diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue
index 98759839..27154bff 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionFormItem.vue
@@ -496,6 +496,9 @@ export default {
       this.$emit('operateImageMarker', { operateStateEnum: 6, question })
     },
     async deleteTableCol(row, index) {
+      let data = row.TableQuestions.Answers[index]
+      let hasMark = Object.keys(data).some(key => this.questionsMarkStatus[`${data.RowId}_${key}`] && this.questionsMarkStatus[`${data.RowId}_${key}`].isMarked)
+      if (hasMark) return this.$alert(this.$t('dicom3D:ReadPage:alert:QuestionToMarkNoDel'))
       let loading = null
       try {
         let confirm = await this.$confirm(this.$t('trials:uploadNonDicoms:message:msg1'))
@@ -691,21 +694,26 @@ export default {
         }
       }
       if (isExistUnSaved) {
-        // 标记未保存是否确认关闭？ 
-        const confirm = await this.$confirm(this.$t("dicom3D:CustomizeQuestionFormItem:confirm:markNoSaveAndclose"), {
-          type: 'warning',
-          distinguishCancelAndClose: true
-        })
-        if (confirm !== 'confirm') return
-        // 清除绑定关系
-        let obj = {}
-        if (!this.QuestionsForm.RowId) {
-          obj.markTableQuestions = this.markTableQuestions
-          obj.questionId = this.question.Id
-          this.$emit('unBindAnnotationToQuestion', obj)
-        }
+        if (this.addOrEdit.type = 'add') {
+          // 标记未保存是否确认关闭？ 
+          const confirm = await this.$confirm(this.$t("dicom3D:CustomizeQuestionFormItem:confirm:markNoSaveAndclose"), {
+            type: 'warning',
+            distinguishCancelAndClose: true
+          })
+          if (confirm !== 'confirm') return
+          // 清除绑定关系
+          let obj = {}
+          if (!this.QuestionsForm.RowId) {
+            obj.markTableQuestions = this.markTableQuestions
+            obj.questionId = this.question.Id
+            this.$emit('unBindAnnotationToQuestion', obj)
+          }
+
+          return this.addOrEdit.visible = false
+        }
+        // 标记未保存无法关闭？ 
+        return this.$alert(this.$t('dicom3D:CustomizeQuestionFormItem:alert:markNoSaveNoclose'))
 
-        this.addOrEdit.visible = false
       } else {
         this.addOrEdit.visible = false
       }
@@ -1185,21 +1193,25 @@ export default {
           }
         }
         if (isExistUnSaved) {
-          //标记未保存是否确认关闭？ 
-          const confirm = await this.$confirm(this.$t("dicom3D:CustomizeQuestionFormItem:confirm:markNoSaveAndclose"), {
-            type: 'warning',
-            distinguishCancelAndClose: true
-          })
-          if (confirm !== 'confirm') return
-          // 清除绑定关系
-          let obj = {}
-          if (!this.QuestionsForm.RowId) {
-            obj.markTableQuestions = this.markTableQuestions
-            obj.questionId = this.question.Id
-            this.$emit('unBindAnnotationToQuestion', obj)
-          }
+          if (this.addOrEdit.type = 'add') {
+            //标记未保存是否确认关闭？ 
+            const confirm = await this.$confirm(this.$t("dicom3D:CustomizeQuestionFormItem:confirm:markNoSaveAndclose"), {
+              type: 'warning',
+              distinguishCancelAndClose: true
+            })
+            if (confirm !== 'confirm') return
+            // 清除绑定关系
+            let obj = {}
+            if (!this.QuestionsForm.RowId) {
+              obj.markTableQuestions = this.markTableQuestions
+              obj.questionId = this.question.Id
+              this.$emit('unBindAnnotationToQuestion', obj)
+            }
 
-          done()
+            return done()
+          }
+          // 标记未保存无法关闭？ 
+          return this.$alert(this.$t('dicom3D:CustomizeQuestionFormItem:alert:markNoSaveNoclose'))
           // this.$alert('存在标记信息未保存！')
         } else {
           done()
diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue
index f4d62d6f..051eb25c 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/customize/QuestionList.vue
@@ -922,13 +922,15 @@ export default {
         return
       }
       this.questionMarkInfoList = questionMarkInfoList.filter(item => {
-        const { TableQuestionId, QuestionId } = item || {}
-        if ((TableQuestionId && QuestionId === questionId && markTableQuestions.includes(TableQuestionId))) {
+        const { TableQuestionId, QuestionId, RowId } = item || {}
+        if ((TableQuestionId && QuestionId === questionId && markTableQuestions.includes(TableQuestionId)) && !RowId) {
           if (questionsMarkStatus && questionsMarkStatus[TableQuestionId]) {
             delete questionsMarkStatus[TableQuestionId]
+          }else {
+            return item
           }
         } else {
-          return
+          return item
         }
       })
     },