diff --git a/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue b/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
index c3b4d767..31cb75b7 100644
--- a/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
+++ b/src/views/trials/trials-panel/reading/dicoms3D/components/ReadPage.vue
@@ -708,7 +708,8 @@ export default {
       studyList: [],
       volumeData: {},
       fusionSerieId: {},
-      loadingText: null
+      loadingText: null,
+      resetAnnotation: false , // 是否初始化标记 （融合时使用）
     }
   },
   computed: {
@@ -1471,6 +1472,7 @@ export default {
     async customAnnotationRemovedListener(e) {
       const { annotation } = e.detail
       try{
+        if ( this.resetAnnotation && this.isFusion ) return false
         if (!annotation) return false
         if (this.readingTaskState === 2) throw 'annotation Not allowed to operate'
         if (annotation.visitTaskId === this.taskInfo.VisitTaskId && annotation.seriesId) {
@@ -2733,6 +2735,9 @@ export default {
         let { ct, pt } = data
         this.loading = true
         this.loadingText = this.$t('trials:lugano:message:loadVolumes')
+        this.resetAnnotation = true
+        cornerstoneTools.annotation.state.removeAllAnnotations()
+        this.renderedTaskIds = []
         if ( this.verifyFusionData(ct, pt) ) {
           this.loading = false
           this.loadingText = null
@@ -2740,6 +2745,7 @@ export default {
           this.$refs[`viewport-1`][0].setSeriesInfo(pt)
           this.$refs[`viewport-2`][0].setSeriesInfo(pt)
           this.$refs[`viewport-3`][0].setSeriesInfo(pt)
+          this.resetAnnotation = false
           return true
         }
         if (!this.fusionSerieId.ct || this.fusionSerieId.ct !== ct.SeriesInstanceUid ) {
@@ -2779,6 +2785,7 @@ export default {
         this.$refs[`viewport-fusion-1`][0].setSeriesInfo(ptData, { colorMap: true})
         this.$refs[`viewport-fusion-2`][0].setSeriesInfo(fusionData, { isFusion: true, colorMap: true })
         this.$refs[`viewport-fusion-3`][0].setSeriesInfo(ptData, { isMip: true, colorMap: true })
+        this.resetAnnotation = false
         this.$nextTick(() => {
           this.$refs[`colorMap`].init()
         })