diff --git a/src/views/trials/trials-panel/visit/crc-upload/components/uploadDicomFiles2.vue b/src/views/trials/trials-panel/visit/crc-upload/components/uploadDicomFiles2.vue
index 7199264d..b170469b 100644
--- a/src/views/trials/trials-panel/visit/crc-upload/components/uploadDicomFiles2.vue
+++ b/src/views/trials/trials-panel/visit/crc-upload/components/uploadDicomFiles2.vue
@@ -132,10 +132,11 @@
       <el-divider content-position="left">{{ $t('trials:uploadedDicoms:title:dicomFilesOnly') }}</el-divider>
       <div class="form-group">
         <div id="directoryInputWrapper" class="btn btn-link file-input">
-          <el-button type="primary" :loading="btnLoading" size="small">{{ $t('trials:uploadedDicomsicom:button:selectFolder') }}</el-button>
+          <el-button type="primary" :disabled="btnLoading" :loading="btnLoading" size="small">{{ $t('trials:uploadedDicomsicom:button:selectFolder') }}</el-button>
           <input
             type="file"
             name="file"
+            :disabled="btnLoading"
             webkitdirectory
             multiple
             @change="beginScanFiles($event)"
@@ -1240,7 +1241,7 @@ export default {
     },
     // 根据是否上传状态决定CheckBox 是否可以勾选
     handleSelectable(row) {
-      if (row.uploadState.selected) {
+      if (row.uploadState.selected || this.btnLoading) {
         return false
       } else {
         return true