group>
       </el-form-item>
+      <!-- 阅片关键点 -->
+      <el-form-item :label="$t('trials:readingUnit:readingRules:title:keyDoc')
+        " prop="KeyFileList">
+        <el-input v-model="form.KeyFileListStr" type="textarea" :autosize="{ minRows: 1, maxRows: 3 }"
+          style="width: 80%" disabled />
+        <el-button :disabled="isConfirm ||
+          !hasPermi(['trials:trials-panel:setting:reading-unit:edit'])
+          " icon="el-icon-plus" circle @click="handleSetKeyFileList" />
+      </el-form-item>
       <el-form-item :label="$t(
         'trials:trials-panel:setting:reading-unit:TrialCriterionAdditionalAssessmentTypeList'
       )
@@ -332,11 +341,45 @@
         </el-button>
       </el-form-item>
     </el-form>
+    <!-- 配置信息确认框 -->
+    <el-dialog v-if="keyDocVisible" :visible.sync="keyDocVisible" :close-on-click-modal="false" width="600px"
+      :title="$t('trials:reading-unit:dialogTitle:keyDoc')" custom-class="base-dialog-wrapper">
+      <div class="base-dialog-body">
+        <div class="upload">
+          <input directory accept=".pdf" type="file" name="uploadFolder" class="select-file" title=""
+            @change="beginScanFiles($event)" />
+          <div class="btn-select">
+            {{ $t('dictionary:template:basicData:button:selectFile') }}
+          </div>
+        </div>
+        <div class="drag" ref="drag" @dragover="handleDragover" @drop="handleDrop">
+          <el-table :data="confirmData" border style="width: 100%" size="small">
+            <el-table-column prop="FileName" :label="$t('trials:reading-unit:table:FileName')" show-overflow-tooltip />
+            <el-table-column :label="$t('common:action:action')" align="left" fixed="right">
+              <template slot-scope="scope">
+                <el-button circle icon="el-icon-view" :title="$t('dictionary:template:keyDocList:button:view')"
+                  @click.stop="view(scope.row)" />
+                <el-button circle icon="el-icon-delete" :title="$t('dictionary:template:keyDocList:button:del')"
+                  @click.stop="del(scope.$index)" />
+              </template>
+            </el-table-column>
+          </el-table>
+        </div>
+
+      </div>
+      <div class="base-dialog-footer" style="text-align: right; margin-top: 10px">
+        <!-- 确认 -->
+        <el-button size="small" type="primary" @click="handleConfirm">
+          {{ $t('trials:reading-unit:button:confirmCfg') }}
+        </el-button>
+      </div>
+    </el-dialog>
   </div>
 </template>
 <script>
 import { getCriterionReadingInfo, setCriterionReadingInfo } from '@/api/trials'
 import { config } from '@/views/trials/trials-panel/reading/dicoms3D/components/toolConfig'
+import { readEntry } from '@/utils/index'
 export default {
   name: 'ReadingRules',
   props: {
@@ -350,9 +393,15 @@ export default {
       type: Number,
       default: 0,
     },
+    TrialReadingCriterionName: {
+      type: String,
+      default: ''
+    }
   },
   data() {
     return {
+      keyDocVisible: false,
+      confirmData: [],
       additionalAssessmentOptionList: [],
       form: {
         TrialId: '',
@@ -387,6 +436,8 @@ export default {
         ImageDownloadEnum: null,
         ImageUploadEnum: null,
         IsImageFilter: false,
+        KeyFileListStr: '',
+        KeyFileList: []
       },
       rules: {
         IsAutoCreate: [
@@ -577,6 +628,83 @@ export default {
     },
   },
   methods: {
+    handleDragover(e) {
+      e.stopPropagation();
+      e.preventDefault();
+    },
+    handleDrop(e) {
+      e.stopPropagation();
+      e.preventDefault();
+      this.beginScanFiles(e, true)
+    },
+    view(row) {
+      this.$preview({
+        path: row.FilePath,
+        type: 'pdf',
+        title: row.FileName,
+      })
+    },
+    del(index) {
+      this.confirmData.splice(index, 1)
+    },
+    handleSetKeyFileList() {
+      this.confirmData = [...this.form.KeyFileList]
+      this.keyDocVisible = true
+    },
+    handleConfirm() {
+      this.form.KeyFileList = [...this.confirmData]
+      this.form.KeyFileListStr = this.form.KeyFileList.map(item => item.FileName).join(',')
+      this.keyDocVisible = false
+    },
+    async beginScanFiles(e, isDrop = false) {
+      try {
+        let files = []
+        if (isDrop) {
+          const items = e.dataTransfer.items;
+          const allFiles = []; // 用于存储所有找到的文件
+
+          // 遍历拖拽项
+          for (const item of items) {
+            const entry = item.webkitGetAsEntry(); // 获取文件系统入口
+            if (entry) {
+              const files = await readEntry(entry); // 递归读取入口内容
+              allFiles.push(...files);
+            }
+          }
+          files = allFiles
+        } else {
+          files = [...e.target.files]
+        }
+        for (let i = 0; i < files.length; i++) {
+          let file = files[i]
+          let name = file.name
+          if (!this.checkFileSuffix(name)) continue
+          file = await this.fileToBlob(file)
+          let scope = this
+          let res = await this.OSSclient.put(
+            `/${this.$route.query.trialId}/ReadingModule/${this.TrialReadingCriterionName}/${scope.getGuid(Date.now() + '_' + name.split('.')[0])}.pdf`,
+            file
+          )
+          let data = {
+            FilePath: this.$getObjectName(res.url),
+            FileName: name
+          }
+          this.confirmData.push(data)
+        }
+      } catch (err) {
+        console.log(err)
+        this.loading = false;
+      }
+    },
+    checkFileSuffix(fileName) {
+      var index = fileName.lastIndexOf('.')
+      var suffix = fileName.substring(index + 1, fileName.length)
+      if ('.pdf'.toLocaleLowerCase().search(suffix.toLocaleLowerCase()) === -1) {
+        return false
+      } else {
+        return true
+      }
+    },
     // 阅片工具选择
     handleReadingToolInput(val) {
       this.form.ReadingToolList = []
@@ -625,6 +753,9 @@ export default {
               this.form[k] = res.Result[k]
             }
           }
+          if (Array.isArray(this.form.KeyFileList) && this.form.KeyFileList.length > 0) {
+            this.form.KeyFileListStr = this.form.KeyFileList.map(item => item.FileName).join(',')
+          }
           if (this.CriterionType === 0) {
             if (this.form.ReadingTool === 0 || this.form.ReadingTool === 2) {
               this.tools = [...config.customizeStandards]
@@ -727,4 +858,46 @@ export default {
     color: red;
   }
 }
+
+.upload {
+  display: inline-block;
+  height: 30px;
+  width: 90px;
+  padding: 2px 10px;
+  line-height: 23px;
+  position: relative;
+  text-decoration: none;
+  border-radius: 3px;
+  overflow: hidden;
+  text-align: center;
+  background: #428bca;
+  border-color: #428bca;
+  color: #fff;
+
+  .select-file {
+    height: 30px;
+    width: 90px;
+    position: absolute;
+    overflow: hidden;
+    left: 0;
+    top: 0;
+    opacity: 0;
+    font-size: 0;
+  }
+
+  .btn-select {
+    //给显示在页面上的按钮写样式
+    width: 90px;
+    height: 30px;
+    line-height: 30px;
+    text-align: center;
+    cursor: pointer;
+    border-radius: 24px;
+    overflow: hidden;
+    position: absolute;
+    top: 0;
+    left: 0;
+    pointer-events: none; //pointer-events:none用来控制该标签的点击穿透事件
+  }
+}
 </style>
diff --git a/src/views/trials/trials-panel/setting/reading-unit/index.vue b/src/views/trials/trials-panel/setting/reading-unit/index.vue
index f6a65cd6..999de213 100644
--- a/src/views/trials/trials-panel/setting/reading-unit/index.vue
+++ b/src/views/trials/trials-panel/setting/reading-unit/index.vue
@@ -19,11 +19,11 @@
               <el-collapse-item :title="$t('trials:readingUnit:readingRules')" name="1">
                 <ReadingRules :ref="`readingRules${item.TrialReadingCriterionId}`"
                   :trial-reading-criterion-id="TrialReadingCriterionId" :CriterionType="item.CriterionType"
-                  @setConfirm="setConfirm" @reloadArbitrationRules="reloadArbitrationRules"
-                  @setArbitrationReading="setArbitrationReading" @setAdditionalAssessment="setAdditionalAssessment"
-                  @setIsClinicalReading="setIsClinicalReading" @setGlobalReading="setGlobalReading"
-                  @setOncologyReading="setOncologyReading" @setDigitPlaces="setDigitPlaces"
-                  @setReadingTools="setReadingTools" />
+                  :TrialReadingCriterionName="item.TrialReadingCriterionName" @setConfirm="setConfirm"
+                  @reloadArbitrationRules="reloadArbitrationRules" @setArbitrationReading="setArbitrationReading"
+                  @setAdditionalAssessment="setAdditionalAssessment" @setIsClinicalReading="setIsClinicalReading"
+                  @setGlobalReading="setGlobalReading" @setOncologyReading="setOncologyReading"
+                  @setDigitPlaces="setDigitPlaces" @setReadingTools="setReadingTools" />
               </el-collapse-item>
               <!-- 阅片标准 -->
               <el-collapse-item :title="$t('trials:readingUnit:readingCriterion')" name="2">
diff --git a/src/views/trials/trials-panel/visit/qc-check/components/manuals.vue b/src/views/trials/trials-panel/visit/qc-check/components/manuals.vue
index 8857bb8e..9f63da6d 100644
--- a/src/views/trials/trials-panel/visit/qc-check/components/manuals.vue
+++ b/src/views/trials/trials-panel/visit/qc-check/components/manuals.vue
@@ -1,14 +1,9 @@
 <template>
   <div v-loading="loading" class="manuals-wrapper">
     <div class="left-wrapper">
-      <div v-if="fileList.length>0" class="basic-content">
-        <div
-          v-for="file in fileList"
-          :key="file.Id"
-          class="file-item"
-          :class="{activeItem:file.Id === selected.id}"
-          @click.prevent="preview(file)"
-        >
+      <div v-if="fileList.length > 0" class="basic-content">
+        <div v-for="file in fileList" :key="file.Id" class="file-item" :class="{ activeItem: file.Id === selected.id }"
+          @click.prevent="preview(file)">
           <!-- {{ file.Name }} -->
           <el-tooltip class="item" :content="file.Name" placement="bottom">
             <span>{{ file.Name }} </span>
@@ -21,19 +16,25 @@
     </div>
     <div class="right-wrapper">
       <div class="right-content">
-        <iframe v-if="selected.filePath" :src="`/static/pdfjs/web/viewer.html?file=${OSSclientConfig.basePath}${selected.filePath}?userName=${currentUser}&COMPANY=${COMPANY}`" width="100%" height="100%" frameborder="0" />
+        <iframe v-if="selected.filePath"
+          :src="`/static/pdfjs/web/viewer.html?file=${OSSclientConfig.basePath}${selected.filePath}?userName=${currentUser}&COMPANY=${COMPANY}`"
+          width="100%" height="100%" frameborder="0" />
       </div>
     </div>
   </div>
 </template>
 <script>
-import { getManualList } from '@/api/trials'
+import { getManualList, getTrialCriterionKeyFileList } from '@/api/trials'
 export default {
   name: 'Manuals',
   props: {
     trialId: {
       type: String,
       required: true
+    },
+    justKeyDoc: {
+      type: Boolean,
+      default: false
     }
   },
   data() {
@@ -45,26 +46,49 @@ export default {
       fileList: [],
       loading: false,
       currentUser: zzSessionStorage.getItem('userName'),
-      COMPANY:process.env.VUE_APP_COMPANY_NAME
+      COMPANY: process.env.VUE_APP_COMPANY_NAME
     }
   },
   mounted() {
     this.getList()
   },
   methods: {
-    getList() {
+    async getList() {
       this.loading = true
-      var param = {
-        trialId: this.trialId
-      }
-      getManualList(param).then(res => {
-        this.fileList = res.Result
-
+      this.fileList = []
+      try {
+        var param = {
+          TrialCriterionId: this.$router.currentRoute.query.TrialReadingCriterionId,
+          PageIndex: 1,
+          PageSize: 1000
+        }
+        const res = await getTrialCriterionKeyFileList(param)
+        if (res.IsSuccess) {
+          let list = res.Result.CurrentPageData.map(item => {
+            return {
+              Id: item.Id,
+              Name: item.FileName,
+              Path: item.FilePath
+            }
+          })
+          this.fileList = [...this.fileList, ...list]
+        }
+        if (!this.justKeyDoc) {
+          var param = {
+            trialId: this.trialId
+          }
+          const res = await getManualList(param)
+          if (res.IsSuccess) {
+            this.fileList = [...this.fileList, ...res.Result]
+          }
+        }
         if (this.fileList.length > 0) {
           this.preview(this.fileList[0])
         }
         this.loading = false
-      }).catch(() => { this.loading = false })
+      } catch (e) {
+        this.loading = false
+      }
     },
     preview(file) {
       this.$set(this.selected, 'filePath', file.Path)
@@ -73,38 +97,43 @@ export default {
   }
 }
 </script>
-<style lang="scss">
-.manuals-wrapper{
+<style lang="scss" scoped>
+.manuals-wrapper {
   display: flex;
   flex-direction: row !important;
   width: 100%;
-  height: 100%;
+  height: 95%;
   padding: 5px;
   overflow: hidden;
+
   ::-webkit-scrollbar {
     width: 7px;
     height: 7px;
   }
+
   ::-webkit-scrollbar-thumb {
     border-radius: 10px;
     background: #d0d0d0;
   }
-  .left-wrapper{
+
+  .left-wrapper {
     box-sizing: border-box;
     margin-right: 10px;
     height: 100%;
     width: 300px;
     border: 1px solid #ddd;
 
-    .basic-content{
+    .basic-content {
       height: 100%;
       overflow: auto;
     }
-    .basic-content-empty{
+
+    .basic-content-empty {
       padding: 5px;
       font-size: 16px;
     }
-    .file-item{
+
+    .file-item {
       box-sizing: border-box;
       border-bottom: 1px solid #f3f3f3;
       height: 50px;
@@ -117,18 +146,21 @@ export default {
       text-overflow: ellipsis;
       width: 100%;
     }
-    .activeItem{
+
+    .activeItem {
       color: #428bca !important;
       border-bottom: 1px solid #f3f3f3 !important;
     }
   }
-  .right-wrapper{
+
+  .right-wrapper {
     flex: 1;
     height: 100%;
     border: 1px solid #ddd;
   }
-  .right-content{
-    height:100%;
+
+  .right-content {
+    height: 100%;
   }
 
 }